Cited by 122Cellular transport and secretionCaveolin-1 and cellular processesAutophagy in Disease and Therapy

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Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface

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Thottacherry, Joseph Jose, Sathe, Mugdha, Prabhakara, Chaitra, Mayor, Satyajit·2019·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev-cellbio-100617-062710PMC PMC6917507

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Abstract

Endocytosis has long been identified as a key cellular process involved in bringing in nutrients, in clearing cellular debris in tissue, in the regulation of signaling, and in maintaining cell membrane compositional homeostasis. While clathrin-mediated endocytosis has been most extensively studied, a number of clathrin-independent endocytic pathways are continuing to be delineated. Here we provide a current survey of the different types of endocytic pathways available at the cell surface and discuss a new classification and plausible molecular mechanisms for some of the less characterized pathways. Along with an evolutionary perspective of the origins of some of these pathways, we provide an appreciation of the distinct roles that these pathways play in various aspects of cellular physiology, including the control of signaling and membrane tension.

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See all 122

Authors: Thottacherry, J. J., Sathe, M., Prabhakara, C., & Mayor, S.
Affiliations: Tata Institute of Fundamental Research (IN)
Corresponding author: Mayor, Satyajit
ORCID: Thottacherry, Joseph Jose
Sathe, Mugdha
Prabhakara, Chaitra
Mayor, Satyajit
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2019-10-06
Volume: 35
Issue: 1
Pages: 55-84
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev-cellbio-100617-062710
PMC: PMC6917507
OpenAlex: W2956919478
Cited by: 122
References: 232
Citations by year: 2026: 15 · 2025: 19 · 2024: 22 · 2023: 16 · 2022: 17 · 2021: 21 · 2020: 12
FWCI: 1.45
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: endocytosis, clathrin-independent endocytosis, clathrin-mediated endocytosis, cell surface, membrane tension, signal transduction regulation
MeSH terms: Animals, Cell Membrane, Endocytosis, Biological Evolution, Homeostasis, Humans, Signal Transduction

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