The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs
Open accessAbstract
Measurements of luminal pH in the normal gastrointestinal tract have shown a progressive increase in pH from the duodenum to the terminal ileum, a decrease in the caecum, and then a slow rise along the colon to the rectum. Some data in patients with ulcerative colitis suggest a substantial reduction below normal values in the right colon, while limited results in Crohn's disease have been contradictory. Determinants of luminal pH in the colon include mucosal bicarbonate and lactate production, bacterial fermentation of carbohydrates and mucosal absorption of short chain fatty acids, and possibly intestinal transit. Alterations in these factors, as a result of mucosal disease and changes in diet, are likely to explain abnormal pH measurements in inflammatory bowel disease (IBD). It is conceivable that reduced intracolonic pH in active ulcerative colitis impairs bioavailability of 5-aminosalicylic acid from pH dependent release formulations (Asacol, Salofalk) and those requiring cleavage by bacterial azo reductase (sulphasalazine, olsalazine, balsalazide), but further pharmacokinetic studies are needed to confirm this possibility. Reports that balsalazide and olsalazine may be more efficacious in active and quiescent ulcerative colitis, respectively, than Asacol suggest that low pH may be a more critical factor in patients taking directly pH dependent release than azo bonded preparations. Reduced intracolonic pH also needs to be considered in the development of pH dependent colonic release formulations of budesonide and azathioprine for use in ulcerative and Crohn's colitis. This paper reviews methods for measuring gut pH, its changes in IBD, and how these may influence current and future therapies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Measurement of gastrointestinal pH profiles in normal ambulant human subjects
Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D. (1988) · Gut · doi:10.1136/gut.29.8.1035 · Cited by 1,240
Self-citationStudies on the mechanism of bowel disturbance in ulcerative colitis
Rao, S. S. C., Read, N. W., Brown, C., Bruce, C., & Holdsworth, C. D. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90554-3 · Cited by 215
Cited by
Links between diet, gut microbiota composition and gut metabolism
Flint, H. J., Duncan, S. H., Scott, K. P., & Louis, P. (2015) · Proceedings of the Nutrition Society · doi:10.1017/s0029665114001463 · Cited by 1,020
Belenguer, A., Duncan, S. H., Calder, A. G., Holtrop, G., Louis, P., Lobley, G. E., & Flint, H. J. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.5.3593-3599.2006 · Cited by 856
The role of pH in determining the species composition of the human colonic microbiota
Duncan, S. H., Louis, P., Thomson, J. M., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01931.x · Cited by 786
Walker, A. W., Duncan, S. H., McWilliam Leitch, E. C., Child, M. W., & Flint, H. J. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.7.3692-3700.2005 · Cited by 796
Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., Che, T., & Zhang, C. (2019) · Pathogens · doi:10.3390/pathogens8030126 · Cited by 771
Chassaing, B., Van de Wiele, T., De Bodt, J., Marzorati, M., & Gewirtz, A. T. (2017) · Gut · doi:10.1136/gutjnl-2016-313099 · Cited by 590
Physicochemical properties of mucus and their impact on transmucosal drug delivery
Leal, J., Smyth, H. D. C., & Ghosh, D. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.09.018 · Cited by 560
Hua, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00524 · Cited by 527
Hua, S., Marks, E., Schneider, J. J., & Keely, S. (2015) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.02.018 · Cited by 494
Yao, C. K., Muir, J. G., & Gibson, P. R. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13456 · Cited by 441
Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches
Amidon, S., Brown, J. E., & Dave, V. S. (2015) · AAPS PharmSciTech · doi:10.1208/s12249-015-0350-9 · Cited by 423
Recent advances in colon drug delivery systems
Arévalo-Pérez, R., Maderuelo, C., & Lanao, J. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.026 · Cited by 179
Zhang, X., Chen, Y., He, H., Wang, S., Lei, Z., & Zhang, F. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202109728 · Cited by 176
Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease
Xiao, B., & Merlin, D. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.730517 · Cited by 145
Blachier, F., Beaumont, M., Portune, K. J., Steuer, N., Lan, A., Audebert, M., Khodorova, N., Andriamihaja, M., Airinei, G., Benamouzig, R., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.09.016 · Cited by 124
Kagan, L., & Hoffman, A. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.6.681 · Cited by 60
Sharpton, T., Lyalina, S., Luong, J., Pham, J., Deal, E. M., Armour, C., Gaulke, C., Sanjabi, S., & Pollard, K. S. (2017) · mSystems · doi:10.1128/msystems.00036-17 · Cited by 45
Metadata
- Authors
- NUGENT, S. G., KUMAR, D., RAMPTON, D. S., & EVANS, D. F.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2001-04-01
- Volume
- 48
- Issue
- 4
- Pages
- 571-577
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W1981461721
- Cited by
- 700
- References
- 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
