Cited by 6,737Cytokine Signaling Pathways and InteractionsT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

The DOI matches its Crossref record; 675 of the 676 references it cites were found in a registry or an index.

Interleukin-10 and the Interleukin-10 Receptor

Moore, Kevin W., de Waal Malefyt, Rene, Coffman, Robert L., O'Garra, Anne·2001·Annual Review of Immunology

Open this paper in CoChat — free account

Abstract

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses. In addition to these activities, IL-10 regulates growth and/or differentiation of B cells, NK cells, cytotoxic and helper T cells, mast cells, granulocytes, dendritic cells, keratinocytes, and endothelial cells. IL-10 plays a key role in differentiation and function of a newly appreciated type of T cell, the T regulatory cell, which may figure prominently in control of immune responses and tolerance in vivo. Uniquely among hemopoietic cytokines, IL-10 has closely related homologs in several virus genomes, which testify to its crucial role in regulating immune and inflammatory responses. This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease.

Integrity signals

Registry

Crossref · 10.1146/annurev.immunol.19.1.683

Cites

675 of 675 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Immunobiology of Dendritic Cells
Banchereau, J., Brière, F., Caux, C., Davoust, J. M., Lebecque, S., Liu, Y., Pulendran, B., & Palucka, K. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.767 · Cited by 6,755
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
Bone marrow transplant
Goycoolea, A. (1997) · Cited by 3,615
A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Groux, H., O’Garra, A., Bigler, M., Rouleau, M., Antonenko, S. V., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588
Self-citation
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
Self-citation
Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma
Robinson, D. S., Hamid, Q. A., Ying, S., Tsicopoulos, A., Barkans, J. R., Bentley, A. M., Corrigan, C. J., Durham, S. R., & Kay, A. B. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201303260504 · Cited by 2,769
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.
Fiorentino, D. F., Bond, M. W., & Mosmann, T. R. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.6.2081 · Cited by 2,733
Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis
Chen, Y., Kuchroo, V. K., Inobe, J.-I., Hafler, D. A., & Weiner, H. L. (1994) · Science · doi:10.1126/science.7520605 · Cited by 1,969

Show all 676 references

Research works printed but not linked: 35

de Waal Malefyt R, de Vries J. 1996. In Interleukin-10 , ed. B. Aggarwal, J. Gutterman, pp. 19–42. Cambridge MA: Blackwell Sci.
Lazarus M, 1997, J. Rheumatol., 24, 2314
Jiang H, 1995, Oncogene, 11, 2477
Ho AS-Y, 1994, Ther. Immunol., 1, 173
Dokter WHA, 1996, Leukemia, 10, 1308
Zissel G, 1996, Eur. Cytokine Netw., 7, 59
Jenkins JK, 1994, Lymphokine Cytokine Res., 13, 47
Aste-Amezaga M, 1998, J. Immunol., 160, 5936
Stearns ME, 1995, Oncol. Res., 7, 157
Stearns ME, 1999, Clin. Cancer Res., 5, 189
Calzada-Wack JC, 1996, J. Inflamm., 46, 78
Spittler A, 1995, Immunology, 85, 311
Niiro H, 1992, Lymphokine Cytokine Res., 11, 209
Kuga S, 1996, Exp. Hematol., 24, 151
10.1182/blood.V95.8.2484 · DOI
10.1182/blood.V89.5.1621 · DOI
Cox G, 1996, Am. J. Physiol., 271, L566
Clinchy B, 1994, Immunology, 82, 376
Marchant A, 1994, Prog. Clin. Biol. Res., 388, 417
Mengozzi M, 1994, Immunology, 82, 207
Gasim S, 1998, Clin. Exp. Immunol., 111, 64
Yamamura M, 1991, Science, 254, 277
Llorente L, 1993, Eur. Cytokine Netw., 4, 421
De Vita F, 2000, Oncol. Rep., 7, 357
Smith DR, 1994, Am. J. Pathol., 145, 18
Sato T, 1996, Clin. Cancer Res., 2, 1383
Wojciechowska-Lacka A, 1996, Neoplasma, 43, 155
Voorzanger N, 1996, Cancer Res., 56, 5499
Bruserud O, 1995, Leukemia, 9, 1910
Houle M, 1999, Inflammation, 23, 241
Allione A, 1994, Cancer Res., 54, 6022
Huang S, 1996, Clin. Cancer Res., 2, 1969
Stearns ME, 1997, Invasion Metastasis, 17, 62
Stearns ME, 1998, Clin. Cancer Res., 4, 2257
Stearns ME, 1999, Clin. Cancer Res., 5, 711

Sorted by citations

Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Regulation of Wound Healing by Growth Factors and Cytokines
WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
The regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293
Self-citation
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,723
The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470
IL-10: The Master Regulator of Immunity to Infection
Couper, K. N., Blount, D. G., & Riley, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5771 · Cited by 2,288
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,264
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M. F., Ho, S., Antonenko, S. V., Lauerma, A., et al. (2002) · Nature Immunology · doi:10.1038/ni805 · Cited by 2,218
Cancer immunotherapy via dendritic cells
Palucka, K., & Banchereau, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3258 · Cited by 2,109
A cytokine-mediated link between innate immunity, inflammation, and cancer
Lin, W.-W., & Karin, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31537 · Cited by 1,940
Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940
Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
Ouyang, W., Rutz, S., Crellin, N. K., Valdez, P. A., & Hymowitz, S. G. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101312 · Cited by 2,011
IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
Kotenko, S. V., Gallagher, G. E., Baurin, V. V., Lewis-Antes, A., Shen, M., Shah, N. K., Langer, J. A., Sheikh, F. G., Dickensheets, H. L., & Donnelly, R. P. (2002) · Nature Immunology · doi:10.1038/ni875 · Cited by 1,867
CD4 T cells: fates, functions, and faults
Zhu, J., & Paul, W. E. (2008) · Blood · doi:10.1182/blood-2008-05-078154 · Cited by 1,915
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Tedgui, A., & Mallat, Z. (2006) · Physiological Reviews · doi:10.1152/physrev.00024.2005 · Cited by 1,751
Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586
IL-28, IL-29 and their class II cytokine receptor IL-28R
Sheppard, P. O., Kindsvogel, W., Xu, W., Henderson, K., Schlutsmeyer, S., Whitmore, T. E., Kuestner, R. E., Garrigues, U., Birks, C., Roraback, J., et al. (2002) · Nature Immunology · doi:10.1038/ni873 · Cited by 1,563
Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,452
Interleukin-17 and Type 17 Helper T Cells
Miossec, P., Korn, T., & Kuchroo, V. K. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0707449 · Cited by 1,409
Pathological and protective roles of glia in chronic pain
Milligan, E. D., & Watkins, L. R. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2533 · Cited by 1,443
IL-22 Increases the Innate Immunity of Tissues
Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., & Sabat, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.007 · Cited by 1,406
The Immune Response in Tuberculosis
O’Garra, A., Redford, P. S., McNab, F. W., Bloom, C. I., Wilkinson, R. J., & Berry, M. P. R. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095939 · Cited by 1,400
Self-citation
Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
Itzkowitz, S. H., & Yio, X. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00079.2004 · Cited by 1,272
Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation
Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood · doi:10.1182/blood-2009-10-249540 · Cited by 1,246
Induction and effector functions of TH17 cells
Bettelli, E., Korn, T., Oukka, M., & Kuchroo, V. K. (2008) · Nature · doi:10.1038/nature07036 · Cited by 1,243
Cytokines in clinical cancer immunotherapy
Berraondo, P., Sanmamed, M. F., Ochoa, M. C., Etxeberría, I., Aznar, M. A., Perez‐Gracia, J. L., Rodriguez-Ruiz, M. E., Ponz‐Sarvisé, M., Álvarez, E. C., & Melero, I. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0328-y · Cited by 1,218
Regulatory T cells in the control of immune pathology
Maloy, K. J., & Powrie, F. M. (2001) · Nature Immunology · doi:10.1038/ni0901-816 · Cited by 1,177
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
Roncarolo, M. G., Gregori, S., Battaglia, M., Bacchetta, R., Fleischhauer, K., & Levings, M. K. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00420.x · Cited by 1,206
The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update
Okada, H., Kuhn, C., Feillet, H., & Bach, J. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04139.x · Cited by 1,214
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines
Barrat, F. J., Cua, D. J., Boonstra, A., Richards, D. F., Crain, C., Savelkoul, H. F. J., Malefyt, R. D. W., Coffman, R. L., Hawrylowicz, C. M., & O’Garra, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011629 · Cited by 1,161
Self-citation
Signaling through the JAK/STAT pathway, recent advances and future challenges
Kisseleva, T., Bhattacharya, S., Braunstein, J., & Schindler, C. (2002) · Gene · doi:10.1016/s0378-1119(02)00398-0 · Cited by 1,170
Intestinal Inflammation and Cancer
Ullman, T. A., & Itzkowitz, S. H. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.057 · Cited by 1,127
Biology and therapeutic potential of interleukin-10
Saraiva, M., Vieira, P., & O’Garra, A. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190418 · Cited by 1,157
Self-citation
SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
Costela-Ruiz, V. J., Montes, R. I., Puerta, J. M., Ruíz, C., & Melguizo‐Rodríguez, L. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.06.001 · Cited by 1,132
Characterization of a rare IL-10–competent B-cell subset in humans that parallels mouse regulatory B10 cells
Iwata, Y., Matsushita, T., Horikawa, M., DiLillo, D. J., Yanaba, K., Venturi, G. M., Szabolcs, P., Bernstein, S. H., MAGRO, C. M. J., Williams, A. D., et al. (2010) · Blood · doi:10.1182/blood-2010-07-294249 · Cited by 1,107
I nterleukin -10 and R elated C ytokines and R eceptors
Pestka, S., Krause, C. D., Sarkar, D., Walter, M. R., Shi, Y., & Fisher, P. B. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104622 · Cited by 1,097
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
Ouyang, W., & O’Garra, A. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.020 · Cited by 1,141
Self-citation
Interleukin‐10: new perspectives on an old cytokine
Mosser, D. M., & Zhang, X. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00706.x · Cited by 1,077
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
Jego, G., Palucka, A. K., Blanck, J.-P., Chalouni, C., Pascual, V., & Banchereau, J. (2003) · Immunity · doi:10.1016/s1074-7613(03)00208-5 · Cited by 1,067
Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells
Akdis, M., Verhagen, J., Taylor, A., Karamloo, F., Karagiannidis, C., Crameri, R., Thunberg, S., Deniz, G., Valenta, R., Fiebig, H., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032058 · Cited by 1,051
Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells
Ruffell, B., Chang-Strachan, D., Chan, V., Rosenbusch, A., Ho, C. M. T., Pryer, N., Daniel, D., Hwang, E. S., Rugo, H. S., & Coussens, L. M. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.006 · Cited by 1,008
Therapeutic strategies for enhancing angiogenesis in wound healing
Veith, A. P., Henderson, K., Spencer, A., Sligar, A. D., & Baker, A. B. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.010 · Cited by 1,047
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses
Denning, T. L., Wang, Y., Patel, S. R., Williams, I. R., & Pulendran, B. (2007) · Nature Immunology · doi:10.1038/ni1511 · Cited by 995
Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation
Chaudhry, A., Samstein, R. M., Treuting, P., Liang, Y., Pils, M. C., Heinrich, J.-M., Jack, R. S., Wunderlich, F. T., Brüning, J. C., Müller, W., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.018 · Cited by 980
Targeting the progression of chronic kidney disease
Ruiz-Ortega, M., Rayego-Mateos, S., Lamas, S., Ortiz, A., & Rodrigues-Diez, R. R. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0248-y · Cited by 979
Biology of interleukin-10
Sabat, R., Grütz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K., & Geginat, J. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.09.002 · Cited by 977
IL-13 Effector Functions
Wynn, T. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141142 · Cited by 991
The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat
Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952
Interleukin-10 Therapy—Review of a New Approach
Asadullah, K., Sterry, W., & Volk, H. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.4 · Cited by 941
Transcriptional control of the inflammatory response
Medzhitov, R., & Horng, T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2634 · Cited by 1,035
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
de la Cruz-López, K. G., Castro-Muñoz, L. J., Reyes-Hernández, D. O., García-Carrancá, A., & Manzo-Merino, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01143 · Cited by 940
A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses
Volpe, E., Servant, N., Zollinger, R., Bogiatzi, S. I., Hupé, P., Barillot, E., & Soumelis, V. (2008) · Nature Immunology · doi:10.1038/ni.1613 · Cited by 938
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
Barrat, F. J., Meeker, T., Gregorio, J. D., Chan, J. H., Uematsu, S., Akira, S., Chang, B., Duramad, O., & Coffman, R. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050914 · Cited by 932
Self-citation
Interleukin-10 determines viral clearance or persistence in vivo
Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B., & Oldstone, M. B. A. (2006) · Nature Medicine · doi:10.1038/nm1492 · Cited by 937
FOXP3: Of Mice and Men
Ziegler, S. F. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090547 · Cited by 921
IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes
Boniface, K., Bernard, F.-X., Garcia, M., Gurney, A. L., Lecron, J.-C., & Morel, F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3695 · Cited by 864
Differential macrophage programming in the tumor microenvironment
Ruffell, B., Affara, N. I., & Coussens, L. M. (2012) · Trends in Immunology · doi:10.1016/j.it.2011.12.001 · Cited by 878
Prevention of Arthritis by Interleukin 10–producing B Cells
Mauri, C., Gray, D., Mushtaq, N., & Londei, M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021293 · Cited by 858
Pulmonary fibrosis: pathogenesis, etiology and regulation
Wilson, M. S., & Wynn, T. A. (2009) · Mucosal Immunology · doi:10.1038/mi.2008.85 · Cited by 838
Mechanisms of allergen-specific immunotherapy
Akdiş, C. A., & Akdis, M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.030 · Cited by 830
Regulatory T cells and mechanisms of immune system control
O’Garra, A., & Vieira, P. (2004) · Nature Medicine · doi:10.1038/nm0804-801 · Cited by 809
Self-citation
Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease
Zenewicz, L. A., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S. G., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.003 · Cited by 833
Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4
Chang, C.-C., Ciubotariu, R., Manavalan, J. S., Yuan, J., Colovai, A. I., Piazza, F., Lederman, S. M., Colonna, M., Cortesini, R., Dalla‐Favera, R., et al. (2002) · Nature Immunology · doi:10.1038/ni760 · Cited by 803
The germless theory of allergic disease: revisiting the hygiene hypothesis
Wills-Karp, M. A., Santeliz, J., & Karp, C. L. (2001) · Nature reviews. Immunology · doi:10.1038/35095579 · Cited by 794
Elevated immune response in the brain of autistic patients
Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X.-M., Ji, L., Brown, T., & Malik, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.002 · Cited by 786
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
Stumhofer, J. S., Silver, J. S., Laurence, A. D. J., Porrett, P. M., Harris, T. H., Turka, L. A., Ernst, M., Saris, C. J. M., O’Shea, J. J., & Hunter, C. A. (2007) · Nature Immunology · doi:10.1038/ni1537 · Cited by 777
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology · doi:10.1038/ni938 · Cited by 771
Molecular Mechanisms of Treg-Mediated T Cell Suppression
Schmidt, A., Oberle, N., & Krammer, P. H. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00051 · Cited by 814
Cellular responses to viral infection in humans: lessons from Epstein–Barr virus
Hislop, A. D., Taylor, G. S., Sauce, D., & Rickinson, A. B. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141553 · Cited by 766
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease
Friedrich, M., Pohin, M., & Powrie, F. M. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.017 · Cited by 776
Regulatory T cells and infection: a dangerous necessity
Belkaid, Y. (2007) · Nature reviews. Immunology · doi:10.1038/nri2189 · Cited by 746
CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
Maloy, K. J., Salaün, L., Cahill, R., Dougan, G., Saunders, N. J. S. G., & Powrie, F. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021345 · Cited by 740
Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells
Castriconi, R., Cantoni, C., Chiesa, M. D., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Bottino, C., Moretta, L., & Moretta, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730640100 · Cited by 727
Mechanisms of immune suppression by interleukin‐10 and transforming growth factor‐β: the role of T regulatory cells
Taylor, A., Verhagen, J., Blaser, K., Akdis, M., & Akdiş, C. A. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02321.x · Cited by 747
Regulatory T cells: friend or foe in immunity to infection?
Mills, K. H. G. (2004) · Nature reviews. Immunology · doi:10.1038/nri1485 · Cited by 702
Spinal Glia and Proinflammatory Cytokines Mediate Mirror-Image Neuropathic Pain in Rats
Milligan, E. D., Twining, C. M., Chacur, M., Biedenkapp, J. C., O'Connor, K., Poole, S., Tracey, K. J., Martin, D. P., Maier, S. F., & Watkins, L. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-01026.2003 · Cited by 701
Cytokines in Cancer Immunotherapy
Lee, S. Y., & Margolin, K. A. (2011) · Cancers · doi:10.3390/cancers3043856 · Cited by 718
Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694
Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma
Hawrylowicz, C. M., & O’Garra, A. (2005) · Nature reviews. Immunology · doi:10.1038/nri1589 · Cited by 706
Self-citation
Mast cells as sources of cytokines, chemokines, and growth factors
Mukai, K., Tsai, M. M., Saito, H., & Galli, S. J. (2018) · Immunological Reviews · doi:10.1111/imr.12634 · Cited by 704
Type 2 cytokines: mechanisms and therapeutic strategies
Wynn, T. A. (2015) · Nature reviews. Immunology · doi:10.1038/nri3831 · Cited by 683
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease
Remmers, E. F., Coşan, F., Kirino, Y., Ombrello, M. J., Abacı, N., Satorius, C. L., Le, J. M., Yang, B. C., Korman, B. D., Çakiris, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.625 · Cited by 678
GLIA: A novel drug discovery target for clinical pain
Watkins, L. R., & Maier, S. F. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1251 · Cited by 674
An assessment of the toxicity of polypropylene microplastics in human derived cells
Hwang, J., Choi, D., Han, S., Choi, J. H., & Hong, J. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.05.071 · Cited by 687
Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity
Sanjabi, S., Zenewicz, L. A., Kamanaka, M., & Flavell, R. A. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.04.008 · Cited by 681
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
Vieira, P. L., Christensen, J. R., Minaee, S., O’Neill, E. J., Barrat, F. J., Boonstra, A., Barthlott, T., Stockinger, B., Wraith, D. C., & O’Garra, A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.5986 · Cited by 652
Self-citation
Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression: A Double-Blind, Randomized, Placebo-controlled Multicenter Trial
Meisel, C., Schefold, J. C., Pschowski, R., Baumann, T., Hetzger, K., Gregor, J. I., Weber‐Carstens, S., Hasper, D., Keh, D., Zuckermann, H., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0363oc · Cited by 657
IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses
van de Veen, W., Stanić, B., Yaman, G., Wawrzyniak, M., Söllner, S., Akdis, D. G., Rückert, B., Akdiş, C. A., & Akdis, M. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.014 · Cited by 652
Immune modulation by mesenchymal stem cells
Jiang, W., & Xu, J. (2020) · Cell Proliferation · doi:10.1111/cpr.12712 · Cited by 650
T‐cell exhaustion: characteristics, causes and conversion
Yi, J. S., Cox, M. A., & Zajac, A. J. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03255.x · Cited by 675
Immune responses to gene therapy vectors: influence on vector function and effector mechanisms
Bessis, N., Garcia-Cozar, F. J., & Boissier, M. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302364 · Cited by 653
Interleukin-22 but Not Interleukin-17 Provides Protection to Hepatocytes during Acute Liver Inflammation
Zenewicz, L. A., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Karow, M. L., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.023 · Cited by 648
C-reactive protein: Ligands, receptors and role in inflammation
Marnell, L. L., Mold, C., & Clos, T. W. D. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.08.004 · Cited by 625
Immunity and immunopathology to viruses: what decides the outcome?
Rouse, B. T., & Sehrawat, S. (2010) · Nature reviews. Immunology · doi:10.1038/nri2802 · Cited by 636
TH1 cells control themselves by producing interleukin-10
O’Garra, A., & Vieira, P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2097 · Cited by 614
Self-citation
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
Sun, J., Madan, R., Karp, C. L., & Braciale, T. J. (2009) · Nature Medicine · doi:10.1038/nm.1929 · Cited by 626
Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-10
Lang, R., Patel, D. H., Morris, J. J., Rutschman, R., & Murray, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2253 · Cited by 621

Authors: Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A.
Affiliations: Departments of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc., Palo Alto, California 94304;
ORCID: Coffman, Robert L.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2001-04
Volume: 19
Issue: 1
Pages: 683-765
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.19.1.683
OpenAlex: W2161074777
Cited by: 6,737
References: 676
Citations by year: 2026: 141 · 2025: 217 · 2024: 193 · 2023: 228 · 2022: 268 · 2021: 269 · 2020: 222 · 2019: 251 · 2018: 231 · 2017: 249 · 2016: 298 · 2015: 276 · 2014: 312 · 2013: 317 · 2012: 348
FWCI: 23.18
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: IL-10, IL-10 receptor, cytokine signaling, immunomodulation, inflammation, regulatory T cells, immune tolerance, T cell regulation, B cell differentiation, natural killer cells, dendritic cells, hematopoietic cells
MeSH terms: Animals, Autoimmune Diseases, Clinical Trials as Topic, Dendritic Cells, Diabetes Mellitus, Type 1, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Gene Expression Regulation, Herpesviridae, Humans, Infections, Inflammation, Lupus Erythematosus, Systemic, Mice, Inbred NZB, Neoplasms, Neutrophils, Primates, Protein-Tyrosine Kinases, Transcription Factors, Transcription, Genetic, Viral Proteins, Signal Transduction, Lymphocyte Subsets, Mice, Inbred NOD, Interleukin-10, Clinical Trials, Phase II as Topic, Receptors, Interleukin, Mice, Knockout, Mice, Receptors, Interleukin-10

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interleukin-10 and the Interleukin-10 Receptor

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks