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Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease.
Abstract
OBJECTIVE: To determine whether serum concentrations of the cytokines tumour necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6), which regulate C reactive protein, are associated with cardiovascular risk factors and prevalent coronary heart disease. DESIGN: A population based cross sectional study. SUBJECTS AND METHODS: 198 men aged 50 to 69 years were part of a random population sample drawn from south London. Serum cytokine and C reactive protein concentrations were determined by enzyme linked immunosorbent assay. The presence of coronary heart disease was determined by Rose angina questionnaire and Minnesota coded electrocardiogram. RESULTS: Serum TNF alpha concentrations were positively related to body mass index and Helicobacter pylori infection, but inversely related to alcohol consumption. IL-6 concentrations were positively associated with smoking, symptoms of chronic bronchitis, age, and father having a manual occupation. TNF alpha was associated with increased IL-6 and triglycerides, and reduced high density lipoprotein cholesterol. IL-6 was associated with raised fibrinogen, sialic acid, and triglycerides. ECG abnormalities were independently associated with increases in IL-6 and TNF alpha, each by approximately 50% (P < 0.05 for TNF alpha, P < 0.1 for IL-6). The corresponding increases in men with an abnormal ECG or symptomatic coronary heart disease were 28% for TNF alpha and 36% for IL-6 (P = 0.14 for TNF alpha and P < 0.05 for IL-6). CONCLUSIONS: This study confirms that many of the phenomena with which C reactive protein is associated, are also associated with serum levels of cytokine, which may be the mechanism.
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“Thus, the elevated endogenous levels of IL-6 that we and others have observed35,36 may play a role in the increased lung cancer risk to which smokers are prone1.”
From The effect of smoking on chronic inflammation, immune function and blood cell composition (2020) · cites this paper as [36]
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Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Patel, P., Mendall, M. A., Carrington, D., Strachan, D. P., Leatham, E., Molineaux, N., Levy, J., Blakeston, C., Seymour, C. A., Camm, A. J., et al. (1995) · BMJ · doi:10.1136/bmj.311.7007.711 · Cited by 592
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Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
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Ambrose, J. A., & Barua, R. S. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.12.047 · Cited by 2,394
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Second Joint Task Force of European (1998) · European Heart Journal · doi:10.1053/euhj.1998.1243 · Cited by 1,131
Ziccardi, P., Nappo, F., Giugliano, G., Esposito, K., Marfella, R., Cioffi, M., D’Andrea, F., Molinari, A. M., & Giugliano, D. (2002) · Circulation · doi:10.1161/hc0702.104279 · Cited by 994
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Cook, D. G., Mendall, M. A., Whincup, P. H., Carey, I. M., Ballam, L., Morris, J. E., Miller, G. J., & Strachan, D. P. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00312-3 · Cited by 446
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Metadata
- Authors
- Mendall, M. A., Patel, P., Asante, M., Ballam, L., Morris, J., Strachan, D. P., Camm, A. J., & Northfield, T. C.
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1997-09
- Volume
- 78
- Issue
- 3
- Pages
- 273-277
- ISSN
- 1355-6037
- 1468-201X
- Cited by
- 282
- References
- 2
- Language
- en
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