Cited by 462Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationPeriodontal Regeneration and Treatments

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Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine

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Frenette, Paul S., Pinho, Sandra, Lucas, Daniel, Scheiermann, Christoph·2013·Annual Review of Immunology

DOI 10.1146/annurev-immunol-032712-095919

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Abstract

Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs). The ease by which human MSC-like and stromal progenitor cells can be isolated from the bone marrow and other tissues has led to the rapid development of clinical investigations exploring their anti-inflammatory properties, tissue preservation capabilities, and regenerative potential. However, the identity of genuine MSCs and their specific contributions to these various beneficial effects have remained enigmatic. In this article, we examine the definition of MSCs and discuss the importance of rigorously characterizing their stem cell activity. We review their role and that of other putative niche constituents in the regulation of bone marrow HSCs. Additionally, how MSCs and their stromal progeny alter immune function is discussed, as well as potential therapeutic implications.

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Background
Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review
Shah, S., Mansour, H. M., & Lucke-Wold, B. P. (2025) · Cells · doi:10.3390/cells14010042 · Cited by 16
“Different types of stem cells exist, such as neural stem cells (NSCs), mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and embryonic stem cells (ESCs) [43,44].”
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Background
Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts
Zhou, Z., Shen, Y. H., Yin, J., Xi, F., Xu, R., Lin, D., Saijilafu, Chen, J., & Wang, Y. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28438 · Cited by 14
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Evaluation of the Age- and Sex-Related Changes of the Osteogenic Differentiation Potentials of Healthy Bone Marrow-Derived Mesenchymal Stem Cells
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“Being the most exploited source of mesenchymal stem cells, bone marrow-derived mesenchymal stem cells (BMSCs) are of great importance due to their ability to support other progenitors of the immune and blood system [3], engage in the repair system of extramedullary tissues [4], and modulate bone regulation through par…”
Background
Recovery of Donor Hematopoiesis after Graft Failure and Second Hematopoietic Stem Cell Transplantation with Intraosseous Administration of Mesenchymal Stromal Cells
Петинати, Н. А., Дризе, Н. И., Sats, N. V., Risinskaya, N., Sudarikov, A. B., Drokov, M. Y., Дубняк, Д. С., Kraizman, A., Nareyko, M. V., Popova, N. N., et al. (2018) · Stem Cells International · doi:10.1155/2018/6495018 · Cited by 13
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AML‑derived mesenchymal stem cells upregulate CTGF expression through the BMP pathway and induce K562‑ADM fusiform transformation and chemoresistance
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“Mesenchymal stem cells (MSCs), are a key component of the BMM, and are essential for regulating the number of HSPCs, as well as for maintaining normal hematopoietic function (9-11).”
Background
Transforming growth factor‐β boosts the functionality of human bone marrow‐derived mesenchymal stromal cells
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Mesenchymal-Stromal Cell-like Melanoma-Associated Fibroblasts Increase IL-10 Production by Macrophages in a Cyclooxygenase/Indoleamine 2,3-Dioxygenase-Dependent Manner
Çakır, U., Hajdara, A., Széky, B., Mayer, B., Kárpáti, S., Mezey, É., Silló, P., Szakács, G., Füredi, A., Pós, Z., et al. (2021) · Cancers · doi:10.3390/cancers13246173 · Cited by 12
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Background
CXCR4 expression by mesenchymal stromal cells is lost after use of enzymatic dissociation agents, but preserved by use of non-enzymatic methods
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Background
Mesenchymal Stem Cells: Pivotal Players in Hematopoietic Stem Cell Microenvironment
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Background
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Background
TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression
Kälin, R. E., Cai, L., Li, Y., Zhao, D., Zhang, H., Cheng, J., Zhang, W., Wu, Y., Eisenhut, K., Janssen, P., et al. (2021) · Cell Systems · doi:10.1016/j.cels.2021.01.002 · Cited by 13
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“Additionally, in cases where the cell population is anticipated to encompass both progenitor and stem cells, the term “ Mesenchymal Stem and Progenitor cells ” is employed as an analogy to the hematopoietic system [14].”
Background
Bone Marrow Niche Aging: Are Adipocytes Detrimental Cells in the Bone Marrow?
Švajger, U., Milić, P., & Rožman, P. J. (2025) · Cells · doi:10.3390/cells14110814 · Cited by 10
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Urrutia, M., Fernández, S., González, M., Vilches, R. A. V., Rojas, P., Vásquez, M., Kurte, M., Vega-Letter, A. M., Carrión, F., Figueroa, F. E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163735 · Cited by 12
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Clonal MDS/AML cells with enhanced TWIST1 expression reprogram the differentiation of bone marrow MSCs
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Nod-like Receptors Have a Grip on Stem Cells
Fritz, J. H. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.05.017 · Cited by 10
The influence of hypoxia on the differentiation capacities and immunosuppressive properties of clonal mouse mesenchymal stromal cell lines
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Mesenchymal Stem Cells Activate the MEK/ERK Signaling Pathway and Enhance DNA Methylation via DNMT1 in PBMC from Systemic Lupus Erythematosus
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Background
Peritoneal Submesothelial Stromal Cells Support Hematopoiesis and Differentiate into Osteogenic and Adipogenic Cell Lineages
do Amaral, R. J. F. C., Benac, P., Andrade, L. R., Farina, M., Bernardazzi, C., Arcanjo, K. D., Palumbo, A. P., Cordeiro, I. R., Brito, J. M., El-Cheikh, M. C., et al. (2014) · Cells Tissues Organs · doi:10.1159/000377624 · Cited by 10
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Mei, X., Sun, Y., Wu, Z., Pan, W., Zhu, J., & Shi, W. (2015) · Cell Biology International · doi:10.1002/cbin.10455 · Cited by 10
“This capability suggests their potential application in therapeutic tissue repair procedures (Malgieri et al., 2010; Kagami et al., 2011; Duong et al., 2013; Frenette et al., 2013).”
Background
Mesenchymal stem cells promote leukaemic cells aberrant phenotype from B-cell acute lymphoblastic leukaemia
Rodríguez-Pardo, V. M., Aristizabal, J. A., Jaimes, D. C. C., Quijano, S., Reyes, I. D. L., Herrera, M. V., Solano, J. C., & Vernot, J. (2013) · Hematology/Oncology and Stem Cell Therapy · doi:10.1016/j.hemonc.2013.09.002 · Cited by 10
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Efficient In Vitro Generation of IL-22-Secreting ILC3 From CD34+ Hematopoietic Progenitors in a Human Mesenchymal Stem Cell Niche
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Self-citation
The regulatory effect of hyaluronan on human mesenchymal stem cells’ fate modulates their interaction with cancer cells in vitro
Vogeley, C., Degistirici, Ö., Twarock, S., Wladarz, J., Reiners, O., Gorges, T. M., Fischer, J. W., Meisel, R., & Gorges, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-00754-0 · Cited by 8

Authors: Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C.
Affiliations: Albert Einstein College of Medicine (US)
ORCID: Frenette, Paul S.
Pinho, Sandra
Lucas, Daniel
Scheiermann, Christoph
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2013-03-21
Volume: 31
Issue: 1
Pages: 285-316
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-032712-095919
OpenAlex: W2138953281
Cited by: 462
References: 235
Citations by year: 2026: 8 · 2025: 14 · 2024: 27 · 2023: 27 · 2022: 23 · 2021: 39 · 2020: 35 · 2019: 34 · 2018: 41 · 2017: 42 · 2016: 38 · 2015: 51 · 2014: 54 · 2013: 27
FWCI: 7.76
Type: journal article
Language: en
Open access: green
archive-ouverte.unige.ch
Licence: cc-by
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: National Heart, Lung, and Blood Institute (R01HL116340, R01HL097700, R01HL069438, R01HL097819)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords: mesenchymal stem cells, hematopoietic stem cells, bone marrow microenvironment, stromal progenitor cells, immune function, anti-inflammatory activity, regenerative medicine, stem cell therapy
MeSH terms: Animals, Bone Marrow Cells, Humans, Inflammation, Stem Cells, Stromal Cells, Hematopoietic Stem Cell Transplantation, Regenerative Medicine, Mesenchymal Stem Cell Transplantation

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Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine

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