Cited by 462Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationPeriodontal Regeneration and Treatments

The DOI matches its Crossref record; 236 of the 236 references it cites were found in a registry or an index.

Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine

Open access

Frenette, Paul S., Pinho, Sandra, Lucas, Daniel, Scheiermann, Christoph·2013·Annual Review of Immunology

DOI 10.1146/annurev-immunol-032712-095919

Open this paper in CoChat — free account

Abstract

Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs). The ease by which human MSC-like and stromal progenitor cells can be isolated from the bone marrow and other tissues has led to the rapid development of clinical investigations exploring their anti-inflammatory properties, tissue preservation capabilities, and regenerative potential. However, the identity of genuine MSCs and their specific contributions to these various beneficial effects have remained enigmatic. In this article, we examine the definition of MSCs and discuss the importance of rigorously characterizing their stem cell activity. We review their role and that of other putative niche constituents in the regulation of bone marrow HSCs. Additionally, how MSCs and their stromal progeny alter immune function is discussed, as well as potential therapeutic implications.

Integrity signals

Registry

Crossref · 10.1146/annurev-immunol-032712-095919

Cites

236 of 236 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T. R., Lund, T. C., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,523
Retracted
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,762
Mesenchymal stem cells
Caplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,559
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
Prockop, D. J. (1997) · Science · doi:10.1126/science.276.5309.71 · Cited by 4,629
Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
Gronthos, S., Mankani, M. H., Brahim, J. S., Robey, P. G., & Shi, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240309797 · Cited by 4,580
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1
Till, J. E., & McCulloch, E. A. (2010) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991

Show all 235 references

Research works printed but not linked: 10

Friedenstein AJ, 1976, Exp. Hematol., 4, 267
Friedenstein AJ, 1982, Exp. Hematol., 10, 217
Dexter TM, 1977, Biomedicine, 27, 344
Maltman DJ, 2011, Neurochem. Int., 59, 347
in ‘t Anker PS, 2003, Haematologica, 88, 845
Owen M, 1988, Ciba Found. Symp., 136, 42
10.1016/0008-6363(96)00063-6 · DOI
Schofield R, 1978, Blood Cells, 4, 7
Studeny M, 2002, Cancer Res., 62, 3603
Cyranoski D, 2011, Nature, 477, 377

