The Molecular Basis of G Protein–Coupled Receptor Activation

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

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High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

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The Energy Landscapes and Motions of Proteins

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[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors

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The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

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Crystal structure of the human β2 adrenergic G-protein-coupled receptor

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FGF/FGFR signaling in health and disease

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G protein-coupled receptors: structure- and function-based drug discovery

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Common activation mechanism of class A GPCRs

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G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery

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Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

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Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS)

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ProLIF: a library to encode molecular interactions as fingerprints

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Impact of GPCR Structures on Drug Discovery

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Mechanisms of Cryptochrome-Mediated Photoresponses in Plants

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Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress

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AlphaFold 2: Why It Works and Its Implications for Understanding the Relationships of Protein Sequence, Structure, and Function

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Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies

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Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor

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G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

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Multi‐state modeling of G‐protein coupled receptors at experimental accuracy

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Cannabinoids and Cannabinoid Receptors: The Story so Far

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Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

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Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators

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Emerging principles of cytokine pharmacology and therapeutics

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Novel roles of phosphoinositides in signaling, lipid transport, and disease

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Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling

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Imaging neurotransmitter and neuromodulator dynamics in vivo with genetically encoded indicators

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Allosteric Modulator Discovery: From Serendipity to Structure-Based Design

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CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer

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Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

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Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?

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Single-cell transcriptomic evidence for dense intracortical neuropeptide networks

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Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1

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The tethered peptide activation mechanism of adhesion GPCRs

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Cryo-EM structures of GPCRs coupled to Gs, Gi and Go

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G-protein activation by a metabotropic glutamate receptor

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Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling

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G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers

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Chemosensory signal transduction in Caenorhabditis elegans

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Gut microbiota-derived metabolites tune host homeostasis fate

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Structure determination of GPCRs: cryo-EM compared with X-ray crystallography

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Rhodopsin, light-sensor of vision

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AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors

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Molecular basis of opioid receptor signaling

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Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches

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The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

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Non-canonical β-adrenergic activation of ERK at endosomes

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Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling

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Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity

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Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

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Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

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Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms

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Targeting lipid GPCRs to treat type 2 diabetes mellitus — progress and challenges

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Autoregulation of GPCR signalling through the third intracellular loop

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Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

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Short-Chain Fatty Acid Receptors and Cardiovascular Function

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The cancer-immune dialogue in the context of stress

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When trafficking and signaling mix: How subcellular location shapes G protein‐coupled receptor activation of heterotrimeric G proteins

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Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function

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Melatonin Ameliorates Hepatic Ferroptosis in NAFLD by Inhibiting ER Stress via the MT2/cAMP/PKA/IRE1 Signaling Pathway

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Receptor Tyrosine Kinase Signaling and Targeting in Glioblastoma Multiforme

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Bioorthogonal Reactions of Triarylphosphines and Related Analogues

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Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels

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Molecular Insights from Conformational Ensembles via Machine Learning

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Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design

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Snapshot of the cannabinoid receptor 1-arrestin complex unravels the biased signaling mechanism

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Structure of the class D GPCR Ste2 dimer coupled to two G proteins

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Capturing a rhodopsin receptor signalling cascade across a native membrane

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Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery

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Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor

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Cryo-electron microscopy analysis of small membrane proteins

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Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development

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Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1

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Structure and dynamics of the CGRP receptor in apo and peptide-bound forms

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Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2

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Molecular mechanisms regulating Proteinase-Activated Receptors (PARs)

Chandrabalan, A., & Ramachandran, R. (2021) · The FEBS Journal · doi:10.1111/febs.15829 · Cited by 83

Compartmentalized GPCR Signaling from Intracellular Membranes

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Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases

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Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3

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Hormone- and antibody-mediated activation of the thyrotropin receptor

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Structural Insights into CB1 Receptor Biased Signaling

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Energy Landscapes Reveal Agonist Control of G Protein-Coupled Receptor Activation via Microswitches

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A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

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Frizzleds as GPCRs – More Conventional Than We Thought!

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Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias

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Translating the force—mechano-sensing GPCRs

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Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development

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Ligand efficacy modulates conformational dynamics of the µ-opioid receptor

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