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The Aryl Hydrocarbon Receptor: Multitasking in the Immune System
Abstract
The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted the attention of immunologists. The evolutionary conservation of this transcription factor and its widespread expression in the immune system point to important physiological functions that are slowly being unraveled. In particular, the emphasis is now shifting from the role of AhR in the xenobiotic pathway toward its mode of action in response to physiological ligands. In this article, we review the current understanding of the molecular interactions and functions of AhR in the immune system in steady state and in the presence of infection and inflammation, with a focus on barrier organs such as the skin, the gut, and the lung.
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“Accordingly, many phenotypes of Ahr mutant models such as altered hepatovascular development and impaired immune function, do not appear to be directly related to TCDD toxicity or adaptive metabolism (Quintana et al., 2008; Stockinger et al., 2014; Veldhoen et al., 2008; Walisser et al., 2005)”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Stockinger et al., 2014
In the citing paper
“The AhR is a ligand-activated transcription factor with a central role in the intestinal mucosa (Stockinger et al., 2014).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Stockinger et al., 2014
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Metadata
- Authors
- Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H.
- Affiliations
- National Institute for Medical Research (GB)
- Corresponding author
- Duarte, João H.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2014-03-21
- Volume
- 32
- Issue
- 1
- Pages
- 403-432
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2112265988
- Cited by
- 909
- References
- 165
- Citations by year
- 2026: 71 · 2025: 66 · 2024: 84 · 2023: 86 · 2022: 87 · 2021: 76 · 2020: 110 · 2019: 78 · 2018: 77 · 2017: 63 · 2016: 55 · 2015: 40 · 2014: 15
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (100910)
- FP7 Ideas: European Research Council (232782)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- aryl hydrocarbon receptor, immune system, transcription factors, xenobiotic toxicity, 2,3,7,8-tetrachlorodibenzo-p-dioxin, infection, inflammation, skin, intestine, lung
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Immune System, Ligands, Organ Specificity, Protein Binding, Signal Transduction, Receptors, Aryl Hydrocarbon
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