Outcomes of adolescent-onset postural orthostatic tachycardia syndrome
Abstract
Objectives To determine the clinical course of adolescent-onset postural orthostatic tachycardia syndrome (POTS) and to assess health-related quality of life, 2-10 years after diagnosis.Study design Pediatric patients, 13-18 years of age, diagnosed with POTS at Mayo Clinic, Rochester, from 2003 to 2010 were mailed a questionnaire if they were at least 18 years of age at the time of the mailing. The primary outcome measures were norm-based, age- and sex-adjusted, 36-Item Short Form Health Survey physical composite score and mental composite score.Results The survey was mailed to 502 patients with a response rate of 34% (n = 172). The mean duration from diagnosis to survey completion was 5.4 (SD, 1.9) years; the mean age of the respondents at the time of the survey was 21.8 (2.2) years. The responders were predominantly females (84% vs 68% of nonresponders; P < .001). Only 33 (19%) respondents reported complete resolution of symptoms, and an additional 51% reported persistent but improved symptoms, and 28 (16%) had only intermittent symptoms. The majority (71%) consider their health at least "good." The mean physical composite score was significantly lower than the population norm (mean [SD], 36.6 [15.8] vs 50; P < .001), however, the corresponding mean mental composite score was normal (50.1 [11.2]).Conclusions Overall, 86% of adolescents with POTS report resolved, improved, or just intermittent symptoms, when assessed via questionnaire at an average of 5 years after initial treatment. Patients with persistent symptoms have more physical than mental health concerns.
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Many patients with POTS do not achieve permanent remission.
“clinical experience suggests that symptoms and function can improve with treatment, but many patients do not achieve permanent remission.3,15”
From Diagnosis and management of postural orthostatic tachycardia syndrome (2022) · cites this paper as [15]
The estimated prevalence of POTS is between 0.1% and 1% of the United States population.
“it is estimated to affect between 0.1 and 1% of the United States population”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Bhatia et al., 2016
In a Mayo Clinic study with an average 5-year follow-up, about 19% of POTS patients reported recovery, but a significant proportion reported ongoing functional disability.
“In another Mayo Clinic study looking at an average of 5 years of follow-up from initial evaluation, about 19% of patients reported that they had”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Bhatia et al., 2016
POTS patients have mental health scores similar to national norms whether they have improved or not 5 years after diagnosis.
“POTS patients have mental health scores similar to national norms whether they have improved or not 5 years after diagnosis 20.”
From The face of postural tachycardia syndrome – insights from a large cross‐sectional online community‐based survey (2019) · cites this paper as [20]
Around 50% of all POTS patients spontaneously recover within 1-3 years.
“It is estimated that around 50% of all POTS patients spontaneously recover within 1-3 years [65].”
From Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management (2019) · cites this paper as [65]
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- Authors
- Bhatia, R., Kizilbash, S. J., Ahrens, S. P., Killian, J. M., Kimmes, S. A., Knoebel, E. E., Muppa, P., Weaver, A. L., & Fischer, P. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Fischer, Philip R.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 173
- Pages
- 149-153
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2294318906
- Cited by
- 74
- References
- 18
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 10 · 2023: 4 · 2022: 13 · 2021: 8 · 2020: 10 · 2019: 2 · 2018: 10 · 2017: 5 · 2016: 1
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- postural orthostatic tachycardia syndrome, long-term outcomes, health-related quality of life, physical function, mental health, symptom resolution, pediatric patients
- MeSH terms
- Adolescent, Female, Follow-Up Studies, Health Status, Humans, Male, Mental Health, Quality of Life, Surveys and Questionnaires, Recurrence, Remission, Spontaneous, Severity of Illness Index, Postural Orthostatic Tachycardia Syndrome, Young Adult
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