Cited by 836NF-κB Signaling PathwaysInvertebrate Immune Response MechanismsImmune Response and Inflammation

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A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

Belvin, Marcia P., Anderson, Kathryn V.·1996·Annual Review of Cell and Developmental Biology

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Abstract

▪ Abstract The Toll-Dorsal pathway in Drosophila and the interleukin-1 receptor (IL-1R)-NF-κB pathway in mammals are homologous signal transduction pathways that mediate several different biological responses. In Drosophila, genetic analysis of dorsal-ventral patterning of the embryo has defined the series of genes that mediate the Toll-Dorsal pathway. Binding of extracellular ligand activates the transmembrane receptor Toll, which requires the novel protein Tube to activate the cytoplasmic serine/threonine kinase Pelle. Pelle activity controls the degradation of the Cactus protein, which is present in a cytoplasmic complex with the Dorsal protein. Once Cactus is degraded in response to signal, Dorsal is free to move into the nucleus where it regulates transcription of specific target genes. The Toll, tube, pelle, cactus, and dorsal genes also appear to be involved in Drosophila immune response. Because the IL-1R-NF-κB pathway plays a role in vertebrate innate immunity and because plant homologues of the Toll-Dorsal pathway are important in plant disease resistance, it is likely that this pathway arose before the divergence of plants and animals as a defense against pathogens.

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Authors: Belvin, M. P., & Anderson, K. V.
Affiliations: University of California, Berkeley (US)
ORCID: Belvin, Marcia P.
Anderson, Kathryn V.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 1996-11
Volume: 12
Issue: 1
Pages: 393-416
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.12.1.393
OpenAlex: W2098336582
Cited by: 836
References: 0
Citations by year: 2026: 7 · 2025: 14 · 2024: 24 · 2023: 18 · 2022: 23 · 2021: 22 · 2020: 12 · 2019: 21 · 2018: 23 · 2017: 17 · 2016: 17 · 2015: 24 · 2014: 24 · 2013: 25 · 2012: 19
FWCI: 5.77
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: Drosophila, Toll receptor, tubes, dorsoventral patterning, embryonic patterning, innate immunity, interleukin-1 receptor, NF-κB, evolution of signaling pathways, plant disease resistance, conserved signaling pathways
MeSH terms: Animals, Drosophila, Signal Transduction, Gene Expression Regulation, Developmental

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A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

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