Evaluation of spinosad for the oral treatment and control of flea infestations on dogs in Europe
Open accessAbstract
The novel ectoparasiticide spinosad is a naturally occurring mixture of spinosyns A and D formed during a fermentation process. The spinosyns are tetracyclic macrolides with a unique ring system. Their mode of action differs from that of other commercially available insecticides. Laboratory and field trials were conducted to evaluate the use of spinosad in a chewable tablet at a dose range of 45 to 70 mg/kg for the treatment and control of flea infestations on dogs in Europe. Laboratory studies with artificially infested dogs confirmed persistent activity against Ctenocephalides felis of higher than 99 per cent at three weeks post‐treatment with values of 96.5 to 97.8 per cent at four weeks. Two multicentric field trials with naturally infected client‐owned animals in five European countries used selamectin as comparator. Monthly doses were given during the summer when many homes were heavily infested. Households with spinosad‐treated dogs showed cumulative benefits with flea burdens reduced by about 97 per cent at 14 and 30 days and by 99.6 per cent at 60 and 90 days. Corresponding figures for selamectin were significantly lower (P<0.05) at all time points: between 88.5 and 91 per cent at 14 and 30 days, then 97.8 and 98.2 per cent at 60 and 90 days. Thus, the performance of spinosad compared favourably with that of the established reference product.
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Multicentre field trials have demonstrated monthly efficacy of spinosad in naturally infected dogs during the summer.
“As an example, although multicentre field trials have successfully demonstrated the monthly efficacy of spinosad in naturally infected dogs during the summer, i.e. the period of highest level of contamination for homes [148], control of fleas is not imperatively seasonal.”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [148]
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- Authors
- Wolken, S., Franc, M., Bouhsira, E., Wiseman, S., Hayes, B., Schnitzler, B., & Jacobs, D. E.
- Affiliations
- University of Veterinary Medicine Hannover, Foundation (DE)
- École Nationale Vétérinaire de Toulouse (FR)
- Université de Toulouse INP ENVT‐Parasitologie‐Dermatologie Ecole Nationale Vétérinaire 23 chemin des capelles 31076 Toulouse cedex France
- Eli Lilly (United Kingdom) (GB)
- University of London (GB)
- Corresponding author
- Schnitzler, B.
- ORCID
- Venue
- Veterinary Record
- Publisher
- Wiley
- Published
- 2012-01
- Volume
- 170
- Issue
- 4
- Pages
- 99-99
- ISSN
- 0042-4900 (ISSN-L)
- 2042-7670
- OpenAlex
- W2152223962
- Cited by
- 26
- References
- 17
- Citations by year
- 2025: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- Locations
- Veterinary Record (publishedVersion)
- PubMed (publishedVersion)
- RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Keywords
- spinosad, spinosyns, flea infestation, dogs, Ctenocephalides felis, chewable tablets, selamectin, macrolides, field trials
- MeSH terms
- Administration, Oral, Animals, Dog Diseases, Dogs, Dose-Response Relationship, Drug, Drug Combinations, Europe, Female, Insecticides, Ivermectin, Male, Seasons, Treatment Outcome, Macrolides, Flea Infestations
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