Sorted by citations

Items 301–400 of 462

Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome
Wu, T., Pelus, L. M., Plett, P. A., Sampson, C. H., Chua, H. L., Fisher, A., Feng, H., Liu, L., Li, H., Ortíz, M. A., et al. (2023) · Radiation Research · doi:10.1667/rade-22-00208.1 · Cited by 8
A spike-targeting bispecific T cell engager strategy provides dual layer protection against SARS-CoV-2 infection in vivo
Li, F., Xu, W., Zhang, X., Wang, W., Su, S., Han, P., Wang, H., Xu, Y., Li, M., Fan, L., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04955-3 · Cited by 8
“Furthermore, since mesenchymal stem cells (MSCs) have been widely used for treating various diseases and have been demonstrated to have good safety pro ﬁ les in clinical settings 51 , in order to meet urgent clinical needs, we engineered MSCs to stably secrete S-BiTE (Fig.”
Targeting the Molecular and Cellular Interactions of the Bone Marrow Niche in Immunologic Disease
Brozowski, J. M., Billard, M. J., & Tarrant, T. K. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-013-0402-8 · Cited by 9
Sca‐1+mesenchymal stromal cells inhibit splenic marginal zone B lymphocytes commitment through Caspase‐3
Chen, Y., Yang, J., Zhang, H., Fan, H., An, N., Xin, J., Li, N., Xu, J., Yin, W., Wu, Z., et al. (2016) · Cell Biology International · doi:10.1002/cbin.10591 · Cited by 7
“Minimum criteria for definingMSCs are the expression of CD73, CD90, and CD105 and the absence of CD45, CD14 CD19, and class II antigens (human leukocyte antigen [HLA]-DR) (Frenette et al., 2013).”
BackgroundResultInfluential
pH-driven continuous stem cell production with enhanced regenerative capacity from polyamide/chitosan surfaces
Yen, C., Cheng, N., Hsieh, H., Tsai, C.-W., Lee, A., Lu, C.-Y., Chen, Y.-T., & Young, T. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100514 · Cited by 7
Role of mesenchymal stem cells in bone fracture repair and regeneration
Chen, Y., Lin, J., Yu, Y., & Du, X. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819713-4.00007-4 · Cited by 7
Intranasal delivery of stem cells labeled by nanoparticles in neurodegenerative disorders: Challenges and opportunities
Alizadeh, R., Asghari, A., Taghizadeh‐Hesary, F., Moradi, S., Farhadi, M. R., Mehdizadeh, M., Simorgh, S., Nourazarian, A., Shademan, B., Susanabadi, A., et al. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1915 · Cited by 7
Brief Report: Human Mesenchymal Stem-Like Cells Facilitate Floating Tumorigenic Cell Growth via Glutamine-Ammonium Cycle
Tang, K., Hu, L., Ma, J., Zhang, H., Zhang, Y., Li, Y., Ma, R., Luo, S., Liu, D., Long, G., et al. (2015) · Stem Cells · doi:10.1002/stem.2076 · Cited by 7
Bone marrow niches in myeloid neoplasms
Kitagawa, M., Kurata, M., Onishi, I., & Yamamoto, K. (2019) · Pathology International · doi:10.1111/pin.12870 · Cited by 7
Effect of Mesenchymal Stem Cell-derived Microvesicles on Megakaryocytic Differentiation of CD34+ Hematopoietic Stem Cells
Aqmasheh, S., Shamsasenjan, K., Adeli, E. K., Movassaghpourakbari, A., Akbarzadehlaleh, P., Sarvar, D. P., & Timari, H. (2020) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2020.038 · Cited by 7
The protective effects of HMGA2 in the senescence process of bone marrow‐derived mesenchymal stromal cells
Yang, Z., Liu, X., Wang, L., Wang, T., Chen, Y., Teng, X.-M., Li, J., Shao, L., Hui, J., Ye, W., et al. (2020) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3023 · Cited by 7
N-methyl-D-aspartate receptor blockers attenuate bleomycin-induced pulmonary fibrosis by inhibiting endogenous mesenchymal stem cells senescence
Huang, P., Zhou, Y., Li, X.-H., Zhang, Y., Cheng, H., Fu, J.-F., Liu, W. Q., Yue, S., & Luo, Z. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-2507 · Cited by 6
“Endogenous BM-MSCs from BM can also be mobilized into damaged tissues from the circulatory system to participate in the repair and regeneration of damaged tissues (78).”
EPO modified MSCs protects SH-SY5Y cells against ischemia/hypoxia-induced apoptosis via REST-dependent epigenetic remodeling
Yu, J., Li, R., Ban, Y., Zhang, W., Kong, N., Tang, J., Ma, B., Shao, Y., Jin, R., Sun, L., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-74261-3 · Cited by 6
Acute Myeloid Leukemia Causes Serious and Partially Irreversible Changes in Secretomes of Bone Marrow Multipotent Mesenchymal Stromal Cells
Sadovskaya, A. V., Петинати, Н. А., Дризе, Н. И., Smirnov, I. P., Pobeguts, O. V., Arapidi, G. P., Lagarkova, M. A., Belyavsky, A. V., Vasilieva, A., Aleshina, O. A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108953 · Cited by 7
“Within the bone marrow, MSCs are prominently involved in orchestrating the behavior of hematopoietic stem and progenitor cells, ensuring a lifelong blood supply [2,4].”
Background
Development and characterization of AgHNTs@SPU film loaded with letrozole as drug delivery system and its anticancer activity
Bose, N., Danagody, B., Rajappan, K., Munuswamy‐Ramanujam, G., & Karanath‐Anilkumar, A. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104557 · Cited by 6
AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors
Larsen, M. C., Rondelli, C. M., Almeldin, A., Song, Y., N′jai, A. U., Alexander, D. L., Forsberg, E. C., Sheibani, N., & Jefcoate, C. R. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316884 · Cited by 5
“Multipotential BM mesenchymal stem cells (BM-MSC) not only release support factors for each lineage, but also differentiate to adipocytes, osteoblasts, and chondrocytes [4].”
Background
Study on the mechanism of mitigating radiation damage by improving the hematopoietic system and intestinal barrier with Tenebrio molitor peptides
Shang, Y., Cui, P., Chen, Y., Zhang, Z., Li, S., Chen, Z., Ma, A., & Jia, Y. (2024) · Food & Function · doi:10.1039/d4fo01141d · Cited by 6
Modification of Gene Expression, Proliferation, and Function of OP9 Stroma Cells by Bcr-Abl-Expressing Leukemia Cells
Supper, E., Suhail, T., Imai, T., Inoue, J., & Minato, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134026 · Cited by 6
“The stroma cells regulate hematopoiesis via direct interactions with hematopoietic cells and secretion of various hematopoietic cytokines [5, 6].”
Background
Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury
Marchand, T., Akinnola, K. E., Takeishi, S., Maryanovich, M., Pinho, S., Saint‐Vanne, J., Birbrair, A., Lamy, T., Tarte, K., Frenette, P. S., et al. (2025) · eLife · doi:10.7554/elife.101714.3 · Cited by 5
Self-citation
Bortezomib enhances G-CSF-induced hematopoietic stem cell mobilization by decreasing CXCL12 levels and increasing vascular permeability
Matsumoto, T., Takamatsu, Y., Moriyama, H., Terada, K., Mori, M., Ono, K., Migita, K., & Hara, S. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.02.009 · Cited by 6
The Chromatin Remodeling Complex CHD1 Regulates the Primitive State of Mesenchymal Stromal Cells to Control Their Stem Cell Supporting Activity
Lee, H., Yang, S., Choi, H., Kim, J., & Oh, I. (2021) · Stem Cells and Development · doi:10.1089/scd.2020.0166 · Cited by 6
“…mode of action for MSCs is the paracrine support of tissue regeneration both by inhibiting apoptosis and ﬁ-brosis [4], and by stimulating the regeneration of endogenous stem cells such as hematopoietic stem cells (HSCs), neuronal stem cells, and other tissue-speciﬁc endogenous stem cells [5,6].”
Enhanced Osteocyte Differentiation: Cathepsin D and L Secretion by Human Adipose-Derived Mesenchymal Stem Cells
Choi, J., Lim, S., Jung, S. E., Jeong, S., Moon, H., Song, B., Kim, I., Lee, S., Hwang, K., & Kim, S. W. (2023) · Cells · doi:10.3390/cells12242852 · Cited by 5
“They can be largely isolated from the bone marrow and adipose tissue [3], and bone-marrow-derived MSCs (BM-MSCs) have been recognized as the most effective and reliable cell source for a long time despite the low yield of cells and limitations in clinical application [4].”
Background
Influence of Human Bone Marrow Mesenchymal Stem Cells Secretome from Acute Myeloid Leukemia Patients on the Proliferation and Death of K562 and K562-Lucena Leukemia Cell Lineages
de Freitas, F. A., Levy, D., Reichert, C. O., Sampaio‐Silva, J., Giglio, P. N., Lage, L. A. D. P. C., Demange, M. K., Pereira, J. C., & Bydlowski, S. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094748 · Cited by 5
“These are multipotent cells that contribute substantially to the BM niche [7,8], supporting hematopoiesis as well [9], playing an essential role by regulating HSC proliferation and differentiation.”
Background
Organoid Models of Lymphoid Tissues
Bogoslowski, A., Ren, J., Quintard, C., & Penninger, J. M. (2025) · Organoids · doi:10.3390/organoids4020007 · Cited by 5
“Mesenchymal cells are vital in expressing genes that support HSPC maintenance [59].”
A 3D construct based on mesenchymal stromal cells, collagen microspheres and plasma clot supports the survival, proliferation and differentiation of hematopoietic cells in vivo
Bello-Rodriguez, C., Wittig, O., Diaz‐Solano, D., Bolaños, P., & Cardier, J. E. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03265-y · Cited by 5
“Likewise, because it is well known that MSCs support hematopoiesis in vivo and in vitro (Li and Wu 2011; Frenette et al. 2013; Majumdar et al. 2000; Méndez-Ferrer et al. 2010; Crane et al. 2017; Dexter et al. 1977), the persistence of these cells for long-term periods (3 months) may explain the active hematopoiesis ob…”
Background
Rewiring the Niche: Sympathetic Neuropathy Drives Malignant Niche Transformation
Price, T. T., & Sipkins, D. A. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.08.012 · Cited by 5
“…perivascular HSPC niche refers to a region populated bystromal cells that includeCXCL12 reticular cells, Nestin+ MSCs, and LepR+ MSCs expressing multiple soluble and membrane-bound factors that regulate HSPC self-renewal and retention within the niche (Frenette et al., 2013; Doan and Chute, 2012).”
Background
Characterization of adipose tissue mesenchymal stromal cell subsets with distinct plastic adherence
Park, J., Kim, K., Rhie, J. W., & Oh, I. (2016) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-015-0027-1 · Cited by 5
Artificial Hematopoietic Stem Cell Niches-Dimensionality Matters
Gottwald, E. (2017) · Advances in Tissue Engineering & Regenerative Medicine Open Access · doi:10.15406/atroa.2017.02.00042 · Cited by 5
Butyric acid induces spontaneous adipocytic differentiation of porcine bone marrow–derived mesenchymal stem cells
Tugnoli, B., Bernardini, C., Forni, M., Piva, A., Stahl, C. H., & Grilli, E. (2018) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-018-0307-x · Cited by 5
Effects of Sodium Chlorophyllin Copper on APO-1 Expression in Bone Marrow Mesenchymal Stem Cells of Rats with Aplastic Anaemia
Jin, X., Dai, G., Xuan, L., Zhang, M., Jiang, H., & Sui, Y. (2022) · Journal of Immunology Research · doi:10.1155/2022/6792866 · Cited by 5
“Several studies have con ﬁ rmed that the Fas/FasL system is important for T ‐ cell apoptosis in in ﬂ ammatory and immune diseases [28 – 30], and enhancement of Fas/FasL expression is a promising strategy to improve MSC cytotherapy at the molecular level [31].”
MCP‑1/CCR2 axis inhibits the chondrogenic differentiation of human nucleus pulposus mesenchymal stem cells
Ou, X., Wen, T., Ying, J., He, Q. H., Xuan, A., & Ruan, D. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12793 · Cited by 5
Effect of nutritional supplement on bone marrow-derived mesenchymal stem cells from aplastic anaemia
Luo, S., Chen, Y., Zhao, L., Xia, Q., Miao, X., Zhou, H., & Li, J. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518000399 · Cited by 5
“…to identify the regulatory mechanisms that control the differentiation of BMSC into adipocytes or osteoblasts may lead to the development of new clinical applications and enhance our understanding of haematopoiesis, as BMSC are the primary sources of the haematopoietic microenvironment (27) .”
Background
Use of Stem Cells in Wound Healing
Aronson, A., Laageide, L. G., & Powers, J. G. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0233-x · Cited by 6
Sinister Symbiosis: Pathological Hematopoietic-Stromal Interactions in CML
Mullally, A., & Ebert, B. L. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.08.009 · Cited by 5
“Many of the requisite cellular components of the HSC bone marrow niche have now been defined (reviewed in Frenette et al., 2013).”
Background
Chronic stress in cancer development and progression
Niu, X., Wu, T. H., Zeng, L., Wang, F., Lv, W., Zhang, L., & Zhou, F. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.09.034 · Cited by 7
The Sca-1+ mesenchymal stromal cells modulate macrophage commitment and function
Chen, Y., Chen, Y., Yin, D., Wang, Y., Liu, Z., An, N., Fan, W. E. N., Li, N., Xin, J., Hu, X., et al. (2016) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1507-113 · Cited by 4
“MSCs are heterogeneous and capable of differentiating into adipose, bone, cartilage, muscle, and myeloid supportive stromal cells (Frenette et al., 2013).”
Background
Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening
Erdmann, G., Suchánek, M., Horn, P., Graf, F., Volz, C. H., Horn, T., Zhang, X., Wagner, W., Ho, A., & Boutros, M. (2015) · Genome Medicine · doi:10.1186/s13073-015-0170-2 · Cited by 4
“They might play a role as a major cellular component of the bone marrow niche for hematopoietic stem cells [1].”
Background
Effects of in vivo deletion of GATA2 in bone marrow stromal cells
Hasegawa, S., Fujiwara, T., Okitsu, Y., Kato, H., Sato, Y., Fukuhara, N., Onishi, Y., Shimizu, R., Yamamoto, M. P., & Harigae, H. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.08.004 · Cited by 4
“factors have been reported to be involved in this process [1], how the function of BM-MSC is 52”
Background
Bridging Insights From Lymph Node and Synovium Studies in Early Rheumatoid Arthritis
O’Byrne, A. M., de Jong, T. A., & van Baarsen, L. G. M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.820232 · Cited by 4
Characterization of Human, Ovine and Porcine Mesenchymal Stem Cells from Bone Marrow: Critical In Vitro Comparison with Regard to Humans
Westerkowsky, E. K., de Almeida, A. M. S., Selle, M., Harms, O., Bundkirchen, K., Neunaber, C., & Noack, S. (2023) · Life · doi:10.3390/life13030718 · Cited by 4
“Mesenchymal stem cells (MSC) are multipotent, self-renewable cells with the ability to differentiate into various cell types such as chondrocytes, adipocytes and osteoblasts [2].”
Background
Preconditioned Chorionic Villus Mesenchymal Stem/Stromal Cells (CVMSCs) Minimize the Invasive Phenotypes of Breast Cancer Cell Line MDA231 In Vitro
Subayyil, A. M. A., Basmaeil, Y. S., Kulayb, H. N. B., Alrodayyan, M., Alhaber, L. A. A., Almanaa, T. N., & Khatlani, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119569 · Cited by 4
Novel Strategy to Enhance Human Mesenchymal Stromal Cell Immunosuppression: Harnessing Interferon-Gamma Presentation in Metal–Organic Frameworks Embedded on Heparin/Collagen Multilayers
Haseli, M., Pinzon‐Herrera, L., Hao, X., Wickramasinghe, S. R., & Almodóvar, J. (2023) · Langmuir · doi:10.1021/acs.langmuir.3c02355 · Cited by 4
Local chemical sympathectomy of rat bone marrow and its effect on marrow cell composition
Dubový, P., Klusáková, I., Kučera, L., Osičková, J., Chovancová, J., Loja, T., Mayer, J., Doubek, M., & Joukal, M. (2017) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.06.003 · Cited by 4
“In contrast to 6-OHDA, guanethidine induces long-lasting functional sympathectomy in adult rodents (Burnstock et al., 1971; Heath and Burnstock, 1977; Johnson and Manning, 1984), while avoiding non-specific extraneous effects on other tissue cells (Demas and Bartness, 2001; Logan et al.”
The Adult Hematopoietic Niches — Cellular Composition, Histological Organization and Physiological Regulation
Zapata, A. G. (2014) · InTech eBooks · doi:10.5772/58634 · Cited by 5
“, CXCL12, SCF, TGFβ) are selectively deleted from different niche cell types [42, 51].”
Background
Presence of SCF / CXCL 12 double‐positive large blast‐like cells at the site of cutaneous extramedullary haematopoiesis
Kogame, T., Hirata, M., Kataoka, T. R., Seidel, J. A., Ueshima, C., Matsui, M., Nomura, T., & Kabashima, K. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15068 · Cited by 4
Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injuryPreprint
Marchand, T., Akinnola, K. E., Takeishi, S., Maryanovich, M., Pinho, S., Saint‐Vanne, J., Birbrair, A., Lamy, T., Tarte, K., Frenette, P. S., et al. (2024) · eLife · doi:10.7554/elife.101714 · Cited by 4
“…hematopoiesis after injury Introduction Bone marrow mesenchymal stem cells (BM-MSCs) are rare self-renewing multipotent stromal cells which are capable of multilineage differentiation into osteoblasts, chondrocytes, and adipocytes ( Caplan, 1991 ; Dominici et al., 2006 ; Frenette et al., 2013 ).”
Self-citation
The Blood is Rich in Different Types of Mesoderm Derived Stem and Progenitor Cells
Filipović, M. K. (2014) · Acta veterinaria · doi:10.2478/acve-2014-0016 · Cited by 3
Antisense Oligonucleotides against Let-7 Enhance the Therapeutic Potential of Mesenchymal Stromal Cells
Lee, D.-W., Shin, S., Kim, J., Lee, C., Kim, I., & Oh, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108639 · Cited by 3
“Together, these results show that anti-let7-ASO could enhance the supportive function of MSCs on the self-renewing expansion of HPCs, the angiogenesis of endothelial cells, and wound healing, indicating the higher regenerative potential of the cells.”
BackgroundInfluential
Role of Neurotransmitters in Steady State Hematopoiesis, Aging, and Leukemia
Beeraka, N. M., Basappa, B., Nikolenko, V. N., & Mahesh, P. A. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10761-z · Cited by 3
“This complexity arises because and it has crucial functions as an orexigenic peptide [81 , 203 , 204].”
A Novel Injectable Cell-Loaded Hydrogel System for Cartilage Repair: In Vivo and In Vitro Study
Mao, B., Tian, M., Yin, Y., Li, L., Li, J. J., Wei, D., & Fu, W. (2025) · Tissue Engineering Part A · doi:10.1089/ten.tea.2025.0024 · Cited by 3
“While bone marrow, umbilical cord, and adipose-derived MSCs have shown ef ﬁ - cacy, 5,10 their clinical application is constrained by collection dif ﬁ culties.”
Rheb1-Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation via Mesenchymal Stem Cells
Gao, J., Hou, S., Yuan, S., Wang, Y., Gao, Y., Sun, X., Wang, W., Chu, Y., Zhou, Y., Feng, X., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.650599 · Cited by 3
Protective and pathological roles of regulatory immune cells in human cytomegalovirus infection following hematopoietic stem cell transplantation
Namdari, H., Hosseini, M. S., Yazdanifar, M., Farajifard, H., Parvizpour, F., Karamigolbaghi, M., Hamidieh, A. A., & Rezaei, F. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2319 · Cited by 3
“Mesenchymal stromal cells (MSCs) known for their multi lineage differentiation potential, possess pleiotropic immunosuppressive functions.(83,84) Due to their unique features, such as antimicrobial F I GUR E 3 MDSCs produce high level of innate immune effector nitric oxide (NO) which in turn suppresses HCMV replicatio…”
Background
Blood Scent
Silberstein, L., & Scadden, D. T. (2013) · Cell · doi:10.1016/j.cell.2013.11.006 · Cited by 2
A chemically adjustable BMP6-IL6 axis in mesenchymal stem cells drives acute myeloid leukemia cell differentiation
Sun, L., Rao, S., Kerim, K., Li, H., Li, H., Zhao, S., Shen, P., & Sun, W. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116262 · Cited by 3
The Integral Role of Mesenchymal Stem Cells in Stem Cell Transplantation from Promotion of Stem Cell Engraftment to Immunomodulation
Mendiratta, M., Mendiratta, M., Garg, D., Mohanty, S., & Sahoo, R. K. (2024) · Biochemistry · doi:10.5772/intechopen.1008146 · Cited by 3
The Sca1+ mesenchymal stromal subpopulation promotesdendritic cell commitment in the niche
Li, N., Yin, D., Zhang, H., Xu, J., Fan, W. E. N., Liu, Z., Chen, Y., An, N., Xin, J., Yazhou, W. A. N. G., et al. (2017) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1510-81 · Cited by 3
“Mesenchymal stromal cells (MSCs) are the most important components in the niche (Frenette et al., 2013).”
Background
Melanoma-Induced Anemia Could be Rescued by Sca-1 + Mesenchymal Stromal Cells in Mice
An, N., Chen, Y., Yin, D., Zhang, H., Liu, Z., Feng, F., Li, N., Xin, J., Yin, W., Xu, X., et al. (2017) · Stem Cells and Development · doi:10.1089/scd.2016.0139 · Cited by 3
“Recently, many studies showed that MSCs, as an important component in niche, exhibited the function in regulating hematopoiesis [22–25].”
The Skeletal Stem Cell
Park, D., Hoggatt, J., Ferraro, F., & Scadden, D. T. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00007-8 · Cited by 3
Human embryonic stem cell-derived immunity-and-matrix-regulatory cells on collagen scaffold effectively treat rat corneal alkali burn
Lin, H., Guo, B., Li, Z., Wang, C., Wu, W., Lu, Z., Wang, L., Wu, J., Li, J., Hao, J., et al. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110164 · Cited by 2
Carbon Nanomaterials for Neuronal Tissue Engineering
Barrejón, M., & Bosi, S. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839161070-00184 · Cited by 2
Clinical study of late-onset hemorrhagic cystitis after allo-HSCT without in vitro T-cell depletion
Yuan, H., Chen, G., Qu, J., Yang, R., Muhashi, M., Aizezi, G., & Jiang, M. (2022) · Medicine · doi:10.1097/md.0000000000032130 · Cited by 2
“[22] MSCs play a role in promoting tissue repair through the following 2 pathways[23]: directly participating in tissue damage repair under local microenvironments; and indirectly participating in tissue damage repair by secreting a variety of cytokines and cell growth factors to improve the microenvironment at the ti…”
Background
Enzyme‐Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells
Kawai, H., Oo, M. W., Takabatake, K., Tosa, I., Soe, Y., Eain, H. S., Sanou, S., Fushimi, S., Sukegawa, S., Nakano, K., et al. (2023) · JBMR Plus · doi:10.1002/jbm4.10722 · Cited by 2
The Radioprotective Effects of 16, 16 dimethyl Prostaglandin E2 on Survival and Hematopoiesis are Mediated Through Co-Stimulation of the EP3 and EP4 Receptors
Fukuda, S., Patterson, A. M., Wu, T., Singh, P., Plett, P. A., Feng, H., Sampson, C. H., Orschell, C. M., & Pelus, L. M. (2025) · Radiation Research · doi:10.1667/rade-24-00176.1.s1 · Cited by 2
“Since non-hematopoietic/stromal cells in the BM niche contribute to HSPC survival and function ( 33 – 35 ), we evaluated the impact of dmPGE 2 and EP agonists on gene expression in CD45 (cid:2) , Ter119-BM stromal niche cells harvested from BM 1 h post-TBI by RNA-seq.”
The biological time calendar
Duc, H. T. (2014) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2014.03.006 · Cited by 2
Role of mesenchymal stem cells in bone cancer; initiation, propagation and metastasis
Cleton-Jansen, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416721-6.00007-8 · Cited by 2
Bone Marrow Hematopoietic Niches
Wu, J. Y., & Kronenberg, H. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800571-2.00007-4 · Cited by 2
Biological Augmentation of Meniscal Repairs
Anz, A. W. (2017) · Springer eBooks · doi:10.1007/978-3-662-53792-3_13 · Cited by 2
Role of Adipose-Derived Mesenchymal Stem Cells in Full Thickness Wound Healing
Dososaputro, I., Hoekstra, L. T., Rahmania, D., & Perdanakusuma, D. S. (2017) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000398 · Cited by 2
“Some reports described the paracrine role of MSCs in wound healing [22,23].”
Background
Characteristics of Mesenchymal Stem Cells Are Independent of Bone Marrow Storage Temperatures
Schrodi, V., Neunaber, C., Bundkirchen, K., Ye, W., Jiang, Z., Petri, M., Krettek, C., & Noack, S. (2021) · Stem Cells International · doi:10.1155/2021/6864988 · Cited by 2
“Mesenchymal stem cells (MSCs) are multipotent self-renewable cells with the capability to differentiate into various cell types like adipocytes, chondrocytes, and osteoblasts [1].”
Background
Potential role of mesenchymal stem cells in T cell aging
Zhong, X., Chen, J., Bo, W., Wu, X., Li, M., Du, F., Chen, Y., Deng, S., Zhao, Y., Shen, J., et al. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02371-y · Cited by 4
“…organ cells and even activate the proliferation of stem progenitor cells of these tissues and organs, thus repairing the damage of tissues and organs [10]; (3) MSCs can support hematopoietic stem cells production, secrete erythropoietin (EPO) by themselves, and increase blood oxygen levels [11].”
Background
Bone mesenchymal stromal cells exhibit functional inhibition but no chromosomal aberrations in chronic myelogenous leukemia
Xie, J., Chen, J., Wang, B., He, X., & Huang, H. (2018) · Oncology Letters · doi:10.3892/ol.2018.9681 · Cited by 2
“As one of the main components of BMM, bone mesenchymal stromal cells (BMSCs) serve an indispensable role in hematopoiesis regulation (11).”
Background
Hematopoietic Stem Cells
Moore, M. A. S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00047-1 · Cited by 2
Development of a three-dimensional haematopoietic stem cell-permissive bone marrow niche model using magnetic levitation
Lewis, N. S. (2018) · Enlighten: Theses (The University of Glasgow) · Cited by 2
Establishment of iPSC-Derived MSCs Expressing hsa-miR-4662a-5p for Enhanced Immune Modulation in Graft-Versus-Host Disease (GVHD)
Lee, S. O., Kim, E.-W., Lee, H., Lim, S.-U., Jung, C. K., Kang, Y., Jung, G.-A., & Oh, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020847 · Cited by 1
“These therapeutic effects are largely attributed to the paracrine actions of MSCs, mediated by the secretion of growth factors and cytokines that promote endogenous stem-cell proliferation, angiogenesis, and survival signaling [5–7].”
Decoding dental mesenchymal stem cells diversity: single-cell transcriptomics maps heterogeneity in molar development
Zhang, R., Chen, L., Xu, W., Xu, W., & Wu, B. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1712688 · Cited by 1
Myeloid immune reprogramming in bone metastatic cancer: Mechanistic crosstalk, therapeutic targets and unresolved clinical challenges
Khan, S. U., Rai, N., Alissa, M., Safhi, A. Y., Sabei, F. Y., Hanbashi, A., Alnafesah, G. M., Swain, S. K., Alyami, E. M., & Das, S. P. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105185 · Cited by 1
Mesenchymal Stromal Cell-Based Therapies for Lung Disease
Chambers, D. C. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-21082-7_14 · Cited by 1
Alginate Hydrogels for the 3D Culture and Therapeutic Delivery of Cells
Wright, B., & Connon, C. J. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622055-00135 · Cited by 1
Progress of tracking the viability of transplanted stem cells in vivo
Meng, C., Wang, Q., Huang, D., Chen, G., & Lin, S. (2016) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972015-01404 · Cited by 1
Clinical Application of Stem Cells in Liver Diseases: From Bench to Bedside
Xu, Y., & Zhang, Q. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812301-0.00015-3 · Cited by 1
Palliative care for patients with bone metastases
Morillo, V., Piquer, T., & Albiach, C. F. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821666-8.00026-8 · Cited by 1
09 Leucémie myéloïde chronique
Guillaume, E., & Manier, S. (2021) · Hématologie · doi:10.1684/hma.2021.1670 · Cited by 1
No Effect on Tumorigenesis in MG63 Cells Induced by Co-Cultured Mesenchymal Stem Cells
Xing, X., Hu, Y., Wang, Y., Shao, Y., & Zou, M. (2022) · Journal of Oncology · doi:10.1155/2022/4202439 · Cited by 1
“BMSCs exist in the whole life cycle and play an important role in the maintenance and repair of tissue homeostasis [27].”
Background
The nervous system: innervations of the skeleton; bone homeostasis; and peripheral neuropathies (Baxter’s neuropathy, tarsal tunnel syndrome, and peroneal neuropathy)
Pierre-Jerome, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99352-4.00009-7 · Cited by 1
Differential roles of prostaglandin E2 EP4 receptor on stromal cell populations for hematopoietic stem and progenitor cell function
Liu, L., Li, H., Singh, P., Hoggatt, J., & Pelus, L. M. (2023) · Frontiers in Hematology · doi:10.3389/frhem.2023.1292651 · Cited by 1
Lenalidomide and pomalidomide modulate hematopoietic cell expansion and differentiation in the presence of MSC
Fujii, S., & Miura, Y. (2024) · International Journal of Hematology · doi:10.1007/s12185-024-03815-y · Cited by 1
“Hematopoietic cell production within the bone marrow is profoundly influenced by the bone-marrow microenvironment [8], in which mesenchymal stromal/ stem cells (MSCs) play a pivotal role [9].”
Background
Chemical Coaxing of Mesenchymal Stromal Cells by Drug Repositioning for Nestin Induction
Lim, S.-U., Lee, D.-W., Kim, J. H., Kang, Y., Kim, I.-Y., & Oh, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158006 · Cited by 1
“…primarily facilitate tissue regeneration through paracrine mechanisms, which exhibit both anti-apoptotic and anti-fibrotic properties [6] and promote the regeneration of endogenous stem cells such as hematopoietic stem cells (HSCs), neuronal stem cells and other tissue-specific stem cells [7,8].”
Background
Ganglioside expression delineates human mesenchymal stem/stromal cell populations derived from different tissue sources
Groux‐Degroote, S., Martin, K. C., Yamakawa, N., Coddeville, B., Guérardel, Y., & Sackstein, R. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2024.12.001 · Cited by 1
The Hematopoietic Stem Cell Niche: Cell-Cell Interactions and Quiescence
Childress, P., Alvarez, M. B., Chitteti, B. R., Kacena, M. A., & Srour, E. F. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-21702-4_1 · Cited by 1
“Mesenchymal lineage cells expressing Nestin, platelet derived growth factor receptor—alpha (PDGFRα), CD51, CXCL12, Leptin receptor (Lep-R), CD146, and CD105 are reported to possess mesenchymal progenitor activity with self-renewal and multi-lineage differentiation potential [34, 53, 65, 67].”
Background
Cost-effective Storage Solution for Delivering Umbilical Cord with Efficient Isolation of Mesenchymal Stem Cells
Lai, B., Huang, J., Chen, J., Li, W., Wu, H., & Xu, J. (2020) · BioTechniques · doi:10.2144/btn-2019-0146 · Cited by 1
Mesenchymal Stem Cells and Regenerative Medicine
Baker, N., Jiang, Y., & Tuan, R. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.15018-0 · Cited by 1
Heterotopic Ossification and Calcification
Chen, K., Ding, N., & Kan, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.66152-4 · Cited by 1
Clonal MDS/AML cells with enhanced TWIST1 expression reprogram the differentiation of bone marrow MSCsPreprint
Li, X., Li, H., Wang, Y., Yang, F., Feng, S., Chang, K., Yu, X., & Guan, F. (2023) · Research Square · doi:10.21203/rs.3.rs-2775117/v1 · Cited by 1
Epigenenomic and transcriptomic characterization of NPM1 -mutated CN-AML subtypesPreprint
N’Guyen, L., Tellez-Quijorna, C., Vernerey, J., Garciaz, S., Carbuccia, N., Guillé, A., Burny, C., Poplineau, M., Murati, A., Vey, N., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.07.592738 · Cited by 1
Engineering autologous ossicles for the personalized modeling of acute myeloid leukemiaPreprint
Sauter, C., Zacharaki, D., Garcia, A. G., Gil, D. H., Li, Y., Pørtner, E. J., Grigoryan, A., Gabriel, M., Baudet, A., Antón, S. G., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.13.715606 · Cited by 1
An investigation into the role of chemokines in haemopoietic stem cell quiescence
Sinclair, A. (2015) · Enlighten: Theses (The University of Glasgow)
Cultivo de células troncales de médula ósea de rata (rctmo) en matrices de colágeno tipo i, para su uso en Protocolos de regeneración de tejidos
Tobón, T., & Felipe, L. M. V. (2014)
The Microenvironment, Aging and Disease
Geiger, H. (2014) · Else Kröner-Fresenius Symposia · doi:10.1159/000366569
Treating Cancer by Getting on Its Nerves
Nusinovich, Y. A. (2014) · Science Signaling · doi:10.1126/scisignal.2005822
METHOD Open Access
Maretty, L., Sibbesen, J. A., & Krogh, A. (2014)

Authors: Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C.
Affiliations: Albert Einstein College of Medicine (US)
ORCID: Frenette, Paul S.
Pinho, Sandra
Lucas, Daniel
Scheiermann, Christoph
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2013-03-21
Volume: 31
Issue: 1
Pages: 285-316
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-032712-095919
OpenAlex: W2138953281
Cited by: 462
References: 235
Citations by year: 2026: 8 · 2025: 14 · 2024: 27 · 2023: 27 · 2022: 23 · 2021: 39 · 2020: 35 · 2019: 34 · 2018: 41 · 2017: 42 · 2016: 38 · 2015: 51 · 2014: 54 · 2013: 27
FWCI: 7.76
Type: journal article
Language: en
Open access: green
archive-ouverte.unige.ch
Licence: cc-by
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: National Heart, Lung, and Blood Institute (R01HL116340, R01HL097700, R01HL069438, R01HL097819)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords: mesenchymal stem cells, hematopoietic stem cells, bone marrow microenvironment, stromal progenitor cells, immune function, anti-inflammatory activity, regenerative medicine, stem cell therapy
MeSH terms: Animals, Bone Marrow Cells, Humans, Inflammation, Stem Cells, Stromal Cells, Hematopoietic Stem Cell Transplantation, Regenerative Medicine, Mesenchymal Stem Cell Transplantation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks