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Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface
Open accessAbstract
Endocytosis has long been identified as a key cellular process involved in bringing in nutrients, in clearing cellular debris in tissue, in the regulation of signaling, and in maintaining cell membrane compositional homeostasis. While clathrin-mediated endocytosis has been most extensively studied, a number of clathrin-independent endocytic pathways are continuing to be delineated. Here we provide a current survey of the different types of endocytic pathways available at the cell surface and discuss a new classification and plausible molecular mechanisms for some of the less characterized pathways. Along with an evolutionary perspective of the origins of some of these pathways, we provide an appreciation of the distinct roles that these pathways play in various aspects of cellular physiology, including the control of signaling and membrane tension.
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“Given the physiological size of melanosomes (0.3–0.5 μm in diameter), only macropinocytosis and phagocytosis are predicted to allow the internalization of such large cargo [ 51 , 52 , 53 , 54 ].”
From Melanin's Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing (2023) · cites this paper as [54]
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Metadata
- Authors
- Thottacherry, J. J., Sathe, M., Prabhakara, C., & Mayor, S.
- Affiliations
- Tata Institute of Fundamental Research (IN)
- Corresponding author
- Mayor, Satyajit
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2019-10-06
- Volume
- 35
- Issue
- 1
- Pages
- 55-84
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- PMC
- PMC6917507
- OpenAlex
- W2956919478
- Cited by
- 122
- References
- 232
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 22 · 2023: 16 · 2022: 17 · 2021: 21 · 2020: 12
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- endocytosis, clathrin-independent endocytosis, clathrin-mediated endocytosis, cell surface, membrane tension, signal transduction regulation
- MeSH terms
- Animals, Cell Membrane, Endocytosis, Biological Evolution, Homeostasis, Humans, Signal Transduction
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