The DOI matches its Crossref record; 152 of the 153 references it cites were found in a registry or an index.
Plasticity of Dendritic Spines: Subcompartmentalization of Signaling
Open accessAbstract
The ability to induce and study neuronal plasticity in single dendritic spines has greatly advanced our understanding of the signaling mechanisms that mediate long-term potentiation. It is now clear that in addition to compartmentalization by the individual spine, subcompartmentalization of biochemical signals occurs at specialized microdomains within the spine. The spatiotemporal coordination of these complex cascades allows for the concomitant remodeling of the postsynaptic density and actin spinoskeleton and for the regulation of membrane traffic to express functional and structural plasticity. Here, we highlight recent findings in the signaling cascades at spine microdomains as well as the challenges and approaches to studying plasticity at the spine level.
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“Nlg1 is a postsynaptic protein selectively expressed at excitatory synapses which is known to regulate spine formation and synapse stability through binding to presynaptic neurexins [16, 70].”
From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [16]
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“Based on results from modeling (Renner et al., 2009) it has been suggested that crowding in the spine head may contribute to this phenomenon (Colgan and Yasuda, 2014).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Colgan and Yasuda, 2014
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Cites
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Structural basis of long-term potentiation in single dendritic spines
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Learning induces long-term potentiation in the hippocampus
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Cited by
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Zeng, M., Shang, Y., Araki, Y., Guo, T., Huganir, R. L., & Zhang, M. (2016) · Cell · doi:10.1016/j.cell.2016.07.008 · Cited by 612
Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking
Herring, B. E., & Nicoll, R. A. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071753 · Cited by 425
Prada, I., Gabrielli, M., Turola, E., Iorio, A., D’Arrigo, G., Parolisi, R., De Luca, M., Pacifici, M., Bastoni, M., Lombardi, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1803-x · Cited by 312
Araki, Y., Zeng, M., Zhang, M., & Huganir, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.023 · Cited by 271
Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization
Nakahata, Y., & Yasuda, R. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00029 · Cited by 209
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Metadata
- Authors
- Colgan, L. A., & Yasuda, R.
- Affiliations
- Max Planck Florida Institute for Neuroscience (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2014-02-10
- Volume
- 76
- Issue
- 1
- Pages
- 365-385
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- PMC
- PMC4142713
- OpenAlex
- W2109779479
- Cited by
- 124
- References
- 153
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 12 · 2016: 17 · 2015: 13 · 2014: 8
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH080047, R01MH095090)
- National Institute of Neurological Disorders and Stroke (R01NS068410)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic spines, synaptic plasticity, long-term potentiation, postsynaptic density, actin cytoskeleton, membrane trafficking, signaling pathways
- MeSH terms
- Actins, Animals, Cell Membrane, Cytoskeleton, Humans, Neuronal Plasticity, Synapses, Signal Transduction, Dendritic Spines
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