Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration
Abstract
The effects of withdrawal from cocaine on extracellular dopamine (DA) levels in the nucleus accumbens (NAC) were examined by intracranial microdialysis in awake rats after periods (9.5-21.75 h) of unlimited-access, intravenous cocaine self-administration. Cocaine withdrawal was associated with significant reductions in basal DA overflow that persisted up to 12 h. Maximal inhibition of DA release (mean +/- S.E.M. 66.15 +/- 3.30 percent of basal levels) was observed between 4-6 h after cessation of cocaine intake and was positively correlated (r = 0.88) with the duration of the preceding self-administration episode. The results suggest that suppression of basal DA release in the NAC is an adaptive consequence of sustained cocaine exposure and may in part underlie the post-cocaine anhedonia observed in behavioral models of cocaine withdrawal.
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Acute withdrawal from major drugs of abuse including nicotine decreases mesolimbic DAergic activity.
“Acute withdrawal from all major drugs of abuse, including nicotine, decreases activity of the mesolimbic DAergic system, [135–139]”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [139]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Abstinence Symptomatology and Psychiatric Diagnosis in Cocaine Abusers
Gawin, F. H. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020013003 · Cited by 1,143 · see citing works
Self-administration of psychoactive substances by the monkey
Deneau, G. A., Yanagita, T., & Seevers, M. H. (1969) · Psychopharmacology · doi:10.1007/bf00405254 · Cited by 811 · see citing works
Roberts, D. C. S., Koob, G. F., Klonoff, P., & Fibiger, H. C. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90166-5 · Cited by 730 · see citing works
Self-citationNew concepts in cocaine addiction: The dopamine depletion hypothesis
Dackis, C. A., & Gold, M. S. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90022-3 · Cited by 607 · see citing works
Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens
Kalivas, P. W., & Duffy, P. (1990) · Synapse · doi:10.1002/syn.890050104 · Cited by 544 · see citing works
Postcocaine anhedonia. An animal model of cocaine withdrawal.
Markou, A., & Koob, G. F. (1991) · PubMed · Cited by 505 · see citing works
Self-citationPettit, H. O., & Justice, J. B. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90291-8 · Cited by 375 · see citing works
Henry, D. J., Greene, M. A., & White, F. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21086-2 · Cited by 268 · see citing works
Parsons, L. H., Smith, A. D., & Justice, J. B. (1991) · Synapse · doi:10.1002/syn.890090109 · Cited by 260 · see citing works
Toxicity Associated With Long-term Intravenous Heroin and Cocaine Self-administration in the Rat
Bozarth, M. A. (1985) · JAMA · doi:10.1001/jama.1985.03360010087032 · Cited by 260 · see citing works
The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat
Hubner, C. B., & Koob, G. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91112-t · Cited by 218 · see citing works
Self-citationHurd, Y. L., Weiss, F., Koob, G. F., And, N.-E., & Ungerstedt, U. (1989) · Brain Research · doi:10.1016/0006-8993(89)90422-8 · Cited by 198 · see citing works
Self-citationNeurochemical Correlates of Cocaine and Ethanol Self‐Administrationa
Weiss, F., Hurd, Y. L., Ungerstedt, U., Markou, A., Plotsky, P. M., & Koob, G. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25970.x · Cited by 151 · see citing works
Self-citationWeiss, F., Paulus, M. P., Lorang, M. T., & Koob, G. F. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04372.1992 · Cited by 146 · see citing works
Self-citationApparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment
Robertson, M. W., Leslie, C. A., & Bennett, J. P. (1991) · Brain Research · doi:10.1016/0006-8993(91)90451-z · Cited by 123 · see citing works
Lack of long-term monoamine depletions following repeated or continuous exposure to cocaine
Kleven, M. S., Woolverton, W. L., & Seiden, L. S. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90236-5 · Cited by 108 · see citing works
Kokkinidis, L., & McCarter, B. D. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90242-a · Cited by 97 · see citing works
Ng, J. P., Hubert, G. W., & Justice, J. B. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02042.x · Cited by 95 · see citing works
Dwoskin, L. P., Peris, J., Yasuda, R. P., Philpott, K., & Zahniser, N. R. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90634-0 · Cited by 85 · see citing works
Role of Dopamine Receptors in the Nucleus Accumbens in the Rewarding Properties of Cocaine
Robledo, P., Maldonado, R. J., & Koob, G. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb26015.x · Cited by 80 · see citing works
Self-citationCocaine: Clinical and biobehavioral aspects
Schultes, R. E. (1988) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(88)90131-6 · Cited by 72 · see citing works
Graeff, F. G., Leme, J. G., & Silva, M. R. E. (1965) · International Journal of Neuropharmacology · doi:10.1016/0028-3908(65)90043-2 · Cited by 29 · see citing works
Petry, H. M., Agarwala, S., & May, J. G. (1989) · Brain Research · doi:10.1016/0006-8993(89)90026-7 · Cited by 13 · see citing works
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Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
Self-citationWhat is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
Neurobiology of addiction: a neurocircuitry analysis
Koob, G. F., & Volkow, N. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00104-8 · Cited by 3,698 · see citing works
Self-citationDrug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535 · see citing works
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Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
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Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457 · see citing works
Self-citationThe neurobiology of anhedonia and other reward-related deficits
Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130 · see citing works
Self-citationThe psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507 · see citing works
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026 · see citing works
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Markou, A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00113-9 · Cited by 767 · see citing works
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Kreek, M. J., & Koob, G. F. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00064-7 · Cited by 696 · see citing works
Self-citationPharmacology and behavioral pharmacology of the mesocortical dopamine system
Tzschentke, T. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00033-2 · Cited by 481 · see citing works
Witkiewitz, K., & Bowen, S. (2010) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0019172 · Cited by 453 · see citing works
The dark side of emotion: the addiction perspective
Koob, G. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.044 · Cited by 433 · see citing works
Self-citationNeural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal
S. Watkins, G. F. K. (2000) · Nicotine & Tobacco Research · doi:10.1080/14622200050011277 · Cited by 424 · see citing works
The neurocircuitry of addiction: an overview
Feltenstein, M. W., & See, R. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.51 · Cited by 421 · see citing works
The neurobiology of addiction: a neuroadaptational view relevant for diagnosis
Koob, G. F. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01586.x · Cited by 397 · see citing works
Self-citationReward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366 · see citing works
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Self-citationNeurobiology of the nicotine withdrawal syndrome
Kenny, P. J., & Markou, A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00651-7 · Cited by 310 · see citing works
Self-citationSynaptic regulation of mesocorticolimbic dopamine neurons
White, F. J. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.002201 · Cited by 289 · see citing works
Vorel, S. R., Ashby, C. R., Paul, M., Liu, X., Hayes, R., Hagan, J. J., Middlemiss, D. N., Stemp, G., & Gardner, E. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09595.2002 · Cited by 269 · see citing works
Sarnyai, Z., Bíró, É., Gardi, J., Vecsernyés, M., Julesz, J., & Telegdy, G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00043-p · Cited by 255 · see citing works
DI CHIARA, G., TANDA, G., BASSAREO, V., PONTIERI, F., ACQUAS, E., FENU, S., CADONI, C., & CARBONI, E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09283.x · Cited by 242 · see citing works
Shirayama, Y., & Chaki, S. (2006) · Current Neuropharmacology · doi:10.2174/157015906778520773 · Cited by 225 · see citing works
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Hildebrand, B. E., Nomikos, G. G., Hertel, P., Schilström, B., & Svensson, T. H. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01135-9 · Cited by 200 · see citing works
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Self-citationPhasic dopamine release in appetitive behaviors and drug addiction
Wanat, M., Willuhn, I., Clark, J., & Phillips, P. (2009) · Current Drug Abuse Reviewse · doi:10.2174/1874473710902020195 · Cited by 177 · see citing works
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Edwards, S., & Koob, G. F. (2010) · Future Neurology · doi:10.2217/fnl.10.14 · Cited by 157 · see citing works
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Koob, G. F., & Mason, B. J. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103143 · Cited by 121 · see citing works
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Goldner, E. M., Lusted, A., Roerecke, M., Rehm, J., & Fischer, B. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.11.022 · Cited by 102 · see citing works
Porter, J. N., Olsen, A. S., Gurnsey, K., Dugan, B. P., Jedema, H. P., & Bradberry, C. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5426-10.2011 · Cited by 97 · see citing works
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- Authors
- Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Weiss, Friedbert
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1992-10
- Volume
- 593
- Issue
- 2
- Pages
- 314-318
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1991666427
- Cited by
- 318
- References
- 24
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 4 · 2020: 11 · 2019: 4 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 8 · 2012: 10
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f32da005444-01)
- National Institute on Drug Abuse (DA04398, R01DA004398, DA 05843, DA 05444)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cocaine withdrawal, nucleus accumbens, extracellular dopamine, dopamine release, cocaine self-administration, dopamine overflow, anhedonia
- MeSH terms
- Animals, Cocaine, Dopamine, Injections, Intravenous, Male, Nucleus Accumbens, Reference Values, Self Administration, Stereotaxic Techniques, Substance Withdrawal Syndrome, Time Factors, Rats, Wistar, Rats
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