Translating the Genome in Time and Space: Specialized Ribosomes, RNA Regulons, and RNA-Binding Proteins

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,090

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

Sonenberg, N., & Hinnebusch, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.01.042 · Cited by 3,304

Direct analysis of protein complexes using mass spectrometry

Link, A. J., Eng, J. K., Schieltz, D. M., Carmack, E., Mize, G. J., Morris, D. R., Garvik, B. M., & Yates, J. R. (1999) · Nature Biotechnology · doi:10.1038/10890 · Cited by 2,218

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

Ingolia, N. T., Lareau, L. F., & Weissman, J. S. (2011) · Cell · doi:10.1016/j.cell.2011.10.002 · Cited by 2,187

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.031 · Cited by 2,132

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

Pelletier, J., & Sonenberg, N. (1988) · Nature · doi:10.1038/334320a0 · Cited by 1,953

The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists

Alberts, B. (1998) · Cell · doi:10.1016/s0092-8674(00)80922-8 · Cited by 1,411

Translational control in stress and apoptosis

Holčı́k, M., & Sonenberg, N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1618 · Cited by 1,409

CCAAT/enhancer-binding proteins: structure, function and regulation

Ramji, D. P., & Foka, P. (2002) · Biochemical Journal · doi:10.1042/bj20020508 · Cited by 1,404

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

Jang, S. K., Kräusslich, H., Nicklin, M. J. H., Duke, G. M., Palmenberg, A. C., & Wimmer, E. (1988) · Journal of Virology · doi:10.1128/jvi.62.8.2636-2643.1988 · Cited by 1,390

The translational landscape of mTOR signalling steers cancer initiation and metastasis

Hsieh, A. C., Liu, Y., Edlind, M. P., Ingolia, N. T., Janes, M. R., Sher, A., Shi, E. Y., Stumpf, C. R., Christensen, C., Bonham, M. J., et al. (2012) · Nature · doi:10.1038/nature10912 · Cited by 1,313

Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109

A SMALL PARTICULATE COMPONENT OF THE CYTOPLASM

Palade, G. E. (1955) · The Journal of Cell Biology · doi:10.1083/jcb.1.1.59 · Cited by 1,014

A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine

Garlick, P. J., McNurlan, M. A., & Preedy, V. R. (1980) · Biochemical Journal · doi:10.1042/bj1920719 · Cited by 974

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T., & Darnell, R. B. (2001) · Cell · doi:10.1016/s0092-8674(01)00566-9 · Cited by 952

Dendritic Protein Synthesis, Synaptic Plasticity, and Memory

Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 938

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

Calvo, S. E., Pagliarini, D. J., & Mootha, V. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810916106 · Cited by 914

Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo

Rouskin, S., Zubradt, M., Stefan Washietl, A., Kellis, M., & Weissman, J. S. (2013) · Nature · doi:10.1038/nature12894 · Cited by 862

Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE): quantitative RNA structure analysis at single nucleotide resolution

Wilkinson, K. A., Merino, E. J., & Weeks, K. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.249 · Cited by 775

In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features

Ding, Y., Tang, Y., Kwok, C. K., Zhang, Y., Bevilacqua, P. C., & Assmann, S. M. (2014) · Nature · doi:10.1038/nature12756 · Cited by 775

Structural imprints in vivo decode RNA regulatory mechanisms

Spitale, R. C., Flynn, R. A., Zhang, Q. C., Crisalli, P., Lee, B., Jung, J., Kuchelmeister, H. Y., Batista, P. J., Torre, E. A., Kool, E. T., et al. (2015) · Nature · doi:10.1038/nature14263 · Cited by 760

Upstream Open Reading Frames as Regulators of mRNA Translation

Morris, D. R., & Geballe, A. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8635-8642.2000 · Cited by 736

How Common Are Extraribosomal Functions of Ribosomal Proteins?

Warner, J. R., & McIntosh, K. B. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.03.006 · Cited by 735

Specialized ribosomes: a new frontier in gene regulation and organismal biology

Xue, S., & Barna, M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3359 · Cited by 730

Unusual Resistance of Peptidyl Transferase to Protein Extraction Procedures

Noller, H. F., Hoffarth, V., & Zimniak, L. (1992) · Science · doi:10.1126/science.1604315 · Cited by 728

Haematopoietic stem cells require a highly regulated protein synthesis rate

Signer, R. A. J., Magee, J. A., Salic, A., & Morrison, S. J. (2014) · Nature · doi:10.1038/nature13035 · Cited by 674

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasisPreprint

Ruvinsky, I., Sharon, N., Lerer, T., Cohen, H., Stolovich-Rain, M., Nir, T., Dor, Y., Zisman, P., & Meyuhas, O. (2005) · Genes & Development · doi:10.1101/gad.351605 · Cited by 668

Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning

Kondrashov, N., Pusic, A. D., Stumpf, C. R., Shimizu, K., Hsieh, A. C., Xue, S., Ishijima, J., Shiroishi, T., & Barna, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.028 · Cited by 619

High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling

Brar, G. A., Yassour, M., Friedman, N., Regev, A., Ingolia, N. T., & Weissman, J. S. (2012) · Science · doi:10.1126/science.1215110 · Cited by 533

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

Barbosa, C., Peixeiro, I., & Romão, L. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003529 · Cited by 525

The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif

Schaeffer, C., Bardoni, B., Mandel, J., Ehresmann, B., Ehresmann, C., & Moine, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4803 · Cited by 471

Cellular IRES-mediated translation

Komar, A. A., & Hatzoglou, M. (2011) · Cell Cycle · doi:10.4161/cc.10.2.14472 · Cited by 455

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Keersmaecker, K. D., Atak, Z. K., Li, N., Vicente, C., Patchett, S., Girardi, T., Gianfelici, V., Geerdens, E., Clappier, E., Porcu, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2508 · Cited by 445

Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin

Liu, J., Xu, Y., Stoleru, D., & Salic, A. N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111561108 · Cited by 440

Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly

Ceci, M., Gaviraghi, C., Gorrini, C., Sala, L. A., Offenhäuser, N., Marchisio, P. C., & Biffo, S. (2003) · Nature · doi:10.1038/nature02160 · Cited by 437

Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish

Amsterdam, A., Sadler, K. C., Lai, K., Farrington, S. M., Bronson, R. T., Lees, J. A., & Hopkins, N. H. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020139 · Cited by 427

Impaired Control of IRES-Mediated Translation in X-Linked Dyskeratosis Congenita

Yoon, A., Peng, G., Brandenburg, Y., Zollo, O., Xu, W. G., Rego, E. M., & Ruggero, D. (2006) · Science · doi:10.1126/science.1123835 · Cited by 423

Translational control of C/EBP alpha and C/EBP beta isoform expressionPreprint

Calkhoven, C. F., Mueller, C. G., & Leutz, A. (2000) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.1101/gad.14.15.1920 · Cited by 399

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

Melo, J. A., & Ruvkun, G. (2012) · Cell · doi:10.1016/j.cell.2012.02.050 · Cited by 398

The ribosomal protein genes and Minute loci of Drosophila melanogaster

Marygold, S. J., Roote, J., Reuter, G., Lambertsson, A., Ashburner, M., Millburn, G. H., Harrison, P. M., Yu, Z., Kenmochi, N., Kaufman, T. C., et al. (2007) · Genome Biology · doi:10.1186/gb-2007-8-10-r216 · Cited by 385

Differential Requirements for eIF4E Dose in Normal Development and Cancer

Truitt, M., Conn, C. S., Shi, Z., Pang, X., Tokuyasu, T. A., Coady, A. M., Seo, Y., Barna, M., & Ruggero, D. (2015) · Cell · doi:10.1016/j.cell.2015.05.049 · Cited by 383

Cell Cycle–Regulated Modification of the Ribosome by a Variant Multiubiquitin Chain

Spence, J. L., Gali, R. R., Dittmar, G., Sherman, F., Karin, M., & Finley, D. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00011-8 · Cited by 382

Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6

Volarević, S., Stewart, M. J., Ledermann, B., Zilbermann, F., Terracciano, L., Montini, E., Grompe, M., Kozma, S. C., & Thomas, G. (2000) · Science · doi:10.1126/science.288.5473.2045 · Cited by 372

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

McGowan, K. A., Li, J. Z., Park, C. Y., Beaudry, V. G., Tabor, H. K., Sabnis, A. J., Zhang, W., Fuchs, H., de Angelis, M. H., Myers, R., et al. (2008) · Nature Genetics · doi:10.1038/ng.188 · Cited by 363

Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection

Gradi, A., Svitkin, Y. V., Imataka, H., & Sonenberg, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11089 · Cited by 358

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

Barlow, J. L., Drynan, L. F., Hewett, D. R., Holmes, L. R., Lorenzo-Abalde, S., Lane, A. L., Jolin, H. E., Pannell, R., Middleton, A. J., Wong, S. H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2063 · Cited by 349

Rack1, a Receptor for Activated Protein Kinase C, Interacts with Integrin β Subunit

Liliental, J., & Chang, D. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.2379 · Cited by 346

Regulated Release of L13a from the 60S Ribosomal Subunit as A Mechanism of Transcript-Specific Translational Control

Mazumder, B., Sampath, P., Seshadri, V., Maitra, R. K., DiCorleto, P. E., & Fox, P. L. (2003) · Cell · doi:10.1016/s0092-8674(03)00773-6 · Cited by 344

Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control.

Levy, S., Avni, D., Hariharan, N., Perry, R. P., & Meyuhas, O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3319 · Cited by 344

Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry

Moroz, L. L., Edwards, J. R., Puthanveettil, S. V., Kohn, A. B., Ha, T. J., Heyland, A., Knudsen, B., Sahni, A., Yu, F., Liu, L., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.052 · Cited by 330

ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′UTR

Kullmann, M., Göpfert, U., Siewe, B., & Hengst, L. (2002) · Genes & Development · doi:10.1101/gad.248902 · Cited by 327

Identification and Characterization of a Novel Cell Cycle–Regulated Internal Ribosome Entry Site

Cornelis, S., Bruynooghe, Y., Denecker, G., Huffel, S. V., Tinton, S. A., & Beyaert, R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80239-7 · Cited by 326

Structurally Distinct, Stage-Specific Ribosomes Occur in Plasmodium

Gunderson, J. H., Sogin, M. L., Woollett, G. R., Hollingdale, M. R., de la Cruz, V. F., Waters, A. P., & McCutchan, T. F. (1987) · Science · doi:10.1126/science.3672135 · Cited by 325

RNA regulons in Hox 5′ UTRs confer ribosome specificity to gene regulation

Xue, S., Tian, S., Fujii, K., Kladwang, W., Das, R., & Barna, M. (2014) · Nature · doi:10.1038/nature14010 · Cited by 319

Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexesPreprint

Fleischer, T. C., Weaver, C. M., McAfee, K. J., Jennings, J. L., & Link, A. J. (2006) · Genes & Development · doi:10.1101/gad.1422006 · Cited by 308

A new internal-ribosome-entry-site motif potentiates XIAP- mediated cytoprotection

Holčı́k, M., Lefebvre, C. A., Yeh, C., Chow, T. Y.-K., & Korneluk, R. G. (1999) · Nature Cell Biology · doi:10.1038/11109 · Cited by 302

A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation

Sampath, P., Pritchard, D. K., Pabon, L., Reinecke, H., Schwartz, S. M., Morris, D. R., & Murry, C. E. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.03.013 · Cited by 277

Viral IRES RNA structures and ribosome interactions.

Kieft, J. (2008) · TIBS -Trends in Biochemical Sciences. Regular ed · doi:10.1016/j.tibs.2008.04.007 · Cited by 272

Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease

Martin, I., Kim, J. W., Lee, B. D., Kang, H. C., Xu, J.-C., Jia, H., Stankowski, J., Kim, M.-S., Zhong, J., Kumar, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.064 · Cited by 265

Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome

Chen, E., Sharma, M. R., Shi, X., Agrawal, R. K., & Joseph, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.023 · Cited by 253

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation

Tcherkezian, J., Brittis, P. A., Thomas, F., Roux, P. P., & Flanagan, J. G. (2010) · Cell · doi:10.1016/j.cell.2010.04.008 · Cited by 248

uAUG and uORFs in human and rodent 5′untranslated mRNAs

Iacono, M., Mignone, F., & Pesole, G. (2005) · Gene · doi:10.1016/j.gene.2004.11.041 · Cited by 244

Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus.

Gingras, A., Svitkin, Y. V., Belsham, G. J., Pause, A., & Sonenberg, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5578 · Cited by 238

The ribosomal basis of diamond-blackfan anemia: mutation and database update

Boria, I., Garelli, E., Gazda, H. T., Aspesi, A., Quarello, P., Pavesi, E., Ferrante, D., Meerpohl, J. J., Kartal, M., Da Costa, L., et al. (2010) · Human Mutation · doi:10.1002/humu.21383 · Cited by 233

3 The Minute Genes in Drosophila and Their Molecular Functions

Lambertsson, A. (1998) · Advances in genetics · doi:10.1016/s0065-2660(08)60142-x · Cited by 231

Cellular Differences in Protein Synthesis Regulate Tissue Homeostasis

Buszczak, M., Signer, R. A. J., & Morrison, S. J. (2014) · Cell · doi:10.1016/j.cell.2014.09.016 · Cited by 224

LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells

Cho, J., Chang, H., Kwon, S. C., Kim, B., Kim, Y., Choe, J., Ha, M., Kim, Y. K., & Kim, V. N. (2012) · Cell · doi:10.1016/j.cell.2012.10.019 · Cited by 223

Two internal ribosome entry sites mediate the translation of p53 isoforms

Ray, P. S., Grover, R., & Das, S. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400623 · Cited by 207

Ribosomal Protein SA Haploinsufficiency in Humans with Isolated Congenital Asplenia

Bolze, A., Mahlaoui, N., Byun, M., Turner, B., Trede, N. S., Ellis, S. R., Abhyankar, A., Itan, Y., Patin, É., Brebner, S., et al. (2013) · Science · doi:10.1126/science.1234864 · Cited by 199

RACK1 Controls IRES-Mediated Translation of Viruses

Majzoub, K., Hafirassou, M. L., Meignin, C., Goto, A., Marzi, S., Fedorova, A. A., Verdier, Y., Vinh, J., Hoffmann, J. A., Martin, F., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.041 · Cited by 195

Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage

Zhang, Q., Shalaby, N. A., & Buszczak, M. (2014) · Science · doi:10.1126/science.1246384 · Cited by 192

Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide.

Krieg, J., Hofsteenge, J., & Thomas, G. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37981-x · Cited by 190

Deregulation of oncogene‐induced senescence and p53 translational control in X‐linked dyskeratosis congenita

Bellodi, C., Kopmar, N. E., & Ruggero, D. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.83 · Cited by 177

Ablation of Ribosomal Protein L22 Selectively Impairs αβ T Cell Development by Activation of a p53-Dependent Checkpoint

Anderson, S. J., Lauritsen, J. P. H., Hartman, M. G., Foushee, A. M. D., Lefebvre, J. M., Shinton, S. A., Gerhardt, B., Hardy, R. R., Oravecz, T., & Wiest, D. L. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.012 · Cited by 173

A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs

Lee, A. S.-Y., Burdeinick-Kerr, R., & Whelan, S. P. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216454109 · Cited by 169

Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system.

Watson, K. L., Konrad, K. D., Woods, D. F., & Bryant, P. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11302 · Cited by 165

p53 represses ribosomal gene transcription

Budde, A., & Grummt, I. (1999) · Oncogene · doi:10.1038/sj.onc.1202402 · Cited by 157

Direct Link between RACK1 Function and Localization at the Ribosome In Vivo

Coyle, S. M., Gilbert, W. V., & Doudna, J. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01718-08 · Cited by 157

Arabidopsis Ribosomal Proteins RPL23aA and RPL23aB Are Differentially Targeted to the Nucleolus and Are Disparately Required for Normal Development

Degenhardt, R. F., & Bonham‐Smith, P. C. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.111799 · Cited by 156

H/ACA Small RNA Dysfunctions in Disease Reveal Key Roles for Noncoding RNA Modifications in Hematopoietic Stem Cell Differentiation

Bellodi, C., McMahon, M. E., Contreras, A., Juliano, D., Kopmar, N. E., Nakamura, T., Maltby, D. A., Burlingame, A. L., Savage, S. A., Shimamura, A., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.030 · Cited by 154

Ribosomal proteins of Escherichia coli II. Proteins from the 30 s subunit

Moore, P. B., Traut, R. R., Noller, H. F., Pearson, P., & Delius, H. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90420-8 · Cited by 145

Stoichiometric measurements of 30S and 50S ribosomal proteins from Escherichia coli

Weber, H. (1972) · Molecular and General Genetics MGG · doi:10.1007/bf00333861 · Cited by 144

Introns within Ribosomal Protein Genes Regulate the Production and Function of Yeast Ribosomes

Parenteau, J., Durand, M., Morin, G., Gagnon, J., Lucier, J., Wellinger, R. J., Chabot, B., & Elela, S. A. (2011) · Cell · doi:10.1016/j.cell.2011.08.044 · Cited by 144

SYNTHESIS OF PROTEIN IN THE PANCREAS

Allfrey, V. G., Daly, M. M., & Mirsky, A. E. (1953) · The Journal of General Physiology · doi:10.1085/jgp.37.2.157 · Cited by 142

Plant L10 Ribosomal Proteins Have Different Roles during Development and Translation under Ultraviolet-B Stress

Ferreyra, M. L. F., Pezza, A., Biarc, J., Burlingame, A. L., & Casati, P. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.157057 · Cited by 139

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

Golomb, L., Bublik, D. R., Wilder, S., Nevo, R., Kiss, V., Grabusic, K., Volarevic, S., & Oren, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.11.022 · Cited by 137

Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during Gastrulation

Panić, L., Tamarut, S., Sticker-Jantscheff, M., Barkić, M., Solter, D., Uzelac, M., Grabušić, K., & Volarević, S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00751-06 · Cited by 135

The identification of an internal ribosomal entry site in the 5′-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage

Yang, D.-Q., Halaby, M. J., & Zhang, Y. (2006) · Oncogene · doi:10.1038/sj.onc.1209483 · Cited by 134

Ribosomes and translation in plant developmental control

Horiguchi, G., Lijsebettens, M. V., Candela, H., Micol, J. L., & Tsukaya, H. (2012) · Plant Science · doi:10.1016/j.plantsci.2012.04.008 · Cited by 127

O-GlcNAc Cycling Enzymes Associate with the Translational Machinery and Modify Core Ribosomal Proteins

Zeidan, Q., Wang, Z., Maio, A. D., & Hart, G. W. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-11-0941 · Cited by 126

Ribosome heterogeneity: another level of complexity in bacterial translation regulation

Byrgazov, K., Vesper, O., & Moll, I. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.01.009 · Cited by 123

A two-dimensional mutate-and-map strategy for non-coding RNA structure

Kladwang, W., VanLang, C. C., Cordero, P., & Das, R. (2011) · Nature Chemistry · doi:10.1038/nchem.1176 · Cited by 121

Asc1p, a WD40-domain containing adaptor protein, is required for the interaction of the RNA-binding protein Scp160p with polysomes

Sonja, B. A. U. M., Bittins, M., Frey, S., & Seedorf, M. (2004) · Biochemical Journal · doi:10.1042/bj20031962 · Cited by 114

Ribosomal Protein Gene Knockdown Causes Developmental Defects in Zebrafish

Uechi, T., Nakajima, Y., Nakao, A., Torihara, H., Chakraborty, A., Inoue, K., & Kenmochi, N. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000037 · Cited by 113

An Unexpected Type of Ribosomes Induced by Kasugamycin: A Look into Ancestral Times of Protein Synthesis?

Kaberdina, A. C., Szaflarski, W., Nierhaus, K. H., & Moll, I. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.014 · Cited by 111

Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES‐bound complexes

Yu, Y., Ji, H., Doudna, J. A., & Leary, J. A. (2005) · Protein Science · doi:10.1110/ps.041293005 · Cited by 108

Mutations in the Drosophila Gene Encoding Ribosomal Protein S6 Cause Tissue Overgrowth

Stewart, M. J., & Denell, R. E. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2524-2535.1993 · Cited by 104

Control of Hematopoietic Stem Cell Emergence by Antagonistic Functions of Ribosomal Protein Paralogs

Zhang, Y., Duc, A. E., Rao, S., Sun, X., Bilbee, A. N., Rhodes, M. R., Li, Q., Kappes, D. J., Rhodes, J., & Wiest, D. L. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.01.018 · Cited by 101

Transcript Profiling Provides Evidence of Functional Divergence and Expression Networks among Ribosomal Protein Gene Paralogs inBrassica napus

Whittle, C. A., & Krochko, J. E. (2009) · The Plant Cell · doi:10.1105/tpc.109.068411 · Cited by 101

C/EBPβ ΔuORF mice—a genetic model for uORF-mediated translational control in mammalsPreprint

Wethmar, K., Bégay, V., Smink, J. J., Zaragoza, K., Wiesenthal, V., Dörken, B., Calkhoven, C. F., & Leutz, A. (2010) · Genes & Development · doi:10.1101/gad.557910 · Cited by 99

Ribosomal Proteins of E. coli: Stoichiometry and Implications for Ribosome StructurePreprint

Traut, R. R., Delius, H., Ahmad‐Zadeh, C., Bickle, T. A., Pearson, P., & Tissieres, A. (1969) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1969.034.01.007 · Cited by 96

Control of Cyclin-Dependent Kinase Inhibitor p27 Expression by Cap-Independent Translation

Miskimins, W. K., Wang, G., Hawkinson, M., & Miskimins, R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.4960-4967.2001 · Cited by 95

Characterization and Analysis of Posttranslational Modifications of the Human Large Cytoplasmic Ribosomal Subunit Proteins by Mass Spectrometry and Edman Sequencing

Odintsova, T. I., Müller, E., Ivanov, A. V., Egorov, T. A., Bienert, R., Vladimirov, S. N., Kostka, S., Otto, A., Wittmann‐Liebold, B., & Karpova, G. G. (2003) · Journal of Protein Chemistry · doi:10.1023/a:1025068419698 · Cited by 93

The p53 Tumor Suppressor Causes Congenital Malformations in Rpl24-Deficient Mice and Promotes Their Survival

Barkić, M., Crnomarković, S., Grabušić, K., Bogetić, I., Panić, L., Tamarut, S., Brdovčak, M. C., Jerić, I., Vidak, S., & Volarević, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01588-08 · Cited by 92

The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans

Jannot, G., Bajan, S., Giguère, N. J., Bouasker, S., Banville, I., Piquet, S., Hutvágner, G., & Simard, M. J. (2011) · EMBO Reports · doi:10.1038/embor.2011.66 · Cited by 89

Physical and Functional Heterogeneity of E. coli RibosomesPreprint

Kurland, C. G., Voynow, P., HARDY, S. J. S., Randall, L. L., & Lutter, L. C. (1969) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1969.034.01.006 · Cited by 86

The human RPS4 paralogue on Yq11.223 encodes a structurally conserved ribosomal protein and is preferentially expressed during spermatogenesis

Lopes, A. M., Miguel, R. N., Sargent, C. A., Ellis, P. J. I., Amorim, A., & Affara, N. A. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-33 · Cited by 83

Proteomic Analysis of Rodent Ribosomes Revealed Heterogeneity Including Ribosomal Proteins L10-like, L22-like 1, and L39-like

Sugihara, Y., Honda, H., Iida, T., Morinaga, T., Hino, S., Okajima, T., Matsuda, T., & Nadano, D. (2010) · Journal of Proteome Research · doi:10.1021/pr9008964 · Cited by 83

Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish

Lai, K., Amsterdam, A., Farrington, S., Bronson, R. T., Hopkins, N., & Lees, J. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21815 · Cited by 81

Inhibition of CCAAT/Enhancer-binding Protein α and β Translation by Upstream Open Reading Frames

Lincoln, A. J., Monczak, Y., Williams, S. C., & Johnson, P. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9552 · Cited by 81

Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network

Pertz, O. C., Wang, Y., Yang, F., Wang, W., Gay, L. J., Gristenko, M. A., Clauss, T. R., Anderson, D. J., Liu, T., Auberry, K. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706545105 · Cited by 79

Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29

Kirn‐Safran, C. B., Oristian, D., Focht, R. J., Parker, S. G., Vivian, J. L., & Carson, D. D. (2006) · Developmental Dynamics · doi:10.1002/dvdy.21046 · Cited by 78

RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency

Volta, V., Beugnet, A., Gallo, S., Magri, L., Brina, D., Pesce, E., Calamita, P., Sanvito, F., & Biffo, S. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1215-y · Cited by 76

Genetic Analysis of RpL38 and RpL5, Two Minute Genes Located in the Centric Heterochromatin of Chromosome 2 of Drosophila melanogaster

Marygold, S. J., Coelho, C. M. A., & Leevers, S. J. (2004) · Genetics · doi:10.1534/genetics.104.034124 · Cited by 75

Characterization and Analysis of the Composition and Dynamics of the Mammalian Riboproteome

Reschke, M., Clohessy, J. G., Seitzer, N., Goldstein, D. P., Breitkopf, S. B., Schmolze, D. B., Ala, U., Asara, J. M., Beck, A. H., & Pandolfi, P. P. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.014 · Cited by 69

Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex

Zhou, C., Zang, D., Jin, Y., Wu, H., Liu, Z., Du, J., & Zhang, J. (2011) · Human Mutation · doi:10.1002/humu.21503 · Cited by 67

Heterogeneity of ribosomal populations in Escherichia coli cells grown in different media

Deusser, E. (1972) · Molecular and General Genetics MGG · doi:10.1007/bf00333862 · Cited by 63

Down-Regulation of RpS21, a Putative Translation Initiation Factor Interacting with P40, Produces Viable Minute Imagos and Larval Lethality with Overgrown Hematopoietic Organs and Imaginal Discs

Török, I., Herrmann, D., Kiss, I., Tick, G., Speer, G., Schmitt, R., & Mechler, B. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2308 · Cited by 57

Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes

Watkins‐Chow, D. E., Cooke, J., Pidsley, R., Edwards, A., Slotkin, R., Leeds, K. E., Mullen, R., Baxter, L. L., Campbell, T. G., Salzer, M. C., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003094 · Cited by 57

Biological Sciences: Ribosomal Proteins: Variation of the Protein Composition in Escherichia coli Ribosomes as Function of Growth Rate

Deusser, E., & Wittmann, H. G. (1972) · Nature · doi:10.1038/238269a0 · Cited by 54

RPLP1, a Crucial Ribosomal Protein for Embryonic Development of the Nervous System

Perucho, L., Artero‐Castro, A., Llobet, S. G., y Cajal, S. R., LLeonart, M. E., & Wang, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099956 · Cited by 50

The ribosome – a macromolecular machine par excellence

Frank, J. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00127-7 · Cited by 42

Ribosome Heterogeneity

Bickle, T. A., Howard, G. A., & Traut, R. R. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43745-9 · Cited by 36

Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models

Terzian, T., Dumble, M. L., Arbab, F., Christina Thaller, B., Donehower, L. A., Lozano, G., Justice, M. J., Roop, D. R., & Box, N. F. (2011) · The Journal of Pathology · doi:10.1002/path.2891 · Cited by 29

TIF-IA-Dependent Regulation of Ribosome Synthesis in Drosophila Muscle Is Required to Maintain Systemic Insulin Signaling and Larval Growth

Ghosh, A., Rideout, E. J., & Grewal, S. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004750 · Cited by 26

Covalent modifications of ribosomal proteins in growing and aggregation-competent Dictyostelium discoideum: phosphorylation and methylation

RAMAGOPAL, S. (1991) · Biochemistry and Cell Biology · doi:10.1139/o91-040 · Cited by 21

Variation of ribosomal proteins with bacterial growth rate

Milne, A., Mak, W., & Wong, J. T.-F. (1975) · Journal of Bacteriology · doi:10.1128/jb.122.1.89-92.1975 · Cited by 20

Ribosome biogenesis in cancer: new players and therapeutic avenues

Pelletier, J., Thomas, G., & Volarević, S. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.104 · Cited by 837

Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

Sloan, K. E., Warda, A. S., Sharma, S., Entian, K.-D., Lafontaine, D. L. J., & Bohnsack, M. T. (2017) · RNA Biology · doi:10.1080/15476286.2016.1259781 · Cited by 707

Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide

Shi, Z., Fujii, K., Kovary, K. M., Genuth, N. R., Röst, H. L., Teruel, M. N., & Barna, M. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.021 · Cited by 671

Local translation in neurons: visualization and function

Holt, C., Martin, K. C., & Schuman, E. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0263-5 · Cited by 463

The discovery of ribosome heterogeneity and its implications for gene regulation and organismal life

Genuth, N. R., & Barna, M. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.018 · Cited by 511

Specialized ribosomes: a new frontier in gene expression and organismal development (213.3)

Barna, M. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.213.3

Specialized ribosomes: a new frontier in gene regulation and organismal biology

Xue, S., & Barna, M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3359 · Cited by 730

Specialized ribosomes: a new frontier in gene regulation and organismal biology. Nature reviews

Xue, S., & Barna, M. (2016)

Translation specificity and ribosomal heterogeneity

Mooijman, D. (2012) · Utrecht University Repository (Utrecht University)

Pimp My Ribosome: Ribosomal Protein Paralogs Specify Translational Control

Gerst, J. E. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.08.004 · Cited by 75