The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms
Open accessAbstract
Objective: The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics. Design: COVID-19 hospital patients were admitted in the Zhejiang province from 17 January 2020 to 8 February 2020. Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. Bioinformatics were used to analyse features of SARS-CoV-2 from Zhejiang province. Results: Among enrolled 651 patients, 74 (11.4%) presented with at least one GI symptom (nausea, vomiting or diarrhoea), average age of 46.14 years, 4-day incubation period and 10.8% had pre-existing liver disease. Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. Low-dose glucocorticoids and antibiotics were administered to 14.86% and 41.89% of patients, respectively. Sputum production and increased lactate dehydrogenase/glucose levels were risk factors for severe/critical type. Bioinformatics showed sequence mutation of SARS-CoV-2 with m 6 A methylation and changed binding capacity with ACE2. Conclusion: We report COVID-19 cases with GI symptoms with novel features outside Wuhan. Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers.
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Cites
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Metadata
- Authors
- Jin, X., Lian, J.-S., Hu, J.-H., Gao, J., Zheng, L., Zhang, Y.-M., Hao, S.-R., Jia, H.-Y., Cai, H., Zhang, X.-L., Yu, G.-D., Xu, K.-J., Wang, X.-Y., Gu, J.-Q., Zhang, S.-Y., Ye, C.-Y., Jin, C.-L., Lu, Y.-F., Yu, X., Yu, X.-P., Huang, J.-R., Xu, K.-L., Ni, Q., Yu, C.-B., Zhu, B., Li, Y.-T., Liu, J., Zhao, H., Zhang, X., Yu, L., Guo, Y.-Z., Su, J.-W., Tao, J.-J., Lang, G.-J., Wu, X.-X., Wu, W.-R., Qv, T.-T., Xiang, D.-R., Yi, P., Shi, D., Chen, Y., Ren, Y., Qiu, Y.-Q., Li, L.-J., Sheng, J., & Yang, Y.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2020-03-24
- Volume
- 69
- Issue
- 6
- Pages
- 1002-1009
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W3013616922
- Cited by
- 1,385
- References
- 10
- FWCI
- 38.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jin, X., Lian, J.-S., Hu, J.-H., Gao, J., Zheng, L., Zhang, Y.-M., Hao, S.-R., Jia, H.-Y., Cai, H., Zhang, X.-L., Yu, G.-D., Xu, K.-J., Wang, X.-Y., Gu, J.-Q., Zhang, S.-Y., Ye, C.-Y., Jin, C.-L., Lu, Y.-F., Yu, X., . . . Yang, Y. (2020). Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. https://doi.org/10.1136/gutjnl-2020-320926
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