The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

The regulation of IL-10 production by immune cells

Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293

Innate lymphoid cells — a proposal for uniform nomenclature

Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380

Mediator and cohesin connect gene expression and chromatin architecture

Kagey, M. H., Newman, J. J., Bilodeau, S., Zhan, Y., Orlando, D. A., van Berkum, N. L., Ebmeier, C. C., Goossens, J., Rahl, P. B., Levine, S. S., et al. (2010) · Nature · doi:10.1038/nature09380 · Cited by 1,939

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898

Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

Quintana, F. J., Basso, A. S., Iglesias, A. H., Korn, T., Farez, M. F., Bettelli, E., Caccamo, M., Oukka, M., & Weiner, H. L. (2008) · Nature · doi:10.1038/nature06880 · Cited by 1,865

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,674

Innate IL-17-producing cells: the sentinels of the immune system

Cua, D. J., & Tato, C. M. (2010) · Nature reviews. Immunology · doi:10.1038/nri2800 · Cited by 1,640

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

Wang, Z., Zang, C., Cui, K., Schones, D. E., Barski, A., Peng, W., & Zhao, K. (2009) · Cell · doi:10.1016/j.cell.2009.06.049 · Cited by 1,344

Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity

Yoda, T., Tochitani, T., Usui, T., Kouchi, M., Inada, H., Hosaka, T., Kanno, Y., Miyawaki, I., & Yoshinari, K. (2022) · The Journal of Toxicological Sciences · doi:10.2131/jts.47.359 · Cited by 10

A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway

Zablocki-Thomas, L., Menzies, S. A., Lehner, P. J., Manel, N., & Benaroch, P. (2020) · Innate Immunity · doi:10.1177/1753425920915507 · Cited by 10

Aryl hydrocarbon receptor (Ahr)‐dependent Il‐22 expression by type 3 innate lymphoid cells control of acute joint inflammation

Nehmar, R., Fauconnier, L., Alves-Filho, J. C., Togbe, D., de Cauwer, A., Bahram, S., Bert, M. L., Ryffel, B., & Georgel, P. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16433 · Cited by 9

The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis

Zhang, T., Li, R., Li, H., Xiang, N., Tan, Z., Wang, G., & Li, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.823863 · Cited by 10

Discovery of Norisoboldine Analogue III11 as a Novel and Potent Aryl Hydrocarbon Receptor Agonist for the Treatment of Ulcerative Colitis

Lin, L., Liu, Y., Chen, L., Dai, Y., & Xia, Y. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00287 · Cited by 10

Effects of Endocrine Disrupters on Immune Function and Inflammation

Dietert, R. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801139-3.00014-4 · Cited by 10

Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection

Almeida, F. F., Jacquelot, N., & Belz, G. T. (2018) · Immunological Reviews · doi:10.1111/imr.12709 · Cited by 10

Immunoregulation via Cell Density and Quorum Sensing-like Mechanisms: An Underexplored Emerging Field with Potential Translational Implications

Naoun, A. A., Raphael, I., & Forsthuber, T. G. (2022) · Cells · doi:10.3390/cells11152442 · Cited by 9

Aryl hydrocarbon receptor attenuates cholestatic liver injury by regulating bile acid metabolism

Han, Q., Yan, X., Wang, L., Zhang, N., Zhang, W., Li, H., Chen, W., You, H., & Yang, A. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.10.030 · Cited by 9

Acute exercise activates the AHR in peripheral blood mononuclear cells in an intensity-dependent manner

Joisten, N., Walzik, D., Schenk, A., Metcalfe, A. J., Belen, S., Schaaf, K., Jacko, D., Gehlert, S., Spiliopoulou, P., Garzinsky, A., et al. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00282.2024 · Cited by 11

Pre- to Postbiotics: The Beneficial Roles of Pediatric Dysbiosis Associated with Inflammatory Bowel Diseases

Ottria, R., Xynomilakis, O., Casati, S., & Ciuffreda, P. (2024) · Microorganisms · doi:10.3390/microorganisms12081582 · Cited by 9

Autophagy activation within inflammatory microenvironment improved the therapeutic effect of MSC-Derived extracellular Vesicle in SLE

Liao, S., Guo, F., Xiao, Z., Xiao, H., Pan, Q.-R., Guo, Y., Chen, J., Wang, X., Wang, X., Huang, H., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.044 · Cited by 11

CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner

Ching, M. E. A., Hoyeck, M. P., Basu, L., Merhi, R. C., Poleo-Giordani, E., Vanzyl, E. J., Crawley, A. M., & Bruin, J. E. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2024 · Cited by 9

Novel aryl hydrocarbon receptor agonists as potential anti-inflammatory therapeutics: Identification and validation through drug repurposing

Haupt, J., Keminer, O., Neser, C., Windshügel, B., Wiltzsch, V., Schmidt, J. R., Pliushcheuskaya, P., Künze, G., Scholz, U., Müller, C., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117066 · Cited by 12

Supplementation of nicotinamide mononucleotide diminishes COX-2 associated inflammatory responses in macrophages by activating kynurenine/AhR signaling

Liu, J., Hou, W., Zong, Z., Chen, Y., Liu, X., Zhang, R., & Deng, H. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.046 · Cited by 9

Adipocyte-derived kynurenine stimulates malignant transformation of mammary epithelial cells through the aryl hydrocarbon receptor

Diedrich, J. D., Gonzalez-Pons, R., Medeiros, H. C. D., Ensink, E., Liby, K. T., Wellberg, E. A., Lunt, S. Y., & Bernard, J. J. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115763 · Cited by 9

Live‐cell screening platform using human‐induced pluripotent stem cells expressing fluorescence‐tagged cytochrome P450 1A1

Kim, J., Im, I., Kim, H., Jeon, J. S., Kang, E., Jo, S., Chun, H., Yoon, S., Kim, J., Kim, S. K., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201903110r · Cited by 9

Aryl hydrocarbon receptor engagement during redox alteration determines the fate of CD4+ T cells in C57BL/6 mice

Mohammadi, H., Daryabor, G., Ghaffarian‐Bahraman, A., Keshavarzi, M., Kalantar, K., & Mohammadi‐Bardbori, A. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22821 · Cited by 9

Practical Approach To Explore the Effects of Polyphenols on Aryl Hydrocarbon Receptor Regulated Immune Function

Tang, J. S., Cait, A., Li, Y., Abolins-Thompson, H., Gell, K., Herst, P. M., O’Sullivan, D., & Gasser, O. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c02095 · Cited by 9

The AhR ligand 2, 2′-aminophenyl indole (2AI) regulates microglia homeostasis and reduces pro-inflammatory signaling

Khan, A. S., Wolf, A., & Langmann, T. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.09.054 · Cited by 10

A Co-Association Network Analysis Reveals Putative Regulators for Health-Related Traits in Pigs

Crespo‐Piazuelo, D., Ramayo‐Caldas, Y., González-Rodríguez, O., Pascual, M., Quintanilla, R., & Ballester, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.784978 · Cited by 11

Reprogramming Metabolism of Macrophages as a Target for Kidney Dysfunction Treatment in Autoimmune Diseases

Tian, F., Chen, H., Zhang, J., & He, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148024 · Cited by 10

In vitro re-expression of the aryl hydrocarbon receptor (Ahr) in cultured Ahr-deficient mouse antral follicles partially restores the phenotype to that of cultured wild-type mouse follicles

Ziv‐Gal, A., Gao, L., Karman, B. N., & Flaws, J. A. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.11.011 · Cited by 9

Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview

de Almeida, D. C., Evangelista, L., & Câmara, N. O. S. (2017) · World Journal of Stem Cells · doi:10.4252/wjsc.v9.i9.152 · Cited by 10

Nuclear transport of the human aryl hydrocarbon receptor and subsequent gene induction relies on its residue histidine 291

Tkachenko, A., Bermúdez, M., Irmer-Stooff, S., Genkinger, D., Henkler, F., Wolber, G., & Luch, A. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2129-0 · Cited by 11

An endogenous aryl hydrocarbon receptor ligand enhances de novo generation of regulatory T cells in humans

Zamali, I., Rekik, R., Hmida, N. B., Hmid, A. B., Kammoun, O., Barbouche, M., & Ahmed, M. B. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.2ab0518-205rr · Cited by 9

In Silico Comparison Shows that the Pan-Genome of a Dairy-Related Bacterial Culture Collection Covers Most Reactions Annotated to Human Microbiomes

Roder, T., Wüthrich, D., Bär, C., Sattari, Z., von Ah, U., Ronchi, F., Macpherson, A. J., Ganal-Vonarburg, S. C., Bruggmann, R., & Vergères, G. (2020) · Microorganisms · doi:10.3390/microorganisms8070966 · Cited by 9

Engineered Th17 Cell Differentiation Using a Photoactivatable Immune Modulator

Parasar, B., & Chang, P. V. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07485 · Cited by 9

Hypoxia-Ischemia Induced Age-Dependent Gene Transcription Effects at Two Development Stages in the Neonate Mouse Brain

Dupré, N., Derambure, C., Dieu‐Lugon, B. L., Hauchecorne, M., Detroussel, Y., Gonzalez, B. J., Marret, S., & Leroux, P. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.587815 · Cited by 9

Unleashing nature's potential and limitations: Exploring molecular targeted pathways and safe alternatives for the treatment of multiple sclerosis (Review)

Fathallah, S., Abdellatif, A., & Saadeldin, M. K. (2023) · Medicine International · doi:10.3892/mi.2023.102 · Cited by 9

Roles of AhR/CYP1s signaling pathway mediated ROS production in uremic cardiomyopathy

Lu, W., Cheng, S., Xu, J., Xiao, Z., Yu, Y., Xie, Q., Fang, Y., Chen, R., Shen, B., Xie, Y., et al. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.04.005 · Cited by 8

Microbial tryptophan catabolism as an actionable target via diet-microbiome interactions

Huang, Z., Wells, J. M., Fogliano, V., & Capuano, E. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2369947 · Cited by 9

Benvitimod upregulates filaggrin, involucrin and loricrin expressions via aryl hydrocarbon receptor-OVO-like 1 axis

Jia, Q., Liu, P., Wang, X., Hu, J., Jia, J., Zhang, J., & Li, H. (2024) · Archives of Dermatological Research · doi:10.1007/s00403-024-03268-7 · Cited by 8

Integrated colon microbiome and metabolomics to elucidate the antidepressant mechanisms of the Radix Bupleuri-Radix Paeoniae Alba herb pair

Lv, J.-L., Bai, Y., Lv, Y., Chen, C., Qin, X., Du, G., & Zhou, Y. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01450-4 · Cited by 8

Indole-3-lactic acid derived from tryptophan metabolism alleviates the sFlt-1-induced preeclampsia-like phenotype via the activation of aryl hydrocarbon receptor

Wei, Y., Tian, H., Peng, H., Wubulikasimu, A., Wei, M., Li, H., He, Q., Duan, T., Huang, Y., & Wang, K. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123329 · Cited by 8

Aryl hydrocarbon receptor and Krüppel like factor 10 mediate a transcriptional axis modulating immune homeostasis in mosquitoes

Kulkarni, A., Pandey, A., Trainor, P. J., Carlisle, S. M., Yu, W., Kukutla, P., & Xu, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-09817-2 · Cited by 8

Bioluminescence imaging of Cyp1a1-luciferase reporter mice demonstrates prolonged activation of the aryl hydrocarbon receptor in the lung

Veland, N., Gleneadie, H. J., Brown, K. E., Sardini, A., Pombo, J., Dimond, A., Burns, V., Sarkisyan, K. S., Schiering, C., Webster, Z., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06089-6 · Cited by 8

Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation

Furue, M., & Furue, M. (2021) · Exploration of Immunology · doi:10.37349/ei.2021.00005 · Cited by 10

Differential Expression of Genes Involved in Metabolism and Immune Response in Diffuse and Intestinal Gastric Cancers, a Pilot Ptudy

Perrot‐Applanat, M., Pimpie, C., Vacher, S., Bièche, I., Pocard, M. D., & Baud, V. (2022) · Biomedicines · doi:10.3390/biomedicines10020240 · Cited by 8

Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology

Gan, Y., Sha, H., Zou, R., Xu, M., Zhang, Y., Feng, J., & Wu, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.864101 · Cited by 11

MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis

Liu, Y., Zhao, N., Xu, Q., Deng, F., Wang, P., Dong, L., Lu, X., Xia, L., Wang, M., Chen, Z., et al. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s357453 · Cited by 8

“Nuts and Bolts” of Disease Tolerance

Soares, M. P. (2014) · Immunity · doi:10.1016/j.immuni.2014.07.011 · Cited by 7

Aryl hydrocarbon receptor gene transitions (c.-742C>T; c.1661G>A) and idiopathic male infertility: a case-control study with in silico and meta-analysis

Aftabı, Y., Colagar, A. H., Mehrnejad, F., Seyedrezazadeh, E., & Moudi, E. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-9701-2 · Cited by 8

Resolving Inflammation by Targeting an Ancient Innate Immune Sensor with a Bacterial Metabolite

Johnston, A. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.07.815 · Cited by 8

Mammalian watchdog targets bacteria

Kundu, P., & Pettersson, S. (2014) · Nature · doi:10.1038/nature13741 · Cited by 8

Maternal consumption of yoghurt activating the aryl hydrocarbon receptor increases group 3 innate lymphoid cells in murine offspring

Burton-Pimentel, K. J., Röder, T., Bär, C., Christensen, S., Sattari, Z., Kalbermatter, C., von Ah, U., Robert, C. A. M., Mateo, P., Bruggmann, R., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00393-24 · Cited by 7

Epigenetic Remodeling of Regulatory Regions by Indicaxanthin Suggests a Shift in Cell Identity Programs in Colorectal Cancer Cells

Ragusa, M. A., Gentile, C., Nicosia, A., Costa, S., Volpes, S., Greco, L., Naselli, F., & Caradonna, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136072 · Cited by 7

Association between AHR Expression and Immune Dysregulation in Pancreatic Ductal Adenocarcinoma: Insights from Comprehensive Immune Profiling of Peripheral Blood Mononuclear Cells

Bartkevičienė, A., Jasukaitienė, A., Žievytė, I., Stukas, D., Ivanauskienė, S., Urbonienė, D., Maimets, T., Jaudzems, K., Vitkauskienė, A., Matthews, J. B., et al. (2023) · Cancers · doi:10.3390/cancers15184639 · Cited by 6

Human and gut microbiota synergy in a metabolically active superorganism: a cardiovascular perspective

Russo, M. A., Puccetti, M., Costantini, C., Giovagnoli, S., Ricci, M., Garaci, E., & Romani, L. R. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1411306 · Cited by 8

Natural Products as Modulators of Aryl Hydrocarbon Receptor Signaling in Atopic Dermatitis Management

Lee, J., Choi, H., Shin, H. S., & Kim, G.-D. (2024) · Molecules · doi:10.3390/molecules29245951 · Cited by 7

Nicotinamide and Demographic and Disease transitions: Moderation is Best

Williams, A. C., & Hill, L. J. (2019) · International Journal of Tryptophan Research · doi:10.1177/1178646919855940 · Cited by 6

Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor

Alvik, K., Shao, P., Hutin, D., Baglole, C. J., Grant, D. M., & Matthews, J. B. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac132 · Cited by 7

Transcriptomic analysis reveals the regulatory mechanism underlying the indirubin-mediated amelioration of dextran sulfate sodium-induced colitis in mice

Liu, Z., Zhang, J., Huang, Y., Li, X., Zhu, H., Yang, R., & Chen, S. (2023) · Pharmaceutical Biology · doi:10.1080/13880209.2023.2233565 · Cited by 7

Prenatal exposures and exposomics of asthma

Choi, H., Auley, M. T. M., & Lawrence, D. A. (2015) · AIMS environmental science · doi:10.3934/environsci.2015.1.87 · Cited by 7

AHR and the issue of immunotoxicity

Esser, C., Haarmann‐Stemmann, T., Hochrath, K., Schikowski, T., & Krutmann, J. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.03.001 · Cited by 8

Binding of Chlorinated Phenylacrylonitriles to the Aryl Hydrocarbon Receptor: Computational Docking and Molecular Dynamics Simulations

Paula, S., Baker, J. R., Zhu, X., & McCluskey, A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84818 · Cited by 7

Multifaceted Contributions of Epidermal Langerhans Cells to Cutaneous Carcinogenesis

Clausen, B. E., & Grabbe, S. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.520 · Cited by 7

An endogenous aryl hydrocarbon receptor ligand induces preeclampsia‐like phenotypes in rats

Zhao, Y., Zhou, C., Zhang, S., Mishra, J. S., Li, H., Lei, W., Wang, K., Kumar, S., & Zheng, J. J. (2024) · The Journal of Physiology · doi:10.1113/jp287503 · Cited by 6

In vitro assessment of aryl hydrocarbon, estrogen, and androgen receptor-mediated activities of secondary organic aerosols formed from the oxidation of polycyclic aromatic hydrocarbons and furans

Mais, A. E. R. E., D’Anna, B., Albinet, A., & Aı̈t-Aı̈ssa, S. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121220 · Cited by 6

Mechanisms by which tryptophan metabolites enhance intestinal barrier function to prevent necrotizing enterocolitis in preterm infants

Cui, X., Qiu, J., Xu, Y., Guan, Z., Ding, Y., Yu, S., Fan, S., Guihua, S. O. N. G., & Ren, X. X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1782006 · Cited by 6

Development of FluoAHRL: A Novel Synthetic Fluorescent Compound That Activates AHR and Potentiates Anti-Inflammatory T Regulatory Cells

Jonić, N., Koprivica, I., Chatzigiannis, C. M., Tsiailanis, A. D., Kyrkou, S. G., Tzakos, E. P., Pavić, A., Dimitrijević, M., Jovanović, A., Jovanović, M. B., et al. (2024) · Molecules · doi:10.3390/molecules29132988 · Cited by 6

Computational discovery of novel aryl hydrocarbon receptor modulators for psoriasis therapy

Santini, G., Bonati, L., & Motta, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-03626-z · Cited by 8

Normal mast cell numbers in the tissues of AhR‐deficient mice

Pilz, A. C., Feyerabend, T. B., Sonner, J. K., Redaelli, C., Peter, K., Kunze, A., Haas, K., Esser, C., Schäkel, K., Wick, W., et al. (2015) · Experimental Dermatology · doi:10.1111/exd.12864 · Cited by 6

Synergistic effect of endurance training and nettle leaf extract on the IDO1-KYN-AHR pathway homeostasis and inhibiting of liver toxicity in rats with STZ-induced diabetes

Haghshenas, R., Aftabı, Y., Doaei, S., & Gholamalizadeh, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1071424 · Cited by 7

Leishmania major centrin knock-out parasites reprogram tryptophan metabolism to induce a pro-inflammatory response

Oljuskin, T., Azodi, N., Volpedo, G., Bhattacharya, P., Markle, H. L., Hamano, S., Matlashewski, G., Satoskar, A. R., Gannavaram, S., & Nakhasi, H. L. (2023) · iScience · doi:10.1016/j.isci.2023.107593 · Cited by 6

The Sterilization of Human Milk by Holder Pasteurization or by High Hydrostatic Pressure Processing Leads to Differential Intestinal Effects in Mice

Carneiro, L., Marousez, L., Hul, M. V., Tran, L. C., de Lamballerie, M., Ley, D., Cani, P. D., Knauf, C., & Lésage, J. (2023) · Nutrients · doi:10.3390/nu15184043 · Cited by 6

Not your usual tRNA synthetase: hWARS serves as an enterovirus entry factor

Perlman, S. M., & Gallagher, T. (2018) · Journal of Clinical Investigation · doi:10.1172/jci124582 · Cited by 7

Effects of cross-fostering and developmental exposure to mixtures of environmental contaminants on hepatic gene expression in prepubertal 21 days old and adult male Sprague-Dawley rats

Desaulniers, D. M., Khan, N., Cummings‐Lorbetskie, C., Leingartner, K., Xiao, G.-H., Williams, A., & Yauk, C. L. (2019) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2018.1542360 · Cited by 6

Insight into innate immune response in “Yusho”: The impact of natural killer cell and regulatory T cell on inflammatory prone diathesis of Yusho patients

Kamio, Y., Gunge, Y., Koike, Y., Kuwatsuka, Y., Tsuruta, K., Yanagihara, K., Furue, M., & Murota, H. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109415 · Cited by 6

Xenobiotic and endobiotic handling by the mucosal immune system

Chen, M. L., & Sundrud, M. S. (2018) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000478 · Cited by 6

Aryl Hydrocarbon Receptor Activation Limits the Fatty Acid Synthesis and Subsequent “miR-193a-3p-HDAC3-FASN” Signals to Alleviate Intestinal Fibrosis

Wu, X., Miao, X., Xue, X., Qiao, S., Dai, Y., & Wei, Z. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00976 · Cited by 5

Modulation of aryl hydrocarbon receptor activity by halogenated indoles

Vrzalová, A., Vrzal, R., Nádvorník, P., Šebela, M., & Dvořák, Z. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117964 · Cited by 5

Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections

Sun, Z., Wang, Y., Liu, S., Li, H., He, D., & Xu, H. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115524 · Cited by 5

Renal protective effects of extracellular vesicle-encapsulated tumor necrosis factor-α-induced protein 6 derived from mesenchymal stem cells

Morimoto, K., Nakashima, A., Ishiuchi, N., Miyasako, K., Tanaka, Y., Sasaki, K., Matsuda, G., Maeda, S., Miyaki, S., & Masaki, T. (2025) · Stem Cells · doi:10.1093/stmcls/sxaf022 · Cited by 5

Enteric delivery of indole-3-carboxylic acid unlocks therapeutic potential of postbiotic metabolite cascade

Puccetti, M., Pariano, M., Stincardini, C., Fabi, C., Galarini, R., Barola, C., Alabed, H. B. R., Mancini, D. F., Pellegrino, R. M., Garaci, E., et al. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126158 · Cited by 5

Beneficial and detrimental consequences of AHR activation in intestinal infection

Diaz, O. E., Zhou, L., Barrington, C., Lindqvist, D., Graelmann, F. J., Wincent, E., & Stockinger, B. (2025) · Life Science Alliance · doi:10.26508/lsa.202503414 · Cited by 4

Lactucopicrin: A Sesquiterpene Lactone with Anti-Inflammatory Activity Modulates the Crosstalk between NF-kB and AHR Pathways

Ávila‐Gálvez, M. Á., Pinto, C. J. G., Rafael-Pita, C., Silva, I. P., Janowska, A. T., Marinho, S. P., Saitch, R., Lian, Y., Louphrasitthiphol, P., Protze, J., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02294 · Cited by 6

DNA Methylation as a Biomarker in Environmental Epidemiology

Deyssenroth, M. A., & Wright, R. O. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812433-8.00007-1 · Cited by 5

From Molecules to Microbes: Tracing Cutaneous T-Cell Lymphoma Pathogenesis through Malignant Inflammation

Gordon, E. R., Fahmy, L. M., Trager, M. H., Adeuyan, O. O., Lapolla, B. A., Schreidah, C. M., & Geskin, L. J. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.03.022 · Cited by 5

Tapinarof: A Felicitous Discovery in Psoriasis Treatment

Prabath, I., Subramanian, S., & Rani, J. (2022) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.1177/0976500x221130851 · Cited by 5

The Notorious Triumvirate in Pediatric Health: Air Pollution, Respiratory Allergy, and Infection

Endaryanto, A., Darma, A., Sundjaya, T., Masita, B. M., & Basrowi, R. W. (2023) · Children · doi:10.3390/children10061067 · Cited by 5

Aryl Hydrocarbon Receptor Knockout Accelerates PanIN Formation and Fibro-Inflammation in a Mutant Kras-Driven Pancreatic Cancer Model

Walcheck, M. T., Schwartz, P. B., Carrillo, N. D., Matkowskyj, K. A., Nukaya, M., Bradfield, C. A., & Ronnekleiv‐Kelly, S. M. (2024) · Pancreas · doi:10.1097/mpa.0000000000002357 · Cited by 5

Beyond transcription, aryl hydrocarbon receptor plays a protective role in periodontitis by interacting with CaMKII

Zeng, X., Feng, M., Lu, J., Wang, R., Deng, L., Yang, Y., & Luo, L. (2024) · Journal of Periodontology · doi:10.1002/jper.24-0021 · Cited by 6

AHR in the skin: From the mediator of chloracne to a therapeutic panacea?

Merches, K., Haarmann‐Stemmann, T., Weighardt, H., Krutmann, J., & Esser, C. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.02.002 · Cited by 5

Enhanced nuclear translocation and activation of aryl hydrocarbon receptor (AhR) in THP-1 monocytic cell line by a novel niosomal formulation of indole-3-carbinol

Sani, N. A., Hasani, M., Kianmehr, A., Mohammadi, S., Arabi, M. S., & Yazdani, Y. (2019) · Journal of Liposome Research · doi:10.1080/08982104.2019.1600545 · Cited by 5

Nuclear receptors modulate inflammasomes in the pathophysiology and treatment of major depressive disorder

Wang, H., Kan, W., Feng, Y., Feng, L., Yang, Y., Chen, P., Xu, J.-J., Si, T., Zhang, L., Wang, G., et al. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i12.1191 · Cited by 5

Decreased serum tryptophan levels in patients with MOGAD:a cross-sectional survey

Chang, H., Sun, J., Ma, J., Zhao, Y., Guo, T., Wei, Y., Cong, H., Yin, L., Zhang, X., & Wang, H. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.119669 · Cited by 4

Aromatic hydrocarbon receptors in the immune system: Review and hypotheses

Csaba, G. (2019) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/030.66.2019.003 · Cited by 5

2,3,7,8‐tetrachlorodibenzo‐p‐dioxin exposure influence the expression of glutamate transporter GLT‐1 in C6 glioma cells via the Ca2+/protein kinase C pathway

Zhao, J., Zhang, Y., Zhao, J., Wang, C., Mao, J., Li, T., Wang, X., Nie, X., Jiang, S., & Wu, Q. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3294 · Cited by 5

Proceedings of the 2018 National Toxicology Program Satellite Symposium

Elmore, S. A., Carreira, V., Labriola, C. S., Mahapatra, D., McKeag, S., Rinke, M., Shackelford, C. C., Singh, B., Talley, A., Wallace, S. M., et al. (2018) · Toxicologic Pathology · doi:10.1177/0192623318800734 · Cited by 5

Aryl hydrocarbon receptor activity may serve as a surrogate marker for MS disease activity

Sabatino, J. J., & Zamvil, S. S. (2017) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000366 · Cited by 5

Tamarind Seed-Derived Xyloglucan Attenuates Insulin Resistance in Mice through Gut Microbiota

Yang, J., Tan, H., Peng, X., & Nie, S. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c07829 · Cited by 5

Gut microbiota–derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health

Wen, Y. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1807477 · Cited by 5

Role of the Aryl Hydrocarbon Receptor in the Self-Renewal, Differentiation, and Immunomodulation of Adult Stem Cells

Seo, M.-S., Baek, J., & Jeon, M. (2025) · Immune Network · doi:10.4110/in.2025.25.e1 · Cited by 4

IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection

dos Santos, R. O., Carvalho, N. O., de Morais, T. B. D. N., Sobrinho, W. B. S., da Cruz, M. G. S., de Faria, E. S., de Araújo, F. F., Peruhype-Magalhães, V., Lopes, S. C. P., Malheiros, A., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1474447 · Cited by 4

Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization

Griffith, B. D., Kadiyala, P., McGue, J. J., Sun, L., Kumar, A., Espinoza, C. E., Donahue, K. L., Iyer, M. K., Speyer, C. B., Nelson, S., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0377 · Cited by 5

The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface

Costantini, C., Renga, G., Oikonomou, V., Paolicelli, G., Borghi, M., Pariano, M., LUCA, A. D., Puccetti, M., Stincardini, C., Mosci, P., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/7396136 · Cited by 4

Association between urinary concentrations of polycyclic aromatic hydrocarbons and risk of endometriosis in the NHANES 2003–2006

Wang, B., Zhang, H., Zhang, X., Wang, J., Wang, H., & Jiang, J. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-30545-1 · Cited by 4

Differential effects of pesticides on dioxin receptor signaling and p53 activation

Fauteux, M., Côté, N., Bergeron, S., Maréchal, A., & Gaudreau, L. R. (2023) · Scientific Reports · doi:10.1038/s41598-023-48555-x · Cited by 4

Microbial influences on severity and sex bias of systemic autoimmunity

Lee, J. Y. H., Reiman, D. J., Singh, S. P., Chang, A., Morel, L. M., & Chervonsky, A. V. (2024) · Immunological Reviews · doi:10.1111/imr.13341 · Cited by 4

Editorial: Role of the Aryl Hydrocarbon Receptor in Immune Modulation

Kaplan, B. L. F., Baglole, C. J., & Sulentic, C. E. W. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.941665 · Cited by 1

Aryl hydrocarbon receptor and intestinal immunity

Lamas, B., Natividad, J. M., & Sokol, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0019-2 · Cited by 551

The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology

Esser, C., & Rannug, A. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009001 · Cited by 501

The Aryl Hydrocarbon Receptor and Immunity

Ehrlich, A. K., & Sulentic, C. E. W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00144-3

External influences on the immune system via activation of the aryl hydrocarbon receptor

Stockinger, B., Hirota, K., Duarte, J. H., & Veldhoen, M. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.01.008 · Cited by 190