Cited by 133Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersMemory and Neural Mechanisms

The DOI matches its Crossref record; 152 of the 153 references it cites were found in a registry or an index.

Plasticity of Dendritic Spines: Subcompartmentalization of Signaling

Open access

Colgan, Lesley A., Yasuda, Ryohei·2014·Annual Review of Physiology

DOI 10.1146/annurev-physiol-021113-170400PMC PMC4142713

Open this paper in CoChat — free account

Abstract

The ability to induce and study neuronal plasticity in single dendritic spines has greatly advanced our understanding of the signaling mechanisms that mediate long-term potentiation. It is now clear that in addition to compartmentalization by the individual spine, subcompartmentalization of biochemical signals occurs at specialized microdomains within the spine. The spatiotemporal coordination of these complex cascades allows for the concomitant remodeling of the postsynaptic density and actin spinoskeleton and for the regulation of membrane traffic to express functional and structural plasticity. Here, we highlight recent findings in the signaling cascades at spine microdomains as well as the challenges and approaches to studying plasticity at the spine level.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev-physiol-021113-170400

Cites

152 of 152 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Two-photon laser scanning fluorescence microscopy
Denk, W., Strickler, J. H., & Webb, W. W. (1990) · Science · doi:10.1126/science.2321027 · Cited by 9,488
Imaging Intracellular Fluorescent Proteins at Nanometer Resolution
Betzig, E., Patterson, G. H., Sougrat, R., Lindwasser, O. W., Olenych, S. G., Bonifacino, J. S., Davidson, M. W., Lippincott‐Schwartz, J., & Hess, H. F. (2006) · Science · doi:10.1126/science.1127344 · Cited by 8,941
Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
Rust, M., Bates, M., & Zhuang, X. (2006) · Nature Methods · doi:10.1038/nmeth929 · Cited by 7,823
Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy
Hell, S. W., & Wichmann, J. (1994) · Optics Letters · doi:10.1364/ol.19.000780 · Cited by 6,068
Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy: SHORT COMMUNICATION
Gustafsson, M. G. L. (2000) · Journal of Microscopy · doi:10.1046/j.1365-2818.2000.00710.x · Cited by 3,786
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
Bos, J. L., Rehmann, H., & Wittinghofer, A. (2007) · Cell · doi:10.1016/j.cell.2007.05.018 · Cited by 1,903
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.003 · Cited by 1,498

