Cited by 1,842Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.

IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

Weaver, Casey T., Hatton, Robin D., Mangan, Paul R., Harrington, Laurie E.·2007·Annual Review of Immunology

DOI 10.1146/annurev.immunol.25.022106.141557

Open this paper in CoChat — free account

Abstract

Since its conception two decades ago, the Th1-Th2 paradigm has provided a framework for understanding T cell biology and the interplay of innate and adaptive immunity. Naive T cells differentiate into effector T cells with enhanced functional potential for orchestrating pathogen clearance largely under the guidance of cytokines produced by cells of the innate immune system that have been activated by recognition of those pathogens. This secondary education of post-thymic T cells provides a mechanism for appropriately matching adaptive immunity to frontline cues of the innate immune system. Owing in part to the rapid identification of novel cytokines of the IL-17 and IL-12 families using database searches, the factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense.

Integrity signals

Registry

Crossref · 10.1146/annurev.immunol.25.022106.141557

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
Self-citation
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134

Show all 135 references

Research works printed but not linked: 1

10.1172/JCI200112563 · DOI

Sorted by citations

Items 301–400 of 1,001

Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells
Shi, G., Cox, C. A., Vistica, B. P., Tan, C., Wawrousek, E. F., & Gery, I. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7205 · Cited by 157
Host responses to Candida albicans: Th17 cells and mucosal candidiasis
Conti, H. R., & Gaffen, S. L. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.03.013 · Cited by 163
IL-17A Influences Essential Functions of the Monocyte/Macrophage Lineage and Is Involved in Advanced Murine and Human Atherosclerosis
Erbel, C., Akhavanpoor, M., Okuyucu, D., Wangler, S., Dietz, A., Zhao, L., Stellos, K., Little, K. M., Lasitschka, F., Doesch, A. O., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400181 · Cited by 153
Vaccines for Pseudomonas aeruginosa : a long and winding road
Priebe, G. P., & Goldberg, J. B. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2014.890053 · Cited by 158
Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis
Melis, L., Vandooren, B., Kruithof, E., Jacques, P., Vos, M. D., Mielants, H., Verbruggen, G., Keyser, F. D., & Elewaut, D. S. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.107649 · Cited by 154
Metabolism Controls the Balance of Th17/T-Regulatory Cells
Sun, L., Fu, J., & Zhou, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01632 · Cited by 167
T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity
Harbour, S. N., DiToro, D. F., Witte, S. J., Zindl, C. L., Gao, M., Schoeb, T. R., Jones, G. W., Jones, S. A., Hatton, R. D., & Weaver, C. T. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaw2262 · Cited by 151
“Although the role of IL-6 in TH17 cell induction is well characterized (2, 4), it is unknown whether ongoing IL-6 signaling contributes to TH17 maintenance or whether there are additional factors that antagonize lineage-destabilizing signals such as IL-12– and IL-23– induced STAT4 to preserve the TH17 phenotype.”
BackgroundSelf-citation
IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling
Hoge, J., Yan, I., Jänner, N., Schumacher, V., Chalaris, A., Steinmetz, O. M., Engel, D. R., Scheller, J., Rose‐John, S., & Mittrücker, H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201044 · Cited by 158
The link between IL-23 and Th17 cell-mediated immune pathologies
McGeachy, M. J., & Cua, D. J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.012 · Cited by 152
