Cited by 6,737Cytokine Signaling Pathways and InteractionsT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

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Interleukin-10 and the Interleukin-10 Receptor

Moore, Kevin W., de Waal Malefyt, Rene, Coffman, Robert L., O'Garra, Anne·2001·Annual Review of Immunology

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Abstract

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses. In addition to these activities, IL-10 regulates growth and/or differentiation of B cells, NK cells, cytotoxic and helper T cells, mast cells, granulocytes, dendritic cells, keratinocytes, and endothelial cells. IL-10 plays a key role in differentiation and function of a newly appreciated type of T cell, the T regulatory cell, which may figure prominently in control of immune responses and tolerance in vivo. Uniquely among hemopoietic cytokines, IL-10 has closely related homologs in several virus genomes, which testify to its crucial role in regulating immune and inflammatory responses. This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease.

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Authors: Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A.
Affiliations: Departments of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc., Palo Alto, California 94304;
ORCID: Coffman, Robert L.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2001-04
Volume: 19
Issue: 1
Pages: 683-765
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.19.1.683
OpenAlex: W2161074777
Cited by: 6,737
References: 676
Citations by year: 2026: 141 · 2025: 217 · 2024: 193 · 2023: 228 · 2022: 268 · 2021: 269 · 2020: 222 · 2019: 251 · 2018: 231 · 2017: 249 · 2016: 298 · 2015: 276 · 2014: 312 · 2013: 317 · 2012: 348
FWCI: 23.18
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: IL-10, IL-10 receptor, cytokine signaling, immunomodulation, inflammation, regulatory T cells, immune tolerance, T cell regulation, B cell differentiation, natural killer cells, dendritic cells, hematopoietic cells
MeSH terms: Animals, Autoimmune Diseases, Clinical Trials as Topic, Dendritic Cells, Diabetes Mellitus, Type 1, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Gene Expression Regulation, Herpesviridae, Humans, Infections, Inflammation, Lupus Erythematosus, Systemic, Mice, Inbred NZB, Neoplasms, Neutrophils, Primates, Protein-Tyrosine Kinases, Transcription Factors, Transcription, Genetic, Viral Proteins, Signal Transduction, Lymphocyte Subsets, Mice, Inbred NOD, Interleukin-10, Clinical Trials, Phase II as Topic, Receptors, Interleukin, Mice, Knockout, Mice, Receptors, Interleukin-10

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Interleukin-10 and the Interleukin-10 Receptor

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