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Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes
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In adipocytes, ANGPTL4 appears able to inactivate LPL both intracellularly and extracellularly.
“In adipocytes, ANGPTL4 appears able to inactivate LPL both intracellularly (64, 65) and extracellularly (29, 66).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [64]
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Brown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
Dewey, F. E., Gusarova, V., O’Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C. V., Habegger, L., Buckler, D., Lai, K.-M. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1510926 · Cited by 497
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1507652 · Cited by 493
Köster, A., Chao, Y. B., Mosior, M., Ford, A., Gonzalez-DeWhitt, P. A., Hale, J. E., Li, D., Qiu, Y., Fraser, C. C., Yang, D. D., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0476 · Cited by 427 · cited 2×
“CHO pgsA-745 cells were electroporated with an expression vector for Flag-tagged human ANGPTL4 (either the full-length protein hANGPTL4[1–406] or the amino-terminal domain of hANGPTL4 [1–160]) or a vector for V5tagged human LPL (or empty vector).”
BackgroundMethodShah, D. K., & Betts, A. M. (2013) · mAbs · doi:10.4161/mabs.23684 · Cited by 262
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism
Strong, A., Ding, Q., Edmondson, A. C., Millar, J. S., Sachs, K. V., Li, X., Kumaravel, A., Wang, M. Y., Ai, D., Guo, L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63563 · Cited by 222
Pan, M., Maitin, V., Parathath, S., Andreo, U., Lin, S. X., Germain, C. S., Yao, Z., Maxfield, F. R., Williams, K. J., & Fisher, E. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707460104 · Cited by 128
Lipoprotein Lipase in the Brain and Nervous System
Wang, H., & Eckel, R. H. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150703 · Cited by 105
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“ANGPTL4 inhibits LPL activity on the surface of capillary endothelial cells within muscle tissue [37], and interactions between ANGPTL4 and LPL were also observed intracellularly [6,12].”
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Metadata
- Authors
- Dijk, W., Beigneux, A. P., Larsson, M., Bensadoun, A., Young, S. G., & Kersten, S.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 57
- Issue
- 9
- Pages
- 1670-1683
- ISSN
- 0022-2275
- Cited by
- 103
- References
- 8
- Language
- en
- Update notices
- erratum (2016-10-01)
- Licence
- Funders
- Fondation Leducq (12CVD04)
- Office of Extramural Research, National Institutes of Health (HL090533, HL087228)
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