Measurement of gastrointestinal pH profiles in normal ambulant human subjects

Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2

Narisawa, T., Magadia, N. E., Weisburger, J. H., & Wynder, E. L. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.4.1093 · Cited by 704

A Handbook on Biotelemetry and Radio Tracking

(1980) · Elsevier eBooks · doi:10.1016/c2013-0-05926-9 · Cited by 540

Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats.

Reddy, B. S., Watanabe, K., Weisburger, J. H., & Wynder, E. L. (1977) · PubMed · Cited by 438

The geographical distribution of cancer.

Doll, R. (1969) · British Journal of Cancer · doi:10.1038/bjc.1969.1 · Cited by 251

Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device

Bown, R. L., Gibson, J., Sladen, G. E., Hicks, B. D., & Dawson, A. M. (1974) · Gut · doi:10.1136/gut.15.12.999 · Cited by 232

HIGH COLONIC pH PROMOTES COLORECTAL CANCER

THORNTON, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92244-3 · Cited by 220

The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet)

Davis, S. S., Hardy, J. G., Taylor, M. J., WHALLEY, D. R., & WILSON, C. G. (1984) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(84)90191-1 · Cited by 132

pH profile of gut as measured by radiotelemetry capsule.

Watson, B. W., Meldrum, S. J., Riddle, H. C., Brown, R. L., & Sladen, G. E. (1972) · BMJ · doi:10.1136/bmj.2.5805.104 · Cited by 111

Colonic release of 5‐amino salicylic acid from an oral preparation in active ulcerative colitis.

Dew, M. J., Ryder, R. E. J., Evans, N., Evans, B. K., & Rhodes, J. (1983) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1983.tb04983.x · Cited by 111

Ambulatory monitoring of oesophageal pH in reflux oesophagitis using a portable radiotelemetry system.

Branicki, F. J., Evans, D. F., Ogilvie, A. L., Atkinson, M. A., & Hardcastle, J. D. (1982) · Gut · doi:10.1136/gut.23.11.992 · Cited by 107

Lanthanum Carbonate Inhibits Intestinal Oxalate Absorption and Prevents Nephrocalcinosis After Oxalate Loading in Rats

Robijn, S., Vervaet, B. A., Höppe, B., D’Haese, P. C., & Verhulst, A. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.12.004 · Cited by 23

COLON TARGETED DRUG DELIVERY SYSTEM: A REVIEW

Sunil, P., Prakash, J., & Megha, K. (2013) · Cited by 23

Gated Mesoporous Silica Nanocarriers for a “Two-Step” Targeted System to Colonic Tissue

González‐Álvarez, M., Coll, C., González‐Álvarez, I., Giménez, C., Aznar, E., Martínez‐Bisbal, M. C., Lozoya-Agulló, I., Bermejo, M., Martínez‐Máñez, R., & Sancenón, F. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00565 · Cited by 23

Physicochemical interactions with (−)-epigallocatechin-3-gallate drive structural modification of celiac-associated peptide α 2 -gliadin (57–89) at physiological conditions

Buiten, C. B. V., Yennawar, N. H., Pacheco, C., Hatzakis, E., & Elias, R. J. (2019) · Food & Function · doi:10.1039/c9fo00553f · Cited by 23

Meat subtypes and colorectal cancer risk: A pooled analysis of 6 cohort studies in Japan

Islam, Z., Akter, S., Kashino, I., Mizoue, T., Sawada, N., Mori, N., Yamagiwa, Y., Tsugane, S., Naito, M., Tamakoshi, A., et al. (2019) · Cancer Science · doi:10.1111/cas.14188 · Cited by 23

Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats

Yokooji, T., Mori, N., & Murakami, T. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.07.0010 · Cited by 23

Feasibility of Capsule Endoscopy for Direct Imaging of Drug Delivery Systems in the Fasted Upper-Gastrointestinal Tract

Pedersen, P. B., Bar‐Shalom, D., Baldursdóttir, S., Vilmann, P., & Müllertz, A. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1306-6 · Cited by 23

Biofilm Formation and Virulence of Shigella flexneri Are Modulated by pH of Gastrointestinal Tract

Chiang, I.-L., Wang, Y., Fujii, S., Muegge, B. D., Lu, Q., Tarr, P. I., & Stappenbeck, T. S. (2021) · Infection and Immunity · doi:10.1128/iai.00387-21 · Cited by 22

Predicting the oral uptake efficiency of chemicals in mammals: Combining the hydrophilic and lipophilic range

O’Connor, I. A., Huijbregts, M. A. J., Ragas, A. M. J., & Hendriks, A. J. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.10.015 · Cited by 22

Assessment of Lumiracoxib Bioavailability from Targeted Sites in the Human Intestine Using Remotely Activated Capsules and Gamma Scintigraphy

Wilding, I. R., Connor, A. L., Carpenter, P., Rordorf, C. M., Branson, J., Milosavljev, S., & Scott, G. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000019297.07378.bd · Cited by 22

Continuous Intestinal Absorption Model Based on the Convection–Diffusion Equation

Nagar, S., Korzekwa, R. C., & Korzekwa, K. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00286 · Cited by 22

Metamorphic biomaterials

Cardoso, V. F., Ribeiro, C., & Lanceros-Méndez, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100741-9.00003-6 · Cited by 23

Dissolution Kinetics of Nifedipine—Ionizable Polymer Amorphous Solid Dispersion: Comparison Between Bicarbonate and Phosphate Buffers

Sakamoto, A., & Sugano, K. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03153-2 · Cited by 22

pH responsive cationic guar gum-borate self-healing hydrogels for muco-adhesion

Madhavikutty, A. S., Chandel, A. K. S., Tsai, C.-C., Inagaki, N. F., Ohta, S., & Ito, T. (2023) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2023.2175586 · Cited by 22

Radiation synthesis of poly(ethylene glycol)/acrylic acid hydrogel as carrier for site specific drug delivery

Ali, A. E., & Hegazy, E. A. (2006) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30650 · Cited by 22

Nitazoxanide: In vitro and in vivo drug effects against Trichuris muris and Ancylostoma ceylanicum, alone or in combination

Tritten, L., Silbereisen, A., & Keiser, J. (2012) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2012.02.004 · Cited by 22

Oral Nano-Insulin Therapy: Current Progress on Nanoparticle-Based Devices for Intestinal Epithelium-Targeted Insulin Delivery

Othman, A. A. I. (2011) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.s4-007 · Cited by 22

Dynamic release of riboflavin from a starch-based semi IPN via partial enzymatic degradation: part II

Bajpai, S. K., & Saxena, S. (2004) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2004.04.004 · Cited by 22

Thermo- and pH-responsive gels for application in colon delivery systems

Yoshida, M., Asano, M., Suwa, T., & Katakai, R. (1999) · Radiation Physics and Chemistry · doi:10.1016/s0969-806x(99)00210-8 · Cited by 22

Human secretory and serum antibodies recognize environmentally induced antigens of Giardia lamblia

Reiner, D. S., & Gillin, F. D. (1992) · Infection and Immunity · doi:10.1128/iai.60.2.637-643.1992 · Cited by 22

Sol-moiety: Discovery of a water-soluble prodrug technology for enhanced oral bioavailability of insoluble therapeutics

Karbasi, A. B., Barfuss, J. D., Morgan, T. C., Collins, D., Costenbader, D. A., Dennis, D. G., Hinman, A., Ko, K., Messina, C., Nguyen, K. C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52793-6 · Cited by 21

Mimicking prophage induction in the body: induction in the lab with pH gradients

Miller-Ensminger, T., Garretto, A., Stark, N., & Putonti, C. (2020) · PeerJ · doi:10.7717/peerj.9718 · Cited by 21

Drug‐Loaded Mucoadhesive Patch with Active Delivery and Controlled Releasing Ability

Lee, J., Kim, D., Bang, S., & Park, S. (2022) · Advanced Intelligent Systems · doi:10.1002/aisy.202100203 · Cited by 21

Randomly barcoded transposon mutant libraries for gut commensals II: Applying libraries for functional genetics

Voogdt, C. G. P., Tripathi, S. M., Bassler, S. O., McKeithen-Mead, S. A., Guiberson, E. R., Koumoutsi, A., Bravo, A. M., Buie, C., Zimmermann, M., Sonnenburg, J. L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113519 · Cited by 22

Determinants of postprandial flow across the human ileocaecal junction: a combined manometric and scintigraphic study

Dinning, P. G., Szczesniak, M. M., & Cook, I. J. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01145.x · Cited by 21

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Faccia, P. A., Pardini, F. M., & Amalvy, J. I. (2015) · eXPRESS Polymer Letters · doi:10.3144/expresspolymlett.2015.52 · Cited by 21

Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process

Gareb, B., Posthumus, S., Beugeling, M., Koopmans, P., Touw, D. J., Dijkstra, G. D. H., Kosterink, J. G. W., & Frijlink, H. W. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090428 · Cited by 21

Regulating the pH of bicarbonate solutions without purging gases: Application to dissolution testing of enteric coated tablets, pellets and microparticles

Scott, N., Patel, K., Sithole, T., Xenofontos, K., Mohylyuk, V., & Liu, F. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119562 · Cited by 21

Oral colon delivery platform based on a novel combination approach: Design concept and preliminary evaluation

Moutaharrik, S., Maroni, A., Melocchi, A., Zema, L., Foppoli, A., Cerea, M., Palugan, L., Neut, C., Siepmann, F., Siepmann, J., et al. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102919 · Cited by 21

Targeted colonic release formulations of mesalazine – A clinical pharmaco-scintigraphic proof-of-concept study in healthy subjects and patients with mildly active ulcerative colitis

Varum, F., Thorne, H. C., Bravo, R., Gilgen, D., Hartig, C. J., Nicolas, G. P., Wild, D., Liakoni, E., & Haschke, M. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122055 · Cited by 21

Site‐Specific Drug Delivery to the Middle Region of the Small Intestine by Application of Enteric Coating with Hypromellose Acetate Succinate (HPMCAS)

Tanno, F. K., Sakuma, S., Masaoka, Y., Kataoka, M., Kozaki, T., Kamaguchi, R., Ikeda, Y., Kokubo, H., & Yamashita, S. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21172 · Cited by 21

Multiparticulate Chitosan-Dispersed System for Drug Delivery

Shimono, N., Takatori, T., Ueda, M., Mori, M., & Nakamura, Y. (2003) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.51.620 · Cited by 21

A novel pH–enzyme-dependent mesalamine colon-specific delivery system

Cao, Q., Jin, L., Ding, Y., Zhang, Y. X., & Xu, X. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s107283 · Cited by 21

The Molecular Interactions That Influence the Plasticizer Dependent Dissolution of Acrylic Polymer Films

Fadda, H. M., Hernández, M. C., Margetson, D. N., McAllister, S. M., Basit, A. W., Brocchini, S., & Suárez, N. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21292 · Cited by 21

Ionic Strength Dependence of Dissolution for Eudragit S-100 Coated Pellets

Kararli, T. T., Kirchhoff, C. F., & Truelove, J. E. (1995) · Pharmaceutical Research · doi:10.1023/a:1016202814109 · Cited by 21

Implication of distinct proteins in cadmium uptake and transport by intestinal cells HT-29

Lecoeur, S., Huynh-Delerme, C., Blais, A., Duché, A., Tomé, D., & Kolf‐Clauw, M. (2002) · Cell Biology and Toxicology · doi:10.1023/a:1020867707079 · Cited by 21

Bioinspired Smart Nanogels for Rapid Blue Laser‐Activated Hemostasis in Gastrointestinal Bleeding

Dan, R., Huang, Y., Tan, S., Xu, K., Zhang, Y., Luan, Z., Qi, P., Zhang, X., Zhu, D., Zhong, W., et al. (2025) · Advanced Materials · doi:10.1002/adma.202506955 · Cited by 20

Molecular Evaluation of Oral Immunogenicity of Hepatitis B Antigen Delivered by Hydrogel Microparticles

Chen, X. Y., Butt, A. M., & Amin, M. C. I. M. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00483 · Cited by 21

Low-pressure plasma treated polycarbonate and polymethyl methacrylate (PMMA) sheets with different surface patterns to change their surface properties

Gizer, S. G., Bhethanabotla, V. R., Ayyala, R. S., & Şahiner, N. (2023) · Surfaces and Interfaces · doi:10.1016/j.surfin.2023.102646 · Cited by 20

Designing Regenerative Bioadhesives for Tissue Repair and Regeneration

Li, X., Liu, Y., Liu, S., Li‐Jessen, N. Y. K., Haglund, L., Huang, B., & Li, J. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300139 · Cited by 20

Mesoporous silica nanoparticles: An emerging approach in overcoming the challenges with oral delivery of proteins and peptides

