Cited by 1,842Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

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IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

Weaver, Casey T., Hatton, Robin D., Mangan, Paul R., Harrington, Laurie E.·2007·Annual Review of Immunology

DOI 10.1146/annurev.immunol.25.022106.141557

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Abstract

Since its conception two decades ago, the Th1-Th2 paradigm has provided a framework for understanding T cell biology and the interplay of innate and adaptive immunity. Naive T cells differentiate into effector T cells with enhanced functional potential for orchestrating pathogen clearance largely under the guidance of cytokines produced by cells of the innate immune system that have been activated by recognition of those pathogens. This secondary education of post-thymic T cells provides a mechanism for appropriately matching adaptive immunity to frontline cues of the innate immune system. Owing in part to the rapid identification of novel cytokines of the IL-17 and IL-12 families using database searches, the factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense.

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Authors: Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E.
Affiliations: University of Alabama at Birmingham (US)
ORCID: Weaver, Casey T.
Hatton, Robin D.
Harrington, Laurie E.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2007-04-01
Volume: 25
Issue: 1
Pages: 821-852
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.25.022106.141557
OpenAlex: W2156451877
Cited by: 1,842
References: 135
Citations by year: 2026: 18 · 2025: 16 · 2024: 35 · 2023: 33 · 2022: 35 · 2021: 60 · 2020: 47 · 2019: 54 · 2018: 60 · 2017: 79 · 2016: 71 · 2015: 99 · 2014: 124 · 2013: 137 · 2012: 120
FWCI: 18.11
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: IL-17 family cytokines, IL-12 family cytokines, Th17 cells, effector T cell differentiation, Th1/Th2 paradigm, naive T cell activation, innate-adaptive immune interaction, T cell lineage specification, immune regulation, immune pathogenesis, host defense
MeSH terms: Animals, Cell Differentiation, Humans, Immunity, Innate, Structure-Activity Relationship, Protein Structure, Tertiary, Th1 Cells, Th2 Cells, Interleukin-12, Interleukin-17

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IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

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