The DOI matches its Crossref record; 236 of the 236 references it cites were found in a registry or an index.
Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine
Open accessAbstract
Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs). The ease by which human MSC-like and stromal progenitor cells can be isolated from the bone marrow and other tissues has led to the rapid development of clinical investigations exploring their anti-inflammatory properties, tissue preservation capabilities, and regenerative potential. However, the identity of genuine MSCs and their specific contributions to these various beneficial effects have remained enigmatic. In this article, we examine the definition of MSCs and discuss the importance of rigorously characterizing their stem cell activity. We review their role and that of other putative niche constituents in the regulation of bone marrow HSCs. Additionally, how MSCs and their stromal progeny alter immune function is discussed, as well as potential therapeutic implications.
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“For instance, reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations, while microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.320–322”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [322]
In the citing paper
“For instance, reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations, while microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.320–322”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [322]
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Metadata
- Authors
- Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2013-03-21
- Volume
- 31
- Issue
- 1
- Pages
- 285-316
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2138953281
- Cited by
- 462
- References
- 235
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 27 · 2023: 27 · 2022: 23 · 2021: 39 · 2020: 35 · 2019: 34 · 2018: 41 · 2017: 42 · 2016: 38 · 2015: 51 · 2014: 54 · 2013: 27
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Heart, Lung, and Blood Institute (R01HL116340, R01HL097700, R01HL069438, R01HL097819)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Keywords
- mesenchymal stem cells, hematopoietic stem cells, bone marrow microenvironment, stromal progenitor cells, immune function, anti-inflammatory activity, regenerative medicine, stem cell therapy
- MeSH terms
- Animals, Bone Marrow Cells, Humans, Inflammation, Stem Cells, Stromal Cells, Hematopoietic Stem Cell Transplantation, Regenerative Medicine, Mesenchymal Stem Cell Transplantation
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