The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Vertebrate Endoderm Development and Organ Formation
Open accessAbstract
The endoderm germ layer contributes to the respiratory and gastrointestinal tracts and to all of their associated organs. Over the past decade, studies in vertebrate model organisms, including frog, fish, chick, and mouse, have greatly enhanced our understanding of the molecular basis of endoderm organ development. We review this progress with a focus on early stages of endoderm organogenesis including endoderm formation, gut tube morphogenesis and patterning, and organ specification. Lastly, we discuss how developmental mechanisms that regulate endoderm organogenesis are used to direct differentiation of embryonic stem cells into specific adult cell types, which function to alleviate disease symptoms in animal models.
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“The gut endoderm is the precursor of the respiratory and digestive tracts, and their associated organs1,2 (Fig. 1).”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [1]
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“TF expression was exceptionally accurate in predicting AP pseudo-space order (Extended Data Fig. 9c, Correlation: 0.97), indicating that transcriptional regulation, presumably in response to signals from neighboring mesenchyme1, plays a key role in gut tube patterning.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [1]
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Cites
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913
Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843
Efficient differentiation of human embryonic stem cells to definitive endoderm
D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730
Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
Development of definitive endoderm from embryonic stem cells in culture
Kubo, A., Shinozaki, K., Shannon, J. M., Kouskoff, V., Kennedy, M., Woo, S. L. C., Fehling, H. J., & Keller, G. M. (2004) · Development · doi:10.1242/dev.01044 · Cited by 830
Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors
Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S. (1999) · Science · doi:10.1126/science.284.5422.1998 · Cited by 721
Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Origin and organization of the zebrafish fate map
Kimmel, C. B., Warga, R. M., & Schilling, T. F. (1990) · Development · doi:10.1242/dev.108.4.581 · Cited by 698
Ciruna, B. G., & Rossant, J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00017-x · Cited by 695
Research works printed but not linked: 1
- Fukuda-Taira S, 1981, J. Embryol. Exp. Morph., 63, 111
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Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.007 · Cited by 2,019
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K. A., Hoskins, E. E., Kalinichenko, V. V., Wells, S. I., Zorn, A. M., et al. (2010) · Nature · doi:10.1038/nature09691 · Cited by 1,911
Self-citationThe Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate
Sarkar, A., & Hochedlinger, K. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.007 · Cited by 915
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David, C. J., & Massagué, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0007-0 · Cited by 851
An in vivo model of human small intestine using pluripotent stem cells
Watson, C. L., Mahé, M. M., Múnera, J. O., Howell, J. C., Sundaram, N., Poling, H. M., Schweitzer, J. I., Vallance, J. E., Mayhew, C. N., Sun, Y., et al. (2014) · Nature Medicine · doi:10.1038/nm.3737 · Cited by 561
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Metadata
- Authors
- Zorn, A. M., & Wells, J. M.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2009-11-01
- Volume
- 25
- Issue
- 1
- Pages
- 221-251
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- PMC
- PMC2861293
- OpenAlex
- W2137175341
- Cited by
- 812
- References
- 180
- Citations by year
- 2026: 35 · 2025: 51 · 2024: 49 · 2023: 45 · 2022: 64 · 2021: 64 · 2020: 56 · 2019: 57 · 2018: 58 · 2017: 52 · 2016: 52 · 2015: 39 · 2014: 41 · 2013: 49 · 2012: 46
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Child Health Research Foundation
- National Institute of General Medical Sciences (R01GM072915)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080823, R01DK070858, R01DK092456)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- endoderm development, organogenesis, organ specifications, respiratory tract development, gastrointestinal tract development, embryonic stem cell differentiation, vertebrate model organisms
- MeSH terms
- Animals, Endoderm, Humans, Vertebrates, Organogenesis
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