The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Molecular Mechanisms of RNA Interference
Open accessAbstract
Small RNA molecules regulate eukaryotic gene expression during development and in response to stresses including viral infection. Specialized ribonucleases and RNA-binding proteins govern the production and action of small regulatory RNAs. After initial processing in the nucleus by Drosha, precursor microRNAs (pre-miRNAs) are transported to the cytoplasm, where Dicer cleavage generates mature microRNAs (miRNAs) and short interfering RNAs (siRNAs). These double-stranded products assemble with Argonaute proteins such that one strand is preferentially selected and used to guide sequence-specific silencing of complementary target mRNAs by endonucleolytic cleavage or translational repression. Molecular structures of Dicer and Argonaute proteins, and of RNA-bound complexes, have offered exciting insights into the mechanisms operating at the heart of RNA-silencing pathways.
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Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA
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siRNA Nanoparticle Delivery Strategies and Clinical Trial Advances in Tumor Therapy
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C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA
Consalvo, C. D., Aderounmu, A. M., Donelick, H. M., Aruscavage, P. J., Eckert, D. M., Shen, P. S., & Bass, B. L. (2023) · doi:10.1101/2023.09.21.558868 · Cited by 1
Metadata
- Authors
- Wilson, R. C., & Doudna, J. A.
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2013-05-06
- Volume
- 42
- Issue
- 1
- Pages
- 217-239
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- OpenAlex
- W2118980569
- Cited by
- 1,076
- References
- 6
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- green
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