Pamshong, S. R., Bhatane, D., Sarnaik, S., & Alexander, A. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113613 · Cited by 20

The influence of the copolymer composition on the diltiazem hydrochloride release from a series of pH-sensitive poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels

Díez-Peña, E., Frutos, P., Frutos, G., Quijada‐Garrido, I., & Barrales‐Rienda, J. M. (2004) · AAPS PharmSciTech · doi:10.1208/pt050233 · Cited by 20

Development of HIV-1 Rectal-Specific Microbicides and Colonic Tissue Evaluation

Dezzutti, C. S., Russo, J., Wang, L. Q., Abebe, K. Z., Li, J., Friend, D. R., McGowan, I., & Rohan, L. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102585 · Cited by 20

Salicylic acid-based pH-sensitive hydrogels as potential oral insulin delivery systems

Demirdirek, B., & Uhrich, K. E. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1073293 · Cited by 20

New Bismuth Germanate Oxide Nanoparticle Material for Biolabel Applications in Medicine

Oviedo, M. J., Contreras, O. E., Rosenstein, Y., Vázquez-Duhalt, R., Macedo, Z. S., Arízaga, G. G. C., & Hirata, G. A. (2016) · Journal of Nanomaterials · doi:10.1155/2016/9782625 · Cited by 20

Understanding the Mechanism of Enzyme-Induced Formation of Lyotropic Liquid Crystalline Nanoparticles

Hong, L., Salentinig, S., Hawley, A. M., & Boyd, B. J. (2015) · Langmuir · doi:10.1021/acs.langmuir.5b01615 · Cited by 20

Nanoparticles assembled via pH-responsive reversible segregation of cyclodextrins in polyrotaxanes

Tardy, B. L., Tan, S. S. L., Dam, H. H., Ejima, H., Blencowe, A., Qiao, G. G., & Caruso, F. (2016) · Nanoscale · doi:10.1039/c6nr04841b · Cited by 20

CRISPR-Cas system presents multiple transcriptional units including antisense RNAs that are expressed in minimal medium and upregulated by pH in Salmonella enterica serovar Typhi

Medina-Aparicio, L., Rebollar-Flores, J. E., America, A. B., Vázquez, A., Gutiérrez-Ríos, R.-M., Olvera, L., Calva, E., & Hernández-Lucas, I. (2016) · Microbiology · doi:10.1099/mic.0.000414 · Cited by 20

Importance of in vitro dissolution conditions for the in vivo predictability of an amorphous solid dispersion containing a pH-sensitive carrier

Wendelboe, J., Knopp, M. M., Khan, F., Chourak, N., Rades, T., & Holm, R. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.08.078 · Cited by 20

The Ethanolamine Permease EutH Promotes Vacuole Adaptation of Salmonella enterica and Listeria monocytogenes during Macrophage Infection

Anderson, C. J., Satkovich, J., Köseoğlu, V. K., Agaisse, H., & Kendall, M. M. (2018) · Infection and Immunity · doi:10.1128/iai.00172-18 · Cited by 20

Fixed Dose Combination Formulations: Multilayered Platforms Designed for the Management of Cardiovascular Disease

Andrews, G. P., Li, S., Almajaan, A., Yu, T., Martini, L. G. A., Healy, A. M., & Jones, D. S. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01068 · Cited by 20

Controlled Release of Glucose from Orally Delivered Temperature- and pH-Responsive Polysaccharide Microparticle Dispersions

Myrick, J. M., Vendra, V. K., Le, N.-T., Sexton, F. A., & Krishnan, S. (2019) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.9b02402 · Cited by 21

Self-Assembled Amphiphilic Starch Based Drug Delivery Platform: Synthesis, Preparation, and Interactions with Biological Barriers

Phan, V. H. G., Duong, H. T. T., Tran, P., Thambi, T., Ho, D., & Murgia, X. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c01430 · Cited by 20

Practical and operational considerations related to paediatric oral drug formulation: An industry survey

der Veken, M. V., Brouwers, J., Budts, V., Lauwerys, L., Pathak, S. M., Batchelor, H. K., & Augustijns, P. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121670 · Cited by 20

Differential Effects of Mucosal pH on Human (Caco-2) Intestinal Epithelial Cell Motility, Proliferation, and Differentiation

Perdikis, D. A., Davies, R., Zhuravkov, A., Brenner, B. M., Etter, L., & Basson, M. D. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018871016691 · Cited by 20

Development of a multiple unit drug delivery system for positioned release in the gastrointestinal tract

Klokkers-Bethke, K., & Fischer, W. (1991) · Journal of Controlled Release · doi:10.1016/0168-3659(91)90068-o · Cited by 20

Swelling and drug release profile of poly(2‐ethyl‐2‐oxazoline)‐based hydrogels prepared by gamma radiation‐induced copolymerization

Ali, A. E., & AlArifi, A. S. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.33480 · Cited by 20

A Base-Triggerable Catanionic Mixed Lipid System: Isothermal Titration Calorimetric and Single-Crystal X-ray Diffraction Studies

Tarafdar, P. K., Reddy, S. T., & Swamy, M. J. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp104841k · Cited by 20

An oral delivery vehicle based on konjac glucomannan acetate targeting the colon for inflammatory bowel disease therapy

Wang, C., Guo, Z., Liang, J., Li, N., Song, R., Luo, L., Ai, Y., Li, X., & Tang, S. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1025155 · Cited by 19

Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus

Zou, A. J., Kinch, L. N., Chimalapati, S., Garcia, N., Tomchick, D. R., & Orth, K. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104591 · Cited by 19

Structure and Function of Hoc—A Novel Environment Sensing Device Encoded by T4 and Other Bacteriophages

Fokine, A., Islam, M. Z., Fang, Q., Chen, Z., Sun, L., & Rao, V. B. (2023) · Viruses · doi:10.3390/v15071517 · Cited by 19

Process analysis of the anaerobe Phocaeicola vulgatus in a shake flasks and fermenter reveals pH and product inhibition

Keitel, L., Miebach, K., Rummel, L., Yordanov, S., & Büchs, J. (2024) · Annals of Microbiology · doi:10.1186/s13213-023-01745-4 · Cited by 23

Mechanism of 2′-fucosyllactose degradation by human-associated Akkermansia

Padilla, L., Fricker, A. D., Luna, E., Choudhury, B., Hughes, E. R., Panzetta, M. E., Valdivia, R. H., & Flores, G. E. (2024) · Journal of Bacteriology · doi:10.1128/jb.00334-23 · Cited by 19

Drug Crystal Precipitation in Biorelevant Bicarbonate Buffer: A Well-Controlled Comparative Study with Phosphate Buffer

Yamamoto, H., & Sugano, K. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c00028 · Cited by 19

Short communication: A sensitive method for qualitative screening of bile salt hydrolase-active lactobacilli based on thin-layer chromatography

Guo, C. F., Zhang, L., Han, X., Li, J. Y., Du, M., Yi, H., Feng, Z., Zhang, Y. C., & Xu, X. R. (2011) · Journal of Dairy Science · doi:10.3168/jds.2010-3801 · Cited by 19

A Semi-mechanistic Modeling Strategy to Link In Vitro and In Vivo Drug Release for Modified Release Formulations

Bergstrand, M., Söderlind, E., Eriksson, U. G., Weitschies, W., & Karlsson, M. O. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0594-3 · Cited by 19

Changes of sodium nitrate, nitrite, and N-nitrosodiethylamine during in vitro human digestion

Kim, H. S., & Hur, S. J. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.01.036 · Cited by 19

Celiac disease: from etiological factors to evolving diagnostic approaches

Kaur, A., Shimoni, O., & Wallach, M. G. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-017-1357-7 · Cited by 20

In vivo evaluation of pH and time-dependent polymers as coating agent for colonic delivery using central composite design

Moghimipour, E., Dorkoosh, F. A., Rezaei, M., Kouchak, M., Fatahiasl, J., Angali, K. A., Ramezani, Z., Amini, M., & Handali, S. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.09.010 · Cited by 19

Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation

von Volkmann, H. L., Brønstad, I., Gilja, O. H., Tronstad, R. R., Sangnes, D. A., Nortvedt, R., Hausken, T., Dimcevski, G., Fiskerstrand, T., & Nylund, K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185496 · Cited by 19

α-Synuclein Penetrates Mucin Hydrogels Despite Its Mucoadhesive Properties

Marczynski, M., Rickert, C. A., Semerdzhiev, S. A., van Dijk, W. R., Segers‐Nolten, I. M. J., Claessens, M. M. A. E., & Lieleg, O. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00905 · Cited by 19

Characterization of different shellac types and development of shellac coated dosage forms

Farag, Y. (2010) · Cited by 19

Predictable pulsatile release of tramadol hydrochloride for chronotherapeutics of arthritis

Dabhi, C. S., Randale, S. A., Belgamwar, V. S., Gattani, S. G., & Tekade, A. R. (2010) · Drug Delivery · doi:10.3109/10717541003706240 · Cited by 19

Development of a novel tablet-in-capsule formulation of mesalamine for inflammatory bowel disease

Patel, M. M., & Amin, A. F. (2012) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2011.653819 · Cited by 19

“Triple Phase” Budesonide Capsules for the Treatment of Olmesartan-Induced Enteropathy

Hartranft, M. E., & Regal, R. E. (2014) · Annals of Pharmacotherapy · doi:10.1177/1060028014540608 · Cited by 19

Formulation and Evaluation of pH-Responsive Mini-Tablets for Ileo-Colonic Targeted Drug Delivery

Hadi, M., Rao, N., & Rao, A. (2014) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v13i7.3 · Cited by 19

A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine

Miller, D. S., Parsons, A. M., Bresland, J., Herde, P., Pham, D. M., Tan, A., Hsu, H.-Y., Prestidge, C. A., Kuchel, T. R., Begg, R. K., et al. (2015) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400290 · Cited by 19

Liberação específica de fármacos para administração no cólon por via oral. I - O cólon como local de liberação de fármacos

Freire, A. C., Podczeck, F., Sousa, J., & Veiga, F. (2006) · Revista Brasileira De Ciencias Farmaceuticas · doi:10.1590/s1516-93322006000300003 · Cited by 19

Coordination Compounds As Multi-Delivery Systems for Osteoporosis

Barbosa, J. S., Pinto, M., Barreiro, S., Fernandes, C., Mendes, R. F., Lavrador, P., Gaspar, V. M., Mano, J. F., Borges, F., Remião, F., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c09121 · Cited by 18

Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study

Kowalska, G., Rosicka‐Kaczmarek, J., Miśkiewicz, K., Zakłos‐Szyda, M., Rohn, S., Kanzler, C., Wiktorska, M., & Niewiarowska, J. (2022) · Nutrients · doi:10.3390/nu14122529 · Cited by 20

Improving in vitro simulation of the stomach and intestines

Venema, K., Havenaar, R., & Minekus, M. (2009) · Elsevier eBooks · doi:10.1533/9781845696603.2.314 · Cited by 18

Photophysics of Silicon Phthalocyanines in Aqueous Media

Doane, T. L., Chuang, C.-H., Chomas, A., & Burda, C. (2013) · ChemPhysChem · doi:10.1002/cphc.201200962 · Cited by 18

Nanosystem Formulations for Rectal Microbicides: a Call for More Research

Sarmento, B. F. C. C., & das Neves, J. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.139 · Cited by 18

Multiparticulate approach: an emerging trend in colon specific drug delivery for Chronotherapy

Patel, P. B., Rao, L. B., & Dhake, A. S. (2011) · Cited by 18

Plant-expressed Hepatitis B core antigen virus-like particles: Characterization and investigation of their stability in simulated and pig gastro-intestinal fluids

Berardi, A., Lomonossoff, G. P., Evans, D. J., & Barker, S. A. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.03.001 · Cited by 18

Inositol phosphates: health implications, methods of analysis, and occurrence in plant foods

Duong, Q. H., Lapsley, K. G., & Pegg, R. B. (2018) · Journal of Food Bioactives · doi:10.31665/jfb.2018.1126 · Cited by 18

Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study

Schumacher, S. P., Schurgers, L. J., Vervloet, M. G., & Neradová, A. (2018) · Nephrology · doi:10.1111/nep.13245 · Cited by 18

A Brief Overview of the Oral Delivery of Insulin as an Alternative to the Parenteral Delivery

Macedo, A. S., Filipe, P. A., Thomé, N. G., Vieira, J., Oliveira, C., Teodósio, C., Ferreira, R. S., Roque, L., & Fonte, P. (2020) · Current Molecular Medicine · doi:10.2174/1566524019666191010095522 · Cited by 18

Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Suparmi, S., Wesseling, S., & Rietjens, I. M. C. M. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02798-z · Cited by 18

Assimilation of Cholesterol by Monascus purpureus

Nguyen, T. P. T., Garrahan, M. A., Nance, S. A., Seeger, C. E., & Wong, C. (2020) · Journal of Fungi · doi:10.3390/jof6040352 · Cited by 19

Niclosamide-Exfoliated Anionic Clay Nanohybrid Repurposed as an Antiviral Drug for Tackling Covid-19; Oral Formulation with Tween 60/Eudragit S100

Rejinold, N. S., Piao, H., Choi, G., Jin, G., & Choy, J. (2021) · Clays and Clay Minerals · doi:10.1007/s42860-021-00153-6 · Cited by 18

Development of a pressure-sensitive glyceryl tristearate capsule filled with a drug-containing hydrogel

Wilde, L., Bock, M., Glöckl, G., Garbacz, G., & Weitschies, W. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.062 · Cited by 18

pH-responsive dual pulse multiparticulate dosage form for treatment of rheumatoid arthritis

Lotlikar, V., Kedar, U., Shidhaye, S. S., & Kadam, V. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639041003786185 · Cited by 18

Nonredundant Roles of Iron Acquisition Systems in Vibrio cholerae

Peng, E. D., Wyckoff, E. E., Mey, A. R., Fisher, C. R., & Payne, S. M. (2015) · Infection and Immunity · doi:10.1128/iai.01301-15 · Cited by 18

The use of a pH-dependent and Non pH-dependent Natural Hydrophobic Biopolymer (Landolphia owariensis latex) as Capsule Coating Agents in in vitro Controlled Release of Metronidazole for Possible Colon Targeted Delivery

Obitte, N. C., Chukwu, A., & Onyishi, I. V. (2010) · International journal of applied research in natural products · Cited by 18

Effect of olsalazine and mesalazine on human ileal and colonic (Na+ + K+)-ATPase

Scheurlen, C., Allgayer, H., Kruis, W., Erdmann, E., & Sauerbruch, T. (1993) · Journal of Molecular Medicine · doi:10.1007/bf00184728 · Cited by 18

Theophylline-Controlled Release Preparations and Fatty Food: An in Vitro Study Using the Rotating Dialysis Cell Method

El-Arini, S. K., Shiu, G. K., & Skelly, J. P. (1990) · Pharmaceutical Research · doi:10.1023/a:1015976108251 · Cited by 18

Factors Affecting Cellular Uptake of Anthocyanins: The Role of pH, Glucose and Anthocyanin Structure

Cahyana, Y., Mills, C. E., Huda, S., & Gordon, M. H. (2022) · Nutrients · doi:10.3390/nu14224807 · Cited by 17

Sequestration of aflatoxin B1 by lactic acid bacteria: Role of binding and biotransformation

Lemmetty, J. M., Lee, Y., Laitila, T., Bredehorst, S., Coda, R., Katina, K., & Maina, N. H. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115351 · Cited by 17

Colon-specific drug delivery using ethylcellulose and chitosan in the coat of compression-coated tablets

Omwancha, W. S., Kouba, C., Yelamanchili, S., & Neau, S. H. (2011) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2010.551773 · Cited by 17

pH‐Profile and regional transit times of the normal gut measured by a radiotelemetry device

Fallingborg, J., Christensen, L. A., Ingeman‐Nielsen, M., Jacobsen, B. A., ABILDGAARD, K., & Rasmussen, H. H. (1989) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1989.tb00254.x · Cited by 243

Intraluminal pH of the human gastrointestinal tract.

Fallingborg, J. (1999) · PubMed · Cited by 630

pH Profile Varies Along the Small Intestine in Healthy Subjects

Lalezari, D., Hwang, L. J., Arabyan, M., & Soffer, E. (2009) · The American Journal of Gastroenterology · doi:10.14309/00000434-200910003-00303

Accurate localization of a fall in pH within the ileocecal region: validation using a dual-scintigraphic technique

Zárate-López, N., Mohammed, S. D., O’Shaughnessy, E., Newell, M., Yazaki, E. T., Williams, N. S., Lunniss, P. J., Semler, J. R., & Scott, S. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00127.2010 · Cited by 75

Comparison of pH and motility of the small intestine of healthy subjects and patients with symptomatic constipation using the wireless motility capsule

Aburub, A., Fischer, M., Camilleri, M., Semler, J. R., & Fadda, H. M. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.04.031 · Cited by 41