Cited by 1,240Gastrointestinal motility and disordersAnalytical Chemistry and SensorsGastroesophageal reflux and treatments

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Measurement of gastrointestinal pH profiles in normal ambulant human subjects

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Evans, D F, Pye, G, Bramley, R, Clark, A G, Dyson, T J, Hardcastle, J D·1988·Gut

DOI 10.1136/gut.29.8.1035PMC PMC1433896

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Abstract

Gastrointestinal (GI) pH has been measured in 66 normal subjects using a pH sensitive radiotelemetry capsule passing freely through the gastrointestinal tract. Signals were recorded with a portable solid state receiver and recording system, enabling unconstrained measurements with normal ambulatory activities for up to 48 h during normal GI transit. Capsule position in the gut was monitored by surface location using a directional detector. Gastric pH was highly acidic (range 1.0-2.5) in all subjects. The mean pH in the proximal small intestine was 6.6 (0.5) for the first hour of intestinal recording. By comparison the mean pH in the terminal ileum was 7.5 (0.4) (p less than 0.001). In all subjects there was a sharp fall in pH to a mean of 6.4 (0.4) (p less than 0.001) as the capsule passed into the caecum. Values are means (SD). pH then rose progressively from the right to the left colon with a final mean value of 7.0 (0.7) (p less than 0.001).

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Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2
Narisawa, T., Magadia, N. E., Weisburger, J. H., & Wynder, E. L. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.4.1093 · Cited by 704
A Handbook on Biotelemetry and Radio Tracking
(1980) · Elsevier eBooks · doi:10.1016/c2013-0-05926-9 · Cited by 540
Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats.
Reddy, B. S., Watanabe, K., Weisburger, J. H., & Wynder, E. L. (1977) · PubMed · Cited by 438
The geographical distribution of cancer.
Doll, R. (1969) · British Journal of Cancer · doi:10.1038/bjc.1969.1 · Cited by 251
Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device
Bown, R. L., Gibson, J., Sladen, G. E., Hicks, B. D., & Dawson, A. M. (1974) · Gut · doi:10.1136/gut.15.12.999 · Cited by 232
HIGH COLONIC pH PROMOTES COLORECTAL CANCER
THORNTON, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92244-3 · Cited by 220
The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet)
Davis, S. S., Hardy, J. G., Taylor, M. J., WHALLEY, D. R., & WILSON, C. G. (1984) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(84)90191-1 · Cited by 132
pH profile of gut as measured by radiotelemetry capsule.
Watson, B. W., Meldrum, S. J., Riddle, H. C., Brown, R. L., & Sladen, G. E. (1972) · BMJ · doi:10.1136/bmj.2.5805.104 · Cited by 111
Colonic release of 5‐amino salicylic acid from an oral preparation in active ulcerative colitis.
Dew, M. J., Ryder, R. E. J., Evans, N., Evans, B. K., & Rhodes, J. (1983) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1983.tb04983.x · Cited by 111
Ambulatory monitoring of oesophageal pH in reflux oesophagitis using a portable radiotelemetry system.
Branicki, F. J., Evans, D. F., Ogilvie, A. L., Atkinson, M. A., & Hardcastle, J. D. (1982) · Gut · doi:10.1136/gut.23.11.992 · Cited by 107
Self-citation

Flagged first, then by citations

Show all 23 references

Research works printed but not linked: 8

Pietrousti A, Caprilli R, Guilano M, Serrano S, Vita S. Faecal pH in co!orectal cancer. ItalJ Gastroenterol 1985; 17: 88-91.
Evans DF, Jones JA, Hardcastle JD. Ambulatory monitoring of gastrointestinal pH in man using a radiotelemetry capsule and a new solid state recorder. J Physiol 1985; 74: 4P.
Ford PH, Pike GH. Decce series 4 user guide. Nottingham: Nottingham University Press, 1986.
Da Cruz F. Kermit -A file transfer profile. Digital Press, 1984.
Walker ARP, Walker BF, Segal I. Faecal pH value and its modification in S. African black and white schoolchildren. S Afr Med J 1979; 55: 495-8.
Stower MJ, Hardcastle JD. Five year survival of 1,115 patients with colorectal cancer. J Clin Oncol 1985; 11: 119-23.
Evans DF, Pye G, Bramley RB, Dyson TJ, Balfour TW, Hardcastle JD. Is colonic pH important in colorectal cancer? [Abstract]. Gut 1986; 27: A1257.
Pye G, Crompton J, Evans DF, Clark AG, Hardcastle JD. The effect of dietary fibre supplementation on colonic pH in healthy volunteers. [Abstract] Gut 1987; 28: A 1366.

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Zhang, T., Tang, J. Z., Fei, X., Li, Y., Song, Y., Qian, Z., & Peng, Q. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.08.016 · Cited by 53
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Mahmud, N., O’Toole, D., O'Hare, N. J., FREYNE, P. J., Weir, D. G., & Kelleher, D. P. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01155.x · Cited by 52
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Waligora‐Dupriet, A., Barc, M. C., Bourlioux, P., Collignon, A., & Karjalainen, T. K. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.9.4234-4238.1999 · Cited by 52
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Edwards, R. A., & Schifferli, D. M. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.5161875.x · Cited by 52
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Nunes, R., Sarmento, B. F. C. C., & das Neves, J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.09.013 · Cited by 51
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Semdé, R., Pierre, D., Geuskens, G., Devleeschouwer, M. J., & Moes, A. J. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00327-x · Cited by 50
Fabrication and in vivo evaluation of highly pH-responsive acrylic microparticles for targeted gastrointestinal delivery
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Reese, M. J., Bowers, G. D., Humphreys, J. E., Gould, E. P., Ford, S. L., Webster, L. O., & Polli, J. W. (2015) · Xenobiotica · doi:10.3109/00498254.2015.1081993 · Cited by 51
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Authors: Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D.
Affiliations: Queen's Medical Centre (GB)
Venue: Gut
Publisher: BMJ
Published: 1988-08
Volume: 29
Issue: 8
Pages: 1035-1041
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.29.8.1035
PMC: PMC1433896
OpenAlex: W2089407496
Cited by: 1,240
References: 23
Citations by year: 2026: 38 · 2025: 74 · 2024: 52 · 2023: 67 · 2022: 70 · 2021: 84 · 2020: 67 · 2019: 58 · 2018: 47 · 2017: 55 · 2016: 49 · 2015: 59 · 2014: 67 · 2013: 43 · 2012: 56
FWCI: 7.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords: gastrointestinal pH, gastric pH, terminal ileum, cecum, colon, ambulatory pH monitoring, gastrointestinal transit, normal subjects
MeSH terms: Adult, Aged, Aged, 80 and over, Female, Gastrointestinal Contents, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Reference Values

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Measurement of gastrointestinal pH profiles in normal ambulant human subjects

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