The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
REGULATION OF VITAMIN C TRANSPORT
Abstract
▪ Abstract Ascorbic acid and dehydroascorbic acid (DHAA, oxidized vitamin C) are dietary sources of vitamin C in humans. Both nutrients are absorbed from the lumen of the intestine and renal tubules by, respectively, enterocytes and renal epithelial cells. Subsequently vitamin C circulates in the blood and enters all of the other cells of the body. Concerning flux across the plasma membrane, simple diffusion of ascorbic acid plays only a small or negligible role. More important are specific mechanisms of transport and metabolism that concentrate vitamin C intracellularly to enhance its function as an enzyme cofactor and antioxidant. The known transport mechanisms are facilitated diffusion of DHAA through glucose-sensitive and -insensitive transporters, facilitated diffusion of ascorbate through channels, exocytosis of ascorbate in secretory vesicles, and secondary active transport of ascorbate through the sodium-dependent vitamin C transporters SVCT1 and SVCT2 proteins that are encoded by the genes Slc23a1 and Slc23a2, respectively. Evidence is reviewed indicating that these transport pathways are regulated under physiological conditions and altered by aging and disease.
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Cites
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Cited by
Modulation of oxidative stress as an anticancer strategy
Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579
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New developments and novel therapeutic perspectives for vitamin C
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Vitamin C: Update on physiology and pharmacology
Mandl, J., Szarka, A., & Bánhegyi, G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00282.x · Cited by 451
Biomarkers in nutritional epidemiology: applications, needs and new horizons
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Metadata
- Authors
- Wilson, J. X.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2005-08-21
- Volume
- 25
- Issue
- 1
- Pages
- 105-125
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W1998293871
- Cited by
- 377
- References
- 104
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
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