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IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
Abstract
Since its conception two decades ago, the Th1-Th2 paradigm has provided a framework for understanding T cell biology and the interplay of innate and adaptive immunity. Naive T cells differentiate into effector T cells with enhanced functional potential for orchestrating pathogen clearance largely under the guidance of cytokines produced by cells of the innate immune system that have been activated by recognition of those pathogens. This secondary education of post-thymic T cells provides a mechanism for appropriately matching adaptive immunity to frontline cues of the innate immune system. Owing in part to the rapid identification of novel cytokines of the IL-17 and IL-12 families using database searches, the factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense.
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“Exposure to allergens causes differentiation of CD4+ T cells into effector T cells, Th1, Th2 and Th17 cells, which produce lineage-specific cytokines IFNγ, IL-4 and IL-17, respectively [9, 10].”
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Metadata
- Authors
- Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E.
- Affiliations
- University of Alabama at Birmingham (US)
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2007-04-01
- Volume
- 25
- Issue
- 1
- Pages
- 821-852
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2156451877
- Cited by
- 1,842
- References
- 135
- Citations by year
- 2026: 18 · 2025: 16 · 2024: 35 · 2023: 33 · 2022: 35 · 2021: 60 · 2020: 47 · 2019: 54 · 2018: 60 · 2017: 79 · 2016: 71 · 2015: 99 · 2014: 124 · 2013: 137 · 2012: 120
- FWCI
- 18.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- IL-17 family cytokines, IL-12 family cytokines, Th17 cells, effector T cell differentiation, Th1/Th2 paradigm, naive T cell activation, innate-adaptive immune interaction, T cell lineage specification, immune regulation, immune pathogenesis, host defense
- MeSH terms
- Animals, Cell Differentiation, Humans, Immunity, Innate, Structure-Activity Relationship, Protein Structure, Tertiary, Th1 Cells, Th2 Cells, Interleukin-12, Interleukin-17
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