IL-17A Upregulates Keratin 17 Expression in Keratinocytes through STAT1- and STAT3-Dependent Mechanisms
Shi, X., Jin, L., Dang, E., Chang, T., Feng, Z., Liu, Y., & Wang, G. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.222 · Cited by 151
Gut‐associated lymphoid tissue, T cell trafficking, and chronic intestinal inflammation
Koboziev, I., Karlsson, F. J., & Grisham, M. B. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05711.x · Cited by 150
The role of Th17 lymphocytes in the autoimmune and chronic inflammatory diseases
Murdaca, G., Colombo, B. M., & Puppo, F. (2011) · Internal and Emergency Medicine · doi:10.1007/s11739-011-0517-7 · Cited by 152
Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA
Metawi, S. A., Abbas, D., Kamal, M. M., & Ibrahim, M. K. (2011) · Clinical Rheumatology · doi:10.1007/s10067-011-1737-y · Cited by 150
Organization of the skin immune system and compartmentalized immune responses in infectious diseases
Quaresma, J. A. S. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00034-18 · Cited by 149
IL-17 and the Th17 lineage in systemic lupus erythematosus
Garrett‐Sinha, L. A., John, S. A., & Gaffen, S. L. (2008) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328304b6b5 · Cited by 153
A Protective Role by Interleukin-17F in Colon Tumorigenesis
Tong, Z., Yang, X. O., Yan, H., Liu, W., Niu, X., Shi, Y., Fang, W., Xiong, B., Wan, Y., & Dong, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034959 · Cited by 154
Mitochondrial Stat3, the need for design thinking
Yang, R., & Rincon, M. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.15153 · Cited by 147
Prostaglandin E2 enhances Th17 responses via modulation of IL‐17 and IFN‐γ production by memory CD4+ T cells
Napolitani, G., Rodríguez, E. V. A., Lanzavecchia, A., & Sallusto, F. (2009) · European Journal of Immunology · doi:10.1002/eji.200838969 · Cited by 154
IL-17-induced NF-κB Activation via CIKS/Act1
Sønder, S. U., Saret, S., Tang, W., Sturdevant, D. E., Porcella, S. F., & Siebenlist, U. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199547 · Cited by 148
Evolving Insights in the Pathogenesis and Therapy of Cutaneous T‐cell lymphoma (Mycosis Fungoides and Sezary Syndrome)
Wong, H. K., Mishra, A., Hake, T. S., & Porcu, P. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08852.x · Cited by 145
Accumulation of IL‐17‐Positive Cells in Decidua of Inevitable Abortion Cases
Nakashima, A., Ito, M., Shima, T., Bac, N. D., 日高, 隆., & Saito, S. (2010) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00812.x · Cited by 147
Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic Acid
Dunham, R. M., Thapa, M., Velazquez, V. M., Elrod, E. J., Denning, T. L., Pulendran, B., & Grakoui, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201937 · Cited by 151
Notch Signaling Regulates Mouse and Human Th17 Differentiation
Keerthivasan, S., Suleiman, R., Lawlor, R. G., Roderick, J. E., Bates, T. C., Minter, L. M., Anguíta, J., Juncadella, I. J., Nickoloff, B. J., Poole, I. C. L., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003658 · Cited by 150
The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation
Yoshida, Y., Yoshimi, R., Yoshii, H., Kim, D., Dey, A., Xiong, H., Munasinghe, J., Yazawa, I., O'Donovan, M. J., Maximova, O. A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.022 · Cited by 148
Pathogenesis of airway inflammation in bronchial asthma
Nakagome, K., & Nagata, M. (2011) · Auris Nasus Larynx · doi:10.1016/j.anl.2011.01.011 · Cited by 144
Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: Preventive and therapeutic effects on experimental autoimmune encephalomyelitis
Nakano, K., Higashi, T., Hashimoto, K., Takagi, R., Tanaka, Y., & Matsushita, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.012 · Cited by 147
Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis
Sarno, P. D., Axtell, R. C., Raman, C., Roth, K. A., Alessi, D. R., & Jope, R. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.338 · Cited by 146
IL-17A–Producing γδ T and Th17 Lymphocytes Mediate Lung Inflammation but Not Fibrosis in Experimental Silicosis
Re, S. L., Dumoutier, L., Couillin, I., Vyve, C. V., Yakoub, Y., Uwambayinema, F., Marien, B., van den Brûle, S., Snick, J. V., Uyttenhove, C., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0900459 · Cited by 144
Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103+ inducible regulatory T cells
Zhu, J., Davidson, T. S., Wei, G., Jankovic, D. L., Cui, K., Schones, D. E., Guo, L., Zhao, K., Shevach, E. M., & Paul, W. E. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081666 · Cited by 148
Role of IL-17 in asthma pathogenesis and its implications for the clinic
Ramakrishnan, R. K., Heialy, S. A., & Hamid, Q. A. (2019) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1666002 · Cited by 152
Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda
Griffin, A. J., & McSorley, S. J. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.2 · Cited by 146
The Adaptor Protein CIKS/Act1 Is Essential for IL-25-Mediated Allergic Airway Inflammation
Claudio, E., Sønder, S. U., Saret, S., Carvalho, G., Ramalingam, T. R., Wynn, T. A., Chariot, A., García‐Pergañeda, A., Leonardi, A., Paun, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1617 · Cited by 143
The roles of SOCS 3 and STAT 3 in bacterial infection and inflammatory diseases
Gao, Y., Zhao, H., Wang, P., Wang, J., & Zou, L. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12727 · Cited by 143
In Situ Analysis of Interleukin–23– and Interleukin‐12–Positive Cells in the Spine of Patients With Ankylosing Spondylitis
Appel, H., Maier, R., Bleil, J., Hempfing, A., Loddenkemper, C., Schlichting, U., Syrbe, U., & Sieper, J. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37937 · Cited by 147
Distribution and Clinical Significance of Th17 Cells in the Tumor Microenvironment and Peripheral Blood of Pancreatic Cancer Patients
He, S., Fei, M., Wu, Y., Zheng, D., Wan, D., Wang, L., & Li, D. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12117424 · Cited by 152
Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and their Sequelae
Cunningham, M. W. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0045-2018 · Cited by 141
Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus
Martin, J. C., Baeten, D., & Josien, R. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.05.004 · Cited by 144
NF-κB Mediates IL-1β– and IL-17A–Induced MUC5B Expression in Airway Epithelial Cells
Fujisawa, T., Chang, M. M.-J., Velichko, S., Thai, P., Hung, L., Huang, F., Phuong, N. S., Chen, Y., & Wu, R. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0313oc · Cited by 146
Interleukin‐17‐producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor
Chen, W., Lai, Y., Chen, H., Guo, H., Su, I., & Chen, H. H. W. (2013) · Histopathology · doi:10.1111/his.12156 · Cited by 147
Brodalumab for the Treatment of Psoriasis: A Review of Phase III Trials
Farahnik, B., Beroukhim, K., Abrouk, M. E., Nakamura, M., Zhu, T. H., Singh, R., Lee, K. M., Bhutani, T., & Koo, J. Y. M. (2016) · Dermatology and Therapy · doi:10.1007/s13555-016-0121-x · Cited by 138
Anti‐inflammatory and immune‐modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation
Ehteshamfar, S. M., Akhbari, M., Afshari, J. T., Seyedi, M., Nikfar, B., Moghaddam, A. S., Ghanbarzadeh, E., & Momtazi‐Borojeni, A. A. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16049 · Cited by 138
Green tea EGCG, T cells, and T cell-mediated autoimmune diseases
Wu, D., Wang, J., Pae, M., & Meydani, S. N. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.001 · Cited by 138
Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease
Liu, X., Leung, S., Wang, C., Tan, Z., Wang, J., Guo, T. B., Fang, L., Zhao, Y., Wan, B., Qin, X., et al. (2010) · Nature Medicine · doi:10.1038/nm.2077 · Cited by 144
Retracted
TGF-β Receptor II Loss Promotes Mammary Carcinoma Progression by Th17-Dependent Mechanisms
Novitskiy, S. V., Pickup, M. W., Gorska, A. E., Owens, P., Chytil, A., Aakre, M. E., Wu, H., Shyr, Y., & Moses, H. L. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0100 · Cited by 138
NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis
Berzofsky, J. A., & Terabe, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3627 · Cited by 140
Characterization of the immune response in human paracoccidioidomycosis
de Castro, L. F., Ferreira, M. C., da Silva, R. M., Blotta, M. H. S. L., Longhi, L., & Mamoni, R. L. (2013) · Journal of Infection · doi:10.1016/j.jinf.2013.07.019 · Cited by 136
IL-17RA Signaling Reduces Inflammation and Mortality during Trypanosoma cruzi Infection by Recruiting Suppressive IL-10-Producing Neutrophils
Tosello, J., Vesely, M. C. A., Bermejo, D. A., Ramello, M. C., Montes, C. L., Cejas, H., Gruppi, A., & Rodríguez, E. V. A. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002658 · Cited by 138
Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis
Brenu, E. W., van Driel, M. L., Staines, D. R., Ashton, K. J., Hardcastle, S. L., Keane, J., Tajouri, L., Peterson, D., Ramos, S. B., & Marshall-Gradisnik, S. M. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-88 · Cited by 135
Unbalanced Neonatal CD4+ T-Cell Immunity
Debock, I., & Flamand, V. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00393 · Cited by 138
The natural and the inducible: interleukin (IL)-17-producing γδ T cells
Chien, Y., Zeng, X., & Prinz, I. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.11.004 · Cited by 139
Differential requirement of PKC-θ in the development and function of natural regulatory T cells
Gupta, S., Manicassamy, S., Vasu, C., Kumar, A., Shang, W., & Sun, Z. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.08.275 · Cited by 139
Neonatal Sepsis and Inflammatory Mediators
Machado, J. R., Soave, D. F., da Silva, M. V., de Menezes, L. B., Etchebehere, R. M., Monteiro, M. L. G. D. R., dos Reis, M. A., Corrêa, R. R. M., & Celes, M. R. N. (2014) · Mediators of Inflammation · doi:10.1155/2014/269681 · Cited by 134
Cytokine Targeting by miRNAs in Autoimmune Diseases
Salvi, V., Gianello, V., Tiberio, L., Sozzani, S., & Bosisio, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00015 · Cited by 135
Induction of Th17 Cells in the Tumor Microenvironment Improves Survival in a Murine Model of Pancreatic Cancer
Gnerlich, J. L., Mitchem, J. B., Weir, J. S., Sankpal, N. V., Kashiwagi, H., Belt, B. A., Porembka, M. R., Herndon, J. M., Eberlein, T. J., Goedegebuure, P. S., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902609 · Cited by 138
Vitamin D and immune function: autocrine, paracrine or endocrine?
Hewison, M. (2012) · PubMed · doi:10.3109/00365513.2012.682862 · Cited by 133
Cytokines and Their Roles in the Pathogenesis of Systemic Lupus Erythematosus: From Basics to Recent Advances
Yap, D. Y. H., & Lai, K. N. (2010) · BioMed Research International · doi:10.1155/2010/365083 · Cited by 134
IL-17 Receptor Signaling Inhibits C/EBPβ by Sequential Phosphorylation of the Regulatory 2 Domain
Shen, F., Li, N., Gade, P., Kalvakolanu, D. V., Weibley, T., Doble, B. W., Woodgett, J. R., Wood, T. D., & Gaffen, S. L. (2009) · Science Signaling · doi:10.1126/scisignal.2000066 · Cited by 135
Cutting Edge: Leptin-Induced RORγt Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus
Yu, Y., Liu, Y., Shi, F., Zou, H., Matarese, G., & Cava, A. L. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203275 · Cited by 131
