The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
DIETARY n-6 AND n-3 FATTY ACID BALANCE AND CARDIOVASCULAR HEALTH
Abstract
▪ Abstract Epidemiological and clinical studies have established that the n-6 fatty acid, linoleic acid (LA), and the n-3 fatty acids, linolenic acid (LNA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) collectively protect against coronary heart disease (CHD). LA is the major dietary fatty acid regulating low-density lipoprotein (LDL)-C metabolism by downregulating LDL-C production and enhancing its clearance. Further, the available mass of LA is a critical factor determining the hyperlipemic effects of other dietary fat components, such as saturated and trans fatty acids, as well as cholesterol. By contrast, n-3 fatty acids, especially EPA and DHA, are potent antiarryhthmic agents. EPA and DHA also improve vascular endothelial function and help lower blood pressure, platelet sensitivity, and the serum triglyceride level. The distinct functions of these two families make the balance between dietary n-6 and n-3 fatty acids an important consideration influencing cardiovascular health. Based on published literature describing practical dietary intakes, we suggest that consumption of ∼6% en LA, 0.75% en LNA, and 0.25% en EPA + DHA represents adequate and achievable intakes for most healthy adults. This corresponds to an n-6/n-3 ratio of ∼6:1. However, the absolute mass of essential fatty acids consumed, rather than their n-6/n-3 ratio, should be the first consideration when contemplating lifelong dietary habits affecting cardiovascular benefit from their intake.
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Trends in meat consumption in the USA
Daniel, C. R., Cross, A. J., Koebnick, C., & Sinha, R. (2011) · Public Health Nutrition · doi:10.1017/s1368980010002077 · Cited by 504
Essential fatty acids as functional components of foods- a review
Kaur, N., Chugh, V., & Gupta, A. K. (2014) · Journal of Food Science and Technology · doi:10.1007/s13197-012-0677-0 · Cited by 490
Hepatic lipid metabolism and non-alcoholic fatty liver disease
Tessari, P., Coracina, A., Cosma, A., & Tiengo, A. (2009) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.12.015 · Cited by 314
Fats and fatty acid requirements for adults
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Metadata
- Authors
- Wijendran, V., & Hayes, K. C.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2004-07-14
- Volume
- 24
- Issue
- 1
- Pages
- 597-615
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2128568125
- Cited by
- 609
- References
- 12
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
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