Cited by 909Toxic Organic Pollutants ImpactImmune Response and InflammationImmunotoxicology and immune responses

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The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

Stockinger, Brigitta, Meglio, Paola Di, Gialitakis, Manolis, Duarte, João H.·2014·Annual Review of Immunology

DOI 10.1146/annurev-immunol-032713-120245

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Abstract

The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted the attention of immunologists. The evolutionary conservation of this transcription factor and its widespread expression in the immune system point to important physiological functions that are slowly being unraveled. In particular, the emphasis is now shifting from the role of AhR in the xenobiotic pathway toward its mode of action in response to physiological ligands. In this article, we review the current understanding of the molecular interactions and functions of AhR in the immune system in steady state and in the presence of infection and inflammation, with a focus on barrier organs such as the skin, the gut, and the lung.

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Authors: Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H.
Affiliations: National Institute for Medical Research (GB)
Corresponding author: Duarte, João H.
ORCID: Stockinger, Brigitta
Meglio, Paola Di
Gialitakis, Manolis
Duarte, João H.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2014-03-21
Volume: 32
Issue: 1
Pages: 403-432
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-032713-120245
OpenAlex: W2112265988
Cited by: 909
References: 165
Citations by year: 2026: 71 · 2025: 66 · 2024: 84 · 2023: 86 · 2022: 87 · 2021: 76 · 2020: 110 · 2019: 78 · 2018: 77 · 2017: 63 · 2016: 55 · 2015: 40 · 2014: 15
FWCI: 5.96
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (100910)
FP7 Ideas: European Research Council (232782)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: aryl hydrocarbon receptor, immune system, transcription factors, xenobiotic toxicity, 2,3,7,8-tetrachlorodibenzo-p-dioxin, infection, inflammation, skin, intestine, lung
MeSH terms: Animals, Gene Expression Regulation, Humans, Immune System, Ligands, Organ Specificity, Protein Binding, Signal Transduction, Receptors, Aryl Hydrocarbon

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The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

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