Show all 153 references

Sorted by citations

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity
Zeng, M., Shang, Y., Araki, Y., Guo, T., Huganir, R. L., & Zhang, M. (2016) · Cell · doi:10.1016/j.cell.2016.07.008 · Cited by 612
Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking
Herring, B. E., & Nicoll, R. A. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071753 · Cited by 425
Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations
Prada, I., Gabrielli, M., Turola, E., Iorio, A., D’Arrigo, G., Parolisi, R., De Luca, M., Pacifici, M., Bastoni, M., Lombardi, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1803-x · Cited by 312
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP
Araki, Y., Zeng, M., Zhang, M., & Huganir, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.023 · Cited by 271
Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization
Nakahata, Y., & Yasuda, R. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00029 · Cited by 209
Self-citation
BDNF signaling during the lifetime of dendritic spines
Zagrebelsky, M., Tacke, C., & Korte, M. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03226-5 · Cited by 147
TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation
Yadav, S., Osés-Prieto, J. A., Peters, C. J., Zhou, J., Pleasure, S. J., Burlingame, A. L., Jan, L. Y., & Jan, Y. N. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.006 · Cited by 142
Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology
Chang, P. K.-Y., Khatchadourian, A., McKinney, R. A., & Maysinger, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0244-5 · Cited by 124
Early-Life Stress Induces Depression-Like Behavior and Synaptic-Plasticity Changes in a Maternal Separation Rat Model: Gender Difference and Metabolomics Study
Cui, Y., Cao, K., Lin, H., Cui, S., Shen, C., Wen, W., Mo, H., Dong, Z., Bai, S., Yang, L., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00102 · Cited by 122
Positioning of AMPA receptor-containing endosomes regulates synapse architecture
Esteves da Silva, M., Adrian, M., Schätzle, P., Lipka, J., Watanabe, T., Cho, S., Futai, K., Wierenga, C. J., Kapitein, L. C., & Hoogenraad, C. C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.062 · Cited by 126
Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission
Sando, R. C., Bushong, E. A., Zhu, Y., Huang, M., Considine, C., Phan, S., Ju, S., Uytiepo, M., Ellisman, M. H., & Maximov, A. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.047 · Cited by 116
An Integrated Approach to Neuro-development, Neuroplasticity and Cognitive Improvement
Drigas, A. S., Karyotaki, M., & Skianis, C. A. (2018) · International Journal of Recent Contributions from Engineering Science & IT (iJES) · doi:10.3991/ijes.v6i3.9034 · Cited by 109
Dendritic Spine Elimination: Molecular Mechanisms and Implications
Stein, I. S., & Zito, K. (2018) · The Neuroscientist · doi:10.1177/1073858418769644 · Cited by 110
Dendritic function in vivo
Grienberger, C., Chen, X., & Konnerth, A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.002 · Cited by 107
Plasticity of dendritic spines: Molecular function and dysfunction in neurodevelopmental disorders
Nishiyama, J. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12899 · Cited by 96
Unraveling the cellular and molecular mechanisms of repetitive magnetic stimulation
Müller‐Dahlhaus, F., & Vlachos, A. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00050 · Cited by 90
Mirror trends of plasticity and stability indicators in primate prefrontal cortex
García‐Cabezas, M. Á., Joyce, M. K. P., John, Y. J., Zikopoulos, B., & Barbas, H. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13706 · Cited by 88
Synapse-type-specific plasticity in local circuits
Larsen, R. S., & Sjöström, P. J. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.08.001 · Cited by 90
Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination
Ng, L. H. L., Huang, Y., Han, L., Chang, R. C.-C., Chan, Y. S., & Lai, C. S. W. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0321-5 · Cited by 82
STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling
Dittmer, P. J., Wild, A. R., Dell’Acqua, M. L., & Sather, W. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.056 · Cited by 77
Control of dendritic spine morphological and functional plasticity by small GTPases.
Woolfrey, K. M., & Srivastava, D. P. (2016) · Neural Plasticity · doi:10.1155/2016/3025948 · Cited by 76
Calcium, Reactive Oxygen Species, and Synaptic Plasticity
Hidalgo, C., & Arias‐Cavieres, A. (2016) · Physiology · doi:10.1152/physiol.00038.2015 · Cited by 75
Proteomics of the Synapse – A Quantitative Approach to Neuronal Plasticity
Dieterich, D. C., & Kreutz, M. R. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r115.051482 · Cited by 78
Dendritic mitoflash as a putative signal for stabilizing long-term synaptic plasticity
Fu, Z.-X., Tan, X., Fang, H., Lau, P.-M., Wang, X., Cheng, H., & Bi, G. (2017) · Nature Communications · doi:10.1038/s41467-017-00043-3 · Cited by 73
A Neuronal Culture System to Detect Prion Synaptotoxicity
Fang, C., Imberdis, T., Garza, M. C., Wille, H., & Harris, D. A. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005623 · Cited by 67
Pyramidal Neurons in Different Cortical Layers Exhibit Distinct Dynamics and Plasticity of Apical Dendritic Spines
Tjia, M., Yu, X., Jammu, L. S., Lu, J., & Zuo, Y. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00043 · Cited by 73
Barriers in the brain: resolving dendritic spine morphology and compartmentalization
Adrian, M., Kusters, R., Wierenga, C. J., Storm, C., Hoogenraad, C. C., & Kapitein, L. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00142 · Cited by 62
“Based on results from modeling (Renner et al., 2009) it has been suggested that crowding in the spine head may contribute to this phenomenon (Colgan and Yasuda, 2014).”
Input transformation by dendritic spines of pyramidal neurons
Araya, R. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00141 · Cited by 63
CNS Neurons Deposit Laminin α5 to Stabilize Synapses
Omar, M. H., Campbell, M. K., Xiao, X., Zhong, Q., Brunken, W. J., Miner, J. H., Greer, C. A., & Koleske, A. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.028 · Cited by 59
Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity
Wu, Q., Sun, M., Bernard, L. P., & Zhang, H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.782490 · Cited by 61
LTP enhances synaptogenesis in the developing hippocampus
Watson, D. J., Ostroff, L. E., Cao, G., Parker, P. H., Smith, H., & Harris, K. M. (2015) · Hippocampus · doi:10.1002/hipo.22536 · Cited by 55
Paradoxical signaling regulates structural plasticity in dendritic spines
Rangamani, P., Levy, M. G., Khan, S., & OSTER, G. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610391113 · Cited by 52
Brain–immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders
Zhao, F., Li, B., Yang, W., Ge, T., & Cui, R. (2022) · Cell Proliferation · doi:10.1111/cpr.13295 · Cited by 50
Understanding the role of synaptopodin and the spine apparatus in Hebbian synaptic plasticity – New perspectives and the need for computational modeling
Jedlička, P., & Deller, T. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.023 · Cited by 49
A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors
Banghart, M. R., He, X. J., & Sabatini, B. L. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00485 · Cited by 46
The actin-modulating protein synaptopodin mediates long-term survival of dendritic spines
Yap, K. A. F., Drakew, A., Smilović, D., Rietsche, M., Paul, M. H., Vukšić, M., Turco, D. D., & Deller, T. (2020) · eLife · doi:10.7554/elife.62944 · Cited by 47
Structural plasticity of dendritic secretory compartments during LTP-induced synaptogenesis
Kulik, Y. D., Watson, D. J., Cao, G., Kuwajima, M., & Harris, K. M. (2019) · eLife · doi:10.7554/elife.46356 · Cited by 46
Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction
Neuhofer, D., & Kalivas, P. W. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.02.007 · Cited by 41
Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease
Kanjhan, R., Noakes, P. G., & Bellingham, M. C. (2015) · Neural Plasticity · doi:10.1155/2016/3423267 · Cited by 42
Mechanical Principles Governing the Shapes of Dendritic Spines
Alimohamadi, H., Bell, M. K., Halpain, S., & Rangamani, P. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.657074 · Cited by 39
Reelin Exerts Structural, Biochemical and Transcriptional Regulation Over Presynaptic and Postsynaptic Elements in the Adult Hippocampus
Bosch, C., Muhaisen, A., Pujadas, L., Soriano, E., & Martı́nez, A. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00138 · Cited by 34
Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory‐related synaptic plasticity in the mouse hippocampus
Jung, G., Kim, E., Cicvaric, A., Sase, S., Gröger, M., Höger, H., Sialana, F. J., Berger, J., Monje, F. J., & Lübec, G. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13119 · Cited by 35
Rac1 is a downstream effector of PKCα in structural synaptic plasticity
Tu, X., Yasuda, R., & Colgan, L. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-58610-6 · Cited by 31
Self-citation
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity
Miyamoto, T., Kim, D., Knox, J. A., Johnson, E., & Mucke, L. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.666529 · Cited by 33
Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling
Duncan, B. W., Mohan, V., Wade, S. D., Truong, Y. K.-N., Kampov-Polevoi, A., Temple, B. R. S., & Maness, P. F. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02373-2 · Cited by 32
Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo
Chenaux, G., Matt, L., Hill, T. C., Kaur, I., Liu, X.-B., Kirk, L. M., Speca, D. J., McMahon, S. A., Zito, K., Hell, J. W., et al. (2016) · eNeuro · doi:10.1523/eneuro.0130-16.2016 · Cited by 32
Cell-Autonomous Regulation of Dendritic Spine Density by PirB
Vidal, G. S., Djurisic, M. R., Brown, K., Sapp, R. W., & Shatz, C. J. (2016) · eNeuro · doi:10.1523/eneuro.0089-16.2016 · Cited by 31
Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex
Sancho, L., & Bloodgood, B. L. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.070 · Cited by 28
Brain is modulated by neuronal plasticity during postnatal development
Kourosh‐Arami, M., Hosseini, N., & Komaki‬, A. (2021) · The Journal of Physiological Sciences · doi:10.1186/s12576-021-00819-9 · Cited by 36
Calcium signaling in postsynaptic mitochondria: mechanisms, dynamics, and role in ATP production
Feofilaktova, T., Kushnireva, L., Segal, M., & Korkotian, E. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1621070 · Cited by 26
Racing to learn: statistical inference and learning in a single spiking neuron with adaptive kernels
Afshar, S., George, L., Tapson, J. C., André, V. S., & Hamilton, T. J. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00377 · Cited by 26
MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism
Bernard, L. P., & Zhang, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124816 · Cited by 24
Nanoscale 3D EM Reconstructions Reveal Intrinsic Mechanisms of Structural Diversity of Chemical Synapses
Zhu, Y., Uytiepo, M., Bushong, E. A., Haberl, M. G., Beutter, E., Scheiwe, F., Zhang, W., Chang, L., Luu, D., Chui, B., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.108953 · Cited by 22
Selective activation of BK channels in small‐headed dendritic spines suppresses excitatory postsynaptic potentials
Tazerart, S., Blanchard, M. G., Miranda‐Rottmann, S., Mitchell, D. E., Pina, B. N., Thomas, C. I., Kamasawa, N., & Araya, R. (2022) · The Journal of Physiology · doi:10.1113/jp282303 · Cited by 22
Triggering signaling pathways using F-actin self-organization
Colin, A., Bonnemay, L., Gayrard, C., Gautier, J. J., & Gueroui, Z. (2016) · Scientific Reports · doi:10.1038/srep34657 · Cited by 22
Emerging roles of cytoskeletal proteins in regulating gene expression and genome organization during differentiation
Xie, X., Mahmood, S. R., Gjorgjieva, T., & Percipalle, P. (2020) · Nucleus · doi:10.1080/19491034.2020.1742066 · Cited by 22
Alternative splicing coupled to nonsense-mediated decay coordinates downregulation of non-neuronal genes in developing mouse neurons
Zhuravskaya, A., Yap, K., Hamid, F., & Makeyev, E. V. (2024) · Genome biology · doi:10.1186/s13059-024-03305-8 · Cited by 20
POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function
Yao, M., Meng, M., Yang, X., Wang, S., Zhang, H., Zhang, F., Shi, L., Zhang, Y., Zhang, X., & Xu, Z. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110642 · Cited by 21
ADAP1/Centaurin-α1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus
Szatmari, E. M., Moran, C., Cohen, S. J., Jacob, A., Parra-Bueno, P., Kamasawa, N., Guerrero‐Given, D., Klein, M., Stackman, R. W., & Yasuda, R. (2020) · eNeuro · doi:10.1523/eneuro.0111-20.2020 · Cited by 18
Self-citation
Timely regulated sorting from early to late endosomes is required to maintain cerebellar long-term depression
Kim, T., Yamamoto, Y., & Tanaka, K. (2017) · Nature Communications · doi:10.1038/s41467-017-00518-3 · Cited by 19
Postnatal Ablation of Synaptic Retinoic Acid Signaling Impairs Cortical Information Processing and Sensory Discrimination in Mice
Park, E., Tjia, M., Zuo, Y., & Chen, L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3028-17.2018 · Cited by 18
A glutamate receptor C-tail recruits CaMKII to suppress retrograde homeostatic signaling
Perry, S., Han, Y., Qiu, C., Chien, C., Goel, P., Nishimura, S., Sajnani, M. R., Schmid, A., Sigrist, S. J., & Dickman, D. K. (2022) · Nature Communications · doi:10.1038/s41467-022-35417-9 · Cited by 20
Organotypic and primary neural cultures as models to assess effects of different gold nanostructures on glia and neurons
Ji, J. X., Moquin, A., Bertorelle, F., Chang, P. K. ‐., Antoine, R., Luo, J. X. X., McKinney, R. A., & Maysinger, D. (2019) · Nanotoxicology · doi:10.1080/17435390.2018.1543468 · Cited by 19
c-Abl Deficiency Provides Synaptic Resiliency Against Aβ-Oligomers
Gutiérrez, D. A., Vargas, L. M., Chandía-Cristi, A., de la Fuente, C., Leal, N. R., & Alvarez, A. R. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00526 · Cited by 19
Automated Remote Focusing, Drift Correction, and Photostimulation to Evaluate Structural Plasticity in Dendritic Spines
Smirnov, M. S., Evans, P. R., Garrett, T. R., Yan, L., & Yasuda, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170586 · Cited by 16
Self-citation
Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease
Heuer, S. E., Bloss, E. B., & Howell, G. R. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109987 · Cited by 16
Rewiring neuronal microcircuits of the brain via spine head protrusions-a role for synaptopodin and intracellular calcium stores
Verbich, D., Becker, D., Vlachos, A., Mundel, P. H., Deller, T., & McKinney, R. A. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0311-x · Cited by 16
Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers
Codocedo, J. F., Montecinos-Oliva, C., & Inestrosa, N. C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00227 · Cited by 15
Blockage of Drp1 phosphorylation at Ser579 protects neurons against Aβ1‑42‑induced degeneration
Xu, D., Yang, P. C., Yang, Z., Li, Q.-G., Ouyang, Y., Yu, T., Shangguan, J.-H., Wan, Y., Jiang, L., Qu, X.-H., et al. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12296 · Cited by 16
Polarity proteins: Shaping dendritic spines and memory
Voglewede, M. M., & Zhang, H. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.05.007 · Cited by 14
Reassessing synaptic adhesion pathways
Lim, D., Kim, D., Um, J. W., & Ko, J. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.04.004 · Cited by 13
Birefringence Changes of Dendrites in Mouse Hippocampal Slices Revealed with Polarizing Microscopy
Koike‐Tani, M., Tominaga, T., Oldenbourg, R., & Tani, T. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.03.016 · Cited by 24
Biophysical Modeling of Synaptic Plasticity
Lee, C. T., Bell, M. K., Bonilla-Quintana, M., & Rangamani, P. (2024) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-072123-124954 · Cited by 16
Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons
Vallejo, D., Lindsay, C., González-Billault, C., & Inestrosa, N. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15448 · Cited by 10
Cortical Synaptic Reorganization Under Chronic Arsenic Exposure
Niño, S. A., Vázquez-Hernández, N., Arévalo-Villalobos, J. I., Chi-Ahumada, É., Martín-Amaya-Barajas, F. L., Díaz-Cintra, S. Y., Martel‐Gallegos, G., González‐Burgos, I., & Jiménez-Capdeville, M. E. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00409-y · Cited by 13
Probing Single Synapses via the Photolytic Release of Neurotransmitters
Mitchell, D. E., Martineau, É., Tazerart, S., & Araya, R. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00019 · Cited by 13
Methodological approaches to understand the molecular mechanism of structural plasticity of dendritic spines
Mikuni, T., & Uchigashima, M. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14734 · Cited by 11
Instantaneous polarized light imaging reveals activity dependent structural changes of dendrites in mouse hippocampal slicesPreprint
Koike‐Tani, M., Tominaga, T., Oldenbourg, R., & Tani, T. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/523571 · Cited by 10
Imaging neuronal structure dynamics using 2‐photon super‐resolution patterned excitation reconstruction microscopy
Urban, B. E., Xiao, L., Dong, B., Chen, S., Kozorovitskiy, Y., & Zhang, H. F. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201700171 · Cited by 9
Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memory
Voglewede, M. M., Ozsen, E. N., Ivak, N. A., Bernabucci, M., Tang, R., Sun, M., Pang, Z. P., & Zhang, H. (2024) · iScience · doi:10.1016/j.isci.2024.110308 · Cited by 8
Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
Oevel, K., Hohensee, S., Kumar, A., Rosas-Brugada, I., Bartolini, F., Soykan, T., & Haucke, V. (2023) · eLife · doi:10.7554/elife.92755 · Cited by 12
The neurobiological mechanisms underlying the effects of exercise interventions in autistic individuals
Tu, G., Jiang, N., Chen, W., Liu, L., Hu, M., & Liao, B. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0058 · Cited by 12
Dendritic Spines Taxonomy: The Functional and Structural Classification • Time-Dependent Probabilistic Model of Neuronal Activation
Urban, P., Tabar, V. R., Bokota, G., Denkiewicz, M., Basu, S., & Plewczyński, D. (2019) · Journal of Computational Biology · doi:10.1089/cmb.2018.0155 · Cited by 6
Subcellular partitioning of protein kinase activity revealed by functional kinome profiling
Wegman‐Points, L., Alganem, K., Imami, A. S., Mathis, V., Creeden, J. F., McCullumsmith, R. E., & Yuan, L. (2022) · Scientific Reports · doi:10.1038/s41598-022-21026-5 · Cited by 6
Antipsychotic Drugs Reverse MK801-Inhibited Cell Migration and F-actin Condensation by Modulating the Rho Signaling Pathway in B35 Cells
Chen, Y.-C., Tsai, F., & Chen, M. (2020) · Behavioural Neurology · doi:10.1155/2020/4163274 · Cited by 6
Physical Activity Dynamically Regulates the Hippocampal Proteome along the Dorso-Ventral Axis
Frey, S., Schieweck, R., Forné, I., Imhof, A., Straub, T., Popper, B., & Kiebler, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103501 · Cited by 7
GABA‐A receptor‐dependent mechanisms prevent excessive spine elimination during postnatal maturation of the mouse cortex in vivo
Chen, Y. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.10.023 · Cited by 5
Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD
Majumder, P., Chatterjee, B., Akter, K., Ahsan, A., Tan, S. J., Huang, C.-C. S., Chu, J.-F., & Shen, C.-K. J. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00684-5 · Cited by 6
Analysis of the mechanism of synaptic integration focusing on the charge held in the spine
Tsubo, T. (2021) · Biophysics and Physicobiology · doi:10.2142/biophysico.bppb-v18.036 · Cited by 5
Postsynaptic Stability and Variability Described by a Stochastic Model of Endosomal Trafficking
Kim, T., & Tanaka, K. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00072 · Cited by 3
Icariin rescues developmental BPA exposure induced spatial memory deficits in rats
Li, D., Ai, S., Huang, C., Liu, Z., & Wang, H.-L. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116776 · Cited by 3
Rumex acetosa L. enhance learning and cognitive function by modulating NMDA receptor and BDNF pathways in vitro and in vivo
Oh, D.-R., Kim, Y. K. S. Y., Mun, B. Y., Ko, H., Kim, Y., Kim, M., Oh, K., Hong, J., & Bae, D. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01608-8 · Cited by 3
Paradoxical Signaling Regulates Structural Plasticity in Dendritic Spines
Rangamani, P., Levy, M., Khan, S., & OSTER, G. F. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2015.11.2003 · Cited by 3
Astrocyte subdomains respond independently in vivoPreprint
López-Hidalgo, M. A., Kellner, V., & Schummers, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/675769 · Cited by 3
Spine apparatus modulates Ca 2+ in spines through spatial localization of sources and sinksPreprint
Mesa, M. H., García, G. C., Hoerndli, F. J., McCabe, K. J., & Rangamani, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.22.558941 · Cited by 3
Comparing Neural and Digital Circuits on Achieving Basic Functions Necessary for Data Processing
Tsubo, T. (2023) · European Journal of Biophysics · doi:10.11648/j.ejb.20231102.11 · Cited by 2
Endolysosome dysfunction in HAND
Hasler, W. A., Rezagholizadeh, N., & Chen, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99744-7.00034-1 · Cited by 2
Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks
Mesa, M. H., García, G. C., Hoerndli, F. J., McCabe, K. J., & Rangamani, P. (2025) · The Journal of Physiology · doi:10.1113/jp286859 · Cited by 2
CaMKII: A Master Functional and Structural Molecule in Synaptic Plasticity and Memory
Sanhueza, M., & Fernandez, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-24364-1_3 · Cited by 2
Synaptic Plasticity Linked to Ionotropic Glutamate Receptors After Nicotine Exposure
Kazmi, A., & Choe, E. S. (2025) · Current Neuropharmacology · doi:10.2174/011570159x365159250311142852 · Cited by 1

Authors: Colgan, L. A., & Yasuda, R.
Affiliations: Max Planck Florida Institute for Neuroscience (US)
ORCID: Colgan, Lesley A.
Yasuda, Ryohei
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2014-02-10
Volume: 76
Issue: 1
Pages: 365-385
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev-physiol-021113-170400
PMC: PMC4142713
OpenAlex: W2109779479
Cited by: 124
References: 153
Citations by year: 2026: 2 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 12 · 2016: 17 · 2015: 13 · 2014: 8
FWCI: 1.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: National Institute of Mental Health (R01MH080047, R01MH095090)
National Institute of Neurological Disorders and Stroke (R01NS068410)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dendritic spines, synaptic plasticity, long-term potentiation, postsynaptic density, actin cytoskeleton, membrane trafficking, signaling pathways
MeSH terms: Actins, Animals, Cell Membrane, Cytoskeleton, Humans, Neuronal Plasticity, Synapses, Signal Transduction, Dendritic Spines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasticity of Dendritic Spines: Subcompartmentalization of Signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks