Cited by 49Dementia and Cognitive Impairment ResearchHistorical and Modern Theater StudiesAmyotrophic Lateral Sclerosis Research

Social cognition differentiates behavioral variant frontotemporal dementia from other neurodegenerative diseases and psychiatric disorders

Gossink, Flora, Schouws, Sigfried, Krudop, Welmoed, Scheltens, Philip, Stek, Max, Pijnenburg, Yolande, Dols, Annemiek·2018·The American Journal of Geriatric Psychiatry

Abstract

Objective Although deficits in social cognition are established as core features in behavioral variant frontotemporal dementia (bvFTD), it remains unresolved if impaired social cognition distinguishes bvFTD from the broad differential diagnoses in clinical practice. Our aim was to study whether social cognition discriminates bvFTD from other neurodegenerative diseases and psychiatric disorders in patients presenting with late-onset frontal symptoms. Next, we studied the association of social cognition with frontal symptoms and cognitive functioning. Methods In this longitudinal multicenter study, besides clinical rating scales for frontal symptoms, social cognition was determined by Ekman 60 Faces test and Faux Pas in addition to neuropsychological tests for other cognitive domains in patients with probable and definite bvFTD (N = 22), other neurodegenerative diseases (N = 24), and psychiatric disorders (N = 33). Median symptom duration was 2.8 years, and patients were prospectively followed over 2 years. Results Total scores from Ekman 60 Faces test were significantly lower in bvFTD than in other neurodegenerative diseases and psychiatric disorders. Ekman 60 Faces test explained 91.2% of the variance of psychiatric disorders and other neurodegenerative diseases versus bvFTD (χ 2 = 11.02, df = 1, p = 0.001) and was associated with all other cognitive domains. Faux Pas and the other cognitive domains did not differ between these diagnostic groups. Conclusion In this clinical s…

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Crossref · 10.1016/j.jagp.2017.12.008

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Authors
Gossink, F., Schouws, S., Krudop, W., Scheltens, P., Stek, M., Pijnenburg, Y., & Dols, A.
Affiliations
  • GGZ inGeest (NL)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author
Gossink, Flora
Venue
The American Journal of Geriatric Psychiatry
Publisher
Elsevier BV
Published
2018-05
Volume
26
Issue
5
Pages
569-579
ISSN
1064-7481 (ISSN-L)
OpenAlex
W2787512943
Cited by
49
References
50
Citations by year
2026: 4 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 4 · 2021: 8 · 2020: 8 · 2019: 2 · 2018: 6
FWCI
4.69
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
behavioral variant frontotemporal dementia, social cognition, faux pas, differential diagnosis, neurodegenerative diseases, mental illness, cognitive domain, neuropsychological assessment
MeSH terms
Aged, Mental Disorders, Cognition, Diagnosis, Differential, Female, Humans, Longitudinal Studies, Male, Middle Aged, Netherlands, Neuropsychological Tests, ROC Curve, Social Behavior, Linear Models, Logistic Models, Frontotemporal Dementia

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