Prevention of long-term sickness absence and major depression in high-risk employees: a randomised controlled trial

Lexis, Monique A S; Jansen, Nicole W H; Huibers, Marcus J H; van Amelsvoort, Ludovic G P M; Berkouwer, Ate; Tjin A Ton, Gladys; van den Brandt, Piet A; Kant, IJmert

doi:10.1136/oem.2010.057877

Cited by 71Workplace Health and Well-beingMental Health Treatment and AccessDigital Mental Health Interventions

Prevention of long-term sickness absence and major depression in high-risk employees: a randomised controlled trial

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Lexis, Monique A S, Jansen, Nicole W H, Huibers, Marcus J H, van Amelsvoort, Ludovic G P M, Berkouwer, Ate, Tjin A Ton, Gladys, van den Brandt, Piet A, Kant, IJmert·2011·Occupational and Environmental Medicine

DOI 10.1136/oem.2010.057877

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Abstract

Objectives: To examine the efficacy of early intervention on the prevention of long-term sickness absence and major depression among employees at high risk of future sickness absence and with mild to severe depressive complaints. Methods: Randomised controlled trial conducted among employees working in an office environment. 139 employees were identified both at high risk of future sickness absence and with mild to severe depressive complaints through screening. Subsequently, they were randomly assigned to the intervention group (n=69) or the control group (n=70). Objective sickness absence was analysed at 12 and 18 months of follow-up. Depressive complaints were assessed by the Beck Depression Inventory (BDI-II) at baseline, and at 6 and 12 months of follow-up. Results: Intention-to-treat analyses showed a significant difference in total sickness absence duration between the intervention (27.5 calendar days (SD 44.7)) and control group (50.8 days (SD 75.8)) over 12 months of follow-up, a reduction of 46% (p=0.017). The intervention group showed a non-significantly lower proportion of long-term sickness absence spells compared with the control group (p=0.127). Statistically significant and clinically relevant differences in depressive complaints were found after both 6 months (p=0.001) and 12 months (p=0.005) of follow-up, in favour of the intervention group. Relative risk reductions (RRR) were 19.2% and 19.8% respectively. Sickness absence data were available for all participants over 18 months of follow-up. Questionnaire data were available for 99 (at 6 months) and 90 participants (at 12 months). No adverse events or side effects occurred. Conclusions: Early intervention in employees with mild to severe depressive complaints and high risk of future long-term sickness absence proved to be effective in preventing/reducing both sickness absence and depressive complaints.

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Additional file 2 of Exploring expected and perceived facilitators and barriers of an indicated prevention strategy to prevent future long-term sickness absence; a qualitative study among employers and employees
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Effectiveness of a Web-Based Intervention in Reducing Depression and Sickness Absence: Randomized Controlled Trial
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Authors: Lexis, M. A. S., Jansen, N. W. H., Huibers, M. J. H., van Amelsvoort, L. G. P. M., Berkouwer, A., Tjin A Ton, G., van den Brandt, P. A., & Kant, I.
Affiliations: Maastricht University (NL)
ABN AMRO Bank N.V. (Netherlands) (NL)
Corresponding author: Lexis, Monique A S
ORCID: Lexis, Monique A S
Jansen, Nicole W H
Huibers, Marcus J H
Kant, IJmert
Venue: Occupational and Environmental Medicine
Publisher: BMJ
Published: 2010-10-05
Volume: 68
Issue: 6
Pages: 400-407
ISSN: 0007-1072 (ISSN-L)
1351-0711
1470-7926
DOI: 10.1136/oem.2010.057877
OpenAlex: W2154396601
Cited by: 71
References: 37
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 12 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 9 · 2012: 5
FWCI: 9.63
Type: journal article
Language: en
Open access: green
cris.maastrichtuniversity.nl
Licence: other-oa
Locations: Occupational and Environmental Medicine (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders: ZonMw (62200024)
Universiteit Maastricht
Universitair Medisch Centrum Groningen
Care and Public Health Research Institute, Universiteit Maastricht
Topics: Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Keywords: long-term sickness absence, major depressive disorder, depression prevention, early intervention, office workers, occupational health, depressive symptoms
MeSH terms: Absenteeism, Adolescent, Adult, Aged, Major Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Middle Aged, Netherlands, Occupational Health Services, Problem Solving, Psychiatric Status Rating Scales, Cognitive Behavioral Therapy, Treatment Outcome, Sick Leave, Young Adult

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Prevention of long-term sickness absence and major depression in high-risk employees: a randomised controlled trial

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