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Lipoprotein Lipase in the Brain and Nervous System
Open accessAbstract
Lipoprotein lipase (LPL) is rate limiting in the provision of triglyceride-rich lipoprotein-derived lipids into tissues. LPL is also present in the brain, where its function has remained elusive. Recent evidence implicates a role of LPL in the brain in two processes: (a) the regulation of energy balance and body weight and (b) cognition. Mice with neuron-specific deletion of LPL have increases in food intake that lead to obesity, and then reductions in energy expenditure that further contribute to and sustain the phenotype. In other mice with LPL deficiency rescued from neonatal lethality by somatic gene transfer wherein LPL in the brain remains absent, altered cognition ensues. Taking into consideration data that associate LPL mutations with Alzheimer's disease, a role for LPL in learning and memory seems likely. Overall, the time is ripe for new insights into how LPL-mediated lipoprotein metabolism in the brain impacts CNS processes and systems biology.
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“LPL hydrolyzes circulating chylomicrons and very-low-density lipoprotein, is a regulator of brain energy balance, is strongly expressed in the hypothalamus, hippocampus, and striatum, and LPL variants are associated with neurite pathology and Alzheimer disease [96–98].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [96]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“LPL hydrolyzes circulating chylomicrons and very-low-density lipoprotein, is a regulator of brain energy balance, is strongly expressed in the hypothalamus, hippocampus, and striatum, and LPL variants are associated with neurite pathology and Alzheimer disease [96–98].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [96]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the lack of LPL protein expression in control white matter brain tissue (17).”
From Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity (2019) · cites this paper as [17]
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In the citing paper
“LPL hydrolyzes circulating chylomicrons and very-low-density lipoprotein, is a regulator of brain energy balance, is strongly expressed in the hypothalamus, hippocampus, and striatum, and LPL variants are associated with neurite pathology and Alzheimer disease [96–98].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [96]
The cited source says what the claim attributes to it.
In the citing paper
“LPL hydrolyzes circulating chylomicrons and very-low-density lipoprotein, is a regulator of brain energy balance, is strongly expressed in the hypothalamus, hippocampus, and striatum, and LPL variants are associated with neurite pathology and Alzheimer disease [96–98].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [96]
The cited source says what the claim attributes to it.
In the citing paper
“In addition, LPL is present in most regions of the brain, particularly in areas with high levels of neuronal cell bodies, but to a lesser extent in areas rich in glial cells [14].”
From Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity (2015) · cites this paper as [14]
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“The function of LPL in the brain still remains elusive, but it has been implicated in at least two different functions; the regulation of body weight and energy balance as well as cognition [14,15].”
From Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity (2015) · cites this paper as [14]
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Citations
Cites
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors
Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 741
Self-citationCentral Administration of Oleic Acid Inhibits Glucose Production and Food Intake
Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L. (2002) · Diabetes · doi:10.2337/diabetes.51.2.271 · Cited by 654
Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice
Goebbels, S., Bormuth, I., Bode, U., Hermanson, O., Schwab, M. H., & Nave, K. (2006) · genesis · doi:10.1002/dvg.20256 · Cited by 579
Merkel, M., Eckel, R. H., & Goldberg, I. J. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200015-jlr200 · Cited by 520
Self-citationThe NR4A Subgroup: Immediate Early Response Genes with Pleiotropic Physiological Roles
Maxwell, M., & Muscat, G. E. O. (2006) · Nuclear Receptor Signaling · doi:10.1621/nrs.04002 · Cited by 447
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432
Liu, Q., Trotter, J., Zhang, J., Peters, M. M., Cheng, H., Bao, J., Han, X., Weeber, E. J., & Bu, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4067-10.2010 · Cited by 268
Balázs, Z., Panzenboeck, U., Hammer, A., Sovic, A., Quehenberger, O., Malle, E., & Sattler, W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02373.x · Cited by 245
Eisenberg, S., Sehayek, E., Olivecrona, T., & Vlodavsky, I. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116081 · Cited by 244
Rebeck, G. W., Harr, S. D., Hyman, B. T., & Strickland, D. K. (1995) · Annals of Neurology · doi:10.1002/ana.410370212 · Cited by 232
Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.
Péterfy, M., Ben-Zeev, O., Mao, H. Z., Weissglas-Volkov, D., Aouizerat, B. E., Pullinger, C. R., Frost, P. H., Kane, J. P., Malloy, M. J., Reue, K., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.24 · Cited by 226
Takahashi, S., Suzuki, J., Kohno, M., Oida, K., TAMAI, T., Miyabo, S., Yamamoto, T. T., & NAKAI, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15747 · Cited by 226
Levak‐Frank, S., Radner, H., Walsh, A., Stollberger, R., Knipping, G., Höefler, G., Sattler, W., Weinstock, P. H., Breslow, J. L., & Zechner, R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118145 · Cited by 219
Brain-derived neurotrophic factor (BDNF) and food intake regulation: A minireview
Lebrun, B., Bariohay, B., Moyse, E., & Jean, A. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.027 · Cited by 219
Mulder, M., Lombardi, P., Jansen, H., van Berkel, T. J., Frants, R. R., & Havekes, L. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98359-6 · Cited by 214
Kanekiyo, T., Zhang, J., Liu, Q., Liu, C.-C., Zhang, L., & Bu, G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5491-10.2011 · Cited by 212
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
Pocai, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26640 · Cited by 211
Hippocampus as a memory map: Synaptic plasticity and memory encoding by hippocampal neurons
Shapiro, M. L., & Eichenbaum, H. (1999) · Hippocampus · doi:10.1002/(sici)1098-1063(1999)9:4 · Cited by 209
Hypothalamic Responses to Long-chain Fatty Acids Are Nutritionally Regulated
Morgan, K., Obici, S., & Rossetti, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400458200 · Cited by 192
The concept of long term potentiation of transmission at synapses
Bennett, M. R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00006-4 · Cited by 180
Regulation of triglyceride metabolism by Angiopoietin-like proteins
Mattijssen, F., & Kersten, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.010 · Cited by 180
A potential role for the hippocampus in energy intake and body weight regulation
Davidson, T. L., Kanoski, S. E., Schier, L. A., Clegg, D. J., & Benoit, S. C. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.008 · Cited by 178
Lorent, K., Overbergh, L., Moechars, D., Strooper, B. D., LEUVEN, F. V., & BERGHE, H. V. D. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00555-j · Cited by 170
Merkel, M., Kako, Y., Radner, H., Cho, I. S., Ramasamy, R., Brunzell, J. D., Goldberg, I. J., & Breslow, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13841 · Cited by 152
Wang, H., Astarita, G., Taussig, M. D., Bharadwaj, K. G., DiPatrizio, N. V., Nave, K.-A., Piomelli, D., Goldberg, I. J., & Eckel, R. H. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.006 · Cited by 139
Self-citationHypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight
Kim, H.-K., Youn, B., Shin, M.-S., NamKoong, C., Park, K. H., Baik, J., Kim, J. B., Park, J., Lee, K., Kim, Y., et al. (2010) · Diabetes · doi:10.2337/db10-0145 · Cited by 134
Kounnas, M. Z., Chappell, D. A., Strickland, D. K., & Argraves, W. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85224-9 · Cited by 124
Ferreira, L. D., Pulawa, L. K., Jensen, D. R., & Eckel, R. H. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1064 · Cited by 121
Self-citationJensen, D. R., Schlaepfer, I. R., Morin, C. L., Pennington, D. S., Marcell, T., Ammon, S., Gutierrez‐Hartmann, A., & Eckel, R. H. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.2.r683 · Cited by 112
Self-citationHepatic and extrahepatic uptake of intravenously injected lipoprotein lipase
Wallinder, L., Peterson, J., Olivecrona, T., & Bengtsson-Olivecrona, G. (1984) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(84)90181-4 · Cited by 110
Merkel, M., Heeren, J., Dudeck, W., Rinninger, F., Radner, H., Breslow, J. L., Goldberg, I. J., Zechner, R., & Greten, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107914200 · Cited by 105
Adenovirus-mediated Rescue of Lipoprotein Lipase-deficient Mice
Bogner‐Strauß, J. G., Frank, S., Kratky, D., Hämmerle, G., Hrzenjak, A., Knipping, G., von Eckardstein, A., Kostner, G. M., & Zechner, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104430200 · Cited by 104
Liu, Q., Zhang, J., Zerbinatti, C., Zhan, Y., Kolber, B. J., Herz, J., Muglia, L. J., & Bu, G. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000575 · Cited by 93
Mulder, M., Lombardi, P., Jansen, H., van Berkel, T. J. C., Frants, R. R., & Havekes, L. M. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91664-c · Cited by 93
Wang, H., Knaub, L. A., Jensen, D. R., Young Jung, D., Hong, E.-G., Ko, H.-J., Coates, A. M., Goldberg, I. J., de la Houssaye, B. A., Janssen, R. C., et al. (2009) · Diabetes · doi:10.2337/db07-1839 · Cited by 91
Self-citationWolfgang, M. J., Cha, S. H., Millington, D. S., Cline, G. W., Shulman, G. I., Suwa, A., Asaumi, M., Kurama, T., Shimokawa, T., & Lane, M. D. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05255.x · Cited by 90
Lipase maturation factor 1: A lipase chaperone involved in lipid metabolism
Péterfy, M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.006 · Cited by 90
Medh, J. D., Bowen, S. L., Fry, G. L., Ruben, S., Andracki, M., Inoue, I., Lalouel, J.-M., Strickland, D. K., & Chappell, D. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17073 · Cited by 89
Lipoprotein lipase is produced, regulated, and functional in rat brain.
Eckel, R. H., & ROBBINS, R. J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.23.7604 · Cited by 83
Self-citationSynthesis and regulation of lipoprotein lipase in the hippocampus.
Ben-Zeev, O., Doolittle, M., Singh, N., Chang, C., & Schotz, M. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42640-9 · Cited by 82
Papassotiropoulos, A., Wollmer, M. A., Tsolaki, M., Brunner, F., Molyva, D., Lütjohann, D., Nitsch, R. M., & Hock, C. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0720 · Cited by 80
Rinninger, F., Kaiser, T., Mann, W. A., Meyer, N., Greten, H., & Beisiegel†, U. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32514-1 · Cited by 78
Localization of lipoprotein lipase mRNA in selected rat tissues
Goldberg, I. J., Soprano, D. R., Wyatt, M. L., Vanni, T. M., Kirchgessner, T. G., & Schotz, M. C. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38241-9 · Cited by 77
SorLA regulates the activity of lipoprotein lipase by intracellular trafficking
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, M. C., Nyegaard, M., Koster, G., Prabakaran, T., Nilsson, S. K., Kjærgaard, M. M., Bakke, O., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.072538 · Cited by 77
Cellular differences in lipoprotein lipase-mediated uptake of low density lipoproteins.
Obunike, J. C., Edwards, I. J., Rumsey, S. C., Curtiss, L. K., Wagner, W. D., Deckelbaum, R. J., & Goldberg, I. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36808-4 · Cited by 76
Heeren, J., Niemeier, A., Merkel, M., & Beisiegel†, U. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0351-5 · Cited by 75
Seo, T., Al-Haideri, M. T., Treskova, E., Worgall, T. S., Kako, Y., Goldberg, I. J., & Deckelbaum, R. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910327199 · Cited by 75
Chajek, T., Stein, O., & Stein, Y. (1977) · Atherosclerosis · doi:10.1016/0021-9150(77)90122-8 · Cited by 74
Transthyretin knockouts are a new mouse model for increased neuropeptide Y
Nunes, A. F., Saraiva, M. J., & Sousa, M. M. (2005) · The FASEB Journal · doi:10.1096/fj.05-4106fje · Cited by 67
Paradis, É., Clavel, S., Julien, P., Murthy, M. R. V., de Bilbao, F., Arsenijevic, D., Giannakopoulos, P., Vallet, P., & Richard, D. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.09.017 · Cited by 67
Nishitsuji, K., Hosono, T., Uchimura, K., & Michikawa, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.172106 · Cited by 65
Goti, D., Balázs, Z., Panzenboeck, U., Hrzenjak, A., Reicher, H., Wagner, E., Zechner, R., Malle, E., & Sattler, W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203989200 · Cited by 65
Auerbach, B. J., Bisgaier, C. L., Wölle, J., & Saxena, U. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1329 · Cited by 62
Lipoprotein lipase and acid lipase activity in rabbit brain microvessels.
Brecher, P. I., & Kuan, H.-T. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40600-5 · Cited by 62
Xian, X., Liu, T., Yu, J. H., Wang, Y., Miao, Y., Zhang, J., Yu, Y., Ross, C. J., Karasinska, J. M., Hayden, M. R., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0297-09.2009 · Cited by 60
Tongiorgi, E., Domenici, L., & Simonato, M. (2005) · Molecular Neurobiology · doi:10.1385/mn:33:1:017 · Cited by 58
Spinal cord of the rat contains more lipoprotein lipase than other brain regions
Bessesen, D., Richards, C., Etienne, J., Goers, J., & Eckel, R. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40750-3 · Cited by 58
Self-citationFernandez‐Borja, M., Bellido, D., Vilella, E., Olivecrona, G., & Vilaró, S. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37591-x · Cited by 57
Sortilins: new players in lipoprotein metabolism
Willnow, T. E., Kjølby, M., & Nykjær, A. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283416f2b · Cited by 54
Myllykangas, L., Polvikoski, T. M., Sulkava, R. O., Verkkoniemi, A., Tienari, P. J., Niinistö, L., Kontula, K., Hardy, J., Haltia, M., & Pérez‐Tur, J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01467-1 · Cited by 50
Localization of lipoprotein lipase to discrete areas of the guinea pig brain
Vilaró, S., Camps, L., Reina, M., Pérez‐Clausell, J., Llobera, M., & Olivecrona, T. (1990) · Brain Research · doi:10.1016/0006-8993(90)91258-i · Cited by 48
A role for lipoprotein lipase during synaptic remodeling in the adult mouse brain
Blain, J., Paradis, E., Gaudreault, S. B., Champagne, D. L., Richard, D., & Poirier, J. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.001 · Cited by 41
Myllykangas, L., Polvikoski, T. M., Sulkava, R. O., Notkola, I.-L. K., Rastas, S., Verkkoniemi, A., Tienari, P. J., Niinistö, L., Hardy, J., Pérez‐Tur, J., et al. (2001) · Annals of Medicine · doi:10.3109/07853890109002098 · Cited by 41
van Vlijmen, B. J. M., Rohlmann, A., Page, S. T., Bensadoun, A., Bos, I. S. T., van Berkel, T. J. C., Havekes, L. M., & Herz, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.35219 · Cited by 40
A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology
Blain, J., Aumont, N., Théroux, L., Dea, D., & Poirier, J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05007.x · Cited by 39
Paradis, E., Clément, S., Julien, P., & Murthy, M. R. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208452200 · Cited by 39
Lipoprotein Lipase Activity in Developing Rat Brain Areas
Nuñez, M., Peinado‐Onsurbe, J., Vilaró, S., & Llobera, M. (2009) · Biology of the Neonate · doi:10.1159/000244227 · Cited by 35
The gene structure and minimal promoter of the human agouti related protein
Brown, A. M., Mayfield, D. K., Vólaufová, J., & Argyropoulos, G. A. (2001) · Gene · doi:10.1016/s0378-1119(01)00705-3 · Cited by 34
Rinninger, F., Brundert, M., Brosch, I., Donarski, N., Budzinski, R., & Greten, H. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31500-5 · Cited by 33
Obunike, J. C., Sivaram, P., Paka, L., Low, M. G., & Goldberg, I. J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37492-7 · Cited by 31
Scacchi, R., Gambina, G., Broggio, E., Moretto, G., Ruggeri, M., & Corbo, R. M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.111 · Cited by 30
Makoveichuk, E., Castel, S., Vilaró, S., & Olivecrona, G. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.08.015 · Cited by 30
Tacken, P. J., de Beer, F., VARK, L. C. V., Havekes, L. M., Hofker, M. H., & van Dijk, K. W. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3470357 · Cited by 29
Huey, P. U., Marcell, T., Owens, G. C., Etienne, J., & Eckel, R. H. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32468-8 · Cited by 29
Self-citationPanzenboeck, U., Wintersberger, A., Levak‐Frank, S., Zimmermann, R., Zechner, R., Kostner, G. M., Malle, E., & Sattler, W. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37437-x · Cited by 29
Yacoub, L., Vanni, T. M., & Ij, G. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42328-4 · Cited by 28
Lipoprotein lipase is expressed in rat sciatic nerve and regulated in response to crush injury
Huey, P. U., Waugh, K. C., Etienne, J., & Eckel, R. H. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30182-6 · Cited by 26
Self-citationDevelopmental regulation of lipoprotein lipase in rats
Tavangar, K., Murata, Y., Patel, S., Kalinyak, J. E., Pedersen, M. E., Goers, J. F., Hoffman, A. R., & Kraemer, F. B. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.3.e330 · Cited by 26
No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease
Fidani, L., Compton, D., Hardy, J., Petersen, R. C., Tangalos, E. G., Mirtsou, V., Goulas, A., & Vrieze, F. W. D. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00098-8 · Cited by 24
Lack of association of two lipoprotein lipase polymorphisms with Alzheimer's disease
Martin-Rehrmann, M. D., Cho, H. S., & Rebeck, G. W. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00511-6 · Cited by 23
Long, S., Tian, Y., Zhang, R., Yang, L., Xu, Y., Jia, L., & Fu, M. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.11.010 · Cited by 21
Brain lipoprotein lipase is responsive to nutritional and hormonal modulation
Gavin, L. A., Cavalieri, R. R., Moeller, M., McMahon, F. A., Castle, J. N., & Gulli, R. (1987) · Metabolism · doi:10.1016/0026-0495(87)90124-7 · Cited by 21
Schorsch, F., Malle, E., & Sattler, W. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01061-2 · Cited by 16
Existence of lipoprotein lipase in rat brain microvessels.
Shirai, K., Saitō, Y., Yoshida, S., & MATSUOKA, N. (1986) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.149.449 · Cited by 15
Paradis, É., Julien, P., & Murthy, M. R. V. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.12.003 · Cited by 12
Wang, X., Sun, W., & Xu, E. (2009) · Neuropathology · doi:10.1111/j.1440-1789.2009.01061.x · Cited by 10
Could Lipoprotein Lipase Play a Role in Alzheimer's Disease?
Blain, J., & Poirier, J. (2004) · The Scientific World JOURNAL · doi:10.1100/tsw.2004.111 · Cited by 9
Ferreira, L. D. M. C.-B., Huey, P. U., Pulford, B. E., Ishii, D. N., & Eckel, R. H. (2002) · Endocrinology · doi:10.1210/endo.143.4.8723 · Cited by 8
Self-citationNunes, A. F., & Sousa, M. M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.054 · Cited by 6
Provias, J., & Jeynes, B. (2009) · Pathology Research International · doi:10.4061/2010/173496 · Cited by 5
Shi, X., Yao, B., & Liu, D. (2010) · PubMed · Cited by 3
Cole (2000) · doi:10.1002/1097-0029(20000815)50:4
Research works printed but not linked: 5
- 10.1210/en.143.4.1213 · DOI
- Jensen DR, 1997, Am. J. Physiol., 273, R683
- Provias J, 2010, Patholog. Res. Int., 2010, 173496
- Shi X, 2010, Zhongguo Dang. Dai Er. Ke. Za Zhi., 12, 377
- Tavangar K, 1992, Am. J. Physiol., 262, E330
Cited by
Sorted by citations
Zhang, J., Li, X., Ren, Y., Zhao, Y., Xing, A., Jiang, C., Chen, Y., & An, L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00001 · Cited by 255
What are lipoproteins doing in the brain?
Wang, H., & Eckel, R. H. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.10.003 · Cited by 234
Self-citationLeng, L., Yuan, Z., Pan, R., Su, X., Wang, H., Xue, J., Zhuang, K., Gao, J., Chen, Z., Lin, H. Z., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00643-4 · Cited by 196
Self-citationLane-Donovan, C., Wong, W. M., Durakoglugil, M. S., Wasser, C. R., Jiang, S., Xian, X., & Herz, J. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1054-16.2016 · Cited by 115
Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes
Dijk, W., Beigneux, A. P., Larsson, M., Bensadoun, A., Young, S. G., & Kersten, S. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m067363 · Cited by 103
Metadata
- Authors
- Wang, H., & Eckel, R. H.
- Affiliations
- University of Colorado Anschutz (US)
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2012-08-21
- Volume
- 32
- Issue
- 1
- Pages
- 147-160
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- PMC
- PMC4065112
- OpenAlex
- W1990329481
- Cited by
- 105
- References
- 95
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 11 · 2018: 5 · 2017: 11 · 2016: 10 · 2015: 9 · 2014: 6 · 2013: 8
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089309)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- lipoprotein lipase, brain, nervous system, triglyceride-rich lipoproteins, lipoprotein metabolism, energy balance, obesity, dietary intake, energy expenditure, cognition, learning and memory, Alzheimer's disease, somatic gene transfer
- MeSH terms
- Animals, Body Weight, Brain, Central Nervous System, Energy Metabolism, Humans, Learning, Lipoprotein Lipase, Memory, Nerve Tissue Proteins, Neurons, Spinal Cord, Gene Expression Regulation, Enzymologic, Peripheral Nervous System
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