The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Wnt Signaling in Neural Circuit Assembly
Abstract
The Wnt family of secreted proteins plays a crucial role in nervous system wiring. Wnts regulate neuronal positioning, polarization, axon and dendrite development, and synaptogenesis. These diverse roles of Wnt proteins are due not only to the large numbers of Wnt ligands and receptors but also to their ability to signal through distinct signaling pathways in different cell types and developmental contexts. Studies on Wnts have shed new light on novel molecular mechanisms that control the development of complex neuronal connections. This review discusses recent advances on how Wnt signaling influences different aspects of neuronal circuit assembly through changes in gene expression and/or cytoskeletal modulation.
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In the citing paper
“The canonical Wnt signalling pathway participates in the formation of the antero-posterior axis patterning in axonal pathfinding and in synaptogenesis.[11][12][13]”
From Canonical Wnt pathway and the LDL receptor superfamily in neuronal cholesterol homeostasis and function (2024) · cites this paper as [13]
In the citing paper
“However, as clearly summarized by Kalkman (Kalkman, 2012), one must recognize the multiple roles of Wnt signaling, not only in cell adhesion and dendritic remodeling but also in early brain development (Rosso et al., 2005; Salinas and Zou, 2008; Ueda et al., 2008; Wayman et al., 2006; Yu and Malenka, 2003).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Salinas and Zou, 2008
In the citing paper
“Likewise, Wnt signaling is known to shape early cell-cell interactions (Nelson and Nusse, 2004), and to guide cell migration and differentiation of axons and dendrites (Salinas and Zou, 2008; Yu and Malenka, 2003);”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Salinas and Zou, 2008
In the citing paper
“Beta-catenin, via downstream WNT pathways, influences neuronal migration, polarity, and synaptogenesis [71], and constitutive overexpression of beta-catenin in mice results in macrocephaly [72].”
From A de novo convergence of autism genetics and molecular neuroscience (2014) · cites this paper as [71]
Citations
Cites
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors
Gordon, M. D., & Nusse, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600015200 · Cited by 1,333
Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269
Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
Mikels, A. J., & Nusse, R. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040115 · Cited by 1,244
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013
Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements
Veeman, M. T., Slusarski, D. C., Kaykas, A., Louie, S. H., & Moon, R. T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00240-9 · Cited by 945
Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance
Dent, E. W., & Gertler, F. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00633-0 · Cited by 922
Wnt and calcium signaling: β-Catenin-independent pathways
Kohn, A. D., & Moon, R. T. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.022 · Cited by 730
Research works printed but not linked: 1
- Klassen MP, Shen K. 2008. A Wnt signalling pathway inhibits synapse formation in theC. eleganstail. Cell. In press
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Neuroligins and neurexins link synaptic function to cognitive disease
Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849
Microtubule assembly, organization and dynamics in axons and dendrites
Conde, C., & Cáceres, A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2631 · Cited by 1,086
Can we safely target the WNT pathway?
Kahn, M. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4233 · Cited by 1,063
Gilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.021 · Cited by 701
Mechanisms underlying development of visual maps and receptive fields
Huberman, A. D., Feller, M. B., & Chapman, B. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125533 · Cited by 628
Metadata
- Authors
- Salinas, P. C., & Zou, Y.
- Affiliations
- University College London (GB)
- University of California San Diego (US)
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2008-07-01
- Volume
- 31
- Issue
- 1
- Pages
- 339-358
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2149676448
- Cited by
- 274
- References
- 113
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 13 · 2023: 5 · 2022: 20 · 2021: 6 · 2020: 9 · 2019: 9 · 2018: 10 · 2017: 12 · 2016: 9 · 2015: 10 · 2014: 21 · 2013: 34 · 2012: 29
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS047484)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, neural circuit assembly, neuronal positioning, neuronal polarity, axon development, dendrite formation, synaptogenesis, Wnt receptors, gene expression regulation
- MeSH terms
- Animals, Cell Differentiation, Central Nervous System, Cytoskeleton, Humans, Nerve Net, Neural Pathways, Neurons, Signal Transduction, Gene Expression Regulation, Developmental, Wnt Proteins
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