IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589

Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages

Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134

The interleukin-17 pathway is involved in human alcoholic liver disease # †

Lemmers, A., Moreno, C., Gustot, T., Maréchal, R., Degré, D., Demetter, P., de Nadai, P., Geerts, A., Quertinmont, E., Vercruysse, V., et al. (2009) · Hepatology · doi:10.1002/hep.22680 · Cited by 394

Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective

Weaver, C. T., & Hatton, R. D. (2009) · Nature reviews. Immunology · doi:10.1038/nri2660 · Cited by 412

Anomalous Type 17 Response to Viral Infection by CD8 + T Cells Lacking T-bet and Eomesodermin

Intlekofer, A. M., Banerjee, A., Takemoto, N., Gordon, S. M., DeJong, C. S., Shin, H., Hunter, C. A., Wherry, E. J., Lindsten, T., & Reiner, S. L. (2008) · Science · doi:10.1126/science.1159806 · Cited by 410

New insights of T cells in the pathogenesis of psoriasis

Cai, Y., Fleming, C., & Yan, J. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.15 · Cited by 389

Inflammatory Response in the Hippocampus of PS1M146L/APP751SLMouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

Jimenez, S., Baglietto-Vargas, D., Caballero, C., Moreno-Gonzalez, I., Torres, M., Sanchez-Varo, R., Ruano, D., Vizuete, M., Gutierrez, A., & Vitorica, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3024-08.2008 · Cited by 383

Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge

Hamada, H., García-Hernández, M. D. L. L., Reome, J. B., Misra, S. K., Strutt, T. M., McKinstry, K. K., Cooper, A. M., Swain, S. L., & Dutton, R. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801814 · Cited by 396

Obesity predisposes to Th17 bias

Winer, S., Paltser, G., Chan, Y., Tsui, H., Engleman, E. G., Winer, D. A., & Dosch, H. ‐. (2009) · European Journal of Immunology · doi:10.1002/eji.200838893 · Cited by 385

Epithelium: At the interface of innate and adaptive immune responses

Schleimer, R. P., Kato, A., Kern, R. C., Kuperman, D. A., & Avila, P. C. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.08.046 · Cited by 391

T‐helper 17 cells expand in multiple sclerosis and are inhibited by interferon‐β

Durelli, L., Conti, L., Clerico, M., Boselli, D., Contessa, G., Ripellino, P., Ferrero, B., Eid, P., & Novelli, F. (2009) · Annals of Neurology · doi:10.1002/ana.21652 · Cited by 389

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

Guo, B., Chang, E. Y., & Cheng, G. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33342 · Cited by 380

Interleukin-17–Producing Cd4+ T Cells Increase With Severity of Liver Damage in Patients With Chronic Hepatitis B

Zhang, J., Zhang, Z., Lin, F., Zou, Z., Xu, R., Jin, L., Fu, J., Shi, F., Shi, M., Wang, H., et al. (2009) · Hepatology · doi:10.1002/hep.23273 · Cited by 371

Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF-β1–Dependent and –Independent Mechanisms

Mi, S., Li, Z., Yang, H.-Z., Liu, H., Wang, J.-P., Ma, Y.-G., Wang, X.-X., Liu, H.-Z., Sun, W., & Hu, Z.-W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004081 · Cited by 370

Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview

Schinocca, C., Rizzo, C., Fasano, S., Grasso, G., Barbera, L. L., Ciccia, F., & Guggino, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.637829 · Cited by 382

An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment

Liang, S. C., Long, A. J., Bennett, F., Whitters, M. J., Karim, R., Collins, M. A., Goldman, S. J., Dunussi‐Joannopoulos, K., Williams, C. M. M., Wright, J. F., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7791 · Cited by 374

The metastasis-promoting roles of tumor-associated immune cells

Smith, H. A., & Kang, Y. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1021-5 · Cited by 380

Update of Immune Events in the Murine Contact Hypersensitivity Model: Toward the Understanding of Allergic Contact Dermatitis

Honda, T., Egawa, G., Grabbe, S., & Kabashima, K. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.284 · Cited by 365

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

Torchinsky, M. B., Garaude, J., Martin, A. P., & Blander, J. M. (2009) · Nature · doi:10.1038/nature07781 · Cited by 364

IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma

Liu, J., Duan, Y., Cheng, X., Chen, X., Xie, W., Long, H., Lin, Z., & Zhu, B. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.03.021 · Cited by 382

Inhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice

Erbel, C., Chen, L., Bea, F., Wangler, S., Celik, S., Lasitschka, F., Wang, Y., Böckler, D., Katus, H. A., & Dengler, T. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901126 · Cited by 367

Interleukin-17 and its expanding biological functions

Xu, S., & Cao, X. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.21 · Cited by 362

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

Chiurchiù, V., Leuti, A., Dalli, J., Jacobsson, A., Battistini, L., Maccarrone, M., & Serhan, C. N. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf7483 · Cited by 364

T Helper Cell Differentiation, Heterogeneity, and PlasticityPreprint

Zhu, J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a030338 · Cited by 374

Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin

Johansen, C., Usher, P. A., Kjellerup, R. B., Lundsgaard, D., Iversen, L., & Kragballe, K. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08902.x · Cited by 352

Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL‐12

Ma, C. S., Suryani, S., Avery, D. T., Chan, A., Nanan, R. K. H., Santner‐Nanan, B., Deenick, E. K., & Tangye, S. G. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.64 · Cited by 358

Ocular surface immunity: Homeostatic mechanisms and their disruption in dry eye disease

Barabino, S., Chen, Y., Chauhan, S. K., & Dana, R. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.02.003 · Cited by 346

Inflammatory bowel disease

Teitelbaum, D. H., & Coran, A. G. (2006) · CRC Press eBooks · doi:10.1201/b13237-67 · Cited by 341

The role of IL-17 in CNS diseases

Waisman, A., Hauptmann, J., & Regen, T. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1402-7 · Cited by 343

Interleukin 17A: Toward a new understanding of psoriasis pathogenesis

Lynde, C. W., Poulin, Y. P., Vender, R. B., Bourcier, M., & Khalil, S. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.12.036 · Cited by 344

Dual nature of the adaptive immune system in lampreys

Guo, P., Hirano, M., Herrin, B. R., Li, J., Yu, C., Sadlonova, A., & Cooper, M. D. (2009) · Nature · doi:10.1038/nature08068 · Cited by 336

Differential regulation of interleukin 17 and interferon production in inflammatory bowel disease

Rovedatti, L., Kudo, T., Biancheri, P., Sarra, M., Knowles, C. H., Rampton, D. S., Corazza, G. R., Monteleone, G., Sabatino, A. D., & MacDonald, T. T. (2009) · Gut · doi:10.1136/gut.2009.182170 · Cited by 350

Functional Specializations of Intestinal Dendritic Cell and Macrophage Subsets That Control Th17 and Regulatory T Cell Responses Are Dependent on the T Cell/APC Ratio, Source of Mouse Strain, and Regional Localization

Denning, T. L., Norris, B. A., Contreras, O. M., Manicassamy, S., Geem, D., Madan, R., Karp, C. L., & Pulendran, B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002701 · Cited by 336

A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17

Gaffen, S. L., & Hajishengallis, G. (2008) · Journal of Dental Research · doi:10.1177/154405910808700908 · Cited by 334

IL-17 Promotes Tumor Development through the Induction of Tumor Promoting Microenvironments at Tumor Sites and Myeloid-Derived Suppressor Cells

He, D., Li, H., Yusuf, N., Elmets, C. A., Li, J., Mountz, J. D., & Xu, H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902574 · Cited by 350

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets

Palucka, K., Banchereau, J., & Mellman, I. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.007 · Cited by 341

Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6

Uzawa, A., Mori, M., Arai, K., Sato, Y., Hayakawa, S., Masuda, S., Taniguchi, J., & Kuwabara, S. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510379247 · Cited by 328

Infection, Inflammation, and Bone Regeneration: a Paradoxical Relationship

Thomas, M. V., & Puleo, D. A. (2011) · Journal of Dental Research · doi:10.1177/0022034510393967 · Cited by 327

Atopic Dermatitis: A Disease Caused by Innate Immune Defects?

Benedetto, A. D., Agnihothri, R. V., McGirt, L. Y., Bankova, L. G., & Beck, L. A. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.259 · Cited by 332

Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis

Res, P. C. M., Pişkin, G., de Boer, O. J., van der Loos, C. M., Teeling, P., Bos, J. D., & Teunissen, M. B. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014108 · Cited by 335

IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens

Song, X., Zhu, S., Shi, P., Liu, Y., Shi, Y., Levin, S. D., & Qian, Y. (2011) · Nature Immunology · doi:10.1038/ni.2155 · Cited by 312

TGFβ signalling in control of T-cell-mediated self-reactivity

Rubtsov, Y. P., & Rudensky, A. Y. (2007) · Nature reviews. Immunology · doi:10.1038/nri2095 · Cited by 317

Analysis of IL-17+cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response

Appel, H., Maier, R., Wu, P., Scheer, R., Hempfing, A., Kayser, R., Thiel, A., Radbruch, A., Loddenkemper, C., & Sieper, J. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3370 · Cited by 324

Current trends in inflammatory and immunomodulatory mediators in sepsis

Aziz, M., Jacob, A., Yang, W.-L., Matsuda, A., & Wang, P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0912437 · Cited by 314

Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells and the Effector Phase of Experimental Autoimmune Encephalomyelitis

Fitzgerald, D. C., Ćirić, B., Touil, T., Harle, H., Grammatikopolou, J., Sarma, J. D., Gran, B., Zhang, G., & Rostami, A. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3268 · Cited by 312

Sepsis: Inflammation Is a Necessary Evil

Nedeva, C., Menassa, J., & Puthalakath, H. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00108 · Cited by 315

In vitro–differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations

Carlson, M., West, M. L., Coghill, J. M., Panoskaltsis‐Mortari, A., Blazar, B. R., & Serody, J. S. (2008) · Blood · doi:10.1182/blood-2008-06-162420 · Cited by 309

New therapies for inflammatory bowel disease: from the bench to the bedside

Danese, S. (2011) · Gut · doi:10.1136/gutjnl-2011-300904 · Cited by 303

IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma

Song, C., Luo, L., Zhang, L., Li, B., Liang, Z., Liu, G., Li, D., Zhang, G., Huang, B., & Feng, Z. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6117 · Cited by 304

Role of β7 Integrins in Intestinal Lymphocyte Homing and Retention

Gorfu, G., Rivera-Nieves, J., & Ley, K. (2009) · Current Molecular Medicine · doi:10.2174/156652409789105525 · Cited by 292

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

Zaph, C., Du, Y., Saenz, S. A., Nair, M. G., Perrigoue, J., Taylor, B. C., Troy, A. E., Kobuley, D. E., Kastelein, R. A., Cua, D. J., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080720 · Cited by 292

Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis: integrated pooled clinical trial and post-marketing surveillance data

Deodhar, A. A., Mease, P. J., McInnes, I. B., Baraliakos, X., Reich, K., Blauvelt, A., Leonardi, C., Porter, B. O., Gupta, A. D., Widmer, A., et al. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1882-2 · Cited by 294

The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis

Lavelle, E. C., Murphy, C. H., O'Neill, L. A. J., & Creagh, E. M. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.124 · Cited by 297

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

Chalaris, A., Garbers, C., Rabe, B., Rose‐John, S., & Scheller, J. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.10.007 · Cited by 298

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression

Liao, W., Schones, D. E., Oh, J., Cui, Y., Cui, K., Roh, T., Zhao, K., & Leonard, W. J. (2008) · Nature Immunology · doi:10.1038/ni.1656 · Cited by 287

IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential

Zhu, S., & Qian, Y. (2012) · Clinical Science · doi:10.1042/cs20110496 · Cited by 291

Salivary gland tissue expression of interleukin‐23 and interleukin‐17 in Sjögren's syndrome: Findings in humans and mice

Nguyen, C. Q., Hu, M., Li, Y., Stewart, C., & Peck, A. B. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23214 · Cited by 288

Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors

Lü, J., Han, N., Du, J., Guo, L., Luo, Z., & Liu, Y. F. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00262 · Cited by 284

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

Huber, M., Brüstle, A., Reinhard, K., Guralnik, A., Walter, G. J., Mahiny, A. J., von Löw, E., & Lohoff, M. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809077106 · Cited by 289

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

Yi, T., Chen, Y., Wang, L., Du, G., Huang, D. Q., Zhao, D., Johnston, H. F., Young, J. S., Todorov, I., Umetsu, D. T., et al. (2009) · Blood · doi:10.1182/blood-2009-05-219402 · Cited by 283

The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut

Wang, C., Kang, S. G., Lee, J., Sun, Z., & Kim, C. H. (2009) · Mucosal Immunology · doi:10.1038/mi.2008.84 · Cited by 286

Crosstalk pathways between Toll-like receptors and the complement system

Hajishengallis, G., & Lambris, J. D. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.002 · Cited by 280

Translational Mini-Review Series on Th17 Cells: Function and regulation of human T helper 17 cells in health and disease

Crome, S. Q., Wang, A. Y., & Levings, M. K. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04037.x · Cited by 283

Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration

Qin, H., Buckley, J. A., Li, X., Liu, Y., Fox, T. H., Meares, G. P., Yu, H., Yan, Z., Harms, A. S., Li, Y., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4658-15.2016 · Cited by 287

Th17 T cells: Linking innate and adaptive immunity

Stockinger, B., Veldhoen, M., & Martin, B. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.008 · Cited by 282

Increased Circulating Pro-Inflammatory Cytokines and Th17 Lymphocytes in Hashimoto’s Thyroiditis

Figueroa‐Vega, N., Alfonso-Pérez, M., Benedicto, I., Sánchez‐Madrid, F., González‐Amaro, R., & Marazuela, M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1719 · Cited by 269

Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology

Yu, L. C. (2012) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v3.i1.27 · Cited by 280

IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets

Létourneau, S., Krieg, C., Pantaleo, G., & Boyman, O. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.02.011 · Cited by 279

IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines

Ortega, C., Fernández, S., Carrillo, J. M., Romero, P., Molina, I. J., Moreno, J. C., & Santamaria, M. L. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0109046 · Cited by 266

Vitamin D and the Immune System: New Perspectives on an Old Theme

Hewison, M. (2012) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2012.03.012 · Cited by 268

Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood

Duggal, N. A., Pollock, R. D., Lazarus, N. R., Harridge, S., & Lord, J. M. (2018) · Aging Cell · doi:10.1111/acel.12750 · Cited by 261

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

Fina, D., Sarra, M., Fantini, M. C., Rizzo, A., Caruso, R., Caprioli, F., Stolfi, C., Cardolini, I., Dottori, M., Boirivant, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.041 · Cited by 266

Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)

Poddubnyy, D., Hermann, K., Callhoff, J., Listing, J., & Sieper, J. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204248 · Cited by 266

The Effect of Inflammatory Cytokines in Alcoholic Liver Disease

Kawaratani, H., Tsujimoto, T., Douhara, A., Takaya, H., Moriya, K., Namisaki, T., Noguchi, R., Yoshiji, H., Fujimoto, M., & Fukui, H. (2013) · Mediators of Inflammation · doi:10.1155/2013/495156 · Cited by 261

Averting inflammation by targeting the cytokine environment

Köpf, M., Bachmann, M. F., & Marsland, B. J. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2805 · Cited by 262

Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

Shen, F., & Gaffen, S. L. (2008) · Cytokine · doi:10.1016/j.cyto.2007.11.013 · Cited by 266

The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease

Leung, S., Liu, X., Fang, L., Chen, X. X., Guo, T. B., & Zhang, J. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.22 · Cited by 265

Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210

Wang, H., Flach, H., Onizawa, M., Wei, L., McManus, M. T., & Weiss, A. (2014) · Nature Immunology · doi:10.1038/ni.2846 · Cited by 252

IL-12 Produced by Dendritic Cells Augments CD8+ T Cell Activation through the Production of the Chemokines CCL1 and CCL17

Henry, C. J., Ornelles, D. A., Mitchell, L. M., Brzoza‐Lewis, K. L., & Hiltbold, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8576 · Cited by 258

GATA3: a master of many trades in immune regulation

Wan, Y. Y. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.002 · Cited by 248

Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

Teixeira, A. R. L., Hecht, M. M., Guimaro, M. C., Sousa, A. O., & Nitz, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00063-10 · Cited by 248

Inflammatory Cytokines in Systemic Lupus Erythematosus

Ohl, K., & Tenbrock, K. (2011) · BioMed Research International · doi:10.1155/2011/432595 · Cited by 253

Regulation of Airway MUC5AC Expression by IL-1β and IL-17A; the NF-κB Paradigm

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Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists

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References

E, H. L., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., MURPHY, K. M. M., Mangan, P. R., Harrington, L. E., O’Quinn, D. B., Helms, W. S., et al. (2015)

Expanding the effector CD4 T-cell repertoire: the Th17 lineage

Harrington, L. E., Mangan, P. R., & Weaver, C. T. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.017 · Cited by 595

The progression of research on the Th17 lineage

Wu, X.-Z. (2007) · International Journal of Immunology

Th17 cell induction and immune regulatory effects

Bi, Y., Liu, G., & Yang, R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.20973 · Cited by 92

A New Subset of CD4~+T cells: Th17 and Its Biological Effects

Liu, G. (2007) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS