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Lipoprotein Lipase in the Brain and Nervous System
Open accessAbstract
Lipoprotein lipase (LPL) is rate limiting in the provision of triglyceride-rich lipoprotein-derived lipids into tissues. LPL is also present in the brain, where its function has remained elusive. Recent evidence implicates a role of LPL in the brain in two processes: (a) the regulation of energy balance and body weight and (b) cognition. Mice with neuron-specific deletion of LPL have increases in food intake that lead to obesity, and then reductions in energy expenditure that further contribute to and sustain the phenotype. In other mice with LPL deficiency rescued from neonatal lethality by somatic gene transfer wherein LPL in the brain remains absent, altered cognition ensues. Taking into consideration data that associate LPL mutations with Alzheimer's disease, a role for LPL in learning and memory seems likely. Overall, the time is ripe for new insights into how LPL-mediated lipoprotein metabolism in the brain impacts CNS processes and systems biology.
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“LPL hydrolyzes circulating chylomicrons and very-low-density lipoprotein, is a regulator of brain energy balance, is strongly expressed in the hypothalamus, hippocampus, and striatum, and LPL variants are associated with neurite pathology and Alzheimer disease [96–98].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [96]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“LPL hydrolyzes circulating chylomicrons and very-low-density lipoprotein, is a regulator of brain energy balance, is strongly expressed in the hypothalamus, hippocampus, and striatum, and LPL variants are associated with neurite pathology and Alzheimer disease [96–98].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [96]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the lack of LPL protein expression in control white matter brain tissue (17).”
From Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity (2019) · cites this paper as [17]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“LPL hydrolyzes circulating chylomicrons and very-low-density lipoprotein, is a regulator of brain energy balance, is strongly expressed in the hypothalamus, hippocampus, and striatum, and LPL variants are associated with neurite pathology and Alzheimer disease [96–98].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [96]
The cited source says what the claim attributes to it.
In the citing paper
“LPL hydrolyzes circulating chylomicrons and very-low-density lipoprotein, is a regulator of brain energy balance, is strongly expressed in the hypothalamus, hippocampus, and striatum, and LPL variants are associated with neurite pathology and Alzheimer disease [96–98].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [96]
The cited source says what the claim attributes to it.
In the citing paper
“In addition, LPL is present in most regions of the brain, particularly in areas with high levels of neuronal cell bodies, but to a lesser extent in areas rich in glial cells [14].”
From Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity (2015) · cites this paper as [14]
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“The function of LPL in the brain still remains elusive, but it has been implicated in at least two different functions; the regulation of body weight and energy balance as well as cognition [14,15].”
From Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity (2015) · cites this paper as [14]
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Metadata
- Authors
- Wang, H., & Eckel, R. H.
- Affiliations
- University of Colorado Anschutz (US)
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2012-08-21
- Volume
- 32
- Issue
- 1
- Pages
- 147-160
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- PMC
- PMC4065112
- OpenAlex
- W1990329481
- Cited by
- 105
- References
- 95
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 11 · 2018: 5 · 2017: 11 · 2016: 10 · 2015: 9 · 2014: 6 · 2013: 8
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089309)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- lipoprotein lipase, brain, nervous system, triglyceride-rich lipoproteins, lipoprotein metabolism, energy balance, obesity, dietary intake, energy expenditure, cognition, learning and memory, Alzheimer's disease, somatic gene transfer
- MeSH terms
- Animals, Body Weight, Brain, Central Nervous System, Energy Metabolism, Humans, Learning, Lipoprotein Lipase, Memory, Nerve Tissue Proteins, Neurons, Spinal Cord, Gene Expression Regulation, Enzymologic, Peripheral Nervous System
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