The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Alzheimer's disease: the lipid connection
Abstract
Alzheimer’s disease is the most common neurodegenerative disorder. This short review summarizes the current knowledge about the role of lipids, especially cholesterol, sphingolipids, plasmalogens, and polyunsaturated fatty acids in Alzheimer’s disease etiology, pathogenesis, risk‐factors, prevention, treatment, and the function of the amyloid precursor protein and the amyloid peptides in lipid homeostasis.
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Outside lipid rafts, APP is processed at the plasma membrane by α-secretase and -secretases producing sAPP-α via the non-amyloidogenic pathway.
“Outside of lipid rafts, APP is processed at the PM by α-secretase and -secretases producing sAPP-α (non-amyloidogenic pathway) [38–40].”
From Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation (2023) · cites this paper as [38]
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“BACE1 is mainly expressed in neurons and the majority of BACE molecules are located in the Golgi apparatus and endosomes (Vassar et al., 1999).”
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“Numerous epidemiological studies indicate an inverse correlation between DHA intake and AD incidence (Barberger-Gateau et al., 2002; Kalmijn et al., 1997; Morris et al., 2003).”
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Control of Peripheral Nerve Myelination by the ß-Secretase BACE1
Willem, M., Garratt, A. N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P., Birchmeier, C., & Haass, C. (2006) · Science · doi:10.1126/science.1132341 · Cited by 703
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“Lipid metabolism is closely associated with AD at several stages (Hartmann et al., 2007).”
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Metadata
- Authors
- Hartmann, T., Kuchenbecker, J., & Grimm, M. O. W.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2007-11
- Volume
- 103
- Issue
- s1
- Pages
- 159-170
- ISSN
- 0022-3042
- 1471-4159
- Cited by
- 175
- References
- 11
- Language
- en
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