Dietary supplementation of young broiler chickens with Capsicum and turmeric oleoresins increases resistance to necrotic enteritis
Lee, S. H., Lillehoj, H. S., Jang, S. I., Lillehoj, E. P., Min, W., & Bravo, D. M. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512006083 · Cited by 131
The Myeloid Differentiation Factor 88 (MyD88) Is Required for CD4+ T Cell Effector Function in a Murine Model of Inflammatory Bowel Disease
Fukata, M., Breglio, K. J., Chen, A., Vamadevan, A. S., Goo, T., Hsu, D. S., Conduah, D. E., Xu, R., & Abreu, M. T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1886 · Cited by 130
A Role for Th17 Cells in the Immunopathogenesis of Atopic Dermatitis?
Cesare, A. D., Meglio, P. D., & Nestle, F. O. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.283 · Cited by 130
Innate Immune Cell–Produced IL-17 Sustains Inflammation in Bullous Pemphigoid
Jan, S. L., Plée, J., Vallerand, D., Dupont-Deshorgue, A., Delanez, E., Durlach, A., Jackson, P. L., Blalock, J. E., Bernard, P., & Antonicelli, F. D. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.263 · Cited by 131
Human Neutrophil Clearance of Bacterial Pathogens Triggers Anti-Microbial γδ T Cell Responses in Early Infection
Davey, M. S., Lin, C. Y., Roberts, G. W., Heuston, S., Brown, A. C., Chess, J. A., Toleman, M. A., Gahan, C. G. M., Hill, C., Parish, T., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002040 · Cited by 135
The immunology of susceptibility and resistance to scabies
Walton, S. F. (2010) · Parasite Immunology · doi:10.1111/j.1365-3024.2010.01218.x · Cited by 129
The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling
Garg, A. V., Ahmed, M., Vallejo, A. N., Ma, A., & Gaffen, S. L. (2013) · Science Signaling · doi:10.1126/scisignal.2003699 · Cited by 128
CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T‐cell recruitment to target tissues
Villares, R., Cadenas, V., Lozano, M. D., Almonacid, L., Zaballos, Á., Martínez‐A, C., & Varona, R. (2009) · European Journal of Immunology · doi:10.1002/eji.200839123 · Cited by 127
Chapter 5 Emergence of the Th17 Pathway and Its Role in Host Defense
O’Quinn, D. B., Palmer, M. T., Lee, Y. K., & Weaver, C. T. (2008) · Advances in immunology · doi:10.1016/s0065-2776(08)00605-6 · Cited by 130
Self-citation
Effect of stress on brain inflammation and multiple sclerosis
Karagkouni, A., Alevizos, M., & Theoharides, T. C. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.02.006 · Cited by 132
The Role of IL-17 in Protection against Mucosal Candida Infections
Mengesha, B., & Conti, H. R. (2017) · Journal of Fungi · doi:10.3390/jof3040052 · Cited by 127
IL-17RC Is Required for Immune Signaling via an Extended SEF/IL-17R Signaling Domain in the Cytoplasmic Tail
Ho, A. W., Shen, F., Conti, H. R., Patel, N. M., Childs, E. E., Peterson, A., Hernández‐Santos, N., Kolls, J. K., Kane, L., Ouyang, W., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903739 · Cited by 129
The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis
Nuovo, G. J., Hagood, J. S., Magro, C. M., Chin, N., Kapil, R., Davis, L., Marsh, C. B., & Folcik, V. A. (2012) · Modern Pathology · doi:10.1038/modpathol.2011.166 · Cited by 123
Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity
Zhang, F., Lu, Y., & Malley, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307228110 · Cited by 123
The pathogenesis of thyroid autoimmune diseases: New T lymphocytes – Cytokines circuits beyond the Th1−Th2 paradigm
Li, Q., Wang, B., Mu, K., & Zhang, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27180 · Cited by 126
Potential plasma markers of type 1 and type 2 leprosy reactions: a preliminary report
Stefani, M. M. A., Guerra, J. G., Sousa, A. L. M., Costa, M. B., de Oliveira, M. L. W.-D.-R., Martelli, C. M. T., & Scollard, D. M. (2009) · BMC Infectious Diseases · doi:10.1186/1471-2334-9-75 · Cited by 123
Interleukin-17 Contributes to Generation of Th1 Immunity and Neutrophil Recruitment duringChlamydia muridarumGenital Tract Infection but Is Not Required for Macrophage Influx or Normal Resolution of Infection
Scurlock, A. M., Frazer, L. C., Andrews, C. W., O’Connell, C. M., Foote, I. P., Bailey, S. L., Chandra-Kuntal, K., Kolls, J. K., & Darville, T. L. (2010) · Infection and Immunity · doi:10.1128/iai.00984-10 · Cited by 128
Interleukin 21: a cytokine/cytokine receptor system that has come of age
Leonard, W. J., Zeng, R., & Spolski, R. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0308149 · Cited by 122
Interleukin‐17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule‐1 (ICAM‐1) expression in human intervertebral disc cells
Gabr, M., Jing, L., Helbling, A. R., Sinclair, S. M., Allen, K. D., Shamji, M. F., Richardson, W. J., Fitch, R. D., Setton, L. A., & Chen, J. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21206 · Cited by 122
Interleukin-7 (IL-7) Treatment Accelerates Neutrophil Recruitment through γδ T-Cell IL-17 Production in a Murine Model of Sepsis
Kasten, K. R., Prakash, P. S., Unsinger, J., Goetzman, H. S., England, L. G., Cave, C. M., Seitz, A. P., Mazuski, C. N., Zhou, T. T., Morre, M., et al. (2010) · Infection and Immunity · doi:10.1128/iai.00456-10 · Cited by 122
Natural Killer T Cell–derived IL-17 Mediates Lung Ischemia–Reperfusion Injury
Sharma, A. K., LaPar, D. J., Zhao, Y., Li, L., Lau, C. L., Kron, I. L., Iwakura, Y., Okusa, M. D., & Laubach, V. E. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201007-1173oc · Cited by 122
Characterization of IL-17A–Producing Cells in Celiac Disease Mucosa
Monteleone, I., Sarra, M., Blanco, G. D. V., Paoluzi, O. A., Franzè, E., Fina, D., Fabrizi, A., MacDonald, T. T., Pallone, F., & Monteleone, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901919 · Cited by 122
Regulation of Th1 and Th17 Cell Differentiation and Amelioration of Experimental Autoimmune Encephalomyelitis by Natural Product Compound Berberine
Qin, X., Guo, B.-S., Wan, B., Fang, L., Lü, L., Wu, L., Zang, Y. Q., & Zhang, J. Z. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903853 · Cited by 122
Effect of non-surgical periodontal therapy on the levels of Th17/Th1/Th2 cytokines and their transcription factors in Chinese chronic periodontitis patients
Zhao, L., Zhou, Y., Xu, Y., Sun, Y., Li, L., & Wu, C. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01712.x · Cited by 125
IL-27 Regulates IL-10 and IL-17 from CD4+ Cells in Nonhealing Leishmania major Infection
Anderson, C. F., Stumhofer, J. S., Hunter, C. A., & Sacks, D. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804024 · Cited by 125
Mesenchymal Stem Cells Ameliorate Sepsis-associated Acute Kidney Injury in Mice
Luo, C., Zhang, F., Zhang, L., Geng, Y.-Q., Li, Q., Hong, Q., Fu, B., Zhu, F., Cui, S., Feng, Z., et al. (2013) · Shock · doi:10.1097/shk.0000000000000080 · Cited by 121
Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation
Cui, W., Joshi, N. S., Jiang, A., & Kaech, S. M. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.01.088 · Cited by 121
IL-17 Is a Critical Component of Vaccine-Induced Protection against Lung Infection by Lipopolysaccharide-Heterologous Strains of Pseudomonas aeruginosa
Priebe, G. P., Walsh, R. L., Cederroth, T., Kamei, A., Coutinho-Sledge, Y. S., Goldberg, J. B., & Pier, G. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4965 · Cited by 123
Unraveling the Pathophysiology of Sjogren Syndrome-Associated Dry Eye Disease
Nguyen, C. Q., & Peck, A. B. (2009) · The Ocular Surface · doi:10.1016/s1542-0124(12)70289-6 · Cited by 121
IL-17 signaling in host defense and inflammatory diseases
Qian, Y., Kang, Z., Liu, C., & Li, X. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.27 · Cited by 124
IL-17 signaling in host defense against Candida albicans
Gaffen, S. L., Hernández‐Santos, N., & Peterson, A. (2011) · Immunologic Research · doi:10.1007/s12026-011-8226-x · Cited by 125
Increased Th17 cells contribute to disease progression in patients with HBV‐associated liver cirrhosis
Sun, H. Q., Zhang, J., Zhang, H., Zou, Z., Wang, F. S., & Jia, J. (2012) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2011.01561.x · Cited by 121
Aging Promotes Neutrophil-Induced Mortality by Augmenting IL-17 Production during Viral Infection
Stout-Delgado, H. W., Du, W., Shirali, A. C., Booth, C. J., & Goldstein, D. R. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.09.011 · Cited by 120
New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation
Wei, L., Laurence, A. D. J., & O’Shea, J. J. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.011 · Cited by 126
Neutrophils and macrophages work in concert as inducers and effectors of adaptive immunity against extracellular and intracellular microbial pathogens
Silva, M. T. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1109767 · Cited by 125
The Relation of Interleukin 17 (IL-17) and IL-23 to Th1/Th2 Cytokines and Disease Activity in Systemic Lupus Erythematosus
Mok, M. Y., Wu, H. J., Lo, Y., & Lau, C. S. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100293 · Cited by 119
Type I IFN Promotes IL-10 Production from T Cells to Suppress Th17 Cells and Th17-Associated Autoimmune Inflammation
Zhang, L., Yuan, S., Cheng, G., & Guo, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028432 · Cited by 123
Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis
Marchesan, J. T., Gerow, E. A., Schaff, R., Taut, A. D., Shin, S., Sugai, J. V., Brand, D. D., Burberry, A., Jorns, J. M., Lundy, S. K., et al. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4376 · Cited by 121
Understanding Autoimmunity: Mechanisms, Predisposing Factors, and Cytokine Therapies
Yasmeen, F., Pirzada, R. H., Ahmad, B., Choi, B., & Choi, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147666 · Cited by 131
The Interleukin‐23 / Interleukin‐17 axis in intestinal inflammation
Maloy, K. J. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01950.x · Cited by 121
The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature
Rabin, R. L., & Levinson, A. I. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03679.x · Cited by 119
Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice
Oh, K., Park, H.-B., Byoun, O.-J., Shin, D.-M., Jeong, E. M., Kim, Y. W., Kim, Y. S., Melino, G., Kim, I.-G., & Lee, D.-S. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101457 · Cited by 118

Authors: Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E.
Affiliations: University of Alabama at Birmingham (US)
ORCID: Weaver, Casey T.
Hatton, Robin D.
Harrington, Laurie E.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2007-04-01
Volume: 25
Issue: 1
Pages: 821-852
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.25.022106.141557
OpenAlex: W2156451877
Cited by: 1,842
References: 135
Citations by year: 2026: 18 · 2025: 16 · 2024: 35 · 2023: 33 · 2022: 35 · 2021: 60 · 2020: 47 · 2019: 54 · 2018: 60 · 2017: 79 · 2016: 71 · 2015: 99 · 2014: 124 · 2013: 137 · 2012: 120
FWCI: 18.11
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: IL-17 family cytokines, IL-12 family cytokines, Th17 cells, effector T cell differentiation, Th1/Th2 paradigm, naive T cell activation, innate-adaptive immune interaction, T cell lineage specification, immune regulation, immune pathogenesis, host defense
MeSH terms: Animals, Cell Differentiation, Humans, Immunity, Innate, Structure-Activity Relationship, Protein Structure, Tertiary, Th1 Cells, Th2 Cells, Interleukin-12, Interleukin-17

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks