Cited by 133Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersMemory and Neural Mechanisms

The DOI matches its Crossref record; 152 of the 153 references it cites were found in a registry or an index.

Plasticity of Dendritic Spines: Subcompartmentalization of Signaling

Open access

Colgan, Lesley A., Yasuda, Ryohei·2014·Annual Review of Physiology

DOI 10.1146/annurev-physiol-021113-170400PMC PMC4142713

Open this paper in CoChat — free account

Abstract

The ability to induce and study neuronal plasticity in single dendritic spines has greatly advanced our understanding of the signaling mechanisms that mediate long-term potentiation. It is now clear that in addition to compartmentalization by the individual spine, subcompartmentalization of biochemical signals occurs at specialized microdomains within the spine. The spatiotemporal coordination of these complex cascades allows for the concomitant remodeling of the postsynaptic density and actin spinoskeleton and for the regulation of membrane traffic to express functional and structural plasticity. Here, we highlight recent findings in the signaling cascades at spine microdomains as well as the challenges and approaches to studying plasticity at the spine level.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev-physiol-021113-170400

Cites

152 of 152 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Two-photon laser scanning fluorescence microscopy
Denk, W., Strickler, J. H., & Webb, W. W. (1990) · Science · doi:10.1126/science.2321027 · Cited by 9,488
Imaging Intracellular Fluorescent Proteins at Nanometer Resolution
Betzig, E., Patterson, G. H., Sougrat, R., Lindwasser, O. W., Olenych, S. G., Bonifacino, J. S., Davidson, M. W., Lippincott‐Schwartz, J., & Hess, H. F. (2006) · Science · doi:10.1126/science.1127344 · Cited by 8,941
Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
Rust, M., Bates, M., & Zhuang, X. (2006) · Nature Methods · doi:10.1038/nmeth929 · Cited by 7,823
Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy
Hell, S. W., & Wichmann, J. (1994) · Optics Letters · doi:10.1364/ol.19.000780 · Cited by 6,068
Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy: SHORT COMMUNICATION
Gustafsson, M. G. L. (2000) · Journal of Microscopy · doi:10.1046/j.1365-2818.2000.00710.x · Cited by 3,786
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
Bos, J. L., Rehmann, H., & Wittinghofer, A. (2007) · Cell · doi:10.1016/j.cell.2007.05.018 · Cited by 1,903
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.003 · Cited by 1,498
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208
Mechanisms of CaMKII action in long-term potentiation
Lisman, J., Yasuda, R., & Raghavachari, S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3192 · Cited by 1,134
Self-citation
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).
Luscher, C., & Malenka, R. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005710 · Cited by 1,110 · cited 1×
“In a simplified view of LTP signaling, LTP is induced by NMDAR-dependent Ca2+ influx, followed by a transient activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) (8, 9).”
Background
Autophosphorylation at Thr 286 of the α Calcium-Calmodulin Kinase II in LTP and Learning
Giese, K. P., Fedorov, N. B., Filipkowski, R. K., & Silva, A. J. (1998) · Science · doi:10.1126/science.279.5352.870 · Cited by 1,055
Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]
Harris, K. M., Jensen, F. E., & Tsao, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02685.1992 · Cited by 1,036
Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity
Okamoto, K.-I., Nagai, T., Miyawaki, A., & Hayashi, Y. (2004) · Nature Neuroscience · doi:10.1038/nn1311 · Cited by 854
Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit
Roche, K. W., O'Brien, R. J., Mammen, A. L., Bernhardt, J., & Huganir, R. L. (1996) · Neuron · doi:10.1016/s0896-6273(00)80144-0 · Cited by 812
Structural dynamics of dendritic spines in memory and cognition
Kasai, H., Fukuda, M., Watanabe, S., Hayashi-Takagi, A., & Noguchi, J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.001 · Cited by 804
Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory
Lee, H.-K., Takamiya, K., Han, J.-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00122-3 · Cited by 802
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779
Superresolution Imaging of Chemical Synapses in the Brain
Dani, A., Huang, B., Bergan, J. F., Dulac, C. G., & Zhuang, X. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.021 · Cited by 748
Recycling Endosomes Supply AMPA Receptors for LTP
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730
NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII
Barria, A., & Malinow, R. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.034 · Cited by 709
Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo
Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692
Activation of CaMKII in single dendritic spines during long-term potentiation
Lee, S.-J. R., Escobedo-Lozoya, Y., Szatmari, E. M., & Yasuda, R. (2009) · Nature · doi:10.1038/nature07842 · Cited by 685
Self-citation
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S. M., & Yahata, N. (2000) · RePEc: Research Papers in Economics · Cited by 680
Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation
Shen, K., & Meyer, T. (1999) · Science · doi:10.1126/science.284.5411.162 · Cited by 673
Three-Dimensional Organization of Smooth Endoplasmic Reticulum in Hippocampal CA1 Dendrites and Dendritic Spines of the Immature and Mature Rat
Spacek, J., & Harris, K. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00190.1997 · Cited by 599
The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
Bats, C., Groc, L., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.030 · Cited by 590
Regulation of AMPA receptor trafficking and synaptic plasticity
Anggono, V., & Huganir, R. L. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.12.006 · Cited by 588 · cited 1×
“The incorporation of additional AMPARs into the PSD is believed to be the central mechanism of LTP expression (12, 13, 54).”
Background
Local, persistent activation of Rho GTPases during plasticity of single dendritic spines
Murakoshi, H., Wang, H., & Yasuda, R. (2011) · Nature · doi:10.1038/nature09823 · Cited by 564
Self-citation
Role of Actin in Anchoring Postsynaptic Receptors in Cultured Hippocampal Neurons: Differential Attachment of NMDA versus AMPA Receptors
Allison, D. W., Gelfand, V. I., Spector, I., & Craig, A. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02423.1998 · Cited by 556
Regulation of AMPA receptor lateral movements
Borgdorff, A. J., & Choquet, D. (2002) · Nature · doi:10.1038/nature00780 · Cited by 542
New insights into the regulation and cellular functions of the ARP2/3 complex
Rotty, J. D., Wu, C., & Bear, J. E. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3492 · Cited by 516
Relative and Absolute Quantification of Postsynaptic Density Proteome Isolated from Rat Forebrain and Cerebellum
Cheng, D., Hoogenraad, C. C., Rush, J., Ramm, E., Schlager, M. A., Duong, D. M., Xu, P., Wijayawardana, S. R., Hanfelt, J., Nakagawa, T., et al. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.d500009-mcp200 · Cited by 510
AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis
Makino, H., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.035 · Cited by 501
Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes
Park, M., Salgado, J. M., Ostroff, L., Helton, T. D., Robinson, C. G., Harris, K. M., & Ehlers, M. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.040 · Cited by 493
The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines
Honkura, N., Matsuzaki, M., Noguchi, J., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.013 · Cited by 490
Glutamate Receptor Exocytosis and Spine Enlargement during Chemically Induced Long-Term Potentiation
Kopec, C. D., Li, B., Wei, W., Boehm, J., & Malinow, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-05.2006 · Cited by 486
Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity
Wang, Z., Edwards, J. G., Riley, N., Provance, D. W., Karcher, R., Li, X.-D., Davison, I. G., Ikebe, M., Mercer, J. A., Kauer, J. A., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.057 · Cited by 470
Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism
Lledo, P. M., Hjelmstad, G. O., Mukherji, S., Soderling, T. R., Malenka, R. C., & Nicoll, R. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11175 · Cited by 456
Role of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S., & Yahata, N. (2000) · Nature · doi:10.1038/35046031 · Cited by 447
Nanoscale Scaffolding Domains within the Postsynaptic Density Concentrate Synaptic AMPA Receptors
MacGillavry, H. D., Song, Y., Raghavachari, S., & Blanpied, T. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.009 · Cited by 442
CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin
Opazo, P., Labrecque, S., Tigaret, C. M., Frouin, A., Wiseman, P. W., Koninck, P. D., & Choquet, D. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.007 · Cited by 434
The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine
Harvey, C. D., Yasuda, R., Zhong, H., & Svoboda, K. (2008) · Science · doi:10.1126/science.1159675 · Cited by 434
Self-citation
High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes
Schwenk, J., Harmel, N., Brechet, A., Zolles, G., Berkefeld, H., Müller, C. S., Bildl, W., Baehrens, D., Hüber, B., Kulik, A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.034 · Cited by 433
Structural plasticity of dendritic spines
Bosch, M., & Hayashi, Y. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.002 · Cited by 415
Increased Expression of the Immediate-Early Gene Arc/Arg3.1 Reduces AMPA Receptor-Mediated Synaptic Transmission
Verde, E. R., Lee‐Osbourne, J., Worley, P. F., Malinow, R., & Cline, H. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.031 · Cited by 413
Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.
Elias, G. M., Funke, L., Stein, V., Grant, S., Bredt, D., & Nicoll, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.012 · Cited by 413
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density
Feng, W., & Zhang, M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2540 · Cited by 405
Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis
Korobova, F., & Svitkina, T. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-07-0596 · Cited by 399
Identification of the Ca2+/Calmodulin-dependent Protein Kinase II Regulatory Phosphorylation Site in the α-Amino-3-hydroxyl-5-methyl4-isoxazole-propionate-type Glutamate Receptor
Barría, A., Derkach, V. A., & Soderling, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32727 · Cited by 395
Dynamics and Regulation of Clathrin Coats at Specialized Endocytic Zones of Dendrites and Spines
Blanpied, T. A., Scott, D. B., & Ehlers, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00979-0 · Cited by 392
Calcium/calmodulin-dependent protein kinase II is associated with the N -methyl- d -aspartate receptor
Leonard, A. S., Lim, I. A., Hemsworth, D. E., Horne, M. C., & Hell, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3239 · Cited by 385
GTPase Networks in Membrane Traffic
Mizuno-Yamasaki, E., Rivera-Molina, F. E., & Novick, P. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052810-093700 · Cited by 366
A GIT1/PIX/Rac/PAK Signaling Module Regulates Spine Morphogenesis and Synapse Formation through MLC
Zhang, H., Webb, D. J., Asmussen, H., Niu, S., & Horwitz, A. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3553-04.2005 · Cited by 365
Mechanism and Regulation of Calcium/Calmodulin-dependent Protein Kinase II Targeting to the NR2B Subunit of the N-Methyl-d-aspartate Receptor
Strack, S., McNeill, R. B., & Colbran, R. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001471200 · Cited by 356
The postsynaptic density proteins Homer and Shank form a polymeric network structure
Hayashi, M. K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M. H., Xu, R.-M., Li, H., Sala, C., & Hayashi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.050 · Cited by 356
Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation
Lin, D.-T., Makino, Y., Sharma, K., Hayashi, T., Neve, R., Takamiya, K., & Huganir, R. L. (2009) · Nature Neuroscience · doi:10.1038/nn.2351 · Cited by 347
CaMKII tethers to L-type Ca2 + channels, establishing a local and dedicated integrator of Ca2 + signals for facilitation
Hudmon, A., Schulman, H., Kim, J., Maltez, J. M., Tsien, R. W., & Pitt, G. S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505155 · Cited by 345
ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity
Gu, J., Lee, C. W., Fan, Y., Komlos, D., Tang, X., Sun, C., Yu, K., Hartzell, H. C., Chen, G., Bamburg, J. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2634 · Cited by 344
Synaptic Plasticity and AMPA Receptor Trafficking
Malenka, R. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.001 · Cited by 333
Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons
Pettit, D. L., Perlman, S., & Malinow, R. (1994) · Science · doi:10.1126/science.7997883 · Cited by 329
The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure
Okamoto, K.-I., Narayanan, R., Lee, S. H., Murata, K., & Hayashi, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701656104 · Cited by 328
Endocytic Trafficking and Recycling Maintain a Pool of Mobile Surface AMPA Receptors Required for Synaptic Potentiation
Petrini, E. M., Lü, J., Cognet, L., Lounis, B., Ehlers, M., & Choquet, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.025 · Cited by 317
LTP requires a reserve pool of glutamate receptors independent of subunit type
Granger, A. J., Shi, Y., Lu, W., Cerpas, M., & Nicoll, R. A. (2013) · Nature · doi:10.1038/nature11775 · Cited by 313
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology
Kim, Y., Sung, J. Y., Ceglia, I., Lee, K.-W., Ahn, J.-H., Halford, J. M., Kim, A. M., Kwak, S. P., Park, J. B., Ho Ryu, S., et al. (2006) · Nature · doi:10.1038/nature04976 · Cited by 307
Organization of the core structure of the postsynaptic density
Chen, X., Winters, C. A., Azzam, R. N., Li, X., Galbraith, J. A., Leapman, R. D., & Reese, T. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800897105 · Cited by 299
CaV1 and CaV2 Channels Engage Distinct Modes of Ca2+ Signaling to Control CREB-Dependent Gene Expression
Wheeler, D. G., Groth, R. D., Ma, H., Barrett, C. F., Owen, S. F., Safa, P., & Tsien, R. W. (2012) · Cell · doi:10.1016/j.cell.2012.03.041 · Cited by 296
Changes in Synaptic Morphology Accompany Actin Signaling during LTP
Chen, L. Y., Rex, C. S., Casale, M. S., Gall, C. M., & Lynch, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0164-07.2007 · Cited by 296
Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines
Kennedy, M. J., Davison, I. G., Robinson, C. G., & Ehlers, M. D. (2010) · Cell · doi:10.1016/j.cell.2010.02.042 · Cited by 294
Translocation of Autophosphorylated Calcium/Calmodulin-dependent Protein Kinase II to the Postsynaptic Density
Strack, S., Choi, S., Lovinger, D. M., & Colbran, R. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13467 · Cited by 293
Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity
Deller, T., Körte, M., Chabanis, S., Drakew, A., Schwegler, H., Stefani, G. G., Zúñiga, A., Schwarz, K., Bonhoeffer, T., Zeller, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1832384100 · Cited by 291
Optical Control of Protein Activity by Fluorescent Protein Domains
Zhou, X. X., Chung, H. K., Lam, A. J., & Lin, M. Z. (2012) · Science · doi:10.1126/science.1226854 · Cited by 289
Synaptic Accumulation of PSD-95 and Synaptic Function Regulated by Phosphorylation of Serine-295 of PSD-95
Kim, M. J., Futai, K., Jo, J., Hayashi, Y., Cho, K., & Sheng, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.007 · Cited by 278
Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines
Frost, N. A., Shroff, H., Kong, H., Betzig, E., & Blanpied, T. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.026 · Cited by 275
Postsynaptic Positioning of Endocytic Zones and AMPA Receptor Cycling by Physical Coupling of Dynamin-3 to Homer
Lu, J., Helton, T. D., Blanpied, T. A., Rácz, B., Newpher, T. M., Weinberg, R. J., & Ehlers, M. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.041 · Cited by 273
Endosomal Compartments Serve Multiple Hippocampal Dendritic Spines from a Widespread Rather Than a Local Store of Recycling Membrane
Cooney, J. R., Hurlburt, J. L., Selig, D. K., Harris, K. M., & Fiala, J. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02215.2002 · Cited by 269
Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines
Bingol, B., Wang, C.-F., Arnott, D., Cheng, D., Peng, J., & Sheng, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.024 · Cited by 268
AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation
Patterson, M. A., Szatmari, E. M., & Yasuda, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913875107 · Cited by 259
Self-citation
Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity
Steiner, P., Higley, M. J., Xu, W., Czervionke, B. L., Malenka, R. C., & Sabatini, B. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.014 · Cited by 259
Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation
Otmakhov, N., Tao-Cheng, J.-H., Carpenter, S., Asrican, B., Dosemeci, A., Reese, T. S., & Lisman, J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2350-04.2004 · Cited by 258
Role of the CaMKII/NMDA Receptor Complex in the Maintenance of Synaptic Strength
Sanhueza, M., Fernandez-Villalobos, G., Stein, I. S., Kasumova, G., Zhang, P., Bayer, K. U., Otmakhov, N., Hell, J. W., & Lisman, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1250-11.2011 · Cited by 248
Motor protein–dependent transport of AMPA receptors into spines during long-term potentiation
Correia, S. S., Bassani, S., Brown, T. C., Lisé, M.-F., Backos, D. S., El-Husseini, A., Passafaro, M., & Esteban, J. A. (2008) · Nature Neuroscience · doi:10.1038/nn2063 · Cited by 244
Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs
Ashby, M. C., De La Rue, S. A., Ralph, G. S., Uney, J., Collingridge, G. L., & Henley, J. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1042-04.2004 · Cited by 244
Activity-Dependent Synaptogenesis: Regulation by a CaM-Kinase Kinase/CaM-Kinase I/βPIX Signaling Complex
Saneyoshi, T., Wayman, G. A., Fortin, D. A., Davare, M. A., Hoshi, N., Nozaki, N., Natsume, T., & Soderling, T. R. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.016 · Cited by 234
Regulation of AMPA receptor surface diffusion by PSD-95 slots
Opazo, P., Sainlos, M., & Choquet, D. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.010 · Cited by 234
Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1
Peixoto, R. T., Kunz, P. A., Kwon, H., Mabb, A. M., Sabatini, B. L., Philpot, B. D., & Ehlers, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.006 · Cited by 233
LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
Jurado, S., Goswami, D., Zhang, Y., Molina, A. J. M., Südhof, T. C., & Malenka, R. C. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.029 · Cited by 232
Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses
Holbro, N., Grunditz, Å., & Oertner, T. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905110106 · Cited by 230
Inhibition of Arp2/3-mediated actin polymerisation by PICK1 regulates neuronal morphology and AMPA receptor endocytosis
Rocca, D. L., Martin, S., Jenkins, E. L., & Hanley, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1688 · Cited by 228
Differential Control of Postsynaptic Density Scaffolds via Actin-Dependent and -Independent Mechanisms
Kuriu, T., Inoue, A., Bito, H., Sobue, K., & Okabe, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0522-06.2006 · Cited by 219
A WAVE-1 and WRP Signaling Complex Regulates Spine Density, Synaptic Plasticity, and Memory
Soderling, S. H., Guire, E. S., Kaech, S., White, J., Zhang, F., Schutz, K., Langeberg, L. K., Banker, G., Raber, J., & Scott, J. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3209-06.2006 · Cited by 217
Real-Time Imaging of Discrete Exocytic Events Mediating Surface Delivery of AMPA Receptors
Yudowski, G. A., Puthenveedu, M. A., Leonoudakis, D., Panicker, S., Thorn, K. S., Beattie, E. C., & von Zastrow, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2465-07.2007 · Cited by 197
Actin in membrane trafficking.
Lanzetti, L. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.04.017 · Cited by 193
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling
Soderling, S. H., Binns, K. L., Wayman, G. A., Davee, S. M., Ong, S. H., Pawson, T. J., & Scott, J. D. (2002) · Nature Cell Biology · doi:10.1038/ncb886 · Cited by 193
Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number
Kwon, H., Kozorovitskiy, Y., Oh, W., Peixoto, R. T., Akhtar, N., Saulnier, J. L., Gu, C., & Sabatini, B. L. (2012) · Nature Neuroscience · doi:10.1038/nn.3256 · Cited by 191
Synaptopodin Regulates Plasticity of Dendritic Spines in Hippocampal Neurons
Vlachos, A., Korkotian, E., Schoenfeld, E., Copanaki, E., Deller, T., & Segal, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5528-08.2009 · Cited by 181
Chemical Two-Photon Uncaging: a Novel Approach to Mapping Glutamate Receptors
Pettit, D. L., Wang, S. S. ‐., Gee, K. R., & Augustine, G. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80361-x · Cited by 180
Interactions between the NR2B Receptor and CaMKII Modulate Synaptic Plasticity and Spatial Learning
Zhou, Y., Takahashi, E., Li, W., Halt, A., Wiltgen, B., Ehninger, D., Li, G.-D., Hell, J. W., Kennedy, M. B., & Silva, A. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4486-07.2007 · Cited by 179
The Shank Family of Postsynaptic Density Proteins Interacts with and Promotes Synaptic Accumulation of the βPIX Guanine Nucleotide Exchange Factor for Rac1 and Cdc42
Park, E., Na, M., Choi, J., Kim, S., Lee, J.-R., Yoon, J., Park, D., Sheng, M., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301052200 · Cited by 175
Disruption of Arp2/3 Results in Asymmetric Structural Plasticity of Dendritic Spines and Progressive Synaptic and Behavioral Abnormalities
Kim, I. H., Racz, B., Wang, H., Burianek, L., Weinberg, R., Yasuda, R., Wetsel, W. C., & Soderling, S. H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0035-13.2013 · Cited by 172
Self-citation
TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers
Sumioka, A., Yan, D., & Tomita, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.035 · Cited by 167
Expression of Long-Term Plasticity at Individual Synapses in Hippocampus Is Graded, Bidirectional, and Mainly Presynaptic: Optical Quantal Analysis
Enoki, R., Hu, Y.-L., Hamilton, D. C., & Fine, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.026 · Cited by 166
Neurexin-Neuroligin Adhesions Capture Surface-Diffusing AMPA Receptors through PSD-95 Scaffolds
Mondin, M., Labrousse, V. F., Hosy, E., Heine, M., Tessier, B., Levet, F., Poujol, C., Blanchet, C., Choquet, D., & Thoumine, O. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6439-10.2011 · Cited by 166
PICK1 is a calcium‐sensor for NMDA‐induced AMPA receptor trafficking
Hanley, J. G., & Henley, J. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600801 · Cited by 162
Imaging spatiotemporal dynamics of neuronal signaling using fluorescence resonance energy transfer and fluorescence lifetime imaging microscopy
Yasuda, R. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.08.012 · Cited by 157
Self-citation
Long-term potentiation: Peeling the onion
Nicoll, R. A., & Roche, K. W. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.010 · Cited by 157
Activity-driven postsynaptic translocation of CaMKII
Merrill, M. A., Chen, Y., Strack, S., & Hell, J. W. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.10.003 · Cited by 155
Super-Resolution Dynamic Imaging of Dendritic Spines Using a Low-Affinity Photoconvertible Actin Probe
Izeddin, I., Specht, C. G., Lelek, M., Darzacq, X., Triller, A., Zimmer, C., & Dahan, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015611 · Cited by 154
Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals
Kim, J., Jung, S.-Y., Lee, Y. K., Park, S., Choi, J.-S., Lee, C. J., Kim, H.-S., Choi, Y.-B., Scheiffele, P., Bailey, C. H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803448105 · Cited by 153
Evidence That Long-Term Potentiation Occurs within Individual Hippocampal Synapses during Learning
Fedulov, V., Rex, C. S., Simmons, D. A., Palmer, L. C., Gall, C. M., & LYNCH, G. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2003-07.2007 · Cited by 152
Structural plasticity with preserved topology in the postsynaptic protein network
Blanpied, T. A., Kerr, J. M., & Ehlers, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711669105 · Cited by 139
Functional Compartmentalization of Endosomal Trafficking for the Synaptic Delivery of AMPA Receptors during Long-Term Potentiation
Brown, T. C., Correia, S. S., Petrok, C. N., & Esteban, J. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4258-07.2007 · Cited by 136
Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP
Ahmad, M., Polepalli, J. S., Goswami, D., Yang, X., Kaeser-Woo, Y. J., Südhof, T. C., & Malenka, R. C. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.020 · Cited by 133
Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways
Saneyoshi, T., Fortin, D. A., & Soderling, T. R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.09.013 · Cited by 133
Nanoscopy of living brain slices with low light levels
Testa, I., Urban, N. T., Jakobs, S., Eggeling, C., Willig, K. I., & Hell, S. W. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.028 · Cited by 131
Subcellular Dynamics of Type II PKA in Neurons
Zhong, H., Sia, G.-M., Sato, T., Gray, N. W., Mao, T., Khuchua, Z. A., Huganir, R. L., & Svoboda, K. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.013 · Cited by 126
Spatial organization of cofilin in dendritic spines
Rácz, B., & Weinberg, R. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.025 · Cited by 125
A role for the spine apparatus in LTP and spatial learning
Jedlička, P., Vlachos, A., Schwarzacher, S. W., & Deller, T. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.033 · Cited by 122
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation
Chao, L. H., Pellicena, P., Deindl, S., Barclay, L. A., Schulman, H., & Kuriyan, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1751 · Cited by 119
The dynamic cytoskeleton: backbone of dendritic spine plasticity
Dent, E. W., Merriam, E. B., & Hu, X. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.08.013 · Cited by 116
A Subtype-Specific Function for the Extracellular Domain of Neuroligin 1 in Hippocampal LTP
Shipman, S. L., & Nicoll, R. A. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.024 · Cited by 106
Tangential synaptic distribution of NMDA and AMPA receptors in rat neocortex
Kharazia, V. N., & Weinberg, R. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00846-x · Cited by 104
Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1
Lü, W., Isozaki, K., Roche, K. W., & Nicoll, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016289107 · Cited by 97
Subsynaptic AMPA Receptor Distribution Is Acutely Regulated by Actin-Driven Reorganization of the Postsynaptic Density
Kerr, J. M., & Blanpied, T. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2927-11.2012 · Cited by 97
Investigating Sub-Spine Actin Dynamics in Rat Hippocampal Neurons with Super-Resolution Optical Imaging
Tatavarty, V., Kim, E., Rodionov, V., & Yu, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007724 · Cited by 95
Identification of Protein Substrates of Ca2+/Calmodulin-Dependent Protein Kinase II in the Postsynaptic Density by Protein Sequencing and Mass Spectrometry
Yoshimura, Y., Shinkawa, T., Taoka, M., Kobayashi, K., Isobe, T., & Yamauchi, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6320 · Cited by 94
The Spine Apparatus, Synaptopodin, and Dendritic Spine Plasticity
Segal, M., Vlachos, A., & Korkotian, E. (2010) · The Neuroscientist · doi:10.1177/1073858409355829 · Cited by 91
Atomic Force Microscopy Reveals Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution
Sharma, S., Grintsevich, E. E., Phillips, M. L., Reisler, E., & Gimzewski, J. K. (2010) · Nano Letters · doi:10.1021/nl104159v · Cited by 91
Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II
Stratton, M. M., Chao, L. H., Schulman, H., & Kuriyan, J. (2013) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2013.04.002 · Cited by 89
A network of networks: cytoskeletal control of compartmentalized function within dendritic spines
Frost, N. A., Kerr, J. M., Lu, H. E., & Blanpied, T. A. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.06.009 · Cited by 68
Stargazin Differentially Controls the Trafficking of α-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and Kainate Receptors
Chen, L., El-Husseini, A., Tomita, S., Bredt, D. S., & Nicoll, R. A. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.3.703 · Cited by 68
RNA Binding Proteins Accumulate at the Postsynaptic Density with Synaptic Activity
Zhang, G., Neubert, T. A., & Jordan, B. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2463-11.2012 · Cited by 65
Interactions between drebrin and Ras regulate dendritic spine plasticity
Biou, V., Brinkhaus, H., Malenka, R. C., & Matus, A. I. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06269.x · Cited by 61
Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines
Penzes, P., & Cahill, M. E. (2012) · Cytoskeleton · doi:10.1002/cm.21015 · Cited by 59
Optical super-resolution microscopy in neurobiology
Sigrist, S. J., & Sabatini, B. L. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.014 · Cited by 58
Lamina‐specific distribution of synaptopodin, an actin‐associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus
Orth, C. B., Vlachos, A., Turco, D. D., Burbach, G. J., Haas, C. A., Mundel, P. H., Feng, G., Frotscher, M., & Deller, T. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20539 · Cited by 56
Displacement of α-Actinin from the NMDA Receptor NR1 C0 Domain By Ca 2+ /Calmodulin Promotes CaMKII Binding
Merrill, M. A., Malik, Z. A., Akyol, Z., Bartos, J. A., Leonard, A. S., Hudmon, A., Shea, M. A., & Hell, J. W. (2007) · Biochemistry · doi:10.1021/bi0623025 · Cited by 54
Quantifying the effects of elastic collisions and non-covalent binding on glutamate receptor trafficking in the post-synaptic density
Santamaria, F., Gonzalez, J., Augustine, G. J., & Raghavachari, S. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000780 · Cited by 53
Drebrin a content correlates with spine head size in the adult mouse cerebral cortex
Kobayashi, C., Aoki, C. J., Kojima, N., Yamazaki, H., & Shirao, T. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21408 · Cited by 44
The excitatory postsynaptic density is a size exclusion diffusion environment
Renner, M. L., Cognet, L., Lounis, B., Triller, A., & Choquet, D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.022 · Cited by 43
Microdomains in Forebrain Spines: an Ultrastructural Perspective
Rácz, B., & Weinberg, R. J. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8345-y · Cited by 41
Studying Signal Transduction in Single Dendritic SpinesPreprint
Yasuda, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005611 · Cited by 33
Self-citation
Synaptopodin and the spine apparatus organelle—Regulators of different forms of synaptic plasticity?
Vlachos, A. (2011) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2011.10.014 · Cited by 32
The role of endosomal-recycling in long-term potentiation
Kelly, E. E., Horgan, C. P., McCaffrey, M. W., & Young, P. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0516-2 · Cited by 27
The Rabs: A family at the root of metazoan evolution
Stenmark, H. (2012) · BMC Biology · doi:10.1186/1741-7007-10-68 · Cited by 21

Sorted by citations

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity
Zeng, M., Shang, Y., Araki, Y., Guo, T., Huganir, R. L., & Zhang, M. (2016) · Cell · doi:10.1016/j.cell.2016.07.008 · Cited by 612
Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking
Herring, B. E., & Nicoll, R. A. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071753 · Cited by 425
Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations
Prada, I., Gabrielli, M., Turola, E., Iorio, A., D’Arrigo, G., Parolisi, R., De Luca, M., Pacifici, M., Bastoni, M., Lombardi, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1803-x · Cited by 312
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP
Araki, Y., Zeng, M., Zhang, M., & Huganir, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.023 · Cited by 271
Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization
Nakahata, Y., & Yasuda, R. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00029 · Cited by 209
Self-citation

See all 133

Authors: Colgan, L. A., & Yasuda, R.
Affiliations: Max Planck Florida Institute for Neuroscience (US)
ORCID: Colgan, Lesley A.
Yasuda, Ryohei
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2014-02-10
Volume: 76
Issue: 1
Pages: 365-385
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev-physiol-021113-170400
PMC: PMC4142713
OpenAlex: W2109779479
Cited by: 124
References: 153
Citations by year: 2026: 2 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 12 · 2016: 17 · 2015: 13 · 2014: 8
FWCI: 1.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: National Institute of Mental Health (R01MH080047, R01MH095090)
National Institute of Neurological Disorders and Stroke (R01NS068410)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dendritic spines, synaptic plasticity, long-term potentiation, postsynaptic density, actin cytoskeleton, membrane trafficking, signaling pathways
MeSH terms: Actins, Animals, Cell Membrane, Cytoskeleton, Humans, Neuronal Plasticity, Synapses, Signal Transduction, Dendritic Spines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasticity of Dendritic Spines: Subcompartmentalization of Signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks