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Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine
Open accessAbstract
Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs). The ease by which human MSC-like and stromal progenitor cells can be isolated from the bone marrow and other tissues has led to the rapid development of clinical investigations exploring their anti-inflammatory properties, tissue preservation capabilities, and regenerative potential. However, the identity of genuine MSCs and their specific contributions to these various beneficial effects have remained enigmatic. In this article, we examine the definition of MSCs and discuss the importance of rigorously characterizing their stem cell activity. We review their role and that of other putative niche constituents in the regulation of bone marrow HSCs. Additionally, how MSCs and their stromal progeny alter immune function is discussed, as well as potential therapeutic implications.
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“For instance, reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations, while microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.320–322”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [322]
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“For instance, reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations, while microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.320–322”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [322]
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“Since MSCs are easily obtained and exhibit impressive paracrine ability as well as multilineage differentiation potential [33], autologous MSCs offer a great advantage when transplanted into ischemic or infarcted heart to regenerate and repopulate the injured myocardium and restore heart function.”
BackgroundCellular players of hematopoietic stem cell mobilization in the bone marrow niche
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“Moreover, they are essential for HSC maintenance and mobilization via forming a structurally unique niche [47, 83, 116].”
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“Bone marrow-derived MSCs have been extensively studied for bone regeneration because they strongly regulate bone homeostasis by regulating osteoblast differentiation and osteoclast activity (Frenette et al., 2013; Liu et al., 2014; Fernandes and Yang, 2016; Guo et al., 2018).”
BackgroundHematopoietic stem cell fate through metabolic control
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Mesenchymal stromal cells (MSCs) for neurodegenerative disease: A promising frontier
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“One example is the haematopoietic stem cells which are positioned next to endothelial cells when residing in the endothelial niche in the bone marrow and whose expansion is dependent on endothelial cells (30).”
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Metadata
- Authors
- Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2013-03-21
- Volume
- 31
- Issue
- 1
- Pages
- 285-316
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2138953281
- Cited by
- 462
- References
- 235
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 27 · 2023: 27 · 2022: 23 · 2021: 39 · 2020: 35 · 2019: 34 · 2018: 41 · 2017: 42 · 2016: 38 · 2015: 51 · 2014: 54 · 2013: 27
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Heart, Lung, and Blood Institute (R01HL116340, R01HL097700, R01HL069438, R01HL097819)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Keywords
- mesenchymal stem cells, hematopoietic stem cells, bone marrow microenvironment, stromal progenitor cells, immune function, anti-inflammatory activity, regenerative medicine, stem cell therapy
- MeSH terms
- Animals, Bone Marrow Cells, Humans, Inflammation, Stem Cells, Stromal Cells, Hematopoietic Stem Cell Transplantation, Regenerative Medicine, Mesenchymal Stem Cell Transplantation
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