The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Vertebrate Endoderm Development and Organ Formation
Open accessAbstract
The endoderm germ layer contributes to the respiratory and gastrointestinal tracts and to all of their associated organs. Over the past decade, studies in vertebrate model organisms, including frog, fish, chick, and mouse, have greatly enhanced our understanding of the molecular basis of endoderm organ development. We review this progress with a focus on early stages of endoderm organogenesis including endoderm formation, gut tube morphogenesis and patterning, and organ specification. Lastly, we discuss how developmental mechanisms that regulate endoderm organogenesis are used to direct differentiation of embryonic stem cells into specific adult cell types, which function to alleviate disease symptoms in animal models.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The gut endoderm is the precursor of the respiratory and digestive tracts, and their associated organs1,2 (Fig. 1).”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“TF expression was exceptionally accurate in predicting AP pseudo-space order (Extended Data Fig. 9c, Correlation: 0.97), indicating that transcriptional regulation, presumably in response to signals from neighboring mesenchyme1, plays a key role in gut tube patterning.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [1]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913
Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843
Efficient differentiation of human embryonic stem cells to definitive endoderm
D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730
Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
Development of definitive endoderm from embryonic stem cells in culture
Kubo, A., Shinozaki, K., Shannon, J. M., Kouskoff, V., Kennedy, M., Woo, S. L. C., Fehling, H. J., & Keller, G. M. (2004) · Development · doi:10.1242/dev.01044 · Cited by 830
Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors
Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S. (1999) · Science · doi:10.1126/science.284.5422.1998 · Cited by 721
Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Origin and organization of the zebrafish fate map
Kimmel, C. B., Warga, R. M., & Schilling, T. F. (1990) · Development · doi:10.1242/dev.108.4.581 · Cited by 698
Ciruna, B. G., & Rossant, J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00017-x · Cited by 695
Research works printed but not linked: 1
- Fukuda-Taira S, 1981, J. Embryol. Exp. Morph., 63, 111
Cited by
Sorted by citations
Integrated genomic characterization of pancreatic ductal adenocarcinoma
Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.007 · Cited by 2,019
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K. A., Hoskins, E. E., Kalinichenko, V. V., Wells, S. I., Zorn, A. M., et al. (2010) · Nature · doi:10.1038/nature09691 · Cited by 1,911
Self-citationThe Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate
Sarkar, A., & Hochedlinger, K. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.007 · Cited by 915
Contextual determinants of TGFβ action in development, immunity and cancer
David, C. J., & Massagué, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0007-0 · Cited by 851
An in vivo model of human small intestine using pluripotent stem cells
Watson, C. L., Mahé, M. M., Múnera, J. O., Howell, J. C., Sundaram, N., Poling, H. M., Schweitzer, J. I., Vallance, J. E., Mayhew, C. N., Sun, Y., et al. (2014) · Nature Medicine · doi:10.1038/nm.3737 · Cited by 561
Self-citationModeling mouse and human development using organoid cultures
Huch, M., & Koo, B. (2015) · Development · doi:10.1242/dev.118570 · Cited by 578
Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids
Ouchi, R., Togo, S., Kimura, M., Shinozawa, T., Koido, M., Koike, H., Thompson, W., Karns, R. A., Mayhew, C. N., McGrath, P. S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.007 · Cited by 537
Self-citationChu, L.-F., Leng, N., Zhang, J., Hou, Z., Mamott, D., Vereide, D. T., Choi, J., Kendziorski, C., Stewart, R., & Thomson, J. A. (2016) · Genome Biology · doi:10.1186/s13059-016-1033-x · Cited by 477
Wong, A. P., Bear, C. E., Chin, S., Pasceri, P., Thompson, T., Huan, L., Ratjen, F. A., Ellis, J., & Rossant, J. (2012) · Nature Biotechnology · doi:10.1038/nbt.2328 · Cited by 422
Generation of lung organoids from human pluripotent stem cells in vitro
Miller, A. J., Dye, B. R., Ferrer-Torres, D., Hill, D. R., Overeem, A. W., Shea, L. D., & Spence, J. R. (2019) · Nature Protocols · doi:10.1038/s41596-018-0104-8 · Cited by 431
Loh, K. M., Ang, L. T., Zhang, J., Kumar, V., Ang, J., Auyeong, J. Q., Lee, K. L., Choo, S. H., Lim, C. Y. Y., Nichane, M., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.007 · Cited by 418
Takebe, T., & Wells, J. M. (2019) · Science · doi:10.1126/science.aaw7567 · Cited by 417
Self-citationWang, Y., Song, W., Wang, J., Wang, T., Xiong, X., Qi, Z., Fu, W., Yang, X., & Chen, Y.-G. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191130 · Cited by 399
Fordham, R. P., Yui, S., Hannan, N. R. F., Soendergaard, C., Madgwick, A., Schweiger, P. J., Nielsen, O. H., Vallier, L., Pedersen, R. A., Nakamura, T., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.015 · Cited by 407
Fang, Y., Chen, H., Wang, C., & Liang, L. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i27.2974 · Cited by 407
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells
Green, M. D., Chen, A. F., Nostro, M. C., D’Souza, S. L., Schaniel, C., Lemischka, I. R., Gouon–Evans, V., Keller, G. M., & Snoeck, H. W. (2011) · Nature Biotechnology · doi:10.1038/nbt.1788 · Cited by 393
Intestinal development and differentiation
Noah, T. K., Donahue, B., & Shroyer, N. F. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.09.006 · Cited by 384
The emergent landscape of the mouse gut endoderm at single-cell resolution
Nowotschin, S., Setty, M., Kuo, Y.-Y., Liu, V., Garg, V., Sharma, R., Simon, C. S., Saiz, N., Gardner, R., Boutet, S. C., et al. (2019) · Nature · doi:10.1038/s41586-019-1127-1 · Cited by 383
Disease modelling in human organoids
Lancaster, M. A., & Huch, M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.039347 · Cited by 390
Orchestrating liver development
Gordillo, M., Evans, T., & Gouon-Evans, V. (2015) · Development · doi:10.1242/dev.114215 · Cited by 375
Organoids — Preclinical Models of Human Disease
Li, M., & Belmonte, J. C. I. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1806175 · Cited by 373
Generation of functional thyroid from embryonic stem cells
Antonica, F., Kasprzyk, D. F., Opitz, R., Iacovino, M., Liao, X.-H., Dumitrescu, A. M., Refetoff, S., Peremans, K., Manto, M., Kyba, M., et al. (2012) · Nature · doi:10.1038/nature11525 · Cited by 359
McCauley, H. A., & Wells, J. M. (2017) · Development · doi:10.1242/dev.140731 · Cited by 322
Self-citationPancreas Organogenesis: From Lineage Determination to Morphogenesis
Shih, H.-P., Wang, A., & Sander, M. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122405 · Cited by 347
Self-organization of a human organizer by combined Wnt and Nodal signalling
Martyn, I., Kanno, T. Y. N., Ruzo, A., Siggia, E. D., & Brivanlou, A. H. (2018) · Nature · doi:10.1038/s41586-018-0150-y · Cited by 301
Mechanisms of thymus organogenesis and morphogenesis
Gordon, J., & Manley, N. R. (2011) · Development · doi:10.1242/dev.059998 · Cited by 294
A Poised Chromatin Platform for TGF-β Access to Master Regulators
Xi, Q., Wang, Z., Zaromytidou, A.-I., Zhang, X. H.-F., Chow-Tsang, L.-F., Liu, J. X., Kim, H., Barlas, A., Manova-Todorova, K. O., Kaartinen, V., et al. (2011) · Cell · doi:10.1016/j.cell.2011.11.032 · Cited by 303
Enhancing the precision of genetic lineage tracing using dual recombinases
He, L., Li, Y., Li, Y., Pu, W., Huang, X., Tian, X., Wang, Y., Zhang, H., Liu, Q., Zhang, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4437 · Cited by 275
Múnera, J. O., Sundaram, N., Rankin, S. A., Hill, D. R., Watson, C. L., Mahé, M. M., Vallance, J. E., Shroyer, N. F., Sinagoga, K. L., Zarzoso-Lacoste, A., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.05.020 · Cited by 252
Self-citationOrganoid Models of Human Gastrointestinal Development and Disease
Dedhia, P. H., Bertaux‐Skeirik, N., Zavros, Y. L., & Spence, J. R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.042 · Cited by 252
Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs
He, S., Wang, L.-H., Liu, Y., Li, Y., Chen, H.-T., Xu, J.-H., Peng, W., Lin, G.-W., Wei, P.-P., Li, B., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02210-0 · Cited by 237
Hawkins, F. J., Krämer, P., Jacob, A., Driver, I. H., Thomas, D. C., McCauley, K. B., Skvir, N. J., Crane, A. M., Kurmann, A. A., Hollenberg, A. N., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89950 · Cited by 232
Wnt/β-catenin promotes gastric fundus specification in mice and humans
McCracken, K. W., Aihara, E., Martin, B., Crawford, C. M., Broda, T. R., Tréguier, J., Zhang, X., Shannon, J. M., Montrose, M. H., & Wells, J. M. (2017) · Nature · doi:10.1038/nature21021 · Cited by 222
Self-citationMorphogenesis and maturation of the embryonic and postnatal intestine
Chin, A. M., Hill, D. R., Aurora, M., & Spence, J. R. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.01.011 · Cited by 236
A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells
Ang, L. T., Tan, A. K. Y., Autio, M. I., Goh, S. H., Choo, S. H., Lee, K. L., Tan, J., Pan, B., Lee, J. J. H., Lum, J. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.087 · Cited by 220
Bioengineering Approaches for the Advanced Organoid Research
Yi, S. A., Zhang, Y., Rathnam, C., Pongkulapa, T., & Lee, K. (2021) · Advanced Materials · doi:10.1002/adma.202007949 · Cited by 218
Vertebrate intestinal endoderm development
Spence, J. R., Lauf, R., & Shroyer, N. F. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22540 · Cited by 231
Gao, S., Yan, L., Wang, R., Li, J., Yong, J., Zhou, X., Wei, Y., Wu, X., Wang, X., Fan, X., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0105-4 · Cited by 208
Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells
Cheng, X., Ying, L., Lü, L., Galvão, A. M., Mills, J. A., Lin, H. C., Kotton, D. N., Shen, S. S., Nostro, M. C., Choi, J. K., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.024 · Cited by 205
Building and Regenerating the Lung Cell by Cell
Whitsett, J. A., Kalin, T. V., Xu, Y. J., & Kalinichenko, V. V. (2018) · Physiological Reviews · doi:10.1152/physrev.00001.2018 · Cited by 210
Gut‐liver axis at the frontier of host‐microbial interactions
Brandl, K., Kumar, V., & Eckmann, L. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00361.2016 · Cited by 201
Human airway organoid engineering as a step toward lung regeneration and disease modeling
Tan, Q., Choi, K. M., Sicard, D., & Tschumperlin, D. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.046 · Cited by 191
Han, L., Chaturvedi, P., Kishimoto, K., Koike, H., Nasr, T., Iwasawa, K., Giesbrecht, K., Witcher, P. C., Eicher, A. K., Haines, L. E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17968-x · Cited by 185
Self-citationMechanisms of Non-Alcoholic Fatty Liver Disease in the Metabolic Syndrome. A Narrative Review
Rinaldi, L., Pafundi, P. C., Galiero, R., Caturano, A., Morone, M. V., Silvestri, C., Giordano, M., Salvatore, T., & Sasso, F. C. (2021) · Antioxidants · doi:10.3390/antiox10020270 · Cited by 180
Marx, U., Walles, H., Hoffmann, S., Lindner, G., Horland, R., Sonntag, F., Klotzbach, U., Sakharov, D. A., Tonevitsky, A., & Lauster, R. (2012) · Alternatives to Laboratory Animals · doi:10.1177/026119291204000504 · Cited by 179
Wells, J. M., & Spence, J. R. (2014) · Development · doi:10.1242/dev.097386 · Cited by 174
Self-citationParent, A. V., Russ, H. A., Khan, I. S., LaFlam, T. N., Metzger, T. C., Anderson, M. S., & Hebrok, M. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.004 · Cited by 173
Diverse mechanisms for endogenous regeneration and repair in mammalian organs
Wells, J. M., & Watt, F. M. (2018) · Nature · doi:10.1038/s41586-018-0073-7 · Cited by 169
Self-citationCellular and molecular mechanisms coordinating pancreas development
Bastidas-Ponce, A., Scheibner, K., Lickert, H., & Bakhti, M. (2017) · Development · doi:10.1242/dev.140756 · Cited by 166
Xu, X., Browning, V. L., & Odorico, J. S. (2011) · Mechanisms of Development · doi:10.1016/j.mod.2011.08.001 · Cited by 157
Anatomy and Physiology of the Small Bowel
Volk, N. R., & Lacy, B. E. (2016) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2016.08.001 · Cited by 157
The lncRNA DEANR1 Facilitates Human Endoderm Differentiation by Activating FOXA2 Expression
Jiang, W., Liu, Y., Liu, R., Zhang, K., & Zhang, Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.008 · Cited by 153
Trisno, S. L., Philo, K. E. D., McCracken, K. W., Catá, E. M., Ruiz-Torres, S., Rankin, S. A., Han, L., Nasr, T., Chaturvedi, P., Rothenberg, M. E., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.008 · Cited by 152
Self-citationSOX17 links gut endoderm morphogenesis and germ layer segregation
Viotti, M., Nowotschin, S., & Hadjantonakis, A.-K. (2014) · Nature Cell Biology · doi:10.1038/ncb3070 · Cited by 150
Generation of intestinal surface: an absorbing tale
Walton, K. D., Freddo, A. M., Wang, S., & Gumucio, D. L. (2016) · Development · doi:10.1242/dev.135400 · Cited by 159
The molecular and morphogenetic basis of pancreas organogenesis
Larsen, H. L., & Grapin‐Botton, A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.01.005 · Cited by 154
Gut–Liver Axis Derangement in Non-Alcoholic Fatty Liver Disease
Poeta, M., Pierri, L., & Vajro, P. (2017) · Children · doi:10.3390/children4080066 · Cited by 147
Charting human development using a multi-endodermal organ atlas and organoid models
Yu, Q., Kilik, U., Holloway, E. M., Tsai, Y.-H., Harmel, C., Wu, A., Wu, J. H., Czerwinski, M. J., Childs, C. J., He, Z., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.028 · Cited by 151
EpCAM Is an Endoderm-Specific Wnt Derepressor that Licenses Hepatic Development
Lu, H., Ma, J., Yang, Y., Shi, W., & Luo, L. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.01.021 · Cited by 142
Jiang, W., Wang, J., & Zhang, Y. (2012) · Cell Research · doi:10.1038/cr.2012.119 · Cited by 142
Gut-like ectodermal tissue in a sea anemone challenges germ layer homology
Steinmetz, P. R. H., Aman, A. J., Kraus, J. E. M., & Technau, U. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0285-5 · Cited by 135
Forsthoefel, D. J., James, N., Escobar, D., Stary, J. M., Vieira, A. P., Waters, F. A., & Newmark, P. A. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.09.008 · Cited by 136
Sun, X., Xu, J., Lu, H., Liu, W., Miao, Z., Sui, X. Y., Liu, H., Li, S., Du, W., He, Q., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.014 · Cited by 133
Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis
Grosse, A. S., Pressprich, M. F., Curley, L. B., Hamilton, K. L., Margolis, B. L., Hildebrand, J. D., & Gumucio, D. L. (2011) · Development · doi:10.1242/dev.065789 · Cited by 131
Wnt and FGF mediated epithelial‐mesenchymal crosstalk during lung development
Volckaert, T., & Langhe, S. D. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24234 · Cited by 135
Gilpin, S. E., Ren, X., Okamoto, T., Guyette, J. P., Mou, H., Rajagopal, J., Mathisen, D. J., Vacanti, J. P., & Ott, H. C. (2014) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2014.05.080 · Cited by 130
Organoid-based modeling of intestinal development, regeneration, and repair
Sprangers, J., Zaalberg, I. C., & Maurice, M. M. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00665-z · Cited by 137
Gkatzis, K., Taghizadeh, S., Huh, D., Stainier, D. Y. R., & Bellusci, S. (2018) · European Respiratory Journal · doi:10.1183/13993003.00876-2018 · Cited by 128
The Dynamics of Morphogenesis in the Early Mouse EmbryoPreprint
Rivera‐Pérez, J. A., & Hadjantonakis, A. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015867 · Cited by 136
Cdx2 regulates patterning of the intestinal epithelium
Grainger, S. J., Savory, J. G. A., & Lohnes, D. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.12.025 · Cited by 135
Li, Q. V., Dixon, G., Verma, N., Rosen, B. P., Gordillo, M., Luo, R., Xu, C., Wang, Q., Soh, C.-L., Yang, D., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0408-9 · Cited by 124
The Gut-Brain Axis in Inflammatory Bowel Disease—Current and Future Perspectives
Günther, C., Rothhammer, V., Karow, M., Neurath, M., & Winner, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168870 · Cited by 123
Stomach Organ and Cell Lineage Differentiation: From Embryogenesis to Adult Homeostasis
Willet, S. G., & Mills, J. C. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.05.006 · Cited by 130
Rankin, S. A., Han, L., McCracken, K. W., Kenny, A. P., Anglin, C. T., Grigg, E., Crawford, C. M., Wells, J. M., Shannon, J. M., & Zorn, A. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.060 · Cited by 116
Self-citationGeneration of pancreatic β cells from CD177+ anterior definitive endoderm
Mahaddalkar, P. U., Scheibner, K., Pfluger, S., Ansarullah, Sterr, M., Beckenbauer, J., Irmler, M., Beckers, J., Knöbel, S., & Lickert, H. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0492-5 · Cited by 115
Drukker, M., Tang, C. Z., Ardehali, R., Rinkevich, Y., Seita, J., Lee, A. S., Mosley, A. R., Weissman, I. L., & Soen, Y. (2012) · Nature Biotechnology · doi:10.1038/nbt.2239 · Cited by 114
Epithelial origin of eosinophilic esophagitis
Rochman, M., Azouz, N. P., & Rothenberg, M. E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.05.008 · Cited by 111
Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
Mithal, A., Capilla, A., Heinze, D. M., Berical, A. C., Villacorta-Martín, C., Vedaie, M., Jacob, A., Abo, K. M., Szymaniak, A. D., Peasley, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13916-6 · Cited by 115
Generation of stomach tissue from mouse embryonic stem cells
Noguchi, T.-A. K., Ninomiya, N., Sekine, M., Komazaki, S., Wang, P., Asashima, M., & Kurisaki, A. (2015) · Nature Cell Biology · doi:10.1038/ncb3200 · Cited by 108
Mechanically induced development and maturation of human intestinal organoids in vivo
Poling, H. M., Wu, D. X.-Y., Brown, N. E., Baker, M. L., Hausfeld, T. A., Huynh, N., Chaffron, S., Dunn, J., Hogan, S. P., Wells, J. M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0243-9 · Cited by 107
Self-citationOrganoids as a model system for studying human lung development and disease
Nadkarni, R. R., Abed, S., & Draper, J. S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.091 · Cited by 106
Taylor, C. A., Hutchens, S., Liu, C., Jursa, T., Shawlot, W., Aschner, M., Smith, D. R., & Mukhopadhyay, S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005628 · Cited by 106
Hynds, R. E., & Giangreco, A. (2012) · Stem Cells · doi:10.1002/stem.1290 · Cited by 107
Brade, T., Kumar, S., Cunningham, T. J., Chatzi, C. A., Zhao, X., Cavallero, S., Li, P., Sucov, H. M., Ruiz‐Lozano, P., & Duester, G. (2010) · Development · doi:10.1242/dev.054239 · Cited by 103
Shojaie, S., Ermini, L., Ackerley, C., Wang, J., Chin, S., Yeganeh, B., Bilodeau, M., Sambi, M., Rogers, I., Rossant, J., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.01.004 · Cited by 102
Role of Intestinal HIF-2α in Health and Disease
Ramakrishnan, S. K., & Shah, Y. M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105202 · Cited by 100
The promise of stem cell-derived islet replacement therapy
Melton, D. (2021) · Diabetologia · doi:10.1007/s00125-020-05367-2 · Cited by 96
Modelling the endocrine pancreas in health and disease
Bakhti, M., Böttcher, A., & Lickert, H. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0132-z · Cited by 103
Miao, Y., Pek, N. M. Q., Tan, C. P. B., Jiang, C., Yu, Z., Iwasawa, K., Shi, M. Y., Kechele, D. O., Sundaram, N., Pastrana-Gomez, V., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.041 · Cited by 104
Self-citationThe endoderm: a divergent cell lineage with many commonalities
Nowotschin, S., Hadjantonakis, A.-K., & Campbell, K. (2019) · Development · doi:10.1242/dev.150920 · Cited by 94
Touboul, T., Chen, S., To, C. C., Mora-Castilla, S., Sabatini, K., Tukey, R. H., & Laurent, L. C. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.028 · Cited by 94
Generating human intestinal tissues from pluripotent stem cells to study development and disease
Sinagoga, K. L., & Wells, J. M. (2015) · The EMBO Journal · doi:10.15252/embj.201490686 · Cited by 95
Self-citationSchmitt, B. M., Rudolph, K. L. M., Karagianni, P., Fonseca, N. A., White, R. J., Talianidis, I., Odom, D. T., Marioni, J. C., & Kutter, C. (2014) · Genome Research · doi:10.1101/gr.176784.114 · Cited by 100
Epithelial cell plasticity drives endoderm formation during gastrulation
Scheibner, K., Schirge, S., Burtscher, I., Büttner, M., Sterr, M., Yang, D., Böttcher, A., Ansarullah, M., Irmler, M., Beckers, J., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00694-x · Cited by 92
Minireview: Intrinsic and Extrinsic Factors in Thyroid Gland Development: An Update
Felice, M. D., & Lauro, R. D. (2011) · Endocrinology · doi:10.1210/en.2011-0204 · Cited by 93
Genga, R. M. J., Kernfeld, E. M., Parsi, K. M., Parsons, T. J., Ziller, M. J., & Maehr, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.076 · Cited by 92
The endocrine pancreas: insights into development, differentiation, and diabetes
Mastracci, T. L., & Sussel, L. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.44 · Cited by 100
Morphogenetics of early thyroid development
Fagman, H., & Nilsson, M. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0084 · Cited by 90
The extracellular matrix of the gastrointestinal tract: a regenerative medicine platform
Hussey, G. S., Keane, T. J., & Badylak, S. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.76 · Cited by 88
Metadata
- Authors
- Zorn, A. M., & Wells, J. M.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2009-11-01
- Volume
- 25
- Issue
- 1
- Pages
- 221-251
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- PMC
- PMC2861293
- OpenAlex
- W2137175341
- Cited by
- 812
- References
- 180
- Citations by year
- 2026: 35 · 2025: 51 · 2024: 49 · 2023: 45 · 2022: 64 · 2021: 64 · 2020: 56 · 2019: 57 · 2018: 58 · 2017: 52 · 2016: 52 · 2015: 39 · 2014: 41 · 2013: 49 · 2012: 46
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Child Health Research Foundation
- National Institute of General Medical Sciences (R01GM072915)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080823, R01DK070858, R01DK092456)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- endoderm development, organogenesis, organ specifications, respiratory tract development, gastrointestinal tract development, embryonic stem cell differentiation, vertebrate model organisms
- MeSH terms
- Animals, Endoderm, Humans, Vertebrates, Organogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
