N OTCH AND P RESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

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Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

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Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

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γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

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The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology

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Notch signalling: a simple pathway becomes complex

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

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Trafficking and Proteolytic Processing of APP

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Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

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BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

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Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

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Delivery of peptide and protein drugs over the blood–brain barrier

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Gene expression profiling in the adult Down syndrome brain

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Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing: Regulated intramembrane proteolysis and APP processing

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TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

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Alzheimer's disease: the lipid connection

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Dynamics of β-Amyloid Reductions in Brain, Cerebrospinal Fluid, and Plasma of β-Amyloid Precursor Protein Transgenic Mice Treated with a γ-Secretase Inhibitor

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Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

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The Familial Dementia BRI2 Gene Binds the Alzheimer Gene Amyloid-β Precursor Protein and Inhibits Amyloid-β Production

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Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities

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Disease modifying therapy for AD?1

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LRP1 shedding in human brain: roles of ADAM10 and ADAM17

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The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

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Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics

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Genetic Heterogeneity in Alzheimer Disease and Implications for Treatment Strategies

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Small things matter: implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer’s disease.

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Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch

Liu, W., Li, R., Yin, J., Guo, S., Chen, Y., Fan, H., Li, G., Li, Z., Li, X., Zhang, X., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1396-5 · Cited by 80

Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis

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Targeting the Role of the Endosome in the Pathophysiology of Alzheimer's Disease: A Strategy for Treatment

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Repeated cocaine exposure decreases dopamine D2‐like receptor modulation of Ca2+homeostasis in rat nucleus accumbens neurons

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A non-human primate model of familial Alzheimer’s disease

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Antisense-Mediated RNA Targeting: Versatile and Expedient Genetic Manipulation in the Brain

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Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice

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