Cited by 1,240Gastrointestinal motility and disordersAnalytical Chemistry and SensorsGastroesophageal reflux and treatments

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Measurement of gastrointestinal pH profiles in normal ambulant human subjects

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Evans, D F, Pye, G, Bramley, R, Clark, A G, Dyson, T J, Hardcastle, J D·1988·Gut

DOI 10.1136/gut.29.8.1035PMC PMC1433896

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Abstract

Gastrointestinal (GI) pH has been measured in 66 normal subjects using a pH sensitive radiotelemetry capsule passing freely through the gastrointestinal tract. Signals were recorded with a portable solid state receiver and recording system, enabling unconstrained measurements with normal ambulatory activities for up to 48 h during normal GI transit. Capsule position in the gut was monitored by surface location using a directional detector. Gastric pH was highly acidic (range 1.0-2.5) in all subjects. The mean pH in the proximal small intestine was 6.6 (0.5) for the first hour of intestinal recording. By comparison the mean pH in the terminal ileum was 7.5 (0.4) (p less than 0.001). In all subjects there was a sharp fall in pH to a mean of 6.4 (0.4) (p less than 0.001) as the capsule passed into the caecum. Values are means (SD). pH then rose progressively from the right to the left colon with a final mean value of 7.0 (0.7) (p less than 0.001).

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Authors: Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D.
Affiliations: Queen's Medical Centre (GB)
Venue: Gut
Publisher: BMJ
Published: 1988-08
Volume: 29
Issue: 8
Pages: 1035-1041
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.29.8.1035
PMC: PMC1433896
OpenAlex: W2089407496
Cited by: 1,240
References: 23
Citations by year: 2026: 38 · 2025: 74 · 2024: 52 · 2023: 67 · 2022: 70 · 2021: 84 · 2020: 67 · 2019: 58 · 2018: 47 · 2017: 55 · 2016: 49 · 2015: 59 · 2014: 67 · 2013: 43 · 2012: 56
FWCI: 7.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords: gastrointestinal pH, gastric pH, terminal ileum, cecum, colon, ambulatory pH monitoring, gastrointestinal transit, normal subjects
MeSH terms: Adult, Aged, Aged, 80 and over, Female, Gastrointestinal Contents, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Reference Values

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Measurement of gastrointestinal pH profiles in normal ambulant human subjects

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