The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

The regulation of IL-10 production by immune cells

Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293

Innate lymphoid cells — a proposal for uniform nomenclature

Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380

Mediator and cohesin connect gene expression and chromatin architecture

Kagey, M. H., Newman, J. J., Bilodeau, S., Zhan, Y., Orlando, D. A., van Berkum, N. L., Ebmeier, C. C., Goossens, J., Rahl, P. B., Levine, S. S., et al. (2010) · Nature · doi:10.1038/nature09380 · Cited by 1,939

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898

Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

Quintana, F. J., Basso, A. S., Iglesias, A. H., Korn, T., Farez, M. F., Bettelli, E., Caccamo, M., Oukka, M., & Weiner, H. L. (2008) · Nature · doi:10.1038/nature06880 · Cited by 1,865

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,674

Innate IL-17-producing cells: the sentinels of the immune system

Cua, D. J., & Tato, C. M. (2010) · Nature reviews. Immunology · doi:10.1038/nri2800 · Cited by 1,640

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

Wang, Z., Zang, C., Cui, K., Schones, D. E., Barski, A., Peng, W., & Zhao, K. (2009) · Cell · doi:10.1016/j.cell.2009.06.049 · Cited by 1,344

A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis

Cepika, A., Banchereau, R., Segura, É., Ohouo, M., Cantarel, B. L., Göller, K., Cantrell, V., Ruchaud, E., Gatewood, E., Nguyen, P., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170412 · Cited by 59

Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells

Calvo‐Barreiro, L., Zhang, L., Abdel‐Rahman, S. A., Naik, S. P., & Gabr, M. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021806 · Cited by 62

Microbiota-Derived Tryptophan Metabolite Indole-3-Propionic Acid-Emerging Role in Neuroprotection

Owe-Larsson, M., Drobek, D., Iwaniak, P., Kloc, R., Urbańska, E. M., & Chwil, M. (2025) · Molecules · doi:10.3390/molecules30173628 · Cited by 64

Preventative role of interleukin-17 producing regulatory T helper type 17 (Treg17) cells in type 1 diabetes in non-obese diabetic mice

Bellemore, S. M., Nikoopour, E., Schwartz, J. A., Krougly, O., Lee‐Chan, E., & Singh, B. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12691 · Cited by 63

Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity

Vogel, C. F. A., Chang, W. L. W., Kado, S. Y., McCulloh, K. L., Vogel, H., Wu, D., Haarmann‐Stemmann, T., Yang, G., Leung, P. S. C., Matsumura, F., et al. (2016) · Environmental Health Perspectives · doi:10.1289/ehp.1510194 · Cited by 57

Genetic Aspects of Pituitary Adenomas

Marques, P., & Korbonits, M. (2017) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.01.004 · Cited by 60

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

Puccetti, M., Xiroudaki, S., Ricci, M., & Giovagnoli, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070624 · Cited by 59

Babies, Bugs, and Barriers: Dietary Modulation of Intestinal Barrier Function in Early Life

Wells, J. M., Gao, Y., de Groot, N., Vonk, M. M., Ulfman, L. H., & van Neerven, R. J. J. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122221-103916 · Cited by 60

Human innate lymphoid cells

Montaldo, E., Vacca, P., Vitale, C., Moretta, F., Locatelli, F., Mingari, M. C., & Moretta, L. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.01.007 · Cited by 61

Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe?

Panfili, E., Gerli, R., Grohmann, U., & Pallotta, M. T. (2020) · Biomolecules · doi:10.3390/biom10091280 · Cited by 58

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension

Masaki, T., Okazawa, M., Asano, R., Inagaki, T., Ishibashi, T., Yamagishi, A., Umeki-Mizushima, S., Nishimura, M., Manabe, Y., Ishibashi‐Ueda, H., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023899118 · Cited by 56

An overview of aryl hydrocarbon receptor ligands in the Last two decades (2002–2022): A medicinal chemistry perspective

Li, L., Dai, Y., & Xia, Y. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114845 · Cited by 60

Gut microbial metabolites in MASLD: Implications of mitochondrial dysfunction in the pathogenesis and treatment

Zhang, R., Yan, Z., Zhong, H., Rong, L., Liu, W., Xiong, S., Liu, Q., & Liu, M. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000484 · Cited by 57

Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis

Donate, P. B., de Lima, K. A., Peres, R. S., Almeida, F. B. D. R., Fukada, S. Y., Silva, T. A., Nascimento, D. C., Cecílio, N. T., Talbot, J., de Oliveira, R. D. R., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017120118 · Cited by 59

Bifidobacterium bifidum relieved DSS-induced colitis in mice potentially by activating the aryl hydrocarbon receptor

Cui, Q.-Y., Tian, X.-Y., Liang, X., Zhang, Z., Wang, R., Zhou, Y., Yi, H., Gong, P.-M., Lin, K. F., Liu, T., et al. (2022) · Food & Function · doi:10.1039/d1fo04219j · Cited by 56

Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15

Vân, N. T. T., Zhang, K., Wigmore, R. M., Kennedy, A., DaSilva, C. R., Huang, J., Ambelil, M., Vilagomez, J. H., O’Connor, G. J., Longman, R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43211-4 · Cited by 57

Gut microbiota in regulatory T cell generation and function: mechanisms and health implications

Sharma, A., Sharma, G., & Im, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2516702 · Cited by 68

Homeostatic control of xeno- and endobiotics in the drug-metabolizing enzyme system

Bock, K. W. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.04.009 · Cited by 55

Exquisite ligand stereoselectivity of a Drosophila juvenile hormone receptor contrasts with its broad agonist repertoire

Bittova, L., Jedlička, P., Dračínský, M., Kirubakaran, P., Vondrášek, J., Hanus, R., & Jindra, M. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005992 · Cited by 55

Microbial Metabolites and Intestinal Stem Cells Tune Intestinal Homeostasis

Xing, P. Y., Pettersson, S., & Kundu, P. (2020) · PROTEOMICS · doi:10.1002/pmic.201800419 · Cited by 55

The role of intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways

Luo, H., Li, M., Wang, F., Yang, Y., Wang, Q. L., Zhao, Y., Du, F., Chen, Y., Shen, J., Zhao, Q., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72600 · Cited by 58

Aryl hydrocarbon receptor (AhR) reveals evidence of antagonistic pleiotropy in the regulation of the aging process

Salminen, A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04520-x · Cited by 59

An integrated cytokine and kynurenine network as the basis of neuroimmune communication

Stone, T. W., Clanchy, F. I. L., Huang, Y., Chiang, N., Darlington, L. G., & Williams, R. O. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002004 · Cited by 57

Roles of human UDP-glucuronosyltransferases in clearance and homeostasis of endogenous substrates, and functional implications

Bock, K. W. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.04.020 · Cited by 56

Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice

Zhou, W., Dantzer, R., Budac, D. P., Walker, A. K., Mao‐Ying, Q., Lee, A. W., Heijnen, C. J., & Kavelaars, A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.01.013 · Cited by 57

Protective role of 6-formylindolo[3,2-b]carbazole (FICZ), an endogenous ligand for arylhydrocarbon receptor, in chronic mite-induced dermatitis

Mari, O. D. A., Uchi, H., Morino‐Koga, S., & Furue, M. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.02.014 · Cited by 53

The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19

Stadio, A. D., Costantini, C., Renga, G., Pariano, M., Ricci, G., & Romani, L. R. (2020) · Life · doi:10.3390/life10120345 · Cited by 55

Differential Regulation of Th17 and T Regulatory Cell Differentiation by Aryl Hydrocarbon Receptor Dependent Xenobiotic Response Element Dependent and Independent Pathways

Mohinta, S., Kannan, A., Gowda, K., Amin, S., Perdew, G. H., & August, A. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv046 · Cited by 58

Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS

Rothhammer, V., Borucki, D. M., Sánchez, M. I. G., Mazzola, M. A., Hemond, C. C., Regev, K., Paul, A., Kivisäkk, P., Bakshi, R., Izquierdo, G., et al. (2017) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000359 · Cited by 56

Role of NF-kB RelB in Aryl Hydrocarbon Receptor-Mediated Ligand Specific Effects

Ishihara, Y., Kado, S. Y., Hoeper, C., Harel, S., & Vogel, C. F. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112652 · Cited by 55

Cryo-EM structure of the cytosolic AhR complex.

Wen, Z., Zhang, Y., Zhang, B., Hang, Y., Xu, L., Chen, Y., Xie, Q., Zhao, Q., Zhang, L., Li, G., et al. (2023) · Structure · doi:10.1016/j.str.2022.12.013 · Cited by 51

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

Segner, H. E., Bailey, C., Tafalla, C., & Bo, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179460 · Cited by 58

The aryl hydrocarbon receptor in immune regulation and autoimmune pathogenesis

Huang, W., Rui, K., Wang, X., Peng, N., Zhou, W., Shi, X., Lu, L., Hu, D., & Tian, J. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103049 · Cited by 59

Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway

Li, Z., Liang, X., Liu, W., Zhao, Y., Yang, H., Li, W., Adamovský, O., & Martyniuk, C. J. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114291 · Cited by 51

Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation

Michaudel, C., Bataille, F., Maillet, I., Fauconnier, L., Colas, C., Sokol, H., Straube, M., Couturier-Maillard, A., Dumoutier, L., Snick, J. V., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00144 · Cited by 55

Staphylococcus epidermidis Activates Aryl Hydrocarbon Receptor Signaling in Human Keratinocytes: Implications for Cutaneous Defense

Rademacher, F., Simanski, M., Hesse, B., Dombrowsky, G., Vent, N., Gläser, R., & Harder, J. (2018) · Journal of Innate Immunity · doi:10.1159/000492162 · Cited by 50

Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France

Esser, C., Lawrence, B. P., Sherr, D. H., Perdew, G. H., Puga, A., Barouki, R., & Coumoul, X. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113603 · Cited by 54

Human AHR functions in vascular tissue: Pro- and anti-inflammatory responses of AHR agonists in atherosclerosis

Bock, K. W. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.11.021 · Cited by 55

Serum Serotonin Differentiates Between Disease Activity States in Crohn’s Patients

Manzella, C. R., Jayawardena, D., Pagani, W., Li, Y., Alrefai, W. A., Bauer, J. I., Jung, B. H., Weber, C. R., & Gill, R. K. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa208 · Cited by 51

Indole-3-carbinol ameliorates necroptosis and inflammation of intestinal epithelial cells in mice with ulcerative colitis by activating aryl hydrocarbon receptor

Peng, C., Wu, C., Xu, X., Pan, L., Lou, Z., Zhao, Y., Jiang, H., He, Z., & Ruan, B. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112638 · Cited by 51

Gut microbial metabolism in Alzheimer's disease and related dementias

Kang, J. W., Vemuganti, V., Kuehn, J. F., Ulland, T. K., Rey, F. E., & Bendlin, B. B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00470 · Cited by 53

Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice

Keskey, R. C., Xiao, J. F., Hyoju, S. K., Lam, A., Kim, D., Sidebottom, A. M., Zaborin, A., Dijkstra, A., Meltzer, R. S., Thakur, A., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-024-01882-9 · Cited by 54

The mannose receptor negatively modulates the Toll-like receptor 4–aryl hydrocarbon receptor–indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization

Salazar, F., Hall, L., Negm, O. H., Awuah, D., Tighe, P. J., Shakib, F., & Ghaemmaghami, A. M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.033 · Cited by 52

Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway

Li, S., Heller, J. J., Bostick, J. W., Lee, A., Schjerven, H., Kastner, P., Chan, S. H., Chen, Z. E., & Zhou, L. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.027 · Cited by 50

The role of STAT3 and AhR in the differentiation of CD4+ T cells into Th17 and Treg cells

Liu, X., Hu, H., Fan, H., Zuo, D., Shou, Z., Liao, Y., Nan, Z., & Tang, Q. (2017) · Medicine · doi:10.1097/md.0000000000006615 · Cited by 50

Microbiota Alterations in Alzheimer’s Disease: Involvement of the Kynurenine Pathway and Inflammation

Garcez, M. L., Jacobs, K. R., & Guillemin, G. J. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00057-3 · Cited by 51

Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation

Zhou, Y.-H., Sun, L. X., Chen, J., Sun, W., Ma, L., Han, Y., Jin, X., Zhao, Q., Li, T., Lu, H., et al. (2019) · mBio · doi:10.1128/mbio.02591-19 · Cited by 51

Air Pollution and Atopic Dermatitis (AD): The Impact of Particulate Matter (PM10) on an AD Mouse-Model

Woo, Y. R., Park, S., Choi, K., Hong, E. S., Kim, S., & Kim, H. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176079 · Cited by 51

The Aryl Hydrocarbon Receptor in Asthma: Friend or Foe?

Poulain‐Godefroy, O., Bouté, M., Carrard, J., Álvarez-Simón, D., Tsicopoulos, A., & de Nadaï, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228797 · Cited by 57

Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration

Khan, A. S., & Langmann, T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01999-8 · Cited by 44

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran

Nichols, R. G., Zhang, J., Cai, J., Murray, I. A., Koo, I., Smith, P. B. W., Perdew, G. H., & Patterson, A. D. (2019) · Metabolites · doi:10.3390/metabo10010001 · Cited by 47

MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors

Amini, A., Pang, D., Hackstein, C.-P., & Klenerman, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584521 · Cited by 49

Gut Bacterial Indole-3-acetic Acid Induced Immune Promotion Mediates Preventive Effects of Fu Brick Tea Polyphenols on Experimental Colitis

Zhang, X., Shi, L. S., Wang, N., Li, Q., Zhang, L., Han, N., Yan, T., Ren, D., Zhang, B., Zhao, Y., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06517 · Cited by 48

Kynurenic Acid/AhR Signaling at the Junction of Inflammation and Cardiovascular Diseases

Grishanova, A. Y., & Perepechaeva, M. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136933 · Cited by 53

The Aryl Hydrocarbon Receptor in Immunity: Tools and Potential

Esser, C. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3139-2_16 · Cited by 49

Triggering Mechanisms and Inflammatory Effects of Combustion Exhaust Particles with Implication for Carcinogenesis

Øvrevik, J., Refsnes, M., Låg, M., Brinchmann, B. C., Schwarze, P. E., & Holme, J. A. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12746 · Cited by 48

Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells

Schiering, C., Vonk, A., Das, S., Stockinger, B., & Wincent, E. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.02.031 · Cited by 48

A decade with the juvenile hormone receptor

Jindra, M., Tumova, S., Miláček, M., & Bittova, L. (2021) · Advances in insect physiology · doi:10.1016/bs.aiip.2021.03.001 · Cited by 55

The cross-talk between opportunistic fungi and the mammalian host via microbiota’s metabolism

Romani, L., Zelante, T., Palmieri, M., Napolioni, V., Picciolini, M., Velardi, A., Aversa, F., & Puccetti, P. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0464-2 · Cited by 47

Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll‐like Receptor Stimulation in Peripheral Monocytes

Orhan, F., Bhat, M., Sandberg, K., Ståhl, S., Piehl, F., Karolinska Schizophrenia Project (KaSP) consortium, Svensson, C., Erhardt, S., & Schwieler, L. (2016) · Scandinavian Journal of Immunology · doi:10.1111/sji.12479 · Cited by 47

Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut

Yoshimatsu, Y., Sujino, T., Miyamoto, K., Harada, Y., Tanemoto, S., Ono, K., Umeda, S., Yoshida, K., Teratani, T., Suzuki, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110773 · Cited by 48

Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation

Landemaine, L., Costa, G. D., Fissier, E., Francis, C., Morand, S. C., Verbeke, J., Michel, M., Briandet, R., Sokol, H., Guéniche, A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098160 · Cited by 50

Association of co-exposure to polycyclic aromatic hydrocarbons and phthalates with oxidative stress and inflammation

Lu, Z., Li, Q., Dai, Y., Pan, X., Luo, X., Peng, R., Guo, C., & Tan, L. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169513 · Cited by 47

Defining Th‐cell subsets in a classical and tissue‐specific manner: Examples from the skin

Eyerich, S., & Zielinski, C. E. (2014) · European Journal of Immunology · doi:10.1002/eji.201444891 · Cited by 52

Lack of the aryl hydrocarbon receptor accelerates aging in mice

Bravo‐Ferrer, I., Cuartero, M. I., Medina, V., Quero, D. L. A., Peña‐Martínez, C., Pérez‐Ruíz, A., Fernández-Valle, M. E., Hernández‐Sánchez, C., Fernández‐Salguero, P. M., Lizasoaín, I., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901333r · Cited by 50

Enteric formulated indole-3-carboxaldehyde targets the aryl hydrocarbon receptor for protection in a murine model of metabolic syndrome

Puccetti, M., Pariano, M., Borghi, M., Barola, C., Moretti, S., Galarini, R., Mosci, P., Ricci, M., Costantini, C., & Giovagnoli, S. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120610 · Cited by 47

Molecular mechanism of benzo [a] pyrene regulating lipid metabolism via aryl hydrocarbon receptor

Lou, W., Zhang, M.-D., Chen, Q., Bai, T., Hu, Y., Gao, F., Li, J., Lv, X., Zhang, Q., & Chang, F. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01627-9 · Cited by 46

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor

Peng, G., Sinkko, H., Alenius, H. T., Lozano, N., Kostarelos, K., Bräutigam, L., & Fadeel, B. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01260-8 · Cited by 46

Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor

Xing, J., Gumerov, V. M., & Zhulin, I. B. (2023) · Science Advances · doi:10.1126/sciadv.adi4517 · Cited by 44

Ethanol-induced changes to the gut microbiome compromise the intestinal homeostasis: a review

Sosnowski, K., & Przybyłkowski, A. M. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2393272 · Cited by 52

Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop

Effner, R., Hiller, J., Eyerich, S., Traidl‐Hoffmann, C., Brockow, K., Triggiani, M., Behrendt, H., Schmidt‐Weber, C. B., & Buters, J. (2017) · Scientific Reports · doi:10.1038/srep44005 · Cited by 50

Smoking and Hepatitis B Virus–Related Hepatocellular Carcinoma Risk: The Mediating Roles of Viral Load and Alanine Aminotransferase

Wang, Y., Chuang, Y., Wu, C., Jan, M., Wu, W., Lin, C., Liu, C., Yang, Y., Chen, P., Lin, S., et al. (2018) · Hepatology · doi:10.1002/hep.30339 · Cited by 46

Human Milk Oligosaccharide-Stimulated Bifidobacterium Species Contribute to Prevent Later Respiratory Tract Infections

Dogra, S. K., Martin, F., Donnicola, D., Julita, M., Berger, B. W., & Sprenger, N. (2021) · Microorganisms · doi:10.3390/microorganisms9091939 · Cited by 50

The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer

Safe, S. H., & Zhang, L. (2022) · Cancers · doi:10.3390/cancers14225574 · Cited by 45

Activation of the Aryl Hydrocarbon Receptor Interferes with Early Embryonic Development

Gialitakis, M., Tolaini, M., Li, Y., Pardo, M., Yu, L., Toribio, A. L., Choudhary, J. S., Niakan, K. K., Papayannopoulos, V., & Stockinger, B. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.09.025 · Cited by 41

Microbe-metabolite-host axis, two-way action in the pathogenesis and treatment of human autoimmunity

Meng, X. L., Zhou, H., Shen, H., Lufumpa, E., Li, X., Guo, B., & Li, B. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.03.006 · Cited by 46

Can intestinal microbiota and circulating microbial products contribute to pulmonary arterial hypertension?

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