γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?
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Ab 1-40 accounts for about 90% of all Ab fragments generated from APP-CTFb in amyloid plaques.
“Ab 1-40 accounts for about 90% of all Ab fragments generated from APP-CTFb in amyloid plaques. 36”
From NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models (2017) · cites this paper as [36]
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- Authors
- Sisodia, S. S., & St George-Hyslop, P. H.
- Affiliations
- University of Chicago (US)
- ORCID
- Sisodia, Sangram S.
- Venue
- Nature Reviews Neuroscience
- Published
- 2002-04
- Volume
- 3
- Issue
- 4
- Pages
- 281-290
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1541961513
- Cited by
- 512
- References
- 138
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 12 · 2018: 11 · 2017: 15 · 2016: 15 · 2015: 13 · 2014: 27 · 2013: 15 · 2012: 23
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Alzheimer Society
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- gamma-secretase, presenilin, Notch signaling, amyloid precursor protein, Alzheimer's disease, amyloid-beta, nicastrin, proteolytic processing, alpha-secretase, beta-secretase, ErbB4, substrate transport
- MeSH terms
- Alzheimer Disease, Animals, Humans, Membrane Proteins, Endopeptidases, Trans-Activators, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, Receptors, Notch, Amyloid Precursor Protein Secretases
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