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Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
Open accessAbstract
BACKGROUND: Patients using cholinesterase inhibitors (ChEIs) have a delay in nursing home (NH) admission compared with those who were not using the medication. There are no long-term studies of the effects of memantine in combination with ChEIs use in Alzheimer disease (AD). This study was conducted to examine the effects of ChEIs and memantine on time to death and time to NH admission. METHODS: Time to NH admission and death was examined in 943 probable AD patients who had at least a 1-year follow-up evaluation. Of these patients, 140 (14.9%) used both ChEIs and memantine, 387 (41%) [corrected] used only ChEIs, and 416 (44.1%) [corrected] used neither. The mean (SD) follow-up time was 62.3 (35.8) months. The analysis was conducted with multivariable Cox proportional hazard models controlling for critical covariates (ie, age, education level, gender, severity of the dementia, hypertension, diabetes mellitus, heart disease, psychiatric symptoms and use of psychotropic medications). RESULTS: Compared with those who never used cognitive enhancers, patients who used ChEIs had a significant delay in NH admission (HR: 0.37, 95% CI 0.27 to 0.49); this effect was significantly augmented with the addition of memantine (HR: 0.29, 95% CI 0.11 to 0.72) (memantine+ChEI vs ChEI alone). ChEIs alone, or in combination with memantine had no significant association on time to death. CONCLUSIONS: This observational study revealed that the addition of the NMDA receptor antagonist memantine to the treatment of AD with ChEI significantly altered the treated history of AD by extending time to nursing home admission.
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“Short-term (6-12 months) RCTs (level I evidence), longer-term (12-36 months) openlabel extensions of RCTs (level II or III evidence), and long-term (2 to 5-plus years) observational prospective clinical cohort effectiveness studies (level II evidence) support the safety and benefits of anti-AD treatments in combination, most frequently as memantine added on to a stable regimen of background ChEI”
From The Alzheimer’s Disease Clinical Spectrum (2019) · cites this paper as [117]
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“Longer-term prospective observational clinical patient cohort studies report reduced clinical decline in patients with AD treated at any stage.[114][115][116][117][118][119]”
From The Alzheimer’s Disease Clinical Spectrum (2019) · cites this paper as [117]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,852
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,007
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 8,167
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056
Overdependence on degraded gist memory in Alzheimer's disease.
Gallo, D. A., Shahid, K. R., Olson, M. A., Solomon, T. M., Schacter, D. L., & Budson, A. E. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.6.625 · Cited by 4,757
A new rating scale for Alzheimer's disease
(1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1356 · Cited by 4,175
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
. Cerebral blood flow in dementia.
Hachinski, V. C., Iliff, L. D., Zilhka, E., Du Boulay, G. H., McAllister, V. L., Marshall, J., Russell, R. W. R., & Symon, L. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490510088009 · Cited by 3,186
Alzheimer Disease in the US Population: Prevalence Estimates Using the 2000 Census
Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A., & Evans, D. A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1119 · Cited by 2,168
Brookmeyer, R., Gray, S. G., & Kawas, C. H. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.9.1337 · Cited by 1,802
Differential behavioral effects in frontal lobe disease
Benton, A. (1968) · Neuropsychologia · doi:10.1016/0028-3932(68)90038-9 · Cited by 1,575
Tariot, P. N., Farlow, M. R., Grossberg, G. T., Graham, S. M., McDonald, S., Gergel, I., & for the Memantine Study Group (2004) · JAMA · doi:10.1001/jama.291.3.317 · Cited by 1,403
McShane, R., Areosa Sastre, A., & Minakaran, N. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003154.pub5 · Cited by 1,155
Rosler, M., Anand, R., Cicin-Sain, A., Gauthier, S., Agid, Y., Dal-Bianco, P., Stahelin, H. B., Hartman, R., Gharabawi, M., & Bayer, T. (1999) · BMJ · doi:10.1136/bmj.318.7184.633 · Cited by 943
The incidence of dementia: A meta-analysis
Jorm, A. F., & Jolley, D. (1998) · Neurology · doi:10.1212/wnl.51.3.728 · Cited by 903
(2004) · The Lancet · doi:10.1016/s0140-6736(04)16499-4 · Cited by 892
Raskind (2000) · doi:10.1212/wnl.54.12.2261 · Cited by 870
Rogers, S. L., & Friedhoff, L. T. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106895 · Cited by 743
A Controlled Trial of Tacrine in Alzheimer's Disease
Farlow, M. R. (1992) · JAMA · doi:10.1001/jama.268.18.2523 · Cited by 632
The Natural History of Alzheimer's Disease: Description of Study Cohort and Accuracy of Diagnosis
Becker, J. T. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540180063015 · Cited by 576
Self-citationImpairment in facial recognition in patients with cerebral disease.
Benton, A., & van Allen, M. V. (1968) · Transactions of the American Neurological Association · doi:10.1016/s0010-9452(68)80018-8 · Cited by 551
Tariot, P. N., Mack, J. L., Patterson, M. B., Edland, S. D., Weiner, M., Fillenbaum, G. G., Blazina, L., Teri, L. L., Rubin, E. H., & Mortimer, J. A. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1349 · Cited by 426
Winblad, B. G., Kilander, L., Eriksson, S., Minthon, L., Båtsman, S., Wetterholm, A.-L., Jansson-Blixt, C., & Haglund, A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68350-5 · Cited by 400
A National Study of the Location of Death for Older Persons with Dementia
Mitchell, S. L., Teno, J. M., Miller, S. C., & Mor, V. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53118.x · Cited by 371
Doody, R. S. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.427 · Cited by 362
Farlow, M., Anand, R., Messina Jr, J., Hartman, R., & Veach, J. (2000) · European Neurology · doi:10.1159/000008243 · Cited by 332
Donepezil Is Associated with Delayed Nursing Home Placement in Patients with Alzheimer's Disease
Geldmacher, D., Provenzano, G., McRae, T. D., Mastey, V., & Ieni, J. R. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1365-2389.2003.51306.x · Cited by 313
AGGRESSIVE BEHAVIOR IN PERSONS WITH DEMENTIA WHO LIVE IN THE COMMUNITY
Ryden, M. B. (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802040-00003 · Cited by 271
Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease
López, O. L. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.3.310 · Cited by 255
Behavioral effects of memantine in Alzheimer disease patients receiving donepezil treatment
Cummings, J. L., Schneider, E., Tariot, P. N., & Graham, S. M. (2006) · Neurology · doi:10.1212/01.wnl.0000223333.42368.f1 · Cited by 227
Predictors and Consequences of Aggressive Behavior by Community-Based Dementia Patients
Hamel, M., Gold, D. P., Andres, D., Reis, M., Dastoor, D., Grauer, H., & Bergman, H. (1990) · The Gerontologist · doi:10.1093/geront/30.2.206 · Cited by 212
Risk-Adjusted Mortality Rates of Elderly Veterans with Hip Fractures
Bass, E., French, D. D., Bradham, D. D., & Rubenstein, L. Z. (2007) · Annals of Epidemiology · doi:10.1016/j.annepidem.2006.12.004 · Cited by 210
Research evaluation and diagnosis of possible Alzheimer’s disease over the last two decades: II
López, O. L., Becker, J. T., Klunk, W. E., Saxton, J. A., Hamilton, R. L., Kaufer, D., Sweet, R. A., MELTZER, C. C., Wisniewski, S. R., Kamboh, M. I., et al. (2000) · Neurology · doi:10.1212/wnl.55.12.1863 · Cited by 188
López, O. L., Wisniewski, S. R., Becker, J. T., Boller, F., & DeKosky, S. T. (1999) · Archives of Neurology · doi:10.1001/archneur.56.10.1266 · Cited by 183
A 24-Week Open-Label Extension Study of Memantine in Moderate to Severe Alzheimer Disease
Reisberg, ., Doody, R. S., Stöffler, A., Schmitt, F. A., Ferris, S. H., & Möbius, H. J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.1.49 · Cited by 183
Survival following dementia onset: Alzheimer's disease and vascular dementia
Fitzpatrick, A. L., Kuller, L. H., López, O. L., Kawas, C. H., & Jagust, W. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.11.022 · Cited by 177
Research evaluation and diagnosis of probable Alzheimer’s disease over the last two decades: I
López, O. L., Becker, J. T., Klunk, W. E., Saxton, J. A., Hamilton, R. L., Kaufer, D., Sweet, R. A., MELTZER, C. C., Wisniewski, S. R., Kamboh, M. I., et al. (2000) · Neurology · doi:10.1212/wnl.55.12.1854 · Cited by 157
Impairment in facial recognition in patients with cerebral disease.
Al, B., & Allen, M. W. V. (1968) · PubMed · Cited by 144
Factors Affecting Decisions to Institutionalize Demented Elderly
Lieberman, M. A., & Kramer, J. H. (1991) · The Gerontologist · doi:10.1093/geront/31.3.371 · Cited by 129
Gilley, D. W., Bienias, J. L., WILSON, R. S., Bennett, D. A., Beck, T. L., & Evans, D. A. (2004) · Psychological Medicine · doi:10.1017/s0033291703001831 · Cited by 125
The handbook of Rey-Osterrieth Complex Figure Usage : clinical and research applications
Knight, J. A., & Kaplan, E. (2003) · Medical Entomology and Zoology · Cited by 108
Psychotropic drugs and injuries among the elderly: a review.
Ray, W. A. (1992) · PubMed · Cited by 99
Eaker, E. D., Vierkant, R. A., & Mickel, S. F. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00498-x · Cited by 96
Cummings, J. L., Koumaras, B., Chen, M. J., & Mirski, D. F. (2005) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/s1543-5946(05)80020-0 · Cited by 92
A comparison of lexical-semantic impairments in left hemisphere stroke and Alzheimer's disease
Huff, F. J., Mack, L. M., Mahlmann, J., & Greenberg, S. (1988) · Brain and Language · doi:10.1016/0093-934x(88)90138-1 · Cited by 80
Areosa, S. A., & Sherriff, F. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003154 · Cited by 60
Sedative-hypnotic drugs and the risk of hip fracture
Wysowski, D. K., Baum, C., Ferguson, W., Lundin, F. E., Ng, M., & Hammerstrom, T. (1996) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(95)00057-7 · Cited by 34
López, O. L., Becker, J. T., Sweet, R. A., Klunk, W. E., Kaufer, D., Saxton, J. A., & DeKosky, S. T. (2003) · Journal of Neuropsychiatry · doi:10.1176/jnp.15.1.67 · Cited by 19
Gene-Environment Interactions With Cognition in Late Life and Compression of Morbidity
Becker, J. T., Mestre, L. T., Ziolko, S. K., & López, O. L. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.849 · Cited by 8
Winblad (1999) · doi:10.1002/(sici)1099-1166(199902)14:2
Flagged first, then by citations
Research works printed but not linked: 1
- [32]APA Diagnostic and statistical manual on mental disorders—Revised (DSM-III-R) 1987 3rd edn. Washington, DC American Psychiatric Press
Cited by
Sorted by citations
Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., & Jones, E. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61349-9 · Cited by 2,336
Alzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758
Therapeutics of Alzheimer's disease: Past, present and future
Anand, R., Gill, K. D., & Mahdi, A. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.004 · Cited by 765
The Alzheimer’s Disease Clinical Spectrum
Atri, A. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2018.10.009 · Cited by 623
The multiplex model of the genetics of Alzheimer's disease
Sims, R., Hill, M., & Williams, J. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0599-5 · Cited by 466
Metadata
- Authors
- Lopez, O. L., Becker, J. T., Wahed, A. S., Saxton, J., Sweet, R. A., Wolk, D. A., Klunk, W., & DeKosky, S. T.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2009-02-09
- Volume
- 80
- Issue
- 6
- Pages
- 600-607
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC2823571
- OpenAlex
- W2171545307
- Cited by
- 266
- References
- 56
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 7 · 2018: 14 · 2017: 14 · 2016: 18 · 2015: 26 · 2014: 18 · 2013: 25 · 2012: 30
- FWCI
- 18.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health (5p01ag003705-04)
- National Institute on Aging (AG 05-133, AG 20098, AG027224, P50AG005133, U01AG016976, AG 03705, R01AG020098, AG-16976, R56AG020098, R01AG027224)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, memantine, cholinesterase inhibitors, combination therapy, nursing home admission, time to death, NMDA receptor antagonists, long-term effects
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cholinesterase Inhibitors, Drug Therapy, Combination, Female, Follow-Up Studies, Homes for the Aged, Humans, Male, Memantine, Mental Status Schedule, Neuropsychological Tests, Nursing Homes, Patient Admission, Survival Analysis, Excitatory Amino Acid Antagonists, Nootropic Agents
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