Cited by 836NF-κB Signaling PathwaysInvertebrate Immune Response MechanismsImmune Response and Inflammation

The DOI matches its Crossref record.

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

Belvin, Marcia P., Anderson, Kathryn V.·1996·Annual Review of Cell and Developmental Biology

Open this paper in CoChat — free account

Abstract

▪ Abstract The Toll-Dorsal pathway in Drosophila and the interleukin-1 receptor (IL-1R)-NF-κB pathway in mammals are homologous signal transduction pathways that mediate several different biological responses. In Drosophila, genetic analysis of dorsal-ventral patterning of the embryo has defined the series of genes that mediate the Toll-Dorsal pathway. Binding of extracellular ligand activates the transmembrane receptor Toll, which requires the novel protein Tube to activate the cytoplasmic serine/threonine kinase Pelle. Pelle activity controls the degradation of the Cactus protein, which is present in a cytoplasmic complex with the Dorsal protein. Once Cactus is degraded in response to signal, Dorsal is free to move into the nucleus where it regulates transcription of specific target genes. The Toll, tube, pelle, cactus, and dorsal genes also appear to be involved in Drosophila immune response. Because the IL-1R-NF-κB pathway plays a role in vertebrate innate immunity and because plant homologues of the Toll-Dorsal pathway are important in plant disease resistance, it is likely that this pathway arose before the divergence of plants and animals as a defense against pathogens.

Integrity signals

Registry

Crossref · 10.1146/annurev.cellbio.12.1.393

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

No references could be resolved yet.

Research works printed but not linked: 106

10.1128/MCB.15.3.1294 · DOI
10.1016/0092-8674(85)90274-0 · DOI · Paper page
10.1038/311223a0 · DOI
Anderson KV, Nüsslein-Volhard C. 1986. Dorsal-group genes of Drosophila. InGametogenesis and the Early Embryo, ed. J Gall, pp. 177–94. New York: Liss
Åsling B, 1995, 36th Annu. Drosophila Res. Conf.
10.1016/0092-8674(88)90382-0 · DOI
10.1128/MCB.13.6.3301 · DOI
10.1101/gad.9.22.2736 · DOI
10.1038/376167a0 · DOI
10.1101/gad.9.7.783 · DOI · Paper page
Betts JC, 1993, J. Biol. Chem., 268, 25624, 10.1016/S0021-9258(19)74435-4 · DOI
10.1126/science.7878466 · DOI · Paper page
10.1126/science.271.5252.1128 · DOI
10.1101/gad.9.13.1586 · DOI
Ciechanover A, 1994, Biol. Chem. Hoppe-Seyler, 375, 565
10.1042/bj3000567 · DOI
10.1074/jbc.270.28.16514 · DOI
10.1128/MCB.15.3.1302 · DOI · Paper page
10.1006/jmbi.1993.1392 · DOI
Fey GH, Gauldie J. 1990. InProgress in Liver Disease, ed. H Topper, F Schaffner, pp. 89–116. Philadelphia: Saunders
Galindo RL, 1995, Development, 121, 2209, 10.1242/dev.121.7.2209 · DOI
10.1091/mbc.3.12.1339 · DOI
10.1016/0092-8674(92)90595-4 · DOI
Gerttula S, 1988, Genetics, 119, 123, 10.1093/genetics/119.1.123 · DOI
10.1128/MCB.14.6.3559 · DOI
10.1016/B978-0-08-030804-3.50017-0 · DOI
10.1128/MCB.16.3.1103 · DOI
10.1038/372563a0 · DOI
10.1006/dbio.1995.1134 · DOI
Hashimoto C, 1991, Development, 111, 1021, 10.1242/dev.111.4.1021 · DOI
10.1016/0092-8674(88)90516-8 · DOI
10.1016/0092-8674(91)90022-Q · DOI
10.1002/j.1460-2075.1993.tb05939.x · DOI
Hecht PM, 1993, Genetics, 135, 405, 10.1093/genetics/135.2.405 · DOI · Paper page
Heguy A, 1992, J. Biol. Chem., 267, 2605, 10.1016/S0021-9258(18)45924-8 · DOI
10.1038/365182a0 · DOI
10.1016/0092-8674(92)90083-O · DOI
10.1016/0952-7915(95)80022-0 · DOI
10.1016/0168-9525(93)90165-E · DOI
10.1016/0092-8674(91)90651-E · DOI
10.1016/0959-437X(94)90133-N · DOI
10.1101/gad.6.9.1728 · DOI
10.1101/gad.6.8.1518 · DOI
10.1016/0092-8674(93)90495-C · DOI
10.1073/pnas.91.12.5350 · DOI
10.1101/gad.6.4.619 · DOI
10.1128/MCB.15.4.2166 · DOI
10.1016/0092-8674(93)90402-C · DOI
10.1002/j.1460-2075.1992.tb05387.x · DOI · Paper page
10.1126/science.7973631 · DOI
10.1002/j.1460-2075.1993.tb05800.x · DOI
10.1002/j.1460-2075.1990.tb07878.x · DOI
10.1016/0092-8674(92)90596-5 · DOI
Koj A. 1985. Liver response to inflammation and synthesis of acute-phase plasma proteins. InThe Acute-Phase Response to Injury and Infection. Research Monographs in Cell and Tissue Physiology, ed. AH Gordon, A Koj, pp. 139–246. Amsterdam: Elsevier
10.1016/S0065-2776(08)60618-5 · DOI
10.1073/pnas.89.17.8145 · DOI
10.1073/pnas.92.22.10242 · DOI
10.1038/371175a0 · DOI
10.1002/j.1460-2075.1995.tb07029.x · DOI
10.1073/pnas.88.3.810 · DOI
10.1002/j.1460-2075.1993.tb06019.x · DOI
10.1073/pnas.92.2.552 · DOI
10.1016/0012-1606(79)90065-4 · DOI
10.1126/science.7902614 · DOI
10.1105/tpc.6.11.1543 · DOI
10.1002/eji.1830240717 · DOI
10.1073/pnas.90.21.10193 · DOI · Paper page
10.1073/pnas.91.26.12740 · DOI
10.1016/S0065-230X(08)60257-2 · DOI
10.1016/0092-8674(94)90507-X · DOI
10.1146/annurev.genet.29.1.371 · DOI
10.1016/0014-5793(95)00541-G · DOI
10.1101/gad.6.9.1654 · DOI
10.1016/0092-8674(92)90426-D · DOI
10.1101/gad.5.10.1892 · DOI
10.1016/0968-0004(94)90115-5 · DOI
10.1002/j.1460-2075.1995.tb07317.x · DOI
Rechsteiner M, 1990, Semin. Cell Biol., 1, 433
Reichhart JM, 1993, CR Acad. Sci. III, 316, 1218
10.1002/j.1460-2075.1992.tb05191.x · DOI
10.1128/MCB.15.5.2413 · DOI
10.1126/science.2876518 · DOI
Roth S, 1991, Development, 112, 371, 10.1242/dev.112.2.371 · DOI
10.1016/0092-8674(89)90774-5 · DOI
10.1016/0092-8674(89)90772-1 · DOI
10.1073/pnas.90.19.8842 · DOI
10.1073/pnas.92.24.11259 · DOI
10.1101/gad.5.5.797 · DOI · Paper page
Schneider DS, 1994, Development, 120, 1243, 10.1242/dev.120.5.1243 · DOI
10.1128/MCB.15.7.3960 · DOI
10.1016/0092-8674(95)90415-8 · DOI
10.1016/0092-8674(93)90071-W · DOI
10.1146/annurev.cb.10.110194.002201 · DOI
Sipe JD. 1985. Cellular and humoral components of the early inflammatory reaction. InThe Acute-Phase Response to Injury and Infection. Research Monographs in Cell and Tissue Physiology, ed. AH Gordon, A Koj, pp. 3–21. Amsterdam: Elsevier
10.1126/science.270.5243.1804 · DOI
10.1126/science.7732374 · DOI
10.1126/science.3118464 · DOI
10.1016/0092-8674(89)90773-3 · DOI
Sun SC, 1991, J. Biol. Chem., 266, 6644, 10.1016/S0021-9258(18)38165-1 · DOI
10.1128/MCB.15.7.3627 · DOI
10.1016/0092-8674(91)90014-P · DOI
10.1002/j.1460-2075.1994.tb06878.x · DOI
10.1016/0092-8674(95)90416-6 · DOI
10.1083/jcb.123.3.523 · DOI
10.1016/0092-8674(94)90283-6 · DOI
10.1016/0092-8674(95)90208-2 · DOI

Sorted by citations

Items 401–500 of 750

Toll-Like Receptors (TLRs) in Health and Disease: An Overview
Kumar, V., & Barrett, J. E. (2022) · Handbook of experimental pharmacology · doi:10.1007/164_2021_568 · Cited by 46
TmCactin plays an important role in Gram-negative and -positive bacterial infection by regulating expression of 7 AMP genes in Tenebrio molitor
Yong, H.-J., Kim, Y. J., Park, K., Seong, J. H., Kim, S., Park, S., Noh, M., Lee, Y. S., & Han, Y.-O.-S. (2017) · Scientific Reports · doi:10.1038/srep46459 · Cited by 40
Isolation and characterization of Toll-like receptor 9 in half-smooth tongue sole Cynoglossus semilaevis.
Yu, Y., Zhong, Q.-W., Li, C., Jiang, L.-M., Yan, F., Wang, Z.-G., & Zhang, Q.-Q. (2009) · Fish and Shellfish Immunology · doi:10.1016/j.fsi.2009.02.005 · Cited by 39
Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase
Tchivileva, I., Nackley, A. G., Qian, L., Wentworth, S. L., Conrad, M., & Diatchenko, L. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-13 · Cited by 39
“Probably, the best studied example of transcriptional repression by NF-κB complex is described for Dorsal transcription factor, a Drosophila Rel family member that can either activate or repress gene expression through the recruitment of coactivators such as CBP or corepressors such as Groucho [58].”
Background
TLR2 and TLR4 agonists synergistically up-regulate SR-A in RAW264.7 through p38.
Xu, W.-Y., Wang, L., Wang, H.-M., Wang, Y.-Q., Liang, Y.-F., Zhao, T.-T., & Wu, Y.-Z. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.11.013 · Cited by 39
SoxB1 downregulation in vegetal lineages of sea urchin embryos is achieved by both transcriptional repression and selective protein turnover
Angerer, L. M., Newman, L. A., & Angerer, R. C. (2005) · Development · doi:10.1242/dev.01650 · Cited by 33
“For example, the dorsal/Nfκb cytoplasmic tether cactus/Iκb is degraded in response to signaling through Toll/cytokine receptors (reviewed by Belvin and Anderson, 1996) and the stability of β-catenin itself is regulated through Wnt signaling (for a review, see Nelson and Nusse, 2004).”
Background
Crystal Structure and Functional Analysis of Drosophila Wind, a Protein-disulfide Isomerase-related Protein*
Ma, Q.-J., Guo, C.-S., Barnewitz, K., Sheldrick, G., Söling, H., Usón, I., & Ferrari, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307966200 · Cited by 39
Mycoplasma fermentans interaction with monocytes/macrophages: molecular basis.
Rawadi, G. (2000) · Microbes and infection · doi:10.1016/s1286-4579(00)00395-6 · Cited by 39
Motorneurons, reactive oxygen, and life span in Drosophila.
Parkes, T. L., Hilliker, A., & Phillips, J. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00086-x · Cited by 39
Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo.
Chen, L.-Y., Wang, J.-C., Hyvert, Y., Lin, H.-P., Perrimon, N., Imler, J., & Hsu, J. (2006) · Current Biology · doi:10.1016/j.cub.2006.05.050 · Cited by 38
“regulate the establishment of embryonic dorsoventral polarity [ 1-3 ].”
Background
Lessons from the fly: pattern recognition in Drosophila melanogaster.
Pal, S., & Wu, L. P. (2009) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4419-0901-5_11 · Cited by 38
Plant Disease Resistance: Progress in Basic Understanding and Practical Application
Keen, N. (1999) · doi:10.1016/s0065-2296(08)60230-x · Cited by 38
SARS‐CoV ‐2 biology and variants: anticipation of viral evolution and what needs to be done
Luo, R., Delaunay, A., Timmis, K. N., & Danchin, A. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15487 · Cited by 36
“This is witnessed, for example, by the discovery – unexpected at the time – of the role of Toll receptors in Drosophila (Belvin and Anderson, 1996).”
Background
A high‐sugar diet affects cellular and humoral immune responses in Drosophila
Yu, S., Zhang, G.-Q., & Jin, L.-H. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.04.032 · Cited by 37
Evidence for positive selection in the TLR9 gene of teleosts.
Chen, J. S., Wang, T.-Y., Tzeng, T.-D., Wang, C.-Y., & Wang, D. (2008) · Fish and Shellfish Immunology · doi:10.1016/j.fsi.2007.11.005 · Cited by 37
Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants
Araki, M., Kurihara, M., Kinoshita, S., Awane, R., Sato, T., Ohkawa, Y., & Inoue, Y. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.037721 · Cited by 36
“Once Cactus is degraded in response to the Toll signal, Dl proteins are free to translocate into the nucleus where they can induce the expression of antimicrobial peptide genes such as Drosomycin ( Drs ) (Belvin and Anderson, 1996; Brennan and Anderson, 2004; Fehlbaum et al., 1994; Hoffmann, 2003).”
Molecular characterization and expression patterns of a non-mammalian toll-like receptor gene (TLR21) in larvae ontogeny of common carp (Cyprinus carpio L.) and upon immune stimulation
Li, H., Li, T., Guo, Y.-J., Li, Y.-J., Zhang, Y., Teng, N., Zhang, F.-M., & Yang, G.-W. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1474-4 · Cited by 36
Structure and regulation of cytoplasmic adapter proteins involved in innate immune signaling
Monie, T., Moncrieffe, M. C., & Gay, N. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00735.x · Cited by 36
“DD-containing proteins and their interactions are crucial for the transduction of signals from the activated Toll receptor in both immunological and developmental contexts (28).”
Background
The Drm-Bowl-Lin relief-of-repression hierarchy controls fore- and hindgut patterning and morphogenesis.
Johansen, K. A., Green, R. B., Iwaki, D., Hernandez, J. B., & Lengyel, J. (2003) · Mechanisms of Development · doi:10.1016/j.mod.2003.08.001 · Cited by 36
Advances in the Immune Regulatory Role of Non-Coding RNAs (miRNAs and lncRNAs) in Insect-Pathogen Interactions
Moure, U. A. E., Tan, T., Sha, L., Lu, X., Shao, Z., Yang, G., Wang, Y., & Cui, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.856457 · Cited by 36
Regulation of the expression of nine antimicrobial peptide genes by TmIMD confers resistance against Gram-negative bacteria
Yong, H.-J., Patnaik, B., Hwang, J.-C., Park, K., Ko, H. J., Kim, C. E., Bae, Y., Jung, W.-J., Lee, Y. S., & Han, Y.-O.-S. (2019) · Scientific Reports · doi:10.1038/s41598-019-46222-8 · Cited by 35
The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injury.
Cao, Z., Hu, Y., Wu, W., Ha, T., Kelley, J., Deng, C., Chen, Q., Li, C., Li, J., & Li, Y.-H. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp234 · Cited by 35
Origin, Diversity, Expansion History, and Functional Evolution of the Plant Receptor-Like Kinase/Pelle Family
Lehti‐Shiu, M. D., Zou, C., & Shiu, S. (2011) · Signaling and communication in plants · doi:10.1007/978-3-642-23044-8_1 · Cited by 38
“melanogaster Pelle is a cytoplasmic kinase that is part of signaling networks involving Toll, a transmembrane receptor without a kinase domain, mediating both innate immunity and development (Hecht and Anderson 1993; Shelton and Wasserman 1993; Belvin and Anderson 1996).”
BackgroundInfluential
Arabidopsis : A weed leading the field of plant-pathogen interactions
Buell, C. (1998) · doi:10.1016/s0981-9428(98)80102-2 · Cited by 35
Molecular cloning and expression analysis of Relish gene from the ridgetail white prawn Exopalaemon carinicauda
Ge, Q.-Q., Liang, J.-P., Li, J.-T., Li, J., Duan, Y.-F., Zhao, F., & Ren, H. (2015) · Fisheries Science · doi:10.1007/s12562-015-0898-z · Cited by 34
Silencing of Pellino1 improves post-infarct cardiac dysfunction and attenuates left ventricular remodelling in mice.
Wu, W., Hu, Y.-P., Li, J.-T., Zhu, W.-N., Ha, T., Que, L., Liu, L., Zhu, Q., Chen, Q., Xu, Y., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu007 · Cited by 34
Does inflammatory acne result from imbalance in the keratinocyte innate immune response?
Grange, P., Weill, B., Dupin, N., & Batteux, F. (2010) · Microbes and infection · doi:10.1016/j.micinf.2010.07.015 · Cited by 34
Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity
Inaki, M., Shinza-Kameda, M., Ismat, A., Frasch, M., & Nose, A. (2010) · Development · doi:10.1242/dev.046672 · Cited by 33
“Toll has been shown to function as a receptor, not a ligand, in other systems, such as in dorsoventral patterning and innate immunity (Belvin and Anderson, 1996; Imler and Hoffmann, 2001).”
Early experience with novel immunomodulators for cancer treatment
Thotathil, Z., & Jameson, M. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.9.1391 · Cited by 33
“Ligand binding is able to initiate a signalling pathway that is similar to the mammalian NFκ B activation cascade [21] .”
Background
Is innate enough? The innate immune response in Drosophila.
Irving, P., Troxler, L., & Hétru, C. (2004) · Comptes rendus. Biologies · doi:10.1016/j.crvi.2004.03.007 · Cited by 33
“Using transgenically modiﬁed ﬂies it was established that these motifs were essential responses had close similarities to those of the Toll signalling pathway, a pathway ﬁrst described for its dorso-ventral patterning role during early embryogenesis in Drosophila (reviewed in [11]).”
Background
Fatty acid synthase plays a positive role in shrimp immune responses against Vibrio parahaemolyticus infection
Zuo, H.-L., Gao, J.-F., Yuan, J., Deng, H., Yang, L.-W., Weng, S., He, J.-G., & Xu, X.-P. (2017) · Fish and Shellfish Immunology · doi:10.1016/j.fsi.2016.11.054 · Cited by 33
The role of faecal microbiota transplantation: looking beyond Clostridioides difficile infection
Goldenberg, S. D., & Merrick, B. (2021) · Therapeutic Advances in Infectious Disease · doi:10.1177/2049936120981526 · Cited by 28
TmToll-7 Plays a Crucial Role in Innate Immune Responses Against Gram-Negative Bacteria by Regulating 5 AMP Genes in Tenebrio molitor
Park, S., Yong, H.-J., Park, K., Ko, H. J., Kim, C. E., Bae, Y., Kim, B., Jun, S.-A., Bang, I., Lee, Y. S., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00310 · Cited by 32
Validation of growth enhancing, immunostimulatory and disease resistance properties of Achyranthes aspera in Labeo rohita fry in pond conditions
Kumar, N., Sharma, J., Singh, S., Singh, A. K., Krishna, V. H., & Chakrabarti, R. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01246 · Cited by 45
Knockdown of genes in the Toll pathway reveals new lethal RNA interference targets for insect pest control
Bingsohn, L., Knorr, E., Billion, A., Narva, K., & Vilcinskas, A. (2017) · Insect molecular biology (Print) · doi:10.1111/imb.12273 · Cited by 32
“Cact is also required for dorsoventral patterning in Drosophila melanogaster embryos (Belvin & Anderson, 1996; Lemaitre, 2004), where it inhibits the activity of the dorsal (dl) and Dorsalrelated immunity factor (Dif) gene products (Valanne et al., 2011).”
Background
Aeromonas salmonicidaInfection Only Moderately Regulates Expression of Factors Contributing to Toll-Like Receptor Signaling but Massively Activates the Cellular and Humoral Branches of Innate Immunity in Rainbow Trout (Oncorhynchus mykiss)
Brietzke, A., Korytář, T., Jaros, J., Köllner, B., Goldammer, T., Seyfert, H., & Rebl, A. (2015) · Journal of Immunology Research · doi:10.1155/2015/901015 · Cited by 35
“This TLR-MYD88-IRAK-TRAF6 signaling pathway is well conserved, not only in vertebrates but also in Drosophila [11, 12].”
Background
DmMyD88 controls dorsoventral patterning of the Drosophila embryo
Kambris, Z., Bilak, H., D'Alessandro, R., Belvin, M., Imler, J., & Capovilla, M. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor714 · Cited by 32
“Genetic screens have led to the identification of maternal effect genes involved in the generation, transmission and interpretation of the signals specifying dorsoventral polarity in the embryo (reviewed in Belvin & Anderson, 1996).”
InfluentialSelf-citation
Dendritic Cells and Natural Killer Cells in the Pathogenesis of HIV Infection
Fortis, C., & Poli, G. (2005) · Immunologic Research · doi:10.1385/ir:33:1:001 · Cited by 26
The αβ/γδ Lineage Decision
Hoffman, E. S., Passoni, L., Dudley, E., Girardi, M., & Hayday, A. (1998) · Humana Press eBooks · doi:10.1007/978-1-4757-2778-4_19 · Cited by 32
The IMD and Toll canonical immune pathways of Triatoma pallidipennis are preferentially activated by Gram-negative and Gram-positive bacteria, respectively, but cross-activation also occurs
Alejandro, A.-D., Lilia, J.-P., Jesús, M.-B., & Henry, R. M. (2022) · Parasites & Vectors · doi:10.1186/s13071-022-05363-y · Cited by 31
“The Toll pathway involves molecules with some parallels to mammalian signaling cascades like the interleukin-1 receptor (IL-1R) and the Toll-like receptors (TLRs) [15].”
Background
Evolution of Toll, Spatzle and MyD88 in insects: the problem of the Diptera bias
Lima, L. F., Torres, A. Q., Jardim, R., Mesquita, R. D., & Schama, R. (2021) · BMC Genomics · doi:10.1186/s12864-021-07886-7 · Cited by 32
“The Toll pathway has first been described as part of the developmental pathway for dorsal-ventral differentiation in Drosophila [36, 37].”
Background
Subpopulation of Macrophage-Like Plasmatocytes Attenuates Systemic Growth via JAK/STAT in the Drosophila Fat Body
Shin, M., Cha, N., Koranteng, F., Cho, B., & Shim, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00063 · Cited by 31
The genomic and transcriptomic analyses of serine proteases and their homologs in an endoparasitoid, Pteromalus puparum.
Yang, L., Lin, Z., Fang, Q., Wang, J.-L., Yan, Z.-C., Zou, Z., Song, Q.-S., & Ye, G.-Y. (2017) · Developmental and Comparative Immunology · doi:10.1016/j.dci.2017.07.014 · Cited by 31
“In Drosophila melanogaster, genetic analyses reveal that a series of genes in 64 the SP pathways are involved in mediating the Toll-D rsal patterning of embryo for 65 ventralization and activating AMP productions (Belvin and Anderson, 1996; Kambris 66 et al., 2006).”
Background
Toll-like receptors: a family of innate sensors of danger that alert and drive immunity
Vega, M. T. M., & de‐Andrés‐Martín, A. (2008) · Allergologia et Immunopathologia · doi:10.1016/s0301-0546(08)75868-3 · Cited by 27
Expression of 18‐wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila
Kleve, C. D., Siler, D. A., Syed, S. K., & Eldon, E. D. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20820 · Cited by 31
Proteolysis and developmental signal transduction
Ye, Y., & Fortini, M. (2000) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2000.0167 · Cited by 25
Muscle structure and innervation are affected by loss of Dorsal in the fruit fly, Drosophila melanogaster.
Cantera, R., Козлова, Т. У., Barillas-Mury, C., & Kafatos, F. (1999) · Molecular and cellular neurosciences · doi:10.1006/mcne.1999.0739 · Cited by 31
Next-Generation Sequencing and the Crustacean Immune System: The Need for Alternatives in Immune Gene Annotation.
Clark, K. F., & Greenwood, S. (2016) · Integrative and Comparative Biology · doi:10.1093/icb/icw023 · Cited by 30
Pathogenic Strains of Acanthamoeba Are Recognized by TLR4 and Initiated Inflammatory Responses in the Cornea
Alizadeh, H., Tripathi, T., Abdi, M., & Smith, A. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092375 · Cited by 30
“TLR family members are transmembrane proteins containing repeated leucine-rich motifs in their extracellular portions, similar to other pattern recognition proteins of the innate immune system [37,38].”
Background
Salicylic acid and NIM1/NPR1-independent gene induction by incompatible Peronospora parasitica in arabidopsis.
Rairdan, G. J., Donofrio, N., & Delaney, T. (2001) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi.2001.14.10.1235 · Cited by 30
Negotiations between animals and bacteria: the 'diplomacy' of the squid-vibrio symbiosis.
McFall-Ngai, M. (2000) · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · doi:10.1016/s1095-6433(00)00233-6 · Cited by 30
Mesoderm-determining transcription in Drosophila is alleviated by mutations in TAF(II)60 and TAF(II)110.
Pham, A.-D., Müller, S., & Sauer, F. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00051-9 · Cited by 30
PYRIN domains and their interactions in the apoptosis and inflammation signaling pathway
Park, H. H. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0775-5 · Cited by 30
The fruit fly Drosophila melanogaster unfolds the secrets of innate immunity
Rämet, M. (2012) · Acta paediatrica · doi:10.1111/j.1651-2227.2012.02740.x · Cited by 29
“mutagenesis screen of Kathryn Anderson and Christiane Nüsslein-Volhard (3).”
BackgroundInfluential
Differential expression of Toll-like receptors in follicular lymphoma, diffuse large B-cell lymphoma and peripheral T-cell lymphoma
Smith, T. J., Yamamoto, K., Kurata, M., Yukimori, A., Suzuki, S., Umeda, S., Sugawara, E., Kojima, Y., Sawabe, M., Nakagawa, Y., et al. (2010) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2010.08.003 · Cited by 23
Point, Counterpoint: The Evolution of Pathogenic Viruses and their Human Hosts
Worobey, M., Bjork, A., & Wertheim, J. O. (2007) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev.ecolsys.38.091206.095722 · Cited by 27
“…pathway was first identified in Drosophila for its role in establishing dorsal-ventral polarity in the developing embryo (Hashimoto et al. 1988), but it was later hypothesized (Belvin & Anderson 1996) and confirmed (Lemaitre et al. 1996) to play an important role in innate immunity as well.”
Background
EcoGenomics--a consilience for comparative immunology?
Chapman, R. (2001) · Developmental and Comparative Immunology · doi:10.1016/s0145-305x(01)00045-3 · Cited by 29
The Immune-Pineal Axis: the Role of Pineal and Extra-Pineal Melatonin in Modulating Inflammation
Markus, R. P., & Ferreira, Z. S. (2011) · Advances in Neuroimmune Biology · doi:10.3233/nib-2011-009 · Cited by 34
“is the NFKB transduction pathway, which occurs in phylogenetically distinct species from insects to mammals [33–35].”
Toll-Like Receptor Family Members and Their Ligands
Beutler, B., & Wagner, H. (2002) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-59430-4 · Cited by 29
Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures
Takahashi, J. B., Palmer, T. D., & Gage, F. H. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199901)38:1 · Cited by 418
Beyond TLR Signaling—The Role of SARM in Antiviral Immune Defense, Apoptosis & Development
Panneerselvam, P., & Ding, J. (2015) · International Reviews of Immunology · doi:10.3109/08830185.2015.1065826 · Cited by 28
“The Toll pathway in Drosophila was initially identified to be important for dorsal-ventral patterning of the embryo [66].”
Background
Evolutionary, Structural and Functional Interplay of the IκB Family Members
Basith, S., Manavalan, B., Gosu, V., & Choi, S.-D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054178 · Cited by 28
“Cactus is a Drosophila homolog of mammalian IkB proteins which forms cytoplasmic complexes with NF-kB [11].”
Background
Evo-devo aspects of classical and molecular data in a historical perspective.
Sander, K., & Schmidt-Ott, U. (2004) · Journal of Experimental Zoology Part B: Molecular and Developmental Evolution · doi:10.1002/jez.b.20003 · Cited by 28
AP-1, but not NF-κB, is required for efficient steroid-triggered cell death in Drosophila
Lehmann, M., Jiang, C., Ip, Y. T., & Thummel, C. S. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401003 · Cited by 26
Cactus‐independent nuclear translocation of Drosophila RELISH
Cornwell, W. D., & Kirkpatrick, R. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1144 · Cited by 28
“…the Toll receptor pathway with dif being implicated only in the immune response [Meng et al., 1999] and dorsal having a dual function regulating both dorsoventral polarity and antimicrobial responses [Kylsten et al., 1990; Reichhart et al., 1993; Lemaitre et al., 1995; Belvin and Anderson, 1996].”
Background
Effects of different temperatures and protein levels on growth performance, physiological response and expression of immune-related genes of juvenile oriental river prawn (Macrobrachium nipponense)
Lv, B., Liu, B., Zhou, Q.-L., Song, C.-Y., Sun, C.-X., Zhang, H.-M., Jiang, Z.-T., Jiang, S.-F., & Liu, M. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736435 · Cited by 27
S100A4 Elevation Empowers Expression of Metastasis Effector Molecules in Human Breast Cancer
Ismail, T. M., Bennett, D., Platt-Higgins, A., Al-Medhity, M., Barraclough, R., & Rudland, P. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1802 · Cited by 27
Terminal tendon cell differentiation requires the glide/gcm complex
Soustelle, L., Jacques, C., Altenhein, B., Technau, G., Volk, T., & Giangrande, A. (2004) · Development · doi:10.1242/dev.01290 · Cited by 27
“While dorso/ventral (D/V) patterning contribution to stripe expression and tendon cell differentiation is not yet elucidated, a microarray study has identified glide as a target of Dorsal (Stathopoulos and Levine, 2002), the maternally provided D/V patterning factor (Belvin and Anderson, 1996).”
Background
Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Liebermann, D., & Hoffman, B. (2003) · Oncogene · doi:10.1016/s1079-9796(03)00160-8 · Cited by 27
Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA.
Cramer, P., Varrot, A., Barillas-Mury, C., Kafatos, F., & Müller, C. W. (1999) · Structure · doi:10.1016/s0969-2126(99)80107-5 · Cited by 27
“An extracellular peptide ligand binds to and activates the Toll receptor [9,12] leading to phosphorylation of Cactus, a member of the IκB family [13], disruption of the Cactus–Rel protein complex and nuclear translocation of the Rel protein.”
The I kappa B kinase: a master regulator of NF-kappa B, innate immunity, and epidermal differentiation.Preprint
Delhase, M., & Karin, M. (1999) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1999.64.491 · Cited by 27
Current Status of Immune Deficiency Pathway in Tenebrio molitor Innate Immunity
Jang, H., Kojour, M. A. M., Patnaik, B., Han, Y.-O.-S., & Yong, H.-J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.906192 · Cited by 26
Co-expression of Dorsal and Rel2 Negatively Regulates Antimicrobial Peptide Expression in the Tobacco Hornworm Manduca sexta
Zhong, X. Y., Rao, X., Yi, H., Lin, X., Huang, X., & Yu, X. (2016) · Scientific Reports · doi:10.1038/srep20654 · Cited by 24
The first Toll receptor from the triangle-shell pearl mussel Hyriopsis cumingii.
Ren, Q., Zhong, X., Yin, S., Hao, F.-Y., Hui, K., Zhang, Z., Zhang, C.-Y., Yu, X.-Q., & Wang, W. (2013) · Fish and Shellfish Immunology · doi:10.1016/j.fsi.2013.02.014 · Cited by 26
Structure of Toll-Like Receptors
Gay, N. J., & Gangloff, M. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72167-3_9 · Cited by 25
“The DNA sequence of these clones revealed that the proteins they encoded had a modular structure similar to that of the Drosophila Toll, a type I transmembrane receptor that functions in dorsoventral patterning and innate immunity in the insect (Belvin and Anderson, 1996; Imler and Hoffmann, 2001).”
Background
The inhibitorκB-ortholog Cactus is necessary for normal neuromuscular function in Drosophila melanogaster
Beramendi, A., Peron, S., Megighian, A., Reggiani, C., & Cantera, R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.046 · Cited by 26
The use ofDrosophila melanogasteras a model organism to study immune-nanotoxicity
Ng, C. T., Yu, L. E., Ong, C. N., Bay, B., & Baeg, G. H. (2018) · Nanotoxicology · doi:10.1080/17435390.2018.1546413 · Cited by 31
“Importantly, this implies that both human and Drosophila use Toll/IL1R-induced activation of the NF-jB pathway for innate immunity (Belvin and Anderson, 1996).”
Background
Calpain A modulates Toll responses by limited Cactus/IκB proteolysis
Fontenele, M., Lim, B., Oliveira, D., Buffolo, M., Perlman, D. H., Schüpbach, T., & Araujo, H. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-02-0113 · Cited by 25
“On receptor oligomerization, the adaptor proteins dMyD88 and Tube recruit the Pelle kinase to the plasma membrane (Belvin and Anderson, 1996; Sun et al., 2002, 2004; Marek and Kagan, 2012).”
Background
IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin.
Chakravorty, M., De, D. D., Choudhury, A., & Roychoudhury, S. (2009) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2008.12.017 · Cited by 25
“Sitcheran R, Gupta P, Fisher PB, Baldwin AS. Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression.”
Background
Synaptic activity modifies the levels of Dorsal and Cactus at the neuromuscular junction of Drosophila.
Bolatto, C., Chifflet, S., Megighian, A., & Cantera, R. (2003) · Journal of Neurobiology · doi:10.1002/neu.10179 · Cited by 25
Molecular cloning and expression of a Toll receptor gene homologue from the silkworm, Bombyx mori.
Imamura, M., & Yamakawa, M. (2002) · Biochimica et Biophysica Acta · doi:10.1016/s0167-4781(02)00336-6 · Cited by 25
Identification, expression pattern and functional characterization of As-MyD88 in bacteria challenge and during different developmental stages of Artemia sinica.
Qin, T., Zhao, X.-X., Luan, H.-F., Ba, H., Yang, L., Li, Z.-I., Hou, L., & Zou, X.-Y. (2015) · Developmental and Comparative Immunology · doi:10.1016/j.dci.2014.12.013 · Cited by 24
“Toll was initially recognized as a protein closely related to the Drosophila embryo anterior– posterior axis development (Belvin and Anderson, 1996).”
Background
Large-scale RNAi screens add both clarity and complexity to Drosophila NF-κB signaling.
Valanne, S., Kallio, J., Kleino, A., & Rämet, M. (2012) · Developmental and Comparative Immunology · doi:10.1016/j.dci.2011.09.001 · Cited by 24
Receptors and signalling components of plant hormones.
Iten, M., Hoffmann, T., & Grill, E. (1999) · Journal of Receptor and Signal Transduction Research · doi:10.3109/10799899909036636 · Cited by 24
Structurally diverse genes encode TLR13 in Nile tilapia: The two receptors can recognize Streptococcus 23S RNA and conduct signal transduction through MyD88.
Gao, F.-Y., Pang, J.-C., Wang, M., Lu, M.-X., Liu, Z.-G., Cao, J.-M., Ke, X., & Yi, M.-M. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.01.020 · Cited by 23
Characterization of Spz5 as a novel ligand for Drosophila Toll-1 receptor.
Nonaka, S., Kawamura, K., Hori, A., Salim, E., Fukushima, K., Nakanishi, Y., & Kuraishi, T. (2018) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2018.10.096 · Cited by 23
Repression of B-Cell Linker (BLNK) and B-Cell Adaptor for Phosphoinositide 3-Kinase (BCAP) Is Important for Lymphocyte Transformation by Rel Proteins
Gupta, N., Delrow, J. J., Drawid, A., Sengupta, A. M., Fan, G., & Gélinas, C. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3169 · Cited by 21
“Interaction with other transcription factors might also influence the transcriptional outcome, as shown for the Drosophila NF-nB protein Dorsal that is converted from a transcriptional activator into a repressor via interaction with DSP1 ( 40 ).”
Background
A toll for T cell costimulation
Liew, F., Komai-Koma, M., & Xu, D.-M. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.028308 · Cited by 23
Characterization of a homologue of the Rel/NF-kappaB transcription factor from a beetle, Allomyrina dichotoma.
Sagisaka, A., Tanaka, H., Furukawa, S., & Yamakawa, M. (2004) · Biochimica et Biophysica Acta · doi:10.1016/j.bbaexp.2004.02.001 · Cited by 23
Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis
Gofflot, F., Gaoua, W., Bourguignon, L., Roux, C., & Picard, J. J. (2001) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 27
Invertebrate Immunity, Natural Transplantation Immunity, Somatic and Germ Cell Parasitism, and Transposon Defense
Kloc, M., Hałasa, M., Kubiak, J. Z., & Ghobrial, R. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021072 · Cited by 25
A Toll-dependent Bre1/Rad6-cact feedback loop in controlling host innate immune response
Cai, Q., Guo, H., Fang, R., Hua, Y., Zhu, Y., Zheng, X., Yan, J., Wang, J., Hu, Y., Zhang, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111795 · Cited by 23
Latitudinal divergence in a widespread amphibian: Contrasting patterns of neutral and adaptive genomic variation
Rödin‐Mörch, P., Luquet, É., Meyer-Lucht, Y., Richter‐Boix, À., Höglund, ‎., & Laurila, A. (2019) · Molecular Ecology · doi:10.1111/mec.15132 · Cited by 24
“While the functions of ECSIT in amphibians are unknown, the innate immunity mediating Toll signalling path‐ way is evolutionary conserved across various groups of organisms (Belvin & Anderson, 1996; Ding, Chen, Kang, Jiang, & Kang, 2014; Medzhitov et al., 1998).”
Background
Toll ligand Spätzle3 controls melanization in the stripe pattern formation in caterpillars
KonDo, Y., Yoda, S., Mizoguchi, T., Ando, T., Yamaguchi, J., Yamamoto, K., Banno, Y., & Fujiwara, H. (2017) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1707896114 · Cited by 22
“It has been reported that Spz-1 works as a ligand of Toll-1 and that the Toll signaling pathway is involved in dorsoventral axis formation (19), muscle development during embryogenesis (32), and the induction of antimicrobial peptide expression in innate immunity (33, 34) (Fig.”
Background
Differential gene expression in silkworm in response to Beauveria bassiana infection.
Hou, C.-X., Qin, G.-X., Liu, T., Mei, X.-L., Zhang, R., Zhao, P.-J., Shen, Z.-Y., & Guo, X.-J. (2011) · Gene · doi:10.1016/j.gene.2011.05.023 · Cited by 22
Dorsal and Snail homologs in leech development
Goldstein, B., Leviten, M. W., & Weisblat, D. A. (2001) · Development Genes and Evolution · doi:10.1007/s004270100160 · Cited by 22
“We note that the entire HRO-DL and HRO-SNA embryonic localization patterns are consistent with the possibility that HRO-DL activates expression of Hro-sna, as is the case for Drosophila Dorsal and Snail (Belvin and Anderson 1996; Rusch and Levine 1996).”
BackgroundInfluential
Transcriptome-wide identification, functional characterization, and expression analysis of two novel invertebrate-type Toll-like receptors from disk abalone (Haliotis discus discus)
Priyathilaka, T. T., Bathige, S. D. N. K., Lee, S., Nam, B., & Lee, J. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.10.062 · Cited by 34
Analogies Between Drosophila and Mammalian TRAF Pathways
Wajant, H., & Scheurich, P. (2003) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-18670-7_3 · Cited by 24
“The Toll pathway has been originally identified due to its pivotal role in the dorsoventral patterning of the Drosophila embryo (Belvin and Anderson 1996).”
Background
BmToll9-1 Is a Positive Regulator of the Immune Response in the Silkworm Bombyx mori
Liu, J.-S., Chen, W., Situ, J., Li, J.-X., Chen, J., Lai, M., Huang, F., & Li, B. (2024) · Insects · doi:10.3390/insects15090643 · Cited by 21
Recent Advances in Researches on Shrimp Immune Pathway Involved in White Spot Syndrome Virus Genes Regulation
Chen, Y.-H., Li, X.-Y., & He, J.-G. (2014) · doi:10.4172/2155-9546.1000228 · Cited by 21

Authors: Belvin, M. P., & Anderson, K. V.
Affiliations: University of California, Berkeley (US)
ORCID: Belvin, Marcia P.
Anderson, Kathryn V.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 1996-11
Volume: 12
Issue: 1
Pages: 393-416
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.12.1.393
OpenAlex: W2098336582
Cited by: 836
References: 0
Citations by year: 2026: 7 · 2025: 14 · 2024: 24 · 2023: 18 · 2022: 23 · 2021: 22 · 2020: 12 · 2019: 21 · 2018: 23 · 2017: 17 · 2016: 17 · 2015: 24 · 2014: 24 · 2013: 25 · 2012: 19
FWCI: 5.77
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: Drosophila, Toll receptor, tubes, dorsoventral patterning, embryonic patterning, innate immunity, interleukin-1 receptor, NF-κB, evolution of signaling pathways, plant disease resistance, conserved signaling pathways
MeSH terms: Animals, Drosophila, Signal Transduction, Gene Expression Regulation, Developmental

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks