Cited by 4,766NF-κB Signaling PathwaysImmune Response and InflammationSignaling Pathways in Disease

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Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

Karin, Michael, Ben-Neriah, Yinon·2000·Annual Review of Immunology

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Abstract

NF-kappaB (nuclear factor-kappaB) is a collective name for inducible dimeric transcription factors composed of members of the Rel family of DNA-binding proteins that recognize a common sequence motif. NF-kappaB is found in essentially all cell types and is involved in activation of an exceptionally large number of genes in response to infections, inflammation, and other stressful situations requiring rapid reprogramming of gene expression. NF-kappaB is normally sequestered in the cytoplasm of nonstimulated cells and consequently must be translocated into the nucleus to function. The subcellular location of NF-kappaB is controlled by a family of inhibitory proteins, IkappaBs, which bind NF-kappaB and mask its nuclear localization signal, thereby preventing nuclear uptake. Exposure of cells to a variety of extracellular stimuli leads to the rapid phosphorylation, ubiquitination, and ultimately proteolytic degradation of IkappaB, which frees NF-kappaB to translocate to the nucleus where it regulates gene transcription. NF-kappaB activation represents a paradigm for controlling the function of a regulatory protein via ubiquitination-dependent proteolysis, as an integral part of a phosphorylationbased signaling cascade. Recently, considerable progress has been made in understanding the details of the signaling pathways that regulate NF-kappaB activity, particularly those responding to the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1. The multisubunit Ika…

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Gadelkarim, M., Elsayed, A., Nazir, A., Elsayed, Y., Habashneh, A., Iqbal, O., & Rawashdeh, B. (2026) · Immunologic research · doi:10.1007/s12026-026-09756-4 · Cited by 2
The infection–microbiome–immunity axis in bladder cancer: mechanistic insights and therapeutic perspectives
Shen, P., Cui, W., Lin, J., Wang, Z., Li, Z., & Liu, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1716230 · Cited by 2
Resolvin D1 Modulates the Inflammatory Processes of Human Periodontal Ligament Cells via NF-κB and MAPK Signaling Pathways
Yan, J., Cai, J., Pan, X., Li, S.-R., Fenton, C. G., Fenton, K., Kantarcı, A., Xue, Y.-X., Xue, Y., & Xing, Z. (2025) · Biomedicines · doi:10.3390/biomedicines13123038 · Cited by 2
“During the resting state, NF-κ B is normally confined to the cytoplasm due to its binding to the inhibitor protein I κ B. NF-κ B dimers are released and moved to the nucleus when IKK phosphorylates inhibitor protein I κ B, leading to its degradation [56,57].”
IKBKE modulates autophagy and progestin resistance in endometrial cancer
Wang, J., & Kong, X.-C. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1590966 · Cited by 2
The Role of Ubiquitination and Deubiquitination in the Pathogenesis of Acute Kidney Injury: Progress in Research
Zhou, Y., Tao, S., Liu, L., & Zhang, L. (2025) · Biomedicines · doi:10.3390/biomedicines13122873 · Cited by 2
Newly synthesized pyranopyrazole nicotinamides derivatives as potent anti-inflammatory agents: In-silico, in-vitro, and in-vivo studies.
Rizk, H., Beltagy, D., Ibrahim, S. A., El-Sayed, H. M., Fares, A. K., & Salem, M. M. (2025) · Bioorganic chemistry (Print) · doi:10.1016/j.bioorg.2025.109205 · Cited by 2
Imidacloprid induces abnormal glucose metabolism through NF-κB-mediated apoptosis of pancreatic β cells based on population exposure levels
Zhang, Z., Fu, J., Li, H., Li, H., Wu, B., Tian, X., Li, M., Dai, Y., Shen, Z., Jia, J., et al. (2025) · Environmental Research · doi:10.1016/j.envres.2025.123171 · Cited by 2
Deciphering the enigma: long noncoding RNAs in disease pathogenesis and therapeutic prospects
Ramesh, P., Muthyala, P., & Kali, S. K. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05368-y · Cited by 3
“Activation leads to the phosphorylation and degradation of IκB proteins by the IκB kinase (IKK) complex, resulting in the release and nuclear translocation of active NF-κB dimers, often including the p50 and RelA (p65) subunits, to activate gene transcription [27].”
Mechanisms and targeted treatments of cobalt-encephalopathy from cobalt-chromium orthopedic implants
Wu, T., Li, H., & Chen, W. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.08.008 · Cited by 3
Unraveling the Effects of Epigallocatechin-3-gallate on Hepatocellular Carcinoma Cells: A Comparative Analysis of Monolayer vs Multicellular Tumor Spheroids
Simpronio, M. D. R., Machado, A. R. T., dos Santos, P. W. D. S., Ribeiro, D. L., Antunes, L. M. G., & Aissa, A. F. (2025) · ACS Omega · doi:10.1021/acsomega.5c00839 · Cited by 3
PPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation
Fang, Q., Liu, B., Cen, J., Li, T.-T., Ji, S.-H., Li, W.-Q., Lu, G., Chen, Z.-J., Wang, X., Bao, J.-Q., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08539-1 · Cited by 2
INO10, a Chaga Mushroom Extract, Alleviates Alzheimer’s Disease-Related Pathology and Cognitive Deficits in 3xTg-AD Mice
Ban, S., Do, T., Pyo, J.-W., Moon, M.-H., & Park, J.-T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104729 · Cited by 2
Chromatin-associated cullin-RING E3 ubiquitin ligases: keeping transcriptionally active NF-κB in check
Gong, M., Luo, J., Liang, Q., Liu, Y., Zheng, Y., & Yang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1584999 · Cited by 2
“Five NF-k B subunits, p50, p52, RelA (p65), RelB and c-Rel assemble into hetero-or homo-dimers in a context-dependent manner with the RelA/p50 heterodimer being the most common form functioning in the classical NF-k B pathway (3, 4).”
Salvianolic acid B (SalB) improves high-fat diet (HFD)-caused cognitive impairment in mice by modulating the Trem2/Dap12 pathway in vivo and in vitro
Li, H., Zheng, J., Tan, K.-W., Su, J., Chen, W., Pang, R.-K., Wu, G., Qiu, Y.-H., Li, X., Cai, Y., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114461 · Cited by 2
Transcription factor Rel regulates the transcription of effector genes involved in immune response by cooperating with IκBs in lamprey (Lethenteron reissneri)
Cai, Y., Du, X., Liu, A., Lv, M., Sun, F., & Su, P. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkae060 · Cited by 2
Discovery of Safe COX‐2 Inhibitors: Achieving Reduced Colitis Side Effects through Balanced COX Inhibition
Zhu, X., Li, Q., Wu, J., & Ju, Z. (2025) · ChemMedChem · doi:10.1002/cmdc.202500096 · Cited by 2
Melatonin’s role in redox homeostasis: A preclinical and clinical perspective
Torres, F. F., Bernardo, V. S., Zucão, A. C. A., Gazarini, L., Reiter, R. J., & da Silva, D. G. H. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100147 · Cited by 2
First Description of the Role of the Relationship Between Serum Amyloid P Components and Nuclear Factors/Pro-Cytokines During Critical Periods of Toxoplasmic Encephalitis
Dincel, G., Atmaca, H., & El-Ashram, S. (2024) · Brain Science · doi:10.3390/brainsci14121298 · Cited by 2
“When stimuli activating NF-κ B are present in the environment, the nuclear translocation of NF-κ B and activation of gene transcription occur [12].”
An integrative epigenome-based strategy for unbiased functional profiling of clinical kinase inhibitors
Gualdrini, F., Rizzieri, S., Polletti, S., Pileri, F., Zhan, Y., Cuomo, A., & Natoli, G. (2024) · Molecular Systems Biology · doi:10.1038/s44320-024-00040-x · Cited by 2
“…innate immune receptor triggering (Janeway and Medzhitov, 2002; Thaiss et al, 2016), signals transduced by multiple kinases (Arthur and Ley, 2013; Karin and Ben-Neriah, 2000; O ’ Shea et al, 2015; Sharma et al, 2003) activate transcription factors (TFs) such as NF-kB, IRF, STAT, and AP-1 family…”
High-throughput prioritization of target proteins for development of new antileishmanial compounds
de Azevedo, L. G., Sosa, E. J., Queiroz, A. T. L., Barral, A. M. P., Wheeler, R. J., Nicolás, M., Farias, L. P., Porto, D. F. D., & Ramos, P. I. P. (2024) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2024.100538 · Cited by 3
Adipose Tissue Macrophage-Mediated Inflammation in Obesity: A Link to Posttranslational Modification
Wei, D., Tian, X., Zhai, X., & Sun, C. (2023) · Immunological Investigations · doi:10.1080/08820139.2023.2205883 · Cited by 4
“This phosphorylation usually isolates NF-κB and prevents it from entering the nucleus (Karin and Ben-Neriah 2000; Viatour et al. 2005).”
Background
RETRACTED ARTICLE: The autocrine glycosylated-GREM1 interacts with TGFB1 to suppress TGFβ/BMP/SMAD-mediated EMT partially by inhibiting MYL9 transactivation in urinary carcinoma
Chan, T., Pan, C., Hsieh, H., Vejvisithsakul, P. P., Wei, R., Yeh, B., Wu, W., Chen, L.-R., Shiao, M., Li, C., et al. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00788-8 · Cited by 9
Retracted
TLR4/NF-κB Signaling Contributes to the Inflammation in Ovary and Inguinal Fats of Polycystic Ovary SyndromePreprint
Sun, B. H., Pan, Z., Kuang, H., Feng, X., Hou, L., Xu, F., Song, F., & Sun, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.14.500077 · Cited by 2
Açai (Euterpe oleracea Mart) modulates oxidative stress and inflammation by NF-κB inactivation and Nrf2 up-regulation in experimental diabetesPreprint
de Lima, D. Y., Rodrigues, A. M., Mouro, M., Seif, E. J. M., Punaro, G., & Higa, E. M. S. (2022) · bioRxiv · doi:10.1101/2022.02.14.480447 · Cited by 2
Pulmonary prophylactic impact of bee venom against alterations induced by gamma irradiation via TLR4/NF-κB signaling pathway in rats
Lotfy, D. M., Hasan, H. F., & Mostafa, D. M. (2021) · Toxin Reviews · doi:10.1080/15569543.2021.1988979 · Cited by 2
“TLR4 is one of the toll-like receptors (TLRs) found on the cell surface of immunological and vascular cells, smooth muscle cells, and inflammatory cells (Mitsui et al. 2020).”
BackgroundInfluential
Expression of Cannabinoid Receptor GPR55 in Human Gingival Fibroblasts and Anti-inflammatory Effects of Cannabidiol via GPR55
Mishiro, S., Igarashi-Takeuchi, H., & Numabe, Y. (2021) · Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) · doi:10.2329/perio.63.11 · Cited by 2
Effects of KMS on the DNCB induced animal Model of Atopic Dermartitis
Song, D.-U., Min, G.-Y., Hong, S., Lim, S.-E., Huh, J., Sohn, Y., & Jung, H.-S. (2019) · Journal of Korean Medicine · doi:10.13048/jkm.19006 · Cited by 2
Linear ubiquitin chain induces apoptosis and inhibits tumor growth
Qin, Z., Jiang, W., Wang, G., Sun, Y., & Xiao, W. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1433-8 · Cited by 2
The serum Arginase-1 correlation to child-pugh scores in predicting the severity of cirrhosis
Purnamaningsih, S. M. (2017) · doi:10.15562/bmj.v6i3.685 · Cited by 2
Postlactational Involution: Molecular Mechanisms and Relevance for Breast Cancer Development
Kordon, E., & Coso, O. (2017) · InTech eBooks · doi:10.5772/66526 · Cited by 2
In vitro anti-inflammatory activity of extracts from Potentilla supina in murine macrophage RAW 264.7 cells
Nam, J.-H., Kim, H.-S., Kim, B.-J., Yu, H.-S., Chang, D., Jin, Y.-I., Yoo, D., Choi, J.-K., Park, H.-J., Lee, S. H., et al. (2017) · doi:10.5010/jpb.2017.44.1.076 · Cited by 2
The human breast cancer-associated protein, the prolactin-inducible protein (PIP), regulates intracellular signaling events and cytokine production by macrophages
Ihedioha, O., Blanchard, A., Balhara, J., Okwor, I. B., Jia, P., Uzonna, J. E., & Myal, Y. (2018) · Immunologic research · doi:10.1007/s12026-018-8987-6 · Cited by 1
“Interestingly, the decreased phosphorylation of STAT3 and MAPKs in PIP macrophages was associated with a concomitant suppression of NF-κB phosphorylation, which is a critical transcription factor that controls the induction of several immune genes including those involved in the production of pro-inflammatory cytokine…”
Background
The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression
Lin, F., Lin, H., Yu, J., Ge, C., Mao, L., Zhang, S.-H., Jin, Y.-Z., Wu, Y.-Y., Chen, T.-Y., Li, J.-J., et al. (2026) · Advancement of science · doi:10.1002/advs.77502 · Cited by 1
Lactate acts as a metabolic brake on inflammation by repressing NLRP3 transcription via NF-κB inhibition
Lin, H.-A., Lin, H.-C., Chiou, C.-Y., Peng, H., Chen, Y.-J., Bao, B.-Y., Tsai, K.-J., Lin, C., Shih, C., Hu, S.-I., et al. (2026) · Inflammation Research · doi:10.1007/s00011-026-02290-x · Cited by 1
“Given that NF-κB is a canonical driver of NLRP3 priming [ 34 , 35] and that its activation requires ATP-dependent phosphorylation [ 36], we next investigated whether this "metabolic exhaustion" interferes with the priming pathway.”
Targeting the IKKα/NF-κB Axis with SGEC-Derived Exosomal miR-23b-3p Rebalances Treg/Th17 Immunity in Sjögren’s Syndrome
Cai, Y., Wang, X., Feng, J., & E, C. (2026) · Antioxidants and Redox Signaling · doi:10.1177/15230864261443868 · Cited by 1
“TNFAIP3 limits in ﬂ ammatory responses via negative regulation of NF-j B (Zhou et al., 2016), while CHUK encodes IKK a , a pivotal upstream kinase in NF-j B activation (Karin and Ben-Neriah, 2000).”
The role of e3 ubiquitin ligases and deubiquitinating enzymes in hepatocellular carcinoma
Wang, L., Zhang, H., Hu, Y., Li, X., Liu, J., & Liang, Y. (2026) · Cell Biology and Toxicology · doi:10.1007/s10565-026-10192-1 · Cited by 1
“In HCC, abnormal IKK activation may induce persistent activation of the NF-κB signaling axis, thereby promoting inflammation and tumorigenesis (Napetschnig and Wu 2013; Karin and Ben-Neriah 2000).”
The long noncoding RNA lnc-FAM164A1-ACLY axis promotes pro-inflammatory responses in human primary macrophages: a systems approach
Wang, J.-G., Ito, S., Hosokawa, D., Nihira, K., Decano, J., Lee, L. H., Higashi, H., Halu, A., Mattson, P. C., Amaral, G., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1776849 · Cited by 1
Yam-Active Protein Protects Against Cyclophosphamide-Induced Testicular Injury by Suppressing Inflammatory Responses
Lu, J.-H., Hao, K., Song, Y.-T., Fang, J.-Q., Hu, B., Liu, W., Hui, G., Xie, Y.-F., & Zhao, Y. (2026) · Molecules · doi:10.3390/molecules31091387 · Cited by 1
NEMO/IKKγ: Emerging player in the NF-κB pathway and potential therapeutic target in inflammation
Karim, C., Sharifi, A., Kamarul, T., & Genasan, K. (2026) · Inflammation · doi:10.1007/s10753-026-02503-9 · Cited by 1
“A phospho-dependent DpSGxxpS/T βTrCP degron motif of IκB proteins [41] is directly phosphorylated by the IKKβ subunit, and IKKα also plays a role in kinase activation through phosphorylating the IKKβ activation loop [42].”
Chronic polystyrene microplastics exposure promotes lung adenocarcinoma metastasis through EREG-regulated phosphorylation-dependent NF-κB activation
Chen, K., Deng, Y., Meng, W., Xie, C., Li, Q., Wang, F., Zhu, J., Liu, J.-Y., Bie, M., & Han, F. (2026) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2026.101114 · Cited by 1
Signaling pathways and potential therapeutic agents in trastuzumab-induced cardiotoxicity
Zhang, H., Lu, C., Cheng, S., Wu, J., Hu, A., Mu, Z., Dong, D., & Sun, M. (2026) · APOPTOSIS · doi:10.1007/s10495-025-02222-w · Cited by 3
Nano-delivery system of milk-derived exosomes loaded with Forsythiaside A: Studies on bovine mammary epithelial cells and mastitis induced mice.
Yang, X., Pan, Y.-Y., Wang, M., Ma, X., Han, X.-H., Li, T.-H., Yang, S., Chang, J.-Y., Liu, H., Yu, S.-J., et al. (2026) · Theriogenology · doi:10.1016/j.theriogenology.2026.117831 · Cited by 1
Dual rescue mission: P-G3 dendrimer addresses ovarian and neuroendocrine roots of obesity-linked subfertility
Nie, Y., Kuang, Z., Si, J., Huang, Y., Zeng, Y., Shen, X. P., Liu, Y., Qiu, L., & Wang, L. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.040 · Cited by 1
“The Rela gene, which encodes the p65 subunit of NF j B, plays critical roles in inﬂammation, immune response [67,68], cell survival [69], proliferation [70], and apoptosis.”
Host-pathogen interplay in African Swine Fever Virus: Immune evasion and genetic resistance driving prevention and control strategies.
Arutkumaran, S., Deb, R., Shanmathi, S., Sengar, G., Chakravarti, S., Das, P. J., Pegu, S., Reis, A., & Gupta, V. K. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108119 · Cited by 1
The correlation between characteristics and pharmacological effects of monoterpene glycosides and tannins in Radix Paeoniae Alba
Zheng, Q., Chen, M., Ying, J., Wang, Z.-C., Shan, Q., Sang, X.-N., & Cao, G. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101471 · Cited by 1
Mesenchymal stem cells suppress NF-κB and ERK signalling while enhancing chemotaxis in CD4+ T cells
Sengun, E., Fröberg, J., He, X., Eleveld, M. J., Smeets, R. L., Koenen, H. J. P. M., Möller‐Hackbarth, K., Wolfs, T. G. A. M., Ophelders, D. R. M. G., Huynen, M. A., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-14373-6 · Cited by 2
“NFKBIA encodes an inhibitor of NF-κB pathway, which prevents NF-κB dimers from phosphorylating and translocating to the nucleus, thereby reducing NF-κB activity 48,49 .”
A type III heat shock protein 40 regulates the expression of antimicrobial peptides and hemocyte phagocytosis in Portunus trituberculatus
Zhang, Y., Xu, J., Zhang, X., Zheng, J., & Cui, Z. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146854 · Cited by 2
Molecular characterization of Mumps virus circulating in Odisha in 2024.
Mamidi, P., Panda, S., Ray, A., Mohapatra, D., Mandal, M., Santra, D., Kumar, K., Dwibedi, B., Dey, A., Chattopadhyay, S., et al. (2025) · Indian Journal of Medical Microbiology · doi:10.1016/j.ijmmb.2025.100949 · Cited by 1
Evaluation of sea cucumber protein paste for mice’s skin wound healing and its potential anti-inflammatory mechanism
Wang, X., Sun, J.-H., Liu, K., Li, S.-Q., Zhao, J., & Yang, J.-F. (2025) · Biomedical Materials · doi:10.1088/1748-605x/addcaa · Cited by 1
“Then inflammation happens [61, 62].”
Transcription factor addictions: exploring the potential Achilles’ Heel of endometriosis
Yang, Y., Du, Y., Ma, X., Yuan, G., Li, G., Zhang, Q., & Zhou, S. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2832-8 · Cited by 1
“Inactive NF-κ B dimers are sequestered in the cytoplasm by a family of I κ B proteins, and I κ B phosphorylated by I κ B kinases (IKKs) releases NF-κ B, enabling its translocation into the nucleus and exerting its transcriptional function (Karin and Ben-Neriah, 2000).”
A novel synthetic oxazolidinone derivative BS-153 attenuated LPS-induced inflammation via inhibiting NF-κB/pkcθ signaling pathway
Xu, L., Huang, J., Wang, R., Feng, J., Wang, L., Li, N., Jin, M., Lin, H., & Chen, X. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110292 · Cited by 1
BEV 2C protein inhibits the NF-κB signalling pathway to promote viral replication by targeting IKBKB and p65
Cui, X., Guo, Y.-D., Zhang, F., Chang, X., Hu, J., Zhang, Q., Zheng, X., Yan, N., & Wang, X. (2025) · Veterinary Research · doi:10.1186/s13567-025-01453-8 · Cited by 1
“The IκB kinase (IKK) complex is essential for activating NF-κB signalling in response to various stimuli, such as those derived from RNA or DNA [19, 20].”
CD40 induces PIR-A+ macrophages to promote chronic allograft rejection.
Chen, S., Zhao, Y.-Y., Yi, W., Zhou, X., Wang, J.-Z., Yang, B., Lan, P., & Chen, Z.-S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114274 · Cited by 1
Deoxynivalenol modulated mucin expression and proinflammatory cytokine production, affecting susceptibility to enteroinvasive Escherichia coli infection in intestinal epithelial cells
Wan, M. L. Y., Co, V. A., Turner, P. C., Nagendra, S. P., & El-Nezami, H. S. (2025) · Journal of Food Science · doi:10.1111/1750-3841.70079 · Cited by 4
“This releases NF-κ B and allows it to translocate freely to the nucleus in a phosphorylated form to activate gene transcription (Karin & Ben-Neriah, 2000; Perkins, 2007).”
Xiaoyou decoction promotes apoptosis and alters inflammatory factor levels in cervical precancerous cells by inhibiting the PI3K/AKT/NF-κB signaling pathway
Qi, D., Ai, W.-X., Han, B.-W., Men, H.-Z., Liang, M.-G., Zhang, M.-S., Zhou, H., Qiao, Y., Zhang, T.-T., Li, D., et al. (2024) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2024.100963 · Cited by 1
Synthesis of the dibenzylbutane lignan LCA derivatives and evaluation of their anti-inflammatory activities
Zhang, J., Gai, C.-H., Wang, J., Zhuo, X.-B., Zou, Y., Yang, J.-S., Song, Y., Zhao, Q.-J., & Chai, X.-Y. (2024) · Medicinal Chemistry Research · doi:10.1007/s00044-024-03332-x · Cited by 1
Cross-generational effects of dietary sea buckthorn on non-alcoholic fatty liver disease in offspring of obese female mice
Zhang, W.-P., Shi, Y., Wang, Y., Liu, X., Yan, J.-C., Chen, H.-R., & Zhao, J. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106398 · Cited by 1
Asiatic acid affects the growth of human osteosarcoma cells by regulating PI3K/AKT and NF-κB dual signal pathways
Huang, Y., Zhou, X., Jiwa, H., Zhang, J., Wang, Y., Xu, J., & Luo, X. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105885 · Cited by 2
Anti-Neoplastic and Cytotoxicity Potency Measuring of Five Medicago sativa L. (Alfalfa) Leaf Extracts Towards Melanoma (UACC62), Breast (MCF7), Prostate (PC3), and Colon (HCT116) Cancer Cells
Simon, M. T., Moses, M. P., & Samson, M. (2023) · Pharmacognosy Journal · doi:10.5530/pj.2023.15.150 · Cited by 1
“7,8 Chemo-preventive phytochemicals can block or reverse the premalignant stage (initiation and promotion) of the multistep carcinogenesis.”
Background
Drosophila innate immunity suppresses the survival of xenografted mammalian tumor cells
Aida, A., Yuswan, K., Kawai, Y., Hasegawa, K., Nakajima, Y.-I., & Kuranaga, E. (2023) · Scientific Reports · doi:10.1038/s41598-023-38489-9 · Cited by 2
Detection of hypoxia in the pulmonary tissues of Xenopus laevis over repeated dives
Fujiyama, S., Okui, T., & Kato, T. (2023) · Development Growth & Differentiation · doi:10.1111/dgd.12837 · Cited by 1
“Yellow arrows indicate regions that are strongly stained with eosin; these represent edema-like features, such as the swelling of cells and stroma and apoptosis with an increased vascular permeability (Karin & Ben-Neriah, 2000).”
Background
Effects of constitutively active IKKβ on cardiac development.
Sugioka, S., Ikeda, S., Harada, M., Kishihata, M., Al-Huseini, I., Kimura, T., & Ashida, N. (2022) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2022.05.019 · Cited by 1
Effect of Sperm 26S Proteasome on Embryo Formation and Development in In Vitro Fertilization
Wang, C., Wang, F., Zheng, M. W., Wu, R., Yang, T., Chen, X., & Shu, J. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00916-z · Cited by 1
Activity of nuclear factor κB in lymphocyte populations of children with psoriasis
Kuptsova, D., Petrichuk, S., Murashkin, N., Kurbatova, O., Radygina, T., Khotko, A., & Ivanov, R. (2022) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2022.012 · Cited by 1
“Under physiological conditions, the NF-κB/I-κB complex is a self-regulating system [22].”
Background
Effect of extraction solvent on in vitro anti-inflammatory, antioxidant activity, total phenol and flavonoid contents in Codonopsis lanceolata
Boo, H., Park, J.-H., Kim, H.-H., Kwon, S.-J., & Woo, S. (2021) · Journal of Crop Science and Biotechnology · doi:10.1007/s12892-020-00062-5 · Cited by 1
Anti-inflammatory Effect of Flower Bud and Fruit of Sweet Persimmon, Diospyros kaki T.
Park, Y.-O., Lee, J. A., Park, S., Min, H., Joo, W., & Kim, D. (2020) · Biomedical Science Letters · doi:10.15616/bsl.2020.26.2.85 · Cited by 1
“3에 나타난 바와 같이 LPS에 의해 IL-1β, IL-6, TNF-α 모 두 발현이 증가하였으나, IL-β와 IL-6는 꽃봉오리 및 과실 추출물에 의해 발현이 현저하게 감소하였고 TNF-α는 과 실 추출물에 의해 발현이 현저하게 감소하였다.”
Influential
Cyclosporin A suppresses Porphyromonas gingivalis lipopolysaccharide induced matrix metalloproteinases activities in the co-culture of human gingival fibroblasts and monocyte cell line THP-1
Jiang, L., Liu, M.-N., Wang, G.-D., Wu, Q., & Zhao, Y.-F. (2020) · Growth Factors · doi:10.1080/08977194.2020.1755280 · Cited by 1
Therapeutic potential of proteasome inhibitors for dihydropyridine-induced gingival overgrowth.
Lu, S.-L., Chang, J., Huang, C.-F., & Chen, L.-S. (2019) · Oral Diseases · doi:10.1111/odi.13260 · Cited by 1
The sleep gene insomniac ubiquitinates targets at postsynaptic densities and is required for retrograde homeostatic signaling
Kikuma, K., Li, X., Perry, S., Li, Q.-L., Goel, P., Chen, C., Kim, D., Stavropoulos, N., & Dickman, D. K. (2018) · bioRxiv · doi:10.1101/430819 · Cited by 1
“Indeed, reciprocal influences of phosphorylation and ubiquitination on common targets are a common regulatory feature in a variety of signaling systems (Haglund and Dikic, 2005; Karin and Ben-Neriah, 2000; Kawabe and Brose, 2011).”
Background
Animal Models of Obesity Characterized by Non-alcoholic Fatty Liver Disease (NAFLD)
Fernandes, M. R., Figueiredo, P. S., SilvaRezende, K., Freitas, K. D. C., Hiane, P., & Guimarães, R. A. (2017) · InTech eBooks · doi:10.5772/intechopen.72707 · Cited by 1
Expression profile and promoter analysis of HEPIS.
Hu, F., & Zhang, Y. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5374 · Cited by 1
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Authors: Karin, M., & Ben-Neriah, Y.
Affiliations: Hebrew University of Jerusalem (IL)
Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction University of California, San Diego, La Jolla, California, 92093-0636;
ORCID: Karin, Michael
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2000-04
Volume: 18
Issue: 1
Pages: 621-663
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.18.1.621
OpenAlex: W2147921405
Cited by: 4,766
References: 243
Citations by year: 2026: 78 · 2025: 109 · 2024: 86 · 2023: 101 · 2022: 114 · 2021: 112 · 2020: 129 · 2019: 114 · 2018: 129 · 2017: 153 · 2016: 156 · 2015: 135 · 2014: 186 · 2013: 201 · 2012: 194
FWCI: 22.12
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01 CA76188, R01CA076188)
National Institute of Allergy and Infectious Diseases (R01AI043477, R01 AI43477)
National Institute of Environmental Health Sciences (R37ES004151, R37 ES04151)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: NF-κB, IκB phosphorylation, ubiquitination, IκB kinase, IKKα, IKKβ, E3 ubiquitin ligase, proteolysis, NF-κB nuclear translocation, TNF signaling, IL-1 signaling, Rel family transcription factors, inflammation, transcriptional regulation
MeSH terms: NF-KappaB Inhibitor alpha, Amino Acid Sequence, Animals, DNA-Binding Proteins, Humans, Molecular Sequence Data, Phosphorylation, Transcription Factors, Ubiquitins, Signal Transduction, Down-Regulation, NF-kappa B, Protein Serine-Threonine Kinases, I-kappa B Proteins, I-kappa B Kinase, NF-kappa B p50 Subunit

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Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

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