The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

The regulation of IL-10 production by immune cells

Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293

Innate lymphoid cells — a proposal for uniform nomenclature

Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380

Mediator and cohesin connect gene expression and chromatin architecture

Kagey, M. H., Newman, J. J., Bilodeau, S., Zhan, Y., Orlando, D. A., van Berkum, N. L., Ebmeier, C. C., Goossens, J., Rahl, P. B., Levine, S. S., et al. (2010) · Nature · doi:10.1038/nature09380 · Cited by 1,939

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898

Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

Quintana, F. J., Basso, A. S., Iglesias, A. H., Korn, T., Farez, M. F., Bettelli, E., Caccamo, M., Oukka, M., & Weiner, H. L. (2008) · Nature · doi:10.1038/nature06880 · Cited by 1,865

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,674

Innate IL-17-producing cells: the sentinels of the immune system

Cua, D. J., & Tato, C. M. (2010) · Nature reviews. Immunology · doi:10.1038/nri2800 · Cited by 1,640

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

Wang, Z., Zang, C., Cui, K., Schones, D. E., Barski, A., Peng, W., & Zhao, K. (2009) · Cell · doi:10.1016/j.cell.2009.06.049 · Cited by 1,344

Discovery and optimisation of pyrazolo[1,5- a ]pyrimidines as aryl hydrocarbon receptor antagonists

Bobrovs, R., Terentjeva, S., Olafsen, N. E., Dambrauskas, Ž., Gulbinas, A., Maimets, T., Teino, I., Jirgensons, A., Matthews, J. B., & Jaudzems, K. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00266k · Cited by 4

An introduction to EpiPol (Epigenetic affecting Polymorphism) concept with an in silico identification of CpG-affecting SNPs in the upstream regulatory sequences of human AHR gene

Aftabı, Y., Khoshkam, Z., Amiri‐Sadeghan, A., Khalili, Y., & Ichihara, G. (2020) · Meta Gene · doi:10.1016/j.mgene.2020.100805 · Cited by 4

The immune system and the microbiota: The two sides of mucosal tolerance

Costantini, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822564-6.00008-2 · Cited by 4

Long-term orally exposure of dioxins affects antigen-specific antibody production in mice

Kakutani, H., Yuzuriha, T., Nakao, T., & Ohta, S. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.12.011 · Cited by 4

Genetics of Pituitary Adenomas

Bogusławska, A., Gilis‐Januszewska, A., & Korbonits, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-90475-3_4 · Cited by 4

Modulation of the Aryl Hydrocarbon Receptor Signaling Pathway Impacts on Junín Virus Replication

Pelaez, M. A., Torti, M. F., Lauro, A. E. A. D., Marquez, A. B., Giovannoni, F., Damonte, E. B., & García, C. C. (2023) · Viruses · doi:10.3390/v15020369 · Cited by 4

A new cell line based coculture system for skin sensitisation testing in one single assay using T cells, aryl hydrocarbon receptor knockout, and co-inhibitory blockage

Sonnenburg, A., Stahlmann, R., Kreutz, R. H., & Peiser, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03506-3 · Cited by 4

The role of the aromatic hydrocarbon receptor in the pathogenesis of atopic dermatitis

Gorodnichev, P. V. (2023) · Vestnik dermatologii i venerologii · doi:10.25208/vdv4775 · Cited by 4

Microbiome in Atopic Dermatitis: Is It All About Staphylococcus aureus?

Gómez‐Casado, C., Unger, Z., Oláh, P., & Homey, B. (2023) · Current Treatment Options in Allergy · doi:10.1007/s40521-023-00350-9 · Cited by 4

Dissecting the long-term neurobehavioral impact of embryonic benz[a]anthracene exposure on zebrafish: Social dysfunction and molecular pathway activation

Zhao, H., Chen, W., Li, F., Wang, X., Pan, X., Liu, Y., Wang, L., Sun, W., Li, F., & Jiang, S. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.172615 · Cited by 4

Tackling Immune Pathogenesis of COVID-19 through Molecular Pharmaceutics

Puccetti, M., Costantini, C., Ricci, M., & Giovagnoli, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040494 · Cited by 4

Novel method for quantifying AhR-ligand binding affinities using Microscale ThermophoresisPreprint

Stinn, A., Furkert, J., Kaufmann, S. H. E., Moura‐Alves, P., & Kolbe, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.26.428246 · Cited by 4

Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis

Wang, L., Lv, W., Mao, H., Chen, Q., Ma, Y., Zhang, L., Ruan, Y., & Zhang, C. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.05.435 · Cited by 3

Lactobacillus murinus Induces CYP1A1 Expression and Modulates TNF-Alpha-Induced Responses in a Human Intestinal Epithelial Cell Model

Ahmed, H., Sher, A. A., Bell, J. A., & Mansfield, L. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311670 · Cited by 3

Interplay between aryl hydrocarbon and estrogen receptor signaling- A possible explanation of endocrine- disrupting and immunomodulatory effects of mycotoxins

Kowalska, K., Elesh, I., & Marko, D. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140838 · Cited by 4

Indoxyl Sulfate in the Gut–Kidney Axis: Pathophysiology and Clinical Significance in CKD-Associated Colorectal Cancer

Shimizu, H., & Niwa, T. (2026) · Toxins · doi:10.3390/toxins18020072 · Cited by 3

Indole-3-Acetic Acid and Skatole Exert Opposing Effects on MDR1 Proteostasis in Human Colonic Epithelial Cells: A Molecular Basis for the Gut Microbial Metabolic Switch

Naito, K., Tomii, A., Ishii, K., & Shimizu, H. (2026) · Journal of Xenobiotics · doi:10.3390/jox16010036 · Cited by 3

In vitro relative potencies of polycyclic aromatic hydrocarbons and selected hydroxylated, oxygenated, and nitrated derivatives to activate aryl hydrocarbon receptor in HepG2 and PLHC-1 cell lines

Mais, A. E. R. E., Maillot‐Maréchal, E., Kone, Y. E., Chardon, C., Albinet, A., & Aı̈t-Aı̈ssa, S. (2026) · Environmental Research · doi:10.1016/j.envres.2026.124827 · Cited by 3

Pulmonary injury in inflammatory bowel disease: intestinal barrier disruption, gut–lung axis remodeling, and treatment-related lung toxicity

Mu, Z., Zhou, R., Hao, W., Chen, Y., Zhu, X., Gu, L., & Lin, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1883855 · Cited by 3

Effects of Cysticercus cellulosae Excretory–Secretory Antigens on the TGF-β Signaling Pathway and Th17 Cell Differentiation in Piglets, a Proteomic Analysis

He, W., Mu, Q., Li, L., Sun, X., Fan, X., Yang, F., Liu, M., & Zhou, B. (2023) · Microorganisms · doi:10.3390/microorganisms11030601 · Cited by 3

Metabolic profiling reveals enrichment of health-related metabolites in yoghurt by variation of strain consortium

Christensen, S., Biederman, D., Sattari, Z., Röder, T., Stern, M. T., Blaser, C., Fuchsmann, P., von Ah, U., Walther, B., Bruggmann, R., et al. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107047 · Cited by 3

Tryptophan metabolic reprogramming modulates cytokine networks in nucleos(t)ide analogue-treated chronic hepatitis B patients

Gao, X., Wu, X., Li, Y., Dai, X., & Cai, B. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1643636 · Cited by 3

A Dramatic Difference in Global Gene Expression between TCDD-Treated Atlantic Tomcod Larvae from the Resistant Hudson River and a Nearby Sensitive Population

Brown, S. M., Heguy, A., Zappile, P., Chen, H., Goradia, A., Wang, Y., Hao, Y., Roy, N. K., Vitale, K., Chambers, R. C., et al. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx159 · Cited by 3

CARM1 is involved in CYP1A1 gene expression as a transcriptional coactivator

Kim, Y. J., Lim, Y., & Lee, E. (2017) · Molecular & Cellular Toxicology · doi:10.1007/s13273-017-0029-2 · Cited by 3

Interaction of alcohol with drugs of abuse and medicines

Singh, A. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819680-9.00002-0 · Cited by 3

Alizarin as a New Activator of the Aryl Hydrocarbon Receptor Signaling Pathway

Lu, Y., Kuan, Y., Lin, C.-Y. G., Chou, Y.-T., Chen, S.-C., Gao, G.-L., Hsu, C. W., & Su, J.-G. J. (2022) · Natural Product Communications · doi:10.1177/1934578x221136669 · Cited by 3

Unveiling the mechanistic role of the Aryl hydrocarbon receptor in environmentally induced Breast cancer

Chatterjee, P., & Banerjee, S. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115866 · Cited by 3

Grafted Sertoli Cells Exert Immunomodulatory Non-Immunosuppressive Effects in Preclinical Models of Infection and Cancer

Chiappalupi, S., Salvadori, L., Borghi, M., Mancuso, F., Pariano, M., Riuzzi, F., Luca, G., Romani, L. R., Arato, I., & Sorci, G. (2024) · Cells · doi:10.3390/cells13060544 · Cited by 3

Dysregulation of Stress Erythropoiesis and Enhanced Susceptibility to Salmonella Typhimurium Infection in Aryl Hydrocarbon Receptor–Deficient Mice

Mayer, M., Cengiz, S. C., Thiem, M. W., Hatzfeld, P., Semeniuk, A., Wang, N., Strugnell, R. A., Förster, I., & Weighardt, H. (2024) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae304 · Cited by 3

On the Non-Redundant Roles of TDO2 and IDO1

Puccetti, P. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00522 · Cited by 3

Development of a novel recombinant cell line for detection and characterization of Ah receptor nuclear translocation in intact cells

Hayashi, A., & Denison, M. S. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104873 · Cited by 3

TCDD exposure alters fecal IgA concentrations in male and female mice

Foxx, C. L., Nagy, M. R., King, A. E., Albin, D., & DeKrey, G. K. (2022) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-022-00563-9 · Cited by 3

Psoriasis, Cutaneous Lupus Erithematosus and Immunobiology of the Skin

Meglio, P. D., & Conrad, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.15008-8 · Cited by 4

Lymphoid malignancies ARNT unstoppable

Gardella, K. A., Tiwary, R., & Wright, C. W. (2016) · Aging · doi:10.18632/aging.101010 · Cited by 3

Cell-intrinsic Aryl Hydrocarbon Receptor signalling is required for the resolution of injury-induced colonic stem cellsPreprint

Shah, K., Maradana, M. R., Delàs, M. J., Metidji, A., Graelmann, F. J., Llorian, M., Chakravarty, P., Li, Y., Tolaini, M., Shapiro, M., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-827700/v1 · Cited by 3

The protective role of anti‐parkinsonian drugs in pancreatic cancer risk: A comprehensive case–control study in Taiwan

Yang, H., Chou, W., Nguyen, P., Nguyen, N. T. H., Phuong, N. T., Wang, C., Hsu, J. C., Lin, M., & Huang, C. (2024) · Cancer Science · doi:10.1111/cas.16422 · Cited by 2

Phytochemical-Mediated Ah Receptor Activity Is Dependent on Dietary Context

Dong, F., Annalora, A. J., Murray, I. A., Chakraborty, D., Coslo, D. M., Marcus, C. B., Patterson, A. D., & Perdew, G. H. (2025) · Nutrients · doi:10.3390/nu17050876 · Cited by 2

Microwave-orchestrated phototherapeutic polypyrrole/soy extraction micro-complex for burn wound healing in a rodent model

Wu, S.-H., Lu, H., Nguyen, H. T., Lin, P.-Y., Pan, W., & Chuang, A. E.-Y. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106911 · Cited by 2

Animal Models of Malaria-Associated Acute Kidney Injury

Mamudu, C. O., Polidoro, R. B., & Gallego‐Delgado, J. (2025) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2025.151616 · Cited by 2

Pivotal role of AhR protein in the therapeutic efficacy of HuangKui capsule against calcium oxalate-induced kidney damage: An integrated study of network pharmacology and experimental verification

Lin, H., Li, X., Shen, A., & Yin, W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145288 · Cited by 2

Aryl hydrocarbon receptor facilitates HSV-1 lytic infection by enhancing viral gene transcription and receptor expression

Huang, P., Pan, X., Chen, H., Lei, M., Ma, Y., Guo, X., Xie, J., Li, J., Sun, J., Hu, Y., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1548038 · Cited by 2

Aryl Hydrocarbon Receptor Is Required for Fasting-Induced Improvement of Gut Barrier Integrity in Caenorhabditis elegans

Sun, J., & Moon, Y. (2025) · Antioxidants · doi:10.3390/antiox14080905 · Cited by 2

Aryl hydrocarbon receptor-ligand hexachlorobenzene promotes immunosuppression leading to mammary tumor growth and metastasis in a HER2-positive syngeneic mouse model

Zárate, L. V., Agudelo, J. A. P., Miret, N. V., Candia, A. J. N., Küper, M. P., Pontillo, C. A., Chiappini, F., Candolfi, M., & Randi, A. S. (2025) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2025.104796 · Cited by 2

A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells

Lin, Y., Geng, F., Shieh, J.-H., Torres, L. K., Sominskaia, M., Gao, M., Wingo, M. E., Chen, K., Rustam, S., Chavez, R., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00716-z · Cited by 2

Aryl Hydrocarbon Receptor-Mediated Disruption of Intestinal Epithelial Barrier Integrity by Dioxin Isomers

Kakutani, H., & Nakao, T. (2025) · Toxics · doi:10.3390/toxics13110993 · Cited by 2

The aryl hydrocarbon receptor: A modulator of skeletal muscle health and aging

Wimberly, K., & RYAN, T. E. (2025) · Biochimie · doi:10.1016/j.biochi.2025.12.012 · Cited by 2

Mammalian AHR2 loss: Evolutionary patterns, mechanisms, and relevance of biological factors

Song, W.-S., Koh, D.-H., Kim, D. H., Nomiyama, K., Iwata, H., & Kim, E.-Y. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.119899 · Cited by 2

Gut microbiota-regulated tryptophan metabolism in breast cancer: mechanisms and therapeutic perspectives

Yan, J., Qian, L., Chen, S., Karekad, M. M. A., Wu, X., Xu, M., & Xu, X. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1765550 · Cited by 3

Treg/Th Cell Imbalance Is Negatively Associated with Gut Microbiota Dysbiosis and Growth Impairment in Children Exposed to PFAS, PAHs, and Phthalates

Zhang, J., Xie, B., Li, K., Qu, S., Chen, J., Kang, R., Tan, L., Xu, X., & Huo, X. (2026) · Environment & Health · doi:10.1021/envhealth.5c00627 · Cited by 2

Chlorogenic acid attenuates rheumatoid arthritis by modulating immunity via the gut microbiota-derived metabolite indolelactic acid

Zhang, L., Gao, H., Xue, G., Pan, Z., Zhang, R., Xie, M., Wang, N., Fan, J., Liu, S., Zhang, H., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116681 · Cited by 2

The AHR: adaptive evolution or one-off?

Kroll, M. H. (2019) · Blood · doi:10.1182/blood.2019003943 · Cited by 2

The role of kynurenine pathway aryl hydrocarbon receptor axis in autoimmune diseases of the skin

Noakes, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85389-7.00009-0 · Cited by 2

A pyrazolopyridine as a novel AhR signaling activator with anti-breast cancer properties in vitro and in vivo.

Abduh, M., Alwassil, O., Aldaqal, S. M., Alfwuaires, M. A., Farhan, M., & Hanieh, H. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116079 · Cited by 2

Protective Effect of Indole-3-Aldehyde in Murine COVID-19-Associated Pulmonary Aspergillosis

Pariano, M., Gidari, A., Stincardini, C., Pierucci, S., Bastianelli, S., Puccetti, M., Giovagnoli, S., Bellet, M. M., Fabi, C., Castronari, R., et al. (2024) · Journal of Fungi · doi:10.3390/jof10070510 · Cited by 2

Nurturing the phenotype: Environmental signals and transcriptional regulation of intestinal γδ T cells

Vogg, L., & Winkler, T. (2024) · European Journal of Immunology · doi:10.1002/eji.202451076 · Cited by 2

How exercise shapes the anti-inflammatory environment in multiple sclerosis – a conceptual framework focusing on tryptophan-derived molecules in T cell differentiation

Chirino, T. Y. W., Joisten, N., Zimmer, P., & Proschinger, S. (2024) · Translational Exercise Biomedicine · doi:10.1515/teb-2024-0037 · Cited by 2

Profile of interleukin-22 in gut mucosal health and disease

Sousa, A. E., Foxall, R. B., & Fernandes, S. M. (2016) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s64856 · Cited by 2

The Role of the Aryl Hydrocarbon Receptor (AhR) in the Immune Response against Microbial Infections

Huang, L., He, R., Zhang, Y., & Yan, Q. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96526 · Cited by 3

Indoleamine 2,3-dioxygenase adjusts neutrophils recruitment and chemotaxis in Aspergillus fumigatus keratitis

Guo, S.-X., Zhang, L., Jiang, W., & Ma, J. (2022) · International Journal of Ophthalmology · doi:10.18240/ijo.2022.03.02 · Cited by 2

A Snapshot of Biomarkers in Psoriasis

Abhale, K., Veeranjaneyulu, A., & Desai, S. M. (2024) · Current Drug Discovery Technologies · doi:10.2174/0115701638278470240312075112 · Cited by 2

The gut way to health : In vitro studies on immunomodulatory food compounds

Koper, J. E. B. (2020) · doi:10.18174/505381 · Cited by 2

Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in ESRDPreprint

Kim, H. Y., Kim, D. H., Lee, S. J., Kang, Y. J., Kim, G., Koh, H. B., Ko, Y. E., Shin, H. M., Lee, H., Yoo, T., et al. (2023) · eLife · doi:10.7554/elife.87316.1 · Cited by 2

The 3′UTR region of the DNA repair gene PARP-1 May increase the severity of COVID-19 by altering the binding of antiviral miRNAs

Yılmaz, B., Genç, G. Ç., Çelik, S., Pişkin, N., HORUZ, E., & Dursun, A. (2023) · Virology · doi:10.1016/j.virol.2023.04.005 · Cited by 1

Immunoregulation of Quercetin and Kynurenic Acid on Human Umbilical Cord Mesenchymal Stem Cells Through Gene Expression of Aryl Hydrocarbon Receptor and Interleukin‐6 in Hyperglycemic Milieu

Nguyen, T. S., Nguyen, T. T. N., Nguyen, T., Ha, T. B. C., Nguyen, M. C., Raza, S. S., Do, V. T., & Chu, H. H. (2025) · Stem Cells International · doi:10.1155/sci/6612312 · Cited by 1

Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques

Jasinska, A. J., Sivanandham, R., Sivanandham, S., Xu, C., Gordevičius, J., Milčiūtė, M., Brooke, R. T., Sette, P., He, T., Brocca‐Cofano, E., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci189574 · Cited by 1

Activation of the aryl hydrocarbon receptor with structurally diverse ligands suppresses class switch to immunoglobulin A

Costa, A. B., & DeKrey, G. K. (2025) · BMC Research Notes · doi:10.1186/s13104-025-07364-3 · Cited by 1

The role of aryl hydrocarbon receptor signalling in COVID-19 pathology and its therapeutic potential

Mbambara, S., Modipane, N. R., Serite, T., Sathekge, M. M., & Kgatle, M. (2025) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2025.1599785 · Cited by 1

Activation of the aryl hydrocarbon receptor relieves acute pancreatitis via the RBX1/HSF1 pathway

Fang, Y., Zhang, C., Yu, J., & Shen, X. (2025) · Journal of Inflammation · doi:10.1186/s12950-025-00481-7 · Cited by 1

Gut Microbiome Strategies for Enhancing ICI Delivery Across the BBB in Glioblastoma

Barati, S., Ghoflchi, S., Nakhaei, A., Yazdi, M., Hosseinzadeh, P., Hosseini, H., & Jalili‐Nik, M. (2026) · BioFactors · doi:10.1002/biof.70077 · Cited by 1

Activation of aryl hydrocarbon receptor alleviates cholestatic liver injury by inhibiting inflammation

Han, Q., Wang, L., Yan, X., Zhang, N., Zhang, W., Li, H., Chen, W., You, H., & Yang, A. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02755-w · Cited by 1

Metabolomic profiling and anti-tumor function of canine NK cells in tumor interaction

He, S., Wu, S., Chen, L., Li, Y., & Wang, B. (2026) · BMC Veterinary Research · doi:10.1186/s12917-026-05343-9 · Cited by 1

Exploration of Agonist and Antagonist Binding Sites within the Cytosolic AHR Complex Using Molecular Modeling

Karabogdan, I., Yanqui-Rivera, F., Sayeeram, D., Sadik, A., Miller, A. K., Trump, S., Röhrig, U. F., & Opitz, C. A. (2026) · ACS Omega · doi:10.1021/acsomega.5c10598 · Cited by 1

Functional segregation of HIF-1α and AhR controls NK cell responsiveness under hypoxia

Giorgetta, S., Cortopassi, F., Chanis, T., Ni, J., Correia, M. P., Sticht, C., Ast, V., Platten, M., Cerwenka, A., & Stojanovic, A. (2026) · iScience · doi:10.1016/j.isci.2026.115492 · Cited by 1

Changes of DNA methylation in smokers and ex-smokers referred for coronary angiography. Results from the LURIC study

Delgado, G. E., Moissl, A. P., Krämer, B. K., Stefan Lorkowski, A., Siekmeier, R., Duerschmied, D., Frey, N., März, W., & Kleber, M. E. (2026) · Clinical Epigenetics · doi:10.1186/s13148-026-02118-9 · Cited by 1

Indole-3-Carbinol (I3C) suppression of IgG2b-triggered signaling in innate cells involves early suppression of p-Akt

Deb, A., Miceli, A., & Kaplan, B. L. F. (2026) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2026.117869 · Cited by 1

Aryl hydrocarbon receptor pharmacology—mechanisms, ligands, and therapeutic potential

Bobrovs, R., Olafsen, N. E., Åhrling, S. S., & Matthews, J. B. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100146 · Cited by 2

Gut microbiota-derived tryptamine activates AhR-NRF2 signaling to modulate airway epithelial barrier function in allergic asthma

Zhang, L., Liu, W., Luo, X., Shen, X., Liu, T., Shi, H., HE, L., & Guo, S. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116990 · Cited by 1

In silico, in vitro, and in vivo profiling of endocrine activity and toxicity of selected oxygenated polycyclic aromatic compounds frequently encountered in PAH-contaminated soils

Mais, A. E. R. E., Brion, F., Khoury, L., Audebert, M., Maillot‐Maréchal, E., Piccini, B., Koala, W.-K. J., Kardouna, N., Michel-Malfait, J., Mombelli, E., et al. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128549 · Cited by 1

Aryl Hydrocarbon Receptor Signaling in Aging: A Key Modulator of Brain Homeostasis

Juárez-Solano, H., Martínez‐Coria, H., Pérez‐Osorio, I. N., Hernández-Esquivel, R. A., & Torres-Ramos, M. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05874-0 · Cited by 1

Intestinal neutral ceramidase exacerbates MASH pathogenesis

Wang, T., Chen, L., Lei, C., Song, X., Tuohongerbieke, A., Feng, J., Gasparetto, R. L., Zhang, X., McClain, C. J., Tan, Y., et al. (2026) · eGastroenterology · doi:10.1136/egastro-2026-100417 · Cited by 1

Divergent immunometabolic reprogramming in psoriasis and atopic dermatitis: a tale of two inflammatory skin diseases

Chen, N., Yue, Y., & Zhou, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1879634 · Cited by 2

Deficiency of the aryl hydrocarbon receptor in intestinal epithelial cells, but not hepatocytes, ameliorates atherosclerosis development by sex-dependently targeting the lipid metabolism

Huchzermeier, R., Rakateli, L., Corcini-Berndt, M., Maas, S. L., Abschlag, K., Pöttgens, C. C. H., Moellmann, J., Pirker, T., Kremer, S., Steitz, J., et al. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.121857 · Cited by 1

The exposome-autoimmunity axis: environmental xenobiotics, gut dysbiosis, and potential pathways to immunosenescence

Daşdemir, F. O., Sari, M. F., Aktaş, B., & Kocazeybek, B. S. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116331 · Cited by 1

Modulation of NF-κB signaling by Alternaria mycotoxins: in vitro and in silico insights into molecular mechanisms of immunosuppression in THP-1 monocytes

Partsch, V., Crudo, F., Schröder, C., Favero, G. D., & Marko, D. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112357 · Cited by 1

Interleukin-22 in the pathogenesis and potential treatment of liver diseases

Yin, S., & Feng, D. (2017) · Liver Research · doi:10.1016/j.livres.2017.09.003 · Cited by 1

Therapeutic strategies to limit tryptophan metabolites toxicity during chronic kidney disease

Barba, C., Fouque, D. P., & Koppe, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818540-7.00003-3 · Cited by 1

Activation of the aryl hydrocarbon receptor improves allergen-specific immunotherapy of murine allergic airway inflammation: a novel adjuvant option?

Heine, S., Alessandrini, F., Grosch, J., Graß, C., Heldner, A., Schnautz, B., Grosch, J., Buters, J., Slusarenko, B. O., Krappmann, D., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1397072 · Cited by 1

Gut microbiota and kidney diseases. Literature review

Shutov, E. V., Bolshakov, S. A., Makarova, T., Fedoseeva, I., Teplyuk, D. A., Pavlov, C. S., & Sorokoletov, S. M. (2024) · Nephrology and Dialysis · doi:10.28996/2618-9801-2024-3-283-302 · Cited by 2

Microbiome in Defence Against Pathogens

Ramanathan, J. (2024) · Springer eBooks · doi:10.1007/978-3-031-70088-0_16 · Cited by 2

Impact of Hericium erinaceus and Ganoderma lucidum metabolites on AhR activation in neuronal HT-22 cells

Tabęcka-Łonczyńska, A., Skóra, B., Szlachcikowska, D., Jastrząb, R., Marć, M. A., Mytych, J., Koszła, O., Sołek, P., & Szychowski, K. A. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00767-w · Cited by 2

The Aryl Hydrocarbon Receptor as a Regulator of Barrier Physiology

Díaz-Díaz, C. J., Wilson, R. H., Vazquez-Rivera, E., Mezrich, J. D., Lee, C. W., Kennedy, G. D., & Bradfield, C. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64217-4 · Cited by 1

The preventive effect of Qing Dai on bisphosphonate-induced gastric cellular injuries

Yasuda, G., Ito, H., Kurokawa, H., Terasaki, M., Suzuki, H., Mizokami, Y., & Matsui, H. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.17-108 · Cited by 1

Modeling inter-kingdom regulation of inflammatory signaling in human intestinal epithelial cells

Maiti, S., Grivas, G., Choi, K., Dai, W., Ding, Y., PEÑARETE, D., Hahn, J., & Jayaraman, A. (2020) · Computers & Chemical Engineering · doi:10.1016/j.compchemeng.2020.106954 · Cited by 1

Molecular characterization of the aryl hydrocarbon receptor 2 gene in black rockfish, Sebastes schlegelii , and its expression patterns upon exposure to benzo[a]pyrene, 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin, and β‐naphthoflavone

Woo, S. J. (2021) · Journal of Applied Toxicology · doi:10.1002/jat.4245 · Cited by 1

influence of dioxines on endometriosis development – study review

Ozga, A., Wójcik-Grudzień, J., Pawłowska, P., & Rozenbajgier, M. (2022) · Journal of Education Health and Sport · doi:10.12775/jehs.2022.12.09.057 · Cited by 1

Microorganisms in Pathogenesis and Management of Systemic Lupus Erythematosus (SLE)

Yi, P., Zhao, M., & Lu, Q. (2022) · Springer eBooks · doi:10.1007/978-981-19-1946-6_20 · Cited by 1

Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)Preprint

Kim, H. Y., Kang, Y. J., Kim, D. H., Jang, J., Lee, S. J., Kim, G., Koh, H. B., Ko, Y. E., Shin, H. M., Lee, H., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.08.503143 · Cited by 1

Leishmania major centrin knock-out parasites alter the kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory responsePreprint

Oljuskin, T., Azodi, N., Volpedo, G., Bhattacharya, P., Ismail, N., Hamano, S., Matlashewski, G., Satoskar, A. R., Gannavaram, S., & Nakhasi, H. L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.15.508117 · Cited by 1

FICZ activating AHR protects against intestinal injury in mice with DSS-induced colitis by regulating intestinal flora and metabolismPreprint

Yin, L., Jiang, L., Zhou, Z., Zhao, J., Tang, J., & Wang, Z. (2023) · Research Square · doi:10.21203/rs.3.rs-2709801/v1 · Cited by 1

Intermittent fasting promotes ILC3s secreting IL-22 contributing to the beigeing of white adipose tissuePreprint

Chen, H., Sun, L., Feng, L., Han, X., Zhang, Y., Zhai, W., Zhang, Z., Mulholland, M. T., Zhang, W., & Yin, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.29.555436 · Cited by 1

Editorial: Role of the Aryl Hydrocarbon Receptor in Immune Modulation

Kaplan, B. L. F., Baglole, C. J., & Sulentic, C. E. W. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.941665 · Cited by 1

Aryl hydrocarbon receptor and intestinal immunity

Lamas, B., Natividad, J. M., & Sokol, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0019-2 · Cited by 551

The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology

Esser, C., & Rannug, A. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009001 · Cited by 501

The Aryl Hydrocarbon Receptor and Immunity

Ehrlich, A. K., & Sulentic, C. E. W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00144-3

External influences on the immune system via activation of the aryl hydrocarbon receptor

Stockinger, B., Hirota, K., Duarte, J. H., & Veldhoen, M. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.01.008 · Cited by 190