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Nanotechnology Applications in Cancer

Nie, Shuming, Xing, Yun, Kim, Gloria J., Simons, Jonathan W.·2007·Annual Review of Biomedical Engineering
DOI 10.1146/annurev.bioeng.9.060906.152025
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Abstract

Cancer nanotechnology is an interdisciplinary area of research in science, engineering, and medicine with broad applications for molecular imaging, molecular diagnosis, and targeted therapy. The basic rationale is that nanometer-sized particles, such as semiconductor quantum dots and iron oxide nanocrystals, have optical, magnetic, or structural properties that are not available from molecules or bulk solids. When linked with tumor targeting ligands such as monoclonal antibodies, peptides, or small molecules, these nanoparticles can be used to target tumor antigens (biomarkers) as well as tumor vasculatures with high affinity and specificity. In the mesoscopic size range of 5–100 nm diameter, nanoparticles also have large surface areas and functional groups for conjugating to multiple diagnostic (e.g., optical, radioisotopic, or magnetic) and therapeutic (e.g., anticancer) agents. Recent advances have led to bioaffinity nanoparticle probes for molecular and cellular imaging, targeted nanoparticle drugs for cancer therapy, and integrated nanodevices for early cancer detection and screening. These developments raise exciting opportunities for personalized oncology in which genetic and protein biomarkers are used to diagnose and treat cancer based on the molecular profiles of individual patients.

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Cites

Research works printed but not linked: 124

  1. 10.1016/S0092-8674(00)81683-9 · DOI · Paper page
  2. 10.1038/nrc795 · DOI
  3. 10.1038/35049567 · DOI
  4. 10.1038/nrd891 · DOI
  5. 10.1097/00001703-200002000-00007 · DOI
  6. 10.1038/labinvest.3780460 · DOI
  7. 10.1021/cr00098a010 · DOI
  8. 10.1021/cr00016a002 · DOI
  9. 10.1002/1521-3773(20011119)40:22<4128::AID-ANIE4128>3.3.CO;2-J · DOI
  10. 10.1038/nbt927 · DOI
  11. 10.1126/science.271.5251.933 · DOI
  12. 10.1146/annurev.bioeng.7.060804.100432 · DOI
  13. 10.1016/j.biomaterials.2005.11.018 · DOI
  14. 10.1126/science.1104274 · DOI
  15. 10.1016/j.copbio.2004.11.003 · DOI
  16. 10.1562/0031-8655(2004)080<0377:QDNFIV>2.0.CO;2 · DOI
  17. 10.1016/S0958-1669(02)00282-3 · DOI
  18. 10.1126/science.1070200 · DOI
  19. 10.1016/S1367-5931(02)00372-1 · DOI
  20. 10.1126/science.294.5540.137 · DOI
  21. 10.1038/nmat702 · DOI
  22. 10.1073/pnas.0236044100 · DOI
  23. 10.1126/science.297.5586.1536 · DOI
  24. 10.1126/science.286.5439.531 · DOI · Paper page
  25. 10.1038/73432 · DOI · Paper page
  26. 10.1038/35000501 · DOI · Paper page
  27. 10.1038/35021093 · DOI
  28. 10.1038/35020115 · DOI
  29. 10.1038/35090585 · DOI
  30. 10.1016/S0002-9440(10)64244-7 · DOI
  31. Rhodes DR, 2002, Cancer Res., 62, 4427
  32. 10.1093/jnci/95.9.661 · DOI
  33. 10.1002/path.892 · DOI
  34. 10.1097/00000478-200203000-00004 · DOI
  35. 10.1001/jama.287.13.1662 · DOI
  36. 10.1056/NEJMra021562 · DOI
  37. Gonzalgo ML, 2003, Clin. Cancer Res., 9, 2673
  38. 10.1038/nrd1497 · DOI
  39. 10.1038/nature02626 · DOI
  40. 10.1016/S0361-090X(02)00092-2 · DOI
  41. Srinivas PR, 2002, Clin. Chem., 48, 1160
  42. 10.1021/cm034081k · DOI · Paper page
  43. 10.1021/ja0434331 · DOI
  44. 10.1038/nbt994 · DOI
  45. Ntziachristos V, 2003, Eur. Radiol., 13, 195, 10.1007/s00330-002-1524-x · DOI
  46. 10.1073/pnas.0401137101 · DOI
  47. 10.1021/bc034151d · DOI
  48. 10.1021/bc049905i · DOI
  49. 10.1021/nl035010n · DOI
  50. 10.1021/ja0496423 · DOI
  51. 10.1021/nl051935m · DOI
  52. 10.1021/bc0600463 · DOI
  53. 10.1023/A:1020398624602 · DOI
  54. 10.1016/0168-3659(94)90152-X · DOI
  55. 10.3109/08982100009031113 · DOI
  56. 10.1021/bc0499127 · DOI
  57. 10.1016/j.cbpa.2004.08.011 · DOI
  58. Matsumura Y, 1986, Cancer Res., 46, 6387
  59. 10.1038/nrd1088 · DOI
  60. 10.1146/annurev.bioeng.1.1.241 · DOI
  61. 10.1016/S0168-3659(01)00306-6 · DOI
  62. 10.1021/bc034153y · DOI
  63. 10.1126/science.1083780 · DOI
  64. 10.1038/nm1247 · DOI
  65. 10.1038/nbt920 · DOI
  66. 10.1073/pnas.152463399 · DOI
  67. 10.1177/002215540305100801 · DOI
  68. Jain RK, 1999, Clin. Cancer Res., 5, 1605
  69. 10.1073/pnas.1735443100 · DOI
  70. 10.1097/01.ju.0000091655.77601.0c · DOI
  71. 10.1021/nl0347334 · DOI
  72. 10.1002/smll.200500105 · DOI
  73. 10.1021/nl047996m · DOI · Paper page
  74. 10.1038/nbt929 · DOI
  75. 10.1038/nbt764 · DOI
  76. 10.1046/j.1365-2818.2003.01219.x · DOI
  77. 10.1152/ajpregu.00449.2005 · DOI
  78. 10.1016/j.ceb.2005.08.001 · DOI
  79. 10.1073/pnas.93.26.15152 · DOI
  80. Hernandez I, 2003, Mol. Cancer Res., 1, 1036
  81. 10.1002/pros.20153 · DOI
  82. 10.1117/1.2032458 · DOI · Paper page
  83. 10.1056/NEJMoa040766 · DOI
  84. 10.1016/S0090-4295(02)02291-4 · DOI
  85. 10.1021/ja049384+ · DOI
  86. 10.1126/science.1088755 · DOI
  87. 10.1073/pnas.0406368102 · DOI
  88. 10.1126/science.1062711 · DOI
  89. 10.1021/nl034853b · DOI
  90. 10.1038/nbt1138 · DOI
  91. 10.1038/27873 · DOI
  92. 10.1038/77332 · DOI
  93. 10.1021/ja031723w · DOI
  94. 10.1038/nnano.2006.170 · DOI
  95. 10.1126/science.8128245 · DOI
  96. 10.1002/polc.5070510111 · DOI · Paper page
  97. 10.1016/S0169-409X(02)00021-2 · DOI
  98. 10.1016/S0167-7799(00)01485-2 · DOI
  99. 10.1016/j.biomaterials.2004.04.008 · DOI
  100. 10.1016/S0169-409X(97)00095-1 · DOI
  101. Mansour AM, 2003, Cancer Res., 63, 4062
  102. 10.1021/ar9703241 · DOI
  103. 10.1038/nrc903 · DOI
  104. 10.1111/j.1349-7006.2004.tb03219.x · DOI
  105. 10.1016/S0169-409X(00)00071-5 · DOI
  106. 10.1016/S0959-8049(05)80025-5 · DOI
  107. 10.1016/S0163-7258(99)00073-X · DOI
  108. Links M, 1999, Expert Rev. Mol. Med., 1999, 1
  109. 10.1016/S0928-0987(00)00114-7 · DOI
  110. 10.1016/j.jconrel.2003.08.005 · DOI
  111. 10.1038/bjc.1997.362 · DOI
  112. 10.1016/S1471-4914(03)00111-4 · DOI
  113. 10.2169/internalmedicine.42.237 · DOI
  114. 10.1016/j.addr.2004.01.008 · DOI
  115. 10.1016/S1359-6446(00)01594-4 · DOI
  116. 10.1002/1520-6017(200011)89:11<1452::AID-JPS8>3.0.CO;2-P · DOI
  117. 10.1016/S0928-0987(02)00251-8 · DOI
  118. 10.1021/bm0300655 · DOI
  119. 10.1074/jbc.M003120200 · DOI
  120. 10.1038/364464a0 · DOI
  121. 10.1016/S0378-5173(01)00986-3 · DOI
  122. 10.1093/jnci/96.2.90 · DOI
  123. 10.1016/S0959-8049(01)00171-X · DOI
  124. 10.1016/j.tibtech.2005.11.006 · DOI

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Metadata

Authors
Nie, S., Xing, Y., Kim, G. J., & Simons, J. W.
Affiliations
Department of Biomedical Engineering and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322;
Venue
Annual Review of Biomedical Engineering
Publisher
Annual Reviews
Published
2007-08-15
Volume
9
Issue
1
Pages
257-288
ISSN
  • 1523-9829
  • 1545-4274
DOI
10.1146/annurev.bioeng.9.060906.152025
Cited by
952
References
5
Language